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The map label for this gene is dapE [H]

Identifier: 50842905

GI number: 50842905

Start: 1543430

End: 1544794

Strand: Reverse

Name: dapE [H]

Synonym: PPA1424

Alternate gene names: 50842905

Gene position: 1544794-1543430 (Counterclockwise)

Preceding gene: 50842909

Following gene: 50842904

Centisome position: 60.34

GC content: 61.76

Gene sequence:

>1365_bases
ATGTCAGATCTGTTCAGTATGACCGCCGAGAACCTTGTCGACGGGCCAGATTGCCCGCAGGCCGAAGTTGTCGACATCTG
CTCGCGAATGATTCAGATCGACTCGCAGAATTTTGGTCCACAGGACGCTCGGGGCGAGGTCGAGATGTGTCACTACGTGA
CCGGGCTCCTCGATGAAATCGGAGTCGGCGTGACCCTCCACGAATCCGAGCCCGGCCGTGTCACCTTGGTCGCCGAGTGG
GCGCCGGAAGGTACCGATACGAGTCGTCCCGCCCTGCTGCTGCACGGCCATAGCGACACCGTCCCCTTCGAGGCTGCCGA
CTGGACTCATCACCCGCTGTCTGGCGAGATCCACGACAACTGCGTGTGGGGGAGGGGCGCCATCGACATGAAGGGGTTTC
TGGCGATGGTCCTCTCGGCTATCCGGGCTCGTCAGCGTCGAGGTGAAGCGCCGTCCCGCCCCATTCGCTTCATCATGTTC
GCCGATGAAGAATGCTCCGGAACCCTCGGTTCAACGTGGCTCGGGGCCACTCATCCGGAGGCCTTTGACGGCGTCACCGA
AGCCATCAGCGAGGTCGGTGGTTTTTCCTTGACGACGCCGCAGGGCAAGCGAGTTTACGTCATCCAGTCCGCCGAGAAGG
GGCTGTGGTGGTTCCGGATGAGCGCCACCGGCAGCGCAGGGCACGGGTCTATGCGCAACCCGGACAACGCCGTCACCCGT
GTGCTTGATGCCCTGTCCCGTATCGACTCCTACCAATGGCCCGACCTACATCACCCGGTCCAGGAAGAGTTCCTTAACCA
GGTCGCCGCCATGTGGGGTCTGACGATCGACCGCGATGATCTCGAATCCAGCCTGTCTCCCATTGGGCCCCTGTCGCGCA
TGGTGGCTGCGTGCTGCGCGCACAATGTCACCCCGACCGTGCTATCGGCGGGTTACAAGGTCAACGTCGTGCCGACGCGT
GCCAGCGCCGAGGTCGACGCCCGATTCATCCCCGGGGCCGAGGAGGATATAATTTTGACGATTAAGTCTTTGGCTGGTCC
TGGAATCGACTTCGAGACGATCTCCCGCAAGCCGGCAACAGCGGCGCCCTTTGAGGGAGCAGCCGTCGATGCGATTCGCC
GGGCCGTTGACGCTGAGGACCCAGGGGCTGTTGTGCTGCCCTACCTCAATTCGGCAGGAACCGACGCTAAAGGGTTCGCA
GTTTTGCCTGACGGTCGACGAATCAATTGCTACGGCTGCACTCCGCTGAGATTGCCGGCCGATTTCGACTTTATCAGTCT
CTTCCACGGAGTCGACGAGAGAGTCCCCGTCAGATCCCTCGTTTTCGGTGCCAAGGTCGTCGATCACATACTGCAGGAGG
CCTGA

Upstream 100 bases:

>100_bases
GTCACAGAACTGTAATGGACCTTCGGCCAGCAATGCAAATCAGTGTCCATTGAGCGCCCCGATTGGGGGCGTAGCCCCTT
CCTGGTGACACAATCGCGAC

Downstream 100 bases:

>100_bases
TGATGAGTGTCCCAAATAAGAAGCCGGAGGGCGGACCAACGGCAACCCTTATCCTGGACGGCCAGGAATACACTTTGCCC
GTTATCGCAGGAACCACCGG

Product: hypothetical protein

Products: NA

Alternate protein names: SDAP desuccinylase [H]

Number of amino acids: Translated: 454; Mature: 453

Protein sequence:

>454_residues
MSDLFSMTAENLVDGPDCPQAEVVDICSRMIQIDSQNFGPQDARGEVEMCHYVTGLLDEIGVGVTLHESEPGRVTLVAEW
APEGTDTSRPALLLHGHSDTVPFEAADWTHHPLSGEIHDNCVWGRGAIDMKGFLAMVLSAIRARQRRGEAPSRPIRFIMF
ADEECSGTLGSTWLGATHPEAFDGVTEAISEVGGFSLTTPQGKRVYVIQSAEKGLWWFRMSATGSAGHGSMRNPDNAVTR
VLDALSRIDSYQWPDLHHPVQEEFLNQVAAMWGLTIDRDDLESSLSPIGPLSRMVAACCAHNVTPTVLSAGYKVNVVPTR
ASAEVDARFIPGAEEDIILTIKSLAGPGIDFETISRKPATAAPFEGAAVDAIRRAVDAEDPGAVVLPYLNSAGTDAKGFA
VLPDGRRINCYGCTPLRLPADFDFISLFHGVDERVPVRSLVFGAKVVDHILQEA

Sequences:

>Translated_454_residues
MSDLFSMTAENLVDGPDCPQAEVVDICSRMIQIDSQNFGPQDARGEVEMCHYVTGLLDEIGVGVTLHESEPGRVTLVAEW
APEGTDTSRPALLLHGHSDTVPFEAADWTHHPLSGEIHDNCVWGRGAIDMKGFLAMVLSAIRARQRRGEAPSRPIRFIMF
ADEECSGTLGSTWLGATHPEAFDGVTEAISEVGGFSLTTPQGKRVYVIQSAEKGLWWFRMSATGSAGHGSMRNPDNAVTR
VLDALSRIDSYQWPDLHHPVQEEFLNQVAAMWGLTIDRDDLESSLSPIGPLSRMVAACCAHNVTPTVLSAGYKVNVVPTR
ASAEVDARFIPGAEEDIILTIKSLAGPGIDFETISRKPATAAPFEGAAVDAIRRAVDAEDPGAVVLPYLNSAGTDAKGFA
VLPDGRRINCYGCTPLRLPADFDFISLFHGVDERVPVRSLVFGAKVVDHILQEA
>Mature_453_residues
SDLFSMTAENLVDGPDCPQAEVVDICSRMIQIDSQNFGPQDARGEVEMCHYVTGLLDEIGVGVTLHESEPGRVTLVAEWA
PEGTDTSRPALLLHGHSDTVPFEAADWTHHPLSGEIHDNCVWGRGAIDMKGFLAMVLSAIRARQRRGEAPSRPIRFIMFA
DEECSGTLGSTWLGATHPEAFDGVTEAISEVGGFSLTTPQGKRVYVIQSAEKGLWWFRMSATGSAGHGSMRNPDNAVTRV
LDALSRIDSYQWPDLHHPVQEEFLNQVAAMWGLTIDRDDLESSLSPIGPLSRMVAACCAHNVTPTVLSAGYKVNVVPTRA
SAEVDARFIPGAEEDIILTIKSLAGPGIDFETISRKPATAAPFEGAAVDAIRRAVDAEDPGAVVLPYLNSAGTDAKGFAV
LPDGRRINCYGCTPLRLPADFDFISLFHGVDERVPVRSLVFGAKVVDHILQEA

Specific function: Displays A Broad Specificity And Can Also Deacylate Substrates Such As Acetylarginine, Acetylhistidine Or Acetylglutamate Semialdehyde. [C]

COG id: COG0624

COG function: function code E; Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M20A family [H]

Homologues:

Organism=Homo sapiens, GI269846968, Length=389, Percent_Identity=26.7352185089974, Blast_Score=90, Evalue=4e-18,
Organism=Homo sapiens, GI4501901, Length=297, Percent_Identity=24.5791245791246, Blast_Score=79, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI71982085, Length=426, Percent_Identity=23.4741784037559, Blast_Score=83, Evalue=3e-16,
Organism=Caenorhabditis elegans, GI71982082, Length=348, Percent_Identity=24.7126436781609, Blast_Score=79, Evalue=7e-15,
Organism=Caenorhabditis elegans, GI71982710, Length=340, Percent_Identity=25, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17538640, Length=284, Percent_Identity=24.6478873239437, Blast_Score=76, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17538642, Length=287, Percent_Identity=25.7839721254355, Blast_Score=73, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6322289, Length=165, Percent_Identity=35.1515151515151, Blast_Score=71, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24649202, Length=377, Percent_Identity=27.0557029177719, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24649204, Length=377, Percent_Identity=27.0557029177719, Blast_Score=91, Evalue=2e-18,
Organism=Drosophila melanogaster, GI24649208, Length=390, Percent_Identity=23.3333333333333, Blast_Score=84, Evalue=3e-16,
Organism=Drosophila melanogaster, GI24649212, Length=349, Percent_Identity=27.7936962750716, Blast_Score=82, Evalue=6e-16,
Organism=Drosophila melanogaster, GI24649210, Length=343, Percent_Identity=25.6559766763848, Blast_Score=76, Evalue=5e-14,
Organism=Drosophila melanogaster, GI21356353, Length=193, Percent_Identity=30.0518134715026, Blast_Score=75, Evalue=9e-14,
Organism=Drosophila melanogaster, GI24649206, Length=189, Percent_Identity=26.984126984127, Blast_Score=74, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001261
- InterPro:   IPR010182
- InterPro:   IPR002933
- InterPro:   IPR011650 [H]

Pfam domain/function: PF07687 M20_dimer; PF01546 Peptidase_M20 [H]

EC number: =3.5.1.18 [H]

Molecular weight: Translated: 49043; Mature: 48912

Theoretical pI: Translated: 4.62; Mature: 4.62

Prosite motif: PS00758 ARGE_DAPE_CPG2_1 ; PS00759 ARGE_DAPE_CPG2_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
2.0 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDLFSMTAENLVDGPDCPQAEVVDICSRMIQIDSQNFGPQDARGEVEMCHYVTGLLDEI
CCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHH
GVGVTLHESEPGRVTLVAEWAPEGTDTSRPALLLHGHSDTVPFEAADWTHHPLSGEIHDN
CCCEEEECCCCCEEEEEEECCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCC
CVWGRGAIDMKGFLAMVLSAIRARQRRGEAPSRPIRFIMFADEECSGTLGSTWLGATHPE
EEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCH
AFDGVTEAISEVGGFSLTTPQGKRVYVIQSAEKGLWWFRMSATGSAGHGSMRNPDNAVTR
HHHHHHHHHHHHCCCEEECCCCCEEEEEEECCCCEEEEEEECCCCCCCCCCCCCHHHHHH
VLDALSRIDSYQWPDLHHPVQEEFLNQVAAMWGLTIDRDDLESSLSPIGPLSRMVAACCA
HHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCHHHHHHHHHHH
HNVTPTVLSAGYKVNVVPTRASAEVDARFIPGAEEDIILTIKSLAGPGIDFETISRKPAT
CCCCHHHHHCCEEEEEEECCCCCCCCEEECCCCCCCEEEEEEHHCCCCCCHHHHCCCCCC
AAPFEGAAVDAIRRAVDAEDPGAVVLPYLNSAGTDAKGFAVLPDGRRINCYGCTPLRLPA
CCCCCCHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCEEECCCCCEEEEECCCCCCCCC
DFDFISLFHGVDERVPVRSLVFGAKVVDHILQEA
CCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SDLFSMTAENLVDGPDCPQAEVVDICSRMIQIDSQNFGPQDARGEVEMCHYVTGLLDEI
CHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHH
GVGVTLHESEPGRVTLVAEWAPEGTDTSRPALLLHGHSDTVPFEAADWTHHPLSGEIHDN
CCCEEEECCCCCEEEEEEECCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCCCCCCC
CVWGRGAIDMKGFLAMVLSAIRARQRRGEAPSRPIRFIMFADEECSGTLGSTWLGATHPE
EEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCH
AFDGVTEAISEVGGFSLTTPQGKRVYVIQSAEKGLWWFRMSATGSAGHGSMRNPDNAVTR
HHHHHHHHHHHHCCCEEECCCCCEEEEEEECCCCEEEEEEECCCCCCCCCCCCCHHHHHH
VLDALSRIDSYQWPDLHHPVQEEFLNQVAAMWGLTIDRDDLESSLSPIGPLSRMVAACCA
HHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHCCCCCHHHHHHHHHHH
HNVTPTVLSAGYKVNVVPTRASAEVDARFIPGAEEDIILTIKSLAGPGIDFETISRKPAT
CCCCHHHHHCCEEEEEEECCCCCCCCEEECCCCCCCEEEEEEHHCCCCCCHHHHCCCCCC
AAPFEGAAVDAIRRAVDAEDPGAVVLPYLNSAGTDAKGFAVLPDGRRINCYGCTPLRLPA
CCCCCCHHHHHHHHHHCCCCCCEEEEECCCCCCCCCCCEEECCCCCEEEEECCCCCCCCC
DFDFISLFHGVDERVPVRSLVFGAKVVDHILQEA
CCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11418146 [H]