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The map label for this gene is ffh [H]

Identifier: 50842924

GI number: 50842924

Start: 1560764

End: 1562350

Strand: Reverse

Name: ffh [H]

Synonym: PPA1445

Alternate gene names: 50842924

Gene position: 1562350-1560764 (Counterclockwise)

Preceding gene: 50842925

Following gene: 50842923

Centisome position: 61.02

GC content: 59.23

Gene sequence:

>1587_bases
GTGTTCGACACTCTCCAAGACCGCCTCGCATCAACCTTCAAGGGATTGCGTGGTAAGGGGCGTCTCACTGATGCCGATAT
CGATGCCACGACTCGCCAGATTCGCATCGCCCTGCTTGAGGCTGACGTCAACTTGTCGGTCGTCAAGGAATTCGTGGCGG
CCATTAAAGAGCGTTGCCACGGCGAGGAGCTTTCTAAAGCGCTCAATCCGACCCAACAGATCGTCAAGATTGTCAACGAG
GAACTCGTCGAGATCCTCGGAGGGCAGACCCGTACGGTTCGGTTTGCGAAGACTCCCCCGACGATCGTCATGCTTGCCGG
CTTGCAAGGTGCTGGCAAGACGACCCTGGCTGGGAAGTTGGCTCGGTGGTTCAAGGAAGAGGGCCACTCCCCGTTGTTGG
CCGCCTGCGACCTCCAGCGGCCCAATGCCGTCACTCAGTTGCAGGTGGTCGGAGAACGTGCCGGGGTGCACGTCTTCGCT
CCTGAACCTGGCAACGGAGTTGGGGATCCCGTCCAGGTAGCCCGTGATGCCGTCGCAGAGGCCGAGCACAAGCTGTACGA
CGTCGTCATCATCGACACCGCTGGTCGTCTGGGCGTCGACGCCGAGATGATGGCTCAAGCGGCTGACATCAAGACTGCTA
CCGACCCTGACGAGACCCTCTTCGTCGTTGACGCCATGATTGGTCAGGACGCGGTCAACACTGCGGTGGCCTTCCAGGAG
GGAGTCGGATTCGACGGCGTTGTCCTGACCAAACTTGACGGCGACGCTCGCGGCGGCGCAGCTCTGTCCATTGCTCGTGT
GGTCGGCAAGCCGATCATGTTTGCTTCCTCGGGTGAGGGTCTCAAGGACTTCGACGTTTTCCATCCCGACCGGATGGCCT
CGCGCATCCTCGATATGGGTGACATGCTCACCCTTATCGAGCAAGCCGAGAAAGCTTTCGATCAGGAGCAATCTCAGGCG
GCTGCGGCCAAGCTCATGGCAGGCAAGGGGGAGTTCGGTCTCGATGACTTCCTCGGTCTCATGCGTCAAATGCGTCGCAT
GGGCCCGATGTCCAAGATCATGGGCATGCTCCCCGGCGTCGGCCAGATGAAAGGCCAGATTGAGAACATCGACGAGCGGG
AGATTGACCGCATTGAGGCCATCATCTGCGCGATGACTCCGGCCGAGCGTGCTGACGTGTCGATCCTCAACGGGTCACGT
CGTGCCCGTATTGCTAACGGGTCTGGCGTGGAAGTTCGTGACGTCAACAACCTGGTCAATCGATTTGTTGACGCTCGGAA
GATGATGAGCCAGATGGGCCAGATGATGGGTCCTGGTGCTGGCCGCATGATGGGGTCCATGGCTAAGCGCGGTTCCAAAC
AGTCGAAGAAGAAGCAGAAGAACCGTAAGGGCTCTGGTAATCCCGCCAAGCGTGCTGCTCAGGCTCGTCAAGCTGCAAAG
AAACCGCAGCGGAGCAGCGGTGAGGCGTTCGGGTTGCAGGGCCAGCAGCAACCCAGTCAGGAAGATCTGCAGAAGGCAAT
GAGTGAATTCAAGATGCCGCCGTCAATGCAGCAGATGTTCAACCAAACGAACAAGAGACCGCGTTGA

Upstream 100 bases:

>100_bases
GTGGCTTGGCCAGTTCGGGCTGTAATTGCCGCCGGGAGTCATGATCGAGTCTGGGACGGTAGTCTGTCCTGGTAAGGAAC
TAGCGCGCTGAAGGACAACC

Downstream 100 bases:

>100_bases
ACCAGCGTCGGTGATGTGTGAAGAGATCGCGAGTTTGACATTACTTCTCCCCGCGACTTCGTGACACGATGGGGCCATGA
CCGAGGACACCCAGCCGTTG

Product: signal recognition particle protein

Products: NA

Alternate protein names: Fifty-four homolog [H]

Number of amino acids: Translated: 528; Mature: 528

Protein sequence:

>528_residues
MFDTLQDRLASTFKGLRGKGRLTDADIDATTRQIRIALLEADVNLSVVKEFVAAIKERCHGEELSKALNPTQQIVKIVNE
ELVEILGGQTRTVRFAKTPPTIVMLAGLQGAGKTTLAGKLARWFKEEGHSPLLAACDLQRPNAVTQLQVVGERAGVHVFA
PEPGNGVGDPVQVARDAVAEAEHKLYDVVIIDTAGRLGVDAEMMAQAADIKTATDPDETLFVVDAMIGQDAVNTAVAFQE
GVGFDGVVLTKLDGDARGGAALSIARVVGKPIMFASSGEGLKDFDVFHPDRMASRILDMGDMLTLIEQAEKAFDQEQSQA
AAAKLMAGKGEFGLDDFLGLMRQMRRMGPMSKIMGMLPGVGQMKGQIENIDEREIDRIEAIICAMTPAERADVSILNGSR
RARIANGSGVEVRDVNNLVNRFVDARKMMSQMGQMMGPGAGRMMGSMAKRGSKQSKKKQKNRKGSGNPAKRAAQARQAAK
KPQRSSGEAFGLQGQQQPSQEDLQKAMSEFKMPPSMQQMFNQTNKRPR

Sequences:

>Translated_528_residues
MFDTLQDRLASTFKGLRGKGRLTDADIDATTRQIRIALLEADVNLSVVKEFVAAIKERCHGEELSKALNPTQQIVKIVNE
ELVEILGGQTRTVRFAKTPPTIVMLAGLQGAGKTTLAGKLARWFKEEGHSPLLAACDLQRPNAVTQLQVVGERAGVHVFA
PEPGNGVGDPVQVARDAVAEAEHKLYDVVIIDTAGRLGVDAEMMAQAADIKTATDPDETLFVVDAMIGQDAVNTAVAFQE
GVGFDGVVLTKLDGDARGGAALSIARVVGKPIMFASSGEGLKDFDVFHPDRMASRILDMGDMLTLIEQAEKAFDQEQSQA
AAAKLMAGKGEFGLDDFLGLMRQMRRMGPMSKIMGMLPGVGQMKGQIENIDEREIDRIEAIICAMTPAERADVSILNGSR
RARIANGSGVEVRDVNNLVNRFVDARKMMSQMGQMMGPGAGRMMGSMAKRGSKQSKKKQKNRKGSGNPAKRAAQARQAAK
KPQRSSGEAFGLQGQQQPSQEDLQKAMSEFKMPPSMQQMFNQTNKRPR
>Mature_528_residues
MFDTLQDRLASTFKGLRGKGRLTDADIDATTRQIRIALLEADVNLSVVKEFVAAIKERCHGEELSKALNPTQQIVKIVNE
ELVEILGGQTRTVRFAKTPPTIVMLAGLQGAGKTTLAGKLARWFKEEGHSPLLAACDLQRPNAVTQLQVVGERAGVHVFA
PEPGNGVGDPVQVARDAVAEAEHKLYDVVIIDTAGRLGVDAEMMAQAADIKTATDPDETLFVVDAMIGQDAVNTAVAFQE
GVGFDGVVLTKLDGDARGGAALSIARVVGKPIMFASSGEGLKDFDVFHPDRMASRILDMGDMLTLIEQAEKAFDQEQSQA
AAAKLMAGKGEFGLDDFLGLMRQMRRMGPMSKIMGMLPGVGQMKGQIENIDEREIDRIEAIICAMTPAERADVSILNGSR
RARIANGSGVEVRDVNNLVNRFVDARKMMSQMGQMMGPGAGRMMGSMAKRGSKQSKKKQKNRKGSGNPAKRAAQARQAAK
KPQRSSGEAFGLQGQQQPSQEDLQKAMSEFKMPPSMQQMFNQTNKRPR

Specific function: Necessary for efficient export of extracytoplasmic proteins. Binds to the signal sequence when it emerges from the ribosomes [H]

COG id: COG0541

COG function: function code U; Signal recognition particle GTPase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GTP-binding SRP family [H]

Homologues:

Organism=Homo sapiens, GI4507215, Length=457, Percent_Identity=29.7592997811816, Blast_Score=209, Evalue=4e-54,
Organism=Homo sapiens, GI226371618, Length=403, Percent_Identity=30.272952853598, Blast_Score=186, Evalue=6e-47,
Organism=Homo sapiens, GI295424842, Length=303, Percent_Identity=30.6930693069307, Blast_Score=134, Evalue=3e-31,
Organism=Homo sapiens, GI23308697, Length=303, Percent_Identity=30.6930693069307, Blast_Score=134, Evalue=3e-31,
Organism=Homo sapiens, GI89061728, Length=160, Percent_Identity=33.75, Blast_Score=96, Evalue=6e-20,
Organism=Escherichia coli, GI1788963, Length=429, Percent_Identity=48.7179487179487, Blast_Score=402, Evalue=1e-113,
Organism=Escherichia coli, GI1789874, Length=256, Percent_Identity=35.546875, Blast_Score=140, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI17539958, Length=466, Percent_Identity=28.1115879828326, Blast_Score=194, Evalue=8e-50,
Organism=Caenorhabditis elegans, GI193206261, Length=297, Percent_Identity=30.3030303030303, Blast_Score=120, Evalue=2e-27,
Organism=Saccharomyces cerevisiae, GI6325345, Length=421, Percent_Identity=30.4038004750594, Blast_Score=205, Evalue=2e-53,
Organism=Saccharomyces cerevisiae, GI6320498, Length=250, Percent_Identity=28, Blast_Score=90, Evalue=1e-18,
Organism=Drosophila melanogaster, GI17647949, Length=442, Percent_Identity=27.8280542986425, Blast_Score=175, Evalue=5e-44,
Organism=Drosophila melanogaster, GI24641198, Length=317, Percent_Identity=27.4447949526814, Blast_Score=120, Evalue=2e-27,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR000897
- InterPro:   IPR013822
- InterPro:   IPR004780
- InterPro:   IPR004125 [H]

Pfam domain/function: PF00448 SRP54; PF02881 SRP54_N; PF02978 SRP_SPB [H]

EC number: NA

Molecular weight: Translated: 57123; Mature: 57123

Theoretical pI: Translated: 9.60; Mature: 9.60

Prosite motif: PS00300 SRP54

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
5.7 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
5.7 %Met     (Mature Protein)
6.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFDTLQDRLASTFKGLRGKGRLTDADIDATTRQIRIALLEADVNLSVVKEFVAAIKERCH
CCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHEEEEEEECCCCHHHHHHHHHHHHHHHC
GEELSKALNPTQQIVKIVNEELVEILGGQTRTVRFAKTPPTIVMLAGLQGAGKTTLAGKL
HHHHHHHCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCEEEEECCCCCCCHHHHHHH
ARWFKEEGHSPLLAACDLQRPNAVTQLQVVGERAGVHVFAPEPGNGVGDPVQVARDAVAE
HHHHHHCCCCCEEEEECCCCCCCHHHHHEECCCCCEEEECCCCCCCCCCHHHHHHHHHHH
AEHKLYDVVIIDTAGRLGVDAEMMAQAADIKTATDPDETLFVVDAMIGQDAVNTAVAFQE
HHHCEEEEEEEECCCCCCCCHHHHHHHHHCCCCCCCCCEEEEHHHHHCCHHHHHHHHHHC
GVGFDGVVLTKLDGDARGGAALSIARVVGKPIMFASSGEGLKDFDVFHPDRMASRILDMG
CCCCCCEEEEEECCCCCCCHHHHHHHHHCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHH
DMLTLIEQAEKAFDQEQSQAAAAKLMAGKGEFGLDDFLGLMRQMRRMGPMSKIMGMLPGV
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHCCCC
GQMKGQIENIDEREIDRIEAIICAMTPAERADVSILNGSRRARIANGSGVEVRDVNNLVN
HHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCEEEECCCCCEEECCCCCCEEHHHHHHHH
RFVDARKMMSQMGQMMGPGAGRMMGSMAKRGSKQSKKKQKNRKGSGNPAKRAAQARQAAK
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHC
KPQRSSGEAFGLQGQQQPSQEDLQKAMSEFKMPPSMQQMFNQTNKRPR
CCCCCCCCEECCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHCCCCC
>Mature Secondary Structure
MFDTLQDRLASTFKGLRGKGRLTDADIDATTRQIRIALLEADVNLSVVKEFVAAIKERCH
CCCHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHEEEEEEECCCCHHHHHHHHHHHHHHHC
GEELSKALNPTQQIVKIVNEELVEILGGQTRTVRFAKTPPTIVMLAGLQGAGKTTLAGKL
HHHHHHHCCHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCEEEEECCCCCCCHHHHHHH
ARWFKEEGHSPLLAACDLQRPNAVTQLQVVGERAGVHVFAPEPGNGVGDPVQVARDAVAE
HHHHHHCCCCCEEEEECCCCCCCHHHHHEECCCCCEEEECCCCCCCCCCHHHHHHHHHHH
AEHKLYDVVIIDTAGRLGVDAEMMAQAADIKTATDPDETLFVVDAMIGQDAVNTAVAFQE
HHHCEEEEEEEECCCCCCCCHHHHHHHHHCCCCCCCCCEEEEHHHHHCCHHHHHHHHHHC
GVGFDGVVLTKLDGDARGGAALSIARVVGKPIMFASSGEGLKDFDVFHPDRMASRILDMG
CCCCCCEEEEEECCCCCCCHHHHHHHHHCCCEEEECCCCCCCCCCCCCHHHHHHHHHHHH
DMLTLIEQAEKAFDQEQSQAAAAKLMAGKGEFGLDDFLGLMRQMRRMGPMSKIMGMLPGV
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCHHHHHHHCCCC
GQMKGQIENIDEREIDRIEAIICAMTPAERADVSILNGSRRARIANGSGVEVRDVNNLVN
HHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCEEEECCCCCEEECCCCCCEEHHHHHHHH
RFVDARKMMSQMGQMMGPGAGRMMGSMAKRGSKQSKKKQKNRKGSGNPAKRAAQARQAAK
HHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCHHHHHHHHHCCCCCCHHHHHHHHHHHHC
KPQRSSGEAFGLQGQQQPSQEDLQKAMSEFKMPPSMQQMFNQTNKRPR
CCCCCCCCEECCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]