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The map label for this gene is pgl [H]

Identifier: 50843039

GI number: 50843039

Start: 1685055

End: 1685789

Strand: Direct

Name: pgl [H]

Synonym: PPA1565

Alternate gene names: 50843039

Gene position: 1685055-1685789 (Clockwise)

Preceding gene: 50843038

Following gene: 50843040

Centisome position: 65.82

GC content: 59.73

Gene sequence:

>735_bases
ATGACAAGCCGACGCCTCATGCGGTACCAATCCGCCCAGGGGCTGGCCGAGGGGGTTGCCCACCGGCTAGTACAGACGAT
CGTCAGGATCCAGGCCGCGCAGGAACGTATCGACCTGTGTCTCACCGGCGGGAGGATCGCCAATATCGTCTATGCCGCTA
TGGAAGACGTTCCCGAATGCGCCAAGATTCGTCCAGACCAGTTACACGTCTGGTGGGGTGATGACCGATTCGTCCCCACC
GGTCATCCTGACCGTAATTCCCTGCAAGCCCTGTCTCTATTGTCGTCAGCTATCCGTCTGGACCCTTCAAAGACCCACGT
TATGCCCGCCGCCGACGGCAAGGCCGATCCCGACGAGGCCGCCTATTCCTACGCCCAGGAGCTCGGCGGTGTCGTCTTCG
ACATTTGTTTGCTGGGGATGGGTACCGACGGCCACGTTGCTTCCCTGTTTCCAGGCCATCCCTCCTTCAATCCCACAACA
GCCGCGCTGGCTGTTGGCGTCACGGATGCTCCCAAGCCTCCGCCGGATCGTCTCTCAGTTACGATGCCTGTCATCAACAG
GTCGAAACGAGTCTGGTTCCTTGTCAGTGGGCCCGAAAAAGCTGAGGCTGTCGAGAAGGTTTTTGCTGGAGACGAGTCCT
TGCCGGCTACCTGGGCCAACGGCACTATCGAGACGAGTTGGATGGTCGACCATGACGCCTCGATCGGTCTACCGAGGTAC
AATTGCTCGCTGTGA

Upstream 100 bases:

>100_bases
AGCTTCGTCGACTCGGCCCCGACAAGGTGTTCACCGCTGTCATGGCTGAAATTCACGATGGGGCGGGCCGAATCTCATTG
ACGAATGGTAGGGATGAGTC

Downstream 100 bases:

>100_bases
TGCCGCGGTAACTACGGCGTCACCACGGTCGTAGCCCCGCTGCGTGGTCCAGCGGCTCACAGACCACACGACCGGGCGAG
TTGTCGCTGACAGCTAACAT

Product: 6-phosphogluconolactonase

Products: NA

Alternate protein names: 6PGL [H]

Number of amino acids: Translated: 244; Mature: 243

Protein sequence:

>244_residues
MTSRRLMRYQSAQGLAEGVAHRLVQTIVRIQAAQERIDLCLTGGRIANIVYAAMEDVPECAKIRPDQLHVWWGDDRFVPT
GHPDRNSLQALSLLSSAIRLDPSKTHVMPAADGKADPDEAAYSYAQELGGVVFDICLLGMGTDGHVASLFPGHPSFNPTT
AALAVGVTDAPKPPPDRLSVTMPVINRSKRVWFLVSGPEKAEAVEKVFAGDESLPATWANGTIETSWMVDHDASIGLPRY
NCSL

Sequences:

>Translated_244_residues
MTSRRLMRYQSAQGLAEGVAHRLVQTIVRIQAAQERIDLCLTGGRIANIVYAAMEDVPECAKIRPDQLHVWWGDDRFVPT
GHPDRNSLQALSLLSSAIRLDPSKTHVMPAADGKADPDEAAYSYAQELGGVVFDICLLGMGTDGHVASLFPGHPSFNPTT
AALAVGVTDAPKPPPDRLSVTMPVINRSKRVWFLVSGPEKAEAVEKVFAGDESLPATWANGTIETSWMVDHDASIGLPRY
NCSL
>Mature_243_residues
TSRRLMRYQSAQGLAEGVAHRLVQTIVRIQAAQERIDLCLTGGRIANIVYAAMEDVPECAKIRPDQLHVWWGDDRFVPTG
HPDRNSLQALSLLSSAIRLDPSKTHVMPAADGKADPDEAAYSYAQELGGVVFDICLLGMGTDGHVASLFPGHPSFNPTTA
ALAVGVTDAPKPPPDRLSVTMPVINRSKRVWFLVSGPEKAEAVEKVFAGDESLPATWANGTIETSWMVDHDASIGLPRYN
CSL

Specific function: Hydrolysis of 6-phosphogluconolactone to 6- phosphogluconate [H]

COG id: COG0363

COG function: function code G; 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily [H]

Homologues:

Organism=Homo sapiens, GI52145310, Length=181, Percent_Identity=35.9116022099448, Blast_Score=92, Evalue=4e-19,
Organism=Homo sapiens, GI6912586, Length=241, Percent_Identity=31.1203319502075, Blast_Score=90, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI115533058, Length=207, Percent_Identity=27.536231884058, Blast_Score=85, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI115533060, Length=207, Percent_Identity=27.536231884058, Blast_Score=85, Evalue=3e-17,
Organism=Saccharomyces cerevisiae, GI6321957, Length=235, Percent_Identity=29.3617021276596, Blast_Score=87, Evalue=3e-18,
Organism=Saccharomyces cerevisiae, GI6319918, Length=217, Percent_Identity=29.9539170506912, Blast_Score=80, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6321687, Length=261, Percent_Identity=26.4367816091954, Blast_Score=77, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6324362, Length=212, Percent_Identity=28.7735849056604, Blast_Score=77, Evalue=3e-15,
Organism=Drosophila melanogaster, GI24641119, Length=215, Percent_Identity=28.8372093023256, Blast_Score=97, Evalue=1e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005900 [H]

Pfam domain/function: NA

EC number: =3.1.1.31 [H]

Molecular weight: Translated: 26429; Mature: 26298

Theoretical pI: Translated: 5.88; Mature: 5.88

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTSRRLMRYQSAQGLAEGVAHRLVQTIVRIQAAQERIDLCLTGGRIANIVYAAMEDVPEC
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCHHHHHHHHHHHCCHHH
AKIRPDQLHVWWGDDRFVPTGHPDRNSLQALSLLSSAIRLDPSKTHVMPAADGKADPDEA
HHCCCCEEEEEECCCEECCCCCCCHHHHHHHHHHHHHHHCCCCHHEEEECCCCCCCHHHH
AYSYAQELGGVVFDICLLGMGTDGHVASLFPGHPSFNPTTAALAVGVTDAPKPPPDRLSV
HHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCHHEEEEECCCCCCCCCCCEEE
TMPVINRSKRVWFLVSGPEKAEAVEKVFAGDESLPATWANGTIETSWMVDHDASIGLPRY
EEEEECCCCEEEEEECCCHHHHHHHHHHCCCCCCCCEECCCEEEEEEEEECCCCCCCCCC
NCSL
CCCC
>Mature Secondary Structure 
TSRRLMRYQSAQGLAEGVAHRLVQTIVRIQAAQERIDLCLTGGRIANIVYAAMEDVPEC
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCHHHHHHHHHHHCCHHH
AKIRPDQLHVWWGDDRFVPTGHPDRNSLQALSLLSSAIRLDPSKTHVMPAADGKADPDEA
HHCCCCEEEEEECCCEECCCCCCCHHHHHHHHHHHHHHHCCCCHHEEEECCCCCCCHHHH
AYSYAQELGGVVFDICLLGMGTDGHVASLFPGHPSFNPTTAALAVGVTDAPKPPPDRLSV
HHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCHHEEEEECCCCCCCCCCCEEE
TMPVINRSKRVWFLVSGPEKAEAVEKVFAGDESLPATWANGTIETSWMVDHDASIGLPRY
EEEEECCCCEEEEEECCCHHHHHHHHHHCCCCCCCCEECCCEEEEEEEEECCCCCCCCCC
NCSL
CCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12000953 [H]