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The map label for this gene is guaA

Identifier: 50843224

GI number: 50843224

Start: 1925968

End: 1927560

Strand: Reverse

Name: guaA

Synonym: PPA1764

Alternate gene names: 50843224

Gene position: 1927560-1925968 (Counterclockwise)

Preceding gene: 50843226

Following gene: 50843217

Centisome position: 75.29

GC content: 60.95

Gene sequence:

>1593_bases
GTGGCGCCAGGTGGGGTCGTGGGCCATAGACTCGCCTTCATGGAACAACTTCACGACGTCGTTCTGGTGGTCGACTTCGG
CGCGCAGTACGCCCAGCTCATTGCCCGCCGGGTGCGTGAGGCGAATGTTTACTCCGAGATCGTCCCGCATAACATGCCAG
TGCGCGACATGCTCGCTAAGGAACCCGCCGCCATTATTCTTTCGGGTGGTCCGGCCTCGGTCTACGTAGAGGGCGCTCCG
AGCGTCGACCCGGCGTTGTTTAACGCTGGTGTGCCGGTGCTGGGCATCTGCTATGGATTCCAGGCCATGGCTCAGGCTCT
CGGCGGTCAGGTGGCTCATACCGGAGCATCGGAGTATGGACGCACCAGCCTGTGCATTACGTCCGCGGGGCAGCTTTTGT
CCCGTATTCCCCACACCATCAGCGTGTGGATGAGTCACGGCGATTCCGTCTCCCGTGCCCCGGAGGGATTTTCGACGTTG
GCCCGCACTGCGGGTGCTCCGGTGGCGGCGTTTGAAGACGTTGAGCGCAGACTCGTTGGCGTGCAGTGGCACCCCGAAGT
GCACCACACGGAGTCCGGACAGACGGTGCTCGAGCACTTCCTTTTCGACATTGCCGGATGCCGTCCTGACTGGAATGCCA
GCTCGATCGTCGGCGACCAGATCGCGCAGATTCGTGGCCAGGTTGGTGACCGGCGTGTCATCTGCGGACTGTCGGGTGGC
GTCGATTCCGCTGTCGCCGCGGCTTTGGTGCAGCGTGCTGTGGGCGACCAGCTCACCTGTGTTTTCGTCGATCACGGACT
GCTGCGTCAAGGGGAGGCCGAGCAAGTCAAGAACGACTTCGTCGCCGCCACGGGCGCAGATTTGGTGGTGGCTGATGAGT
CCCAGCGTTTCCTGGATGCCCTTGCCGGGGTCACCGATCCTGAGACCAAGCGCAAGATCATTGGACGCGAGTTCATTCGG
ACCTTTGAGGACGTTGCCAAGCGTCTCAATGCTGACCAGCCGATCGACTTCTTGGTGCAGGGAACTTTATATCCCGATGT
CGTCGAGTCTGGTGGCGGTGAGGGCGCTGCCAATATCAAGAGTCACCATAATGTTGGTGGGCTCCCTGACGACTTCCAGT
TCAGTCTCGTTGAGCCATTGCGCACCCTCTTTAAGGACGAGGTGCGAGCCGTCGGACTCGAACTTGGTCTGCCCGAGGAC
ATCGTCTGGCGTCAGCCCTTCCCGGGCCCGGGGCTGGCTATCCGCATTATTGGCGAAGTCACCGCGGAGCGTCTGGAGGT
GCTACGCACTGCCGATGCCATCACGCGTGAGGAAATGGGGGCCGCAGGCCTGGATCGCAAGGTATGGCAGTGCCCGGTCG
TCCTCCTGAGCGATGTTCATTCGGTAGGGGTACAGGGTGACGGGCGTACTTATGGTTCTCCCATTGTGCTTCGCCCGGTG
ACGAGCGAGGACGCCATGACTGCGGACTGGGCACGTATCCCATATGACGTACTGGAAAAGATCTCGACTCGCATTACGAA
TGCGTGTCCGCAAATCAACCGGGTGGTACTCGATATCACATCTAAACCGCCGGCCACCATCGAGTGGGAATGA

Upstream 100 bases:

>100_bases
GCCGTGGCCTTCCGGCCAACGGGGACAGGTGGTTTGACGCCATTGTGCGGCATCGTGTCACACGGTCGATGAGGGATCCA
CGCCGATATGGGGACCGCGA

Downstream 100 bases:

>100_bases
GCCCCGTCTCACCGTGAACATGACATGGCCCGCACCTTTCTTGGTGCGGGCCATGCCGTGTTAGTGCGGTCATGTCGGCG
AAATCGATGTTTCGGGTCAG

Product: GMP synthase

Products: NA

Alternate protein names: GMP synthetase; Glutamine amidotransferase

Number of amino acids: Translated: 530; Mature: 529

Protein sequence:

>530_residues
MAPGGVVGHRLAFMEQLHDVVLVVDFGAQYAQLIARRVREANVYSEIVPHNMPVRDMLAKEPAAIILSGGPASVYVEGAP
SVDPALFNAGVPVLGICYGFQAMAQALGGQVAHTGASEYGRTSLCITSAGQLLSRIPHTISVWMSHGDSVSRAPEGFSTL
ARTAGAPVAAFEDVERRLVGVQWHPEVHHTESGQTVLEHFLFDIAGCRPDWNASSIVGDQIAQIRGQVGDRRVICGLSGG
VDSAVAAALVQRAVGDQLTCVFVDHGLLRQGEAEQVKNDFVAATGADLVVADESQRFLDALAGVTDPETKRKIIGREFIR
TFEDVAKRLNADQPIDFLVQGTLYPDVVESGGGEGAANIKSHHNVGGLPDDFQFSLVEPLRTLFKDEVRAVGLELGLPED
IVWRQPFPGPGLAIRIIGEVTAERLEVLRTADAITREEMGAAGLDRKVWQCPVVLLSDVHSVGVQGDGRTYGSPIVLRPV
TSEDAMTADWARIPYDVLEKISTRITNACPQINRVVLDITSKPPATIEWE

Sequences:

>Translated_530_residues
MAPGGVVGHRLAFMEQLHDVVLVVDFGAQYAQLIARRVREANVYSEIVPHNMPVRDMLAKEPAAIILSGGPASVYVEGAP
SVDPALFNAGVPVLGICYGFQAMAQALGGQVAHTGASEYGRTSLCITSAGQLLSRIPHTISVWMSHGDSVSRAPEGFSTL
ARTAGAPVAAFEDVERRLVGVQWHPEVHHTESGQTVLEHFLFDIAGCRPDWNASSIVGDQIAQIRGQVGDRRVICGLSGG
VDSAVAAALVQRAVGDQLTCVFVDHGLLRQGEAEQVKNDFVAATGADLVVADESQRFLDALAGVTDPETKRKIIGREFIR
TFEDVAKRLNADQPIDFLVQGTLYPDVVESGGGEGAANIKSHHNVGGLPDDFQFSLVEPLRTLFKDEVRAVGLELGLPED
IVWRQPFPGPGLAIRIIGEVTAERLEVLRTADAITREEMGAAGLDRKVWQCPVVLLSDVHSVGVQGDGRTYGSPIVLRPV
TSEDAMTADWARIPYDVLEKISTRITNACPQINRVVLDITSKPPATIEWE
>Mature_529_residues
APGGVVGHRLAFMEQLHDVVLVVDFGAQYAQLIARRVREANVYSEIVPHNMPVRDMLAKEPAAIILSGGPASVYVEGAPS
VDPALFNAGVPVLGICYGFQAMAQALGGQVAHTGASEYGRTSLCITSAGQLLSRIPHTISVWMSHGDSVSRAPEGFSTLA
RTAGAPVAAFEDVERRLVGVQWHPEVHHTESGQTVLEHFLFDIAGCRPDWNASSIVGDQIAQIRGQVGDRRVICGLSGGV
DSAVAAALVQRAVGDQLTCVFVDHGLLRQGEAEQVKNDFVAATGADLVVADESQRFLDALAGVTDPETKRKIIGREFIRT
FEDVAKRLNADQPIDFLVQGTLYPDVVESGGGEGAANIKSHHNVGGLPDDFQFSLVEPLRTLFKDEVRAVGLELGLPEDI
VWRQPFPGPGLAIRIIGEVTAERLEVLRTADAITREEMGAAGLDRKVWQCPVVLLSDVHSVGVQGDGRTYGSPIVLRPVT
SEDAMTADWARIPYDVLEKISTRITNACPQINRVVLDITSKPPATIEWE

Specific function: Catalyzes the synthesis of GMP from XMP

COG id: COG0519

COG function: function code F; GMP synthase, PP-ATPase domain/subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GMP-binding domain

Homologues:

Organism=Homo sapiens, GI4504035, Length=546, Percent_Identity=36.2637362637363, Blast_Score=298, Evalue=9e-81,
Organism=Escherichia coli, GI1788854, Length=520, Percent_Identity=50.1923076923077, Blast_Score=493, Evalue=1e-140,
Organism=Escherichia coli, GI1789760, Length=154, Percent_Identity=33.1168831168831, Blast_Score=66, Evalue=6e-12,
Organism=Caenorhabditis elegans, GI71992717, Length=565, Percent_Identity=36.1061946902655, Blast_Score=301, Evalue=8e-82,
Organism=Caenorhabditis elegans, GI71992710, Length=565, Percent_Identity=36.1061946902655, Blast_Score=300, Evalue=8e-82,
Organism=Caenorhabditis elegans, GI133901714, Length=565, Percent_Identity=36.1061946902655, Blast_Score=300, Evalue=1e-81,
Organism=Saccharomyces cerevisiae, GI6323873, Length=521, Percent_Identity=46.257197696737, Blast_Score=475, Evalue=1e-135,
Organism=Saccharomyces cerevisiae, GI6322638, Length=173, Percent_Identity=27.7456647398844, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI281365319, Length=545, Percent_Identity=36.1467889908257, Blast_Score=293, Evalue=2e-79,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): GUAA_PROAC (Q6A6X1)

Other databases:

- EMBL:   AE017283
- RefSeq:   YP_056451.1
- ProteinModelPortal:   Q6A6X1
- SMR:   Q6A6X1
- GeneID:   2933057
- GenomeReviews:   AE017283_GR
- KEGG:   pac:PPA1764
- NMPDR:   fig|267747.1.peg.1728
- HOGENOM:   HBG391775
- OMA:   PSTIEPC
- ProtClustDB:   PRK00074
- BioCyc:   PACN267747:PPA1764-MONOMER
- BRENDA:   6.3.5.2
- HAMAP:   MF_00344
- InterPro:   IPR006220
- InterPro:   IPR001317
- InterPro:   IPR011702
- InterPro:   IPR017926
- InterPro:   IPR000991
- InterPro:   IPR001674
- InterPro:   IPR004739
- InterPro:   IPR022955
- InterPro:   IPR022310
- InterPro:   IPR014729
- Gene3D:   G3DSA:3.40.50.620
- PRINTS:   PR00097
- PRINTS:   PR00099
- PRINTS:   PR00096
- TIGRFAMs:   TIGR00884
- TIGRFAMs:   TIGR00888

Pfam domain/function: PF00117 GATase; PF00958 GMP_synt_C; PF02540 NAD_synthase

EC number: =6.3.5.2

Molecular weight: Translated: 56987; Mature: 56856

Theoretical pI: Translated: 4.86; Mature: 4.86

Prosite motif: PS51273 GATASE_TYPE_1; PS00442 GATASE_TYPE_I

Important sites: ACT_SITE 97-97 ACT_SITE 184-184 ACT_SITE 186-186

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAPGGVVGHRLAFMEQLHDVVLVVDFGAQYAQLIARRVREANVYSEIVPHNMPVRDMLAK
CCCCCHHHHHHHHHHHHHHEEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHC
EPAAIILSGGPASVYVEGAPSVDPALFNAGVPVLGICYGFQAMAQALGGQVAHTGASEYG
CCCEEEEECCCCEEEECCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHCCCEEECCCHHCC
RTSLCITSAGQLLSRIPHTISVWMSHGDSVSRAPEGFSTLARTAGAPVAAFEDVERRLVG
CCEEEHHHHHHHHHHCCHHEEHHHHCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHCC
VQWHPEVHHTESGQTVLEHFLFDIAGCRPDWNASSIVGDQIAQIRGQVGDRRVICGLSGG
CEECCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCC
VDSAVAAALVQRAVGDQLTCVFVDHGLLRQGEAEQVKNDFVAATGADLVVADESQRFLDA
HHHHHHHHHHHHHHCCCEEEEEECCCHHCCCCHHHHHHHHEEECCCCEEEECCHHHHHHH
LAGVTDPETKRKIIGREFIRTFEDVAKRLNADQPIDFLVQGTLYPDVVESGGGEGAANIK
HCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHEEEECCCCHHHHHCCCCCCCCCCC
SHHNVGGLPDDFQFSLVEPLRTLFKDEVRAVGLELGLPEDIVWRQPFPGPGLAIRIIGEV
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEHHHH
TAERLEVLRTADAITREEMGAAGLDRKVWQCPVVLLSDVHSVGVQGDGRTYGSPIVLRPV
HHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEC
TSEDAMTADWARIPYDVLEKISTRITNACPQINRVVLDITSKPPATIEWE
CCCCCCCCHHHHCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCC
>Mature Secondary Structure 
APGGVVGHRLAFMEQLHDVVLVVDFGAQYAQLIARRVREANVYSEIVPHNMPVRDMLAK
CCCCHHHHHHHHHHHHHHEEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHC
EPAAIILSGGPASVYVEGAPSVDPALFNAGVPVLGICYGFQAMAQALGGQVAHTGASEYG
CCCEEEEECCCCEEEECCCCCCCHHHHHCCCCHHHHHHHHHHHHHHHCCCEEECCCHHCC
RTSLCITSAGQLLSRIPHTISVWMSHGDSVSRAPEGFSTLARTAGAPVAAFEDVERRLVG
CCEEEHHHHHHHHHHCCHHEEHHHHCCCCCCCCCCHHHHHHHHCCCCHHHHHHHHHHHCC
VQWHPEVHHTESGQTVLEHFLFDIAGCRPDWNASSIVGDQIAQIRGQVGDRRVICGLSGG
CEECCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCCEEEEEECCC
VDSAVAAALVQRAVGDQLTCVFVDHGLLRQGEAEQVKNDFVAATGADLVVADESQRFLDA
HHHHHHHHHHHHHHCCCEEEEEECCCHHCCCCHHHHHHHHEEECCCCEEEECCHHHHHHH
LAGVTDPETKRKIIGREFIRTFEDVAKRLNADQPIDFLVQGTLYPDVVESGGGEGAANIK
HCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHEEEECCCCHHHHHCCCCCCCCCCC
SHHNVGGLPDDFQFSLVEPLRTLFKDEVRAVGLELGLPEDIVWRQPFPGPGLAIRIIGEV
CCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEHHHH
TAERLEVLRTADAITREEMGAAGLDRKVWQCPVVLLSDVHSVGVQGDGRTYGSPIVLRPV
HHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEC
TSEDAMTADWARIPYDVLEKISTRITNACPQINRVVLDITSKPPATIEWE
CCCCCCCCHHHHCCHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA