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The map label for this gene is csd [H]

Identifier: 50843021

GI number: 50843021

Start: 1663417

End: 1664658

Strand: Reverse

Name: csd [H]

Synonym: PPA1545

Alternate gene names: 50843021

Gene position: 1664658-1663417 (Counterclockwise)

Preceding gene: 50843022

Following gene: 50843020

Centisome position: 65.02

GC content: 60.95

Gene sequence:

>1242_bases
ATGAGCTACGACGTCGAGAAGATCAGGAAAGACTTTCCCATCCTGTCCACCAGGGTGGGGGATTACCCGTTGACGTACCT
CGACTCGGCTAACACTTCCCAAAAACCCCAGGTTGTCATTGACGCTCTGAGCGAGCACTACGCCCGTCACAACGCCAACG
TTGCACGGGCCATGCACCAGCTCGGGTTGGAGTCCACCCAGGCTTATGAGGGTGGGCGGGAACGCCTCGCGCGTTTTATC
GGGGCGGCGCGCCCTGAGGAAGTGGTGGCTCTGTCGAACGCGTCTGAAGCTCTTAATTTGTGCGCGTACACCCTGGGTGA
GCGTCTCGGACCTGATGACGAGGTCGTCATTTCGGTGATGGAGCACCACTCCAACTTGGTTCCGTGGCAGATCGTTTGTC
AGCGCACCGGTGCCACCCTGAGGTGTTTCGACATCACTGATGACGGCCGCCTCGACCTCGAGAAGGCTGAGGCGGAGGGG
CTCATTAATGAGCGCACCAAGGTCGTCTCGTTGACGTTGGCCTCGAACGTGCTGGGGACGATCAATCCCATCGGGAAGAT
TGCCGAGCAGGCCCACTCCGTCGGTGCCGTCATGGTCGTCGACGCGTCTCAGGCCGTGCCTCAGATACCTGTCGATATGA
CGACCTTGGGCGCTGATTTGGTGGCCTTCACCGGTCACAAGATGTGCGGTCCGACGGGTATCGGCATTCTCTGGGGACGC
TATGACCTCCTCGCTGAGCTACCGCCCTTCCTCGGAGGCGGCGAGATGATCGAGGTCGTGCGCATGGAGGGATCGACCTA
CGCCGAGCCTCCACATCGTTTTGAGGCAGGCACCCCGCCGATCGCACAGCTGGCTGCCCTCGGGGTGGCCGCCGACTACC
TAGATGGCATCGGGATGCAGGCCATCGCCGAGCACGAACATGAGCTGGCTGCTCGGATGCTCGAAGAGCTCCAGACCGTC
AAGGGAGTGCACATCCTCGGACCAAGCGACGCCACCGCTCGTACCGGAACGGTGTCTTTCACCATCGAGGGGGTGCATCC
ACATGACGCGATGAGCATCATGGATGGTCATGGCGTTGCGGTGCGAGGCGGTCACCACTGCGCCAGGCCGTTGCATGAGA
GATTGGGAATACAGTCCTCCCTCCGTGCGTCGTCATACTTGTACTCCACTACCGACGAGGTGAACCGCCTCGTCGAATCT
GTCGAGTACGCTCGGAACTTCTTCGCCGGAGGTGTGGCATGA

Upstream 100 bases:

>100_bases
ACGGTCGGGTTGCCGCTACTGGCGGTCCGGAGCTGGGCGAAGAGCTCGAGGCTGAAGGCTACGAGAAGTACCTGTCCGCT
GCCAAGGCCAACGCCTAATT

Downstream 100 bases:

>100_bases
ACGTCGAAGAGATGTACCAGCAGATCATCCTGGACCACTACCGGGAGAAGCATCACAGCGGTCTGCGCGAGAACTATGAC
GCCGAGGTAACGCAGGTCAA

Product: putative cysteine desulfurase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 413; Mature: 412

Protein sequence:

>413_residues
MSYDVEKIRKDFPILSTRVGDYPLTYLDSANTSQKPQVVIDALSEHYARHNANVARAMHQLGLESTQAYEGGRERLARFI
GAARPEEVVALSNASEALNLCAYTLGERLGPDDEVVISVMEHHSNLVPWQIVCQRTGATLRCFDITDDGRLDLEKAEAEG
LINERTKVVSLTLASNVLGTINPIGKIAEQAHSVGAVMVVDASQAVPQIPVDMTTLGADLVAFTGHKMCGPTGIGILWGR
YDLLAELPPFLGGGEMIEVVRMEGSTYAEPPHRFEAGTPPIAQLAALGVAADYLDGIGMQAIAEHEHELAARMLEELQTV
KGVHILGPSDATARTGTVSFTIEGVHPHDAMSIMDGHGVAVRGGHHCARPLHERLGIQSSLRASSYLYSTTDEVNRLVES
VEYARNFFAGGVA

Sequences:

>Translated_413_residues
MSYDVEKIRKDFPILSTRVGDYPLTYLDSANTSQKPQVVIDALSEHYARHNANVARAMHQLGLESTQAYEGGRERLARFI
GAARPEEVVALSNASEALNLCAYTLGERLGPDDEVVISVMEHHSNLVPWQIVCQRTGATLRCFDITDDGRLDLEKAEAEG
LINERTKVVSLTLASNVLGTINPIGKIAEQAHSVGAVMVVDASQAVPQIPVDMTTLGADLVAFTGHKMCGPTGIGILWGR
YDLLAELPPFLGGGEMIEVVRMEGSTYAEPPHRFEAGTPPIAQLAALGVAADYLDGIGMQAIAEHEHELAARMLEELQTV
KGVHILGPSDATARTGTVSFTIEGVHPHDAMSIMDGHGVAVRGGHHCARPLHERLGIQSSLRASSYLYSTTDEVNRLVES
VEYARNFFAGGVA
>Mature_412_residues
SYDVEKIRKDFPILSTRVGDYPLTYLDSANTSQKPQVVIDALSEHYARHNANVARAMHQLGLESTQAYEGGRERLARFIG
AARPEEVVALSNASEALNLCAYTLGERLGPDDEVVISVMEHHSNLVPWQIVCQRTGATLRCFDITDDGRLDLEKAEAEGL
INERTKVVSLTLASNVLGTINPIGKIAEQAHSVGAVMVVDASQAVPQIPVDMTTLGADLVAFTGHKMCGPTGIGILWGRY
DLLAELPPFLGGGEMIEVVRMEGSTYAEPPHRFEAGTPPIAQLAALGVAADYLDGIGMQAIAEHEHELAARMLEELQTVK
GVHILGPSDATARTGTVSFTIEGVHPHDAMSIMDGHGVAVRGGHHCARPLHERLGIQSSLRASSYLYSTTDEVNRLVESV
EYARNFFAGGVA

Specific function: Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L- selenocystine to produce L-alanine [H]

COG id: COG0520

COG function: function code E; Selenocysteine lyase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=292, Percent_Identity=25.3424657534247, Blast_Score=91, Evalue=2e-18,
Organism=Escherichia coli, GI1787970, Length=404, Percent_Identity=42.5742574257426, Blast_Score=330, Evalue=1e-91,
Organism=Escherichia coli, GI1789175, Length=403, Percent_Identity=33.7468982630273, Blast_Score=238, Evalue=6e-64,
Organism=Escherichia coli, GI48994898, Length=364, Percent_Identity=26.0989010989011, Blast_Score=92, Evalue=4e-20,
Organism=Caenorhabditis elegans, GI193211090, Length=366, Percent_Identity=27.5956284153005, Blast_Score=99, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI25143064, Length=230, Percent_Identity=25.6521739130435, Blast_Score=85, Evalue=9e-17,
Organism=Saccharomyces cerevisiae, GI6319831, Length=239, Percent_Identity=27.6150627615063, Blast_Score=94, Evalue=4e-20,
Organism=Drosophila melanogaster, GI20129463, Length=243, Percent_Identity=28.3950617283951, Blast_Score=103, Evalue=3e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR010970
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7 [H]

Molecular weight: Translated: 44510; Mature: 44379

Theoretical pI: Translated: 5.06; Mature: 5.06

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSYDVEKIRKDFPILSTRVGDYPLTYLDSANTSQKPQVVIDALSEHYARHNANVARAMHQ
CCCCHHHHHHCCCCHHHCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHH
LGLESTQAYEGGRERLARFIGAARPEEVVALSNASEALNLCAYTLGERLGPDDEVVISVM
HCCCHHHHHCCHHHHHHHHHCCCCCCCEEEECCHHHHHHHHHHHHHHHCCCCHHHHHHHH
EHHSNLVPWQIVCQRTGATLRCFDITDDGRLDLEKAEAEGLINERTKVVSLTLASNVLGT
HHCCCCCCHHHHEECCCCEEEEEECCCCCCCCHHHHHHCCHHHCCCEEEEEEHHHHHHHC
INPIGKIAEQAHSVGAVMVVDASQAVPQIPVDMTTLGADLVAFTGHKMCGPTGIGILWGR
CCHHHHHHHHHHCCCEEEEEECCCCCCCCCCCHHHHCCHHHHHCCCCCCCCCCCCHHHHH
YDLLAELPPFLGGGEMIEVVRMEGSTYAEPPHRFEAGTPPIAQLAALGVAADYLDGIGMQ
HHHHHHCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHH
AIAEHEHELAARMLEELQTVKGVHILGPSDATARTGTVSFTIEGVHPHDAMSIMDGHGVA
HHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCCEEEEEEECCCCCHHHHHCCCCCEE
VRGGHHCARPLHERLGIQSSLRASSYLYSTTDEVNRLVESVEYARNFFAGGVA
EECCCHHHHHHHHHHCCHHHHHHHHHEECCHHHHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
SYDVEKIRKDFPILSTRVGDYPLTYLDSANTSQKPQVVIDALSEHYARHNANVARAMHQ
CCCHHHHHHCCCCHHHCCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHCCHHHHHHHH
LGLESTQAYEGGRERLARFIGAARPEEVVALSNASEALNLCAYTLGERLGPDDEVVISVM
HCCCHHHHHCCHHHHHHHHHCCCCCCCEEEECCHHHHHHHHHHHHHHHCCCCHHHHHHHH
EHHSNLVPWQIVCQRTGATLRCFDITDDGRLDLEKAEAEGLINERTKVVSLTLASNVLGT
HHCCCCCCHHHHEECCCCEEEEEECCCCCCCCHHHHHHCCHHHCCCEEEEEEHHHHHHHC
INPIGKIAEQAHSVGAVMVVDASQAVPQIPVDMTTLGADLVAFTGHKMCGPTGIGILWGR
CCHHHHHHHHHHCCCEEEEEECCCCCCCCCCCHHHHCCHHHHHCCCCCCCCCCCCHHHHH
YDLLAELPPFLGGGEMIEVVRMEGSTYAEPPHRFEAGTPPIAQLAALGVAADYLDGIGMQ
HHHHHHCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHCCCHH
AIAEHEHELAARMLEELQTVKGVHILGPSDATARTGTVSFTIEGVHPHDAMSIMDGHGVA
HHHHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCCEEEEEEECCCCCHHHHHCCCCCEE
VRGGHHCARPLHERLGIQSSLRASSYLYSTTDEVNRLVESVEYARNFFAGGVA
EECCCHHHHHHHHHHCCHHHHHHHHHEECCHHHHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12000953 [H]