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The map label for this gene is pccB [H]

Identifier: 50843169

GI number: 50843169

Start: 1860626

End: 1862200

Strand: Direct

Name: pccB [H]

Synonym: PPA1707

Alternate gene names: 50843169

Gene position: 1860626-1862200 (Clockwise)

Preceding gene: 50843168

Following gene: 50843170

Centisome position: 72.67

GC content: 60.44

Gene sequence:

>1575_bases
ATGGAGATCGACATCCACACCACGGCCGGGAAGATCGCCGACCTCGGTCGGAGGATCGACGAGGCCGTCAATGCCGCATC
CCCCTCGGCCATCGAAAAGCAACATGCCACCGGAAAGATGACCGCCCGGGAGCGCATCTTACGGCTACTCGATGAAGATT
CCTTTACTGAGCTTGACGAGTTCGCCCGTCACCGCTCAACGAACTTCGGCATGGACCGCAAACGTCCGTACACCGACGGG
GTCATCACCGGTGTCGGCGCGATCCATGGTCGCCCGGTTTGTGTATTCAGCCAGGACGTCACTATCTTCGGCGGATCCCT
CGGCGAAGTCTACGGCGAGAAAATCTGCAAAATCATTGACTTCGCCGTCAAGACTGGTTGTCCCCTTATCGGCATCAATG
AGGGCGGCGGCGCACGCATCCAAGAGGGAGTGGCCTCCCTGGCCCGCTTCGGTGATATTTTCCGCCGCAACACCAGGGCC
TCCGGTGTTATCCCCCAGATCTCCATCATCATGGGTGCGGCGGCCGGAGGCCACGTCTACTCTCCTGCCCTCACTGACTT
CATTGTTATGGTCGACCAGACCTCCCAGATGTTCATCACCGGCCCGGCTGTCGTCAAGCAAGTCACCGGTGAGGACGTCT
CTCTCGAAGAGCTGGGCGGCGCACGCACCCACTCCGTCAAGTCAGGCAATTCCCACTACCTGGCCAATGACGAGGACGAT
GCTCTCGAGTTCGTCCGCGACCTCATTAGCTATCTTCCGCAGAACAACCTTGAGGATCCGCCGTTCTACGACGATGGCGA
GGCCGACCTGACGATCACCGATCACGACCGCAAGCTCGACGTTCTCATCCCGGACTCTTCACATCAGCCCTATGACATGC
ACGAGGTCATTACGACCGTGCTGGACGAAGACACCTTCCTGGAGATCCACGAACTTTTCGCCCCCAACGTCATCTGCGGA
TTCGGACGCATTGAAGGTCGTGCGATCGGCATCGTCGCCAACCAACCGATGATCAATGCCGGCACCCTCGACATCGACGC
ATCTGAGAAGGCCGCCCGGTTCGTACGCACCTGCGACTCTTTTAACATTCCGGTGCTCACCTTCGTCGACACCCCTGGTT
TCCTGCCCGGCGTCGAGCAAGAGCACGACGGCATTATCCGCCGCGGCGCCAAACTCATTTATGCCTACGCTGAGGCCACC
GTGCCGCTGCTGACCGTCGTCACCCGCAAGGCCTACGGCGGCGCCTACATCGTGATGGGGTCCAAGACCCTCGGCGCCGA
CGTCAATCTGGCCTGGCCTACCGCGCAGATTGCCGTCATGGGGGCCGAGGGGGCCGTCAGCATCCTGCATCGACGCACTC
TTGCCATGGATCCTGATCCACAGGCCAAGCGCAAAGAGCTCATTGACGAATACGAGACGACGCTATCGAACCCGTACCAG
GCTGCCGAGCGCGGTTGGATCGACCAGGTTATCCATCCGCACGAGACTCGCGCCTCGGTCATCCGCACCCTTCGTCTGCT
GCGTACCAAGCGTGAGACCCTGCCTCCCAAGAAGCACGGAAACATCCCGCTGTGA

Upstream 100 bases:

>100_bases
CCCAGTGATCCCGCGGCACCATTAAATCGTCCCGGGGATAAGTCGTCCCGGGGAGCGGCCCGGCACCACATTTGTCGCCT
CTGACGGATAGTCTCAGCAT

Downstream 100 bases:

>100_bases
GTGAGGGCGCCATGAACGATGCAATTACGGTGACGAAGGGGAATCTCACCGACGAGGAGCTCGGCGCGCTGGTGACGGTG
TTGGCCGAGCTCACTCGCCC

Product: propionyl-CoA carboxylase beta chain

Products: NA

Alternate protein names: PCCase; Propanoyl-CoA:carbon dioxide ligase [H]

Number of amino acids: Translated: 524; Mature: 524

Protein sequence:

>524_residues
MEIDIHTTAGKIADLGRRIDEAVNAASPSAIEKQHATGKMTARERILRLLDEDSFTELDEFARHRSTNFGMDRKRPYTDG
VITGVGAIHGRPVCVFSQDVTIFGGSLGEVYGEKICKIIDFAVKTGCPLIGINEGGGARIQEGVASLARFGDIFRRNTRA
SGVIPQISIIMGAAAGGHVYSPALTDFIVMVDQTSQMFITGPAVVKQVTGEDVSLEELGGARTHSVKSGNSHYLANDEDD
ALEFVRDLISYLPQNNLEDPPFYDDGEADLTITDHDRKLDVLIPDSSHQPYDMHEVITTVLDEDTFLEIHELFAPNVICG
FGRIEGRAIGIVANQPMINAGTLDIDASEKAARFVRTCDSFNIPVLTFVDTPGFLPGVEQEHDGIIRRGAKLIYAYAEAT
VPLLTVVTRKAYGGAYIVMGSKTLGADVNLAWPTAQIAVMGAEGAVSILHRRTLAMDPDPQAKRKELIDEYETTLSNPYQ
AAERGWIDQVIHPHETRASVIRTLRLLRTKRETLPPKKHGNIPL

Sequences:

>Translated_524_residues
MEIDIHTTAGKIADLGRRIDEAVNAASPSAIEKQHATGKMTARERILRLLDEDSFTELDEFARHRSTNFGMDRKRPYTDG
VITGVGAIHGRPVCVFSQDVTIFGGSLGEVYGEKICKIIDFAVKTGCPLIGINEGGGARIQEGVASLARFGDIFRRNTRA
SGVIPQISIIMGAAAGGHVYSPALTDFIVMVDQTSQMFITGPAVVKQVTGEDVSLEELGGARTHSVKSGNSHYLANDEDD
ALEFVRDLISYLPQNNLEDPPFYDDGEADLTITDHDRKLDVLIPDSSHQPYDMHEVITTVLDEDTFLEIHELFAPNVICG
FGRIEGRAIGIVANQPMINAGTLDIDASEKAARFVRTCDSFNIPVLTFVDTPGFLPGVEQEHDGIIRRGAKLIYAYAEAT
VPLLTVVTRKAYGGAYIVMGSKTLGADVNLAWPTAQIAVMGAEGAVSILHRRTLAMDPDPQAKRKELIDEYETTLSNPYQ
AAERGWIDQVIHPHETRASVIRTLRLLRTKRETLPPKKHGNIPL
>Mature_524_residues
MEIDIHTTAGKIADLGRRIDEAVNAASPSAIEKQHATGKMTARERILRLLDEDSFTELDEFARHRSTNFGMDRKRPYTDG
VITGVGAIHGRPVCVFSQDVTIFGGSLGEVYGEKICKIIDFAVKTGCPLIGINEGGGARIQEGVASLARFGDIFRRNTRA
SGVIPQISIIMGAAAGGHVYSPALTDFIVMVDQTSQMFITGPAVVKQVTGEDVSLEELGGARTHSVKSGNSHYLANDEDD
ALEFVRDLISYLPQNNLEDPPFYDDGEADLTITDHDRKLDVLIPDSSHQPYDMHEVITTVLDEDTFLEIHELFAPNVICG
FGRIEGRAIGIVANQPMINAGTLDIDASEKAARFVRTCDSFNIPVLTFVDTPGFLPGVEQEHDGIIRRGAKLIYAYAEAT
VPLLTVVTRKAYGGAYIVMGSKTLGADVNLAWPTAQIAVMGAEGAVSILHRRTLAMDPDPQAKRKELIDEYETTLSNPYQ
AAERGWIDQVIHPHETRASVIRTLRLLRTKRETLPPKKHGNIPL

Specific function: This Protein Is A Component Of The Acetyl Coenzyme A Carboxylase Complex; First, Biotin Carboxylase Catalyzes The Carboxylation Of The Carrier Protein And Then The Transcarboxylase Transfers The Carboxyl Group To Form Malonyl-CoA. [C]

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI119943100, Length=496, Percent_Identity=53.4274193548387, Blast_Score=514, Evalue=1e-146,
Organism=Homo sapiens, GI295821216, Length=516, Percent_Identity=51.3565891472868, Blast_Score=502, Evalue=1e-142,
Organism=Homo sapiens, GI11545863, Length=476, Percent_Identity=31.7226890756302, Blast_Score=199, Evalue=5e-51,
Organism=Escherichia coli, GI1788655, Length=191, Percent_Identity=27.2251308900524, Blast_Score=75, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI25147362, Length=517, Percent_Identity=51.8375241779497, Blast_Score=515, Evalue=1e-146,
Organism=Caenorhabditis elegans, GI25147359, Length=517, Percent_Identity=51.8375241779497, Blast_Score=514, Evalue=1e-146,
Organism=Caenorhabditis elegans, GI17552936, Length=530, Percent_Identity=30.9433962264151, Blast_Score=229, Evalue=4e-60,
Organism=Saccharomyces cerevisiae, GI6323863, Length=386, Percent_Identity=22.5388601036269, Blast_Score=65, Evalue=2e-11,
Organism=Drosophila melanogaster, GI24586065, Length=521, Percent_Identity=30.7101727447217, Blast_Score=222, Evalue=4e-58,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000438
- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: =6.4.1.3 [H]

Molecular weight: Translated: 57285; Mature: 57285

Theoretical pI: Translated: 5.17; Mature: 5.17

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIDIHTTAGKIADLGRRIDEAVNAASPSAIEKQHATGKMTARERILRLLDEDSFTELDE
CEEEEECCHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCHHHHHHHHHHHCCCCHHHHHH
FARHRSTNFGMDRKRPYTDGVITGVGAIHGRPVCVFSQDVTIFGGSLGEVYGEKICKIID
HHHHCCCCCCCCCCCCCCCCHHCCCCCCCCCEEEEEECCCEEECCCHHHHHHHHHHHHHH
FAVKTGCPLIGINEGGGARIQEGVASLARFGDIFRRNTRASGVIPQISIIMGAAAGGHVY
HHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCCC
SPALTDFIVMVDQTSQMFITGPAVVKQVTGEDVSLEELGGARTHSVKSGNSHYLANDEDD
CHHHHEEEEEEECCCCEEEECHHHHHHHCCCCCCHHHHCCCCEECCCCCCCCCCCCCCHH
ALEFVRDLISYLPQNNLEDPPFYDDGEADLTITDHDRKLDVLIPDSSHQPYDMHEVITTV
HHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEECCCCEEEEEECCCCCCCCHHHHHHHHH
LDEDTFLEIHELFAPNVICGFGRIEGRAIGIVANQPMINAGTLDIDASEKAARFVRTCDS
HCCCHHHHHHHHHCCCEEEECCCCCCEEEEEEECCCEECCCEEECCCHHHHHHHHHHHCC
FNIPVLTFVDTPGFLPGVEQEHDGIIRRGAKLIYAYAEATVPLLTVVTRKAYGGAYIVMG
CCCCEEEEECCCCCCCCCCCHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHCCCCEEEEEC
SKTLGADVNLAWPTAQIAVMGAEGAVSILHRRTLAMDPDPQAKRKELIDEYETTLSNPYQ
CCCCCCCCEEECCCEEEEEECCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCHH
AAERGWIDQVIHPHETRASVIRTLRLLRTKRETLPPKKHGNIPL
HHHCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC
>Mature Secondary Structure
MEIDIHTTAGKIADLGRRIDEAVNAASPSAIEKQHATGKMTARERILRLLDEDSFTELDE
CEEEEECCHHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCHHHHHHHHHHHCCCCHHHHHH
FARHRSTNFGMDRKRPYTDGVITGVGAIHGRPVCVFSQDVTIFGGSLGEVYGEKICKIID
HHHHCCCCCCCCCCCCCCCCHHCCCCCCCCCEEEEEECCCEEECCCHHHHHHHHHHHHHH
FAVKTGCPLIGINEGGGARIQEGVASLARFGDIFRRNTRASGVIPQISIIMGAAAGGHVY
HHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEEECCCCCCCC
SPALTDFIVMVDQTSQMFITGPAVVKQVTGEDVSLEELGGARTHSVKSGNSHYLANDEDD
CHHHHEEEEEEECCCCEEEECHHHHHHHCCCCCCHHHHCCCCEECCCCCCCCCCCCCCHH
ALEFVRDLISYLPQNNLEDPPFYDDGEADLTITDHDRKLDVLIPDSSHQPYDMHEVITTV
HHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEECCCCEEEEEECCCCCCCCHHHHHHHHH
LDEDTFLEIHELFAPNVICGFGRIEGRAIGIVANQPMINAGTLDIDASEKAARFVRTCDS
HCCCHHHHHHHHHCCCEEEECCCCCCEEEEEEECCCEECCCEEECCCHHHHHHHHHHHCC
FNIPVLTFVDTPGFLPGVEQEHDGIIRRGAKLIYAYAEATVPLLTVVTRKAYGGAYIVMG
CCCCEEEEECCCCCCCCCCCHHHHHHHCCCCEEEEEHHHHHHHHHHHHHHCCCCEEEEEC
SKTLGADVNLAWPTAQIAVMGAEGAVSILHRRTLAMDPDPQAKRKELIDEYETTLSNPYQ
CCCCCCCCEEECCCEEEEEECCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCHH
AAERGWIDQVIHPHETRASVIRTLRLLRTKRETLPPKKHGNIPL
HHHCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8830278 [H]