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The map label for this gene is gltA [H]

Identifier: 50842904

GI number: 50842904

Start: 1542120

End: 1543430

Strand: Reverse

Name: gltA [H]

Synonym: PPA1423

Alternate gene names: 50842904

Gene position: 1543430-1542120 (Counterclockwise)

Preceding gene: 50842905

Following gene: 50842902

Centisome position: 60.28

GC content: 58.43

Gene sequence:

>1311_bases
ATGATGAGTGTCCCAAATAAGAAGCCGGAGGGCGGACCAACGGCAACCCTTATCCTGGACGGCCAGGAATACACTTTGCC
CGTTATCGCAGGAACCACCGGCGATCGAGTCATCGACATTTCTAACCTTCGTCAACTAACCGGCGGGGTGACAACCTTCG
ACCCGGCATTCGCCAATACTGCGTCCTGCCGCTCGGCGATCTCGTGGATCGACGGCGAAGAAGGCGTGCTCACCTATCGT
GGCCTACCCATCGAGACCTTAGCTAAGGAGCGCGTCTCCTTTGTGGAGACCGCCTGGCTGCTGATCTTCGGTCACCTGCC
CACTGAGGCTCAACGCGACGACTTCCGGAATCGCTTGACCGAGTATTCGGCATTACACCGGTCGATGAACCTTCACTTCA
ATGCCTTCCCACCTAACGGCCACCCGATGGCGATCATGTCCTCGATGATCAACGCGATGAGCACCCACGACCGTCCGAGA
ATCACTGATGAGGAGTCCTTCACCGACGCGGCTGCCAAGCTCATGTCCAAGGTGAGGACGATCGCGGCTGCTTCTTATAA
GGCGTCTATTGGGGAGCCAGCGATTTACCCGCGCTATGACCTCAAATATGTCGAAAATTTCATGCACATGATGTTTTCTC
TGCCGTACCGCGCCTACGAGCCGGATCCGGTGGCGGCAAGAGCCCTCAACCTGTTCTTCGTGCTACACGCTGATCACGGC
CAGAACTGTTCGACCTCGACAGTGCGGATGGTTGGGTCCTCGGGTGCCAACCTTTTCACGTCGTGTTCAGCCGGAGTGTG
CGCTCTGTGGGGAGACCGCCACGGTGGCGCCAACGTCAACGCTGTGCTCGCCTTACAACGTATCCGCAATTCTGGACTCA
CCCCACGTCAATACCTGGCGAAGGCCAAAGATTCGGGGGAGAGGATTTCTGGCTTCGGGCATCGCGTCTACCGCAATTGG
GACCCCCGAGCGAGAATCTTCCGCAGTGTCGTCGGTCCGCTGCTCGACACCATGCACAAACCGGATCCGCTGCTCGACGT
TGCCATGGAGCTGGAGGAAGCTGTGCTGGCCGACGACTACTTCATCGAGCGCAGGCTGTACCCCAACGTGGACTTCTATT
CCGGGATCGTTTTACGCGCGCTCGGCATCCCGCTGAACATGTTCACTGTCATGTTCGCTATCGGGCGGATGGCTGGTTGG
ATCGCCCACTGGAAGGAGGTTTTTGAGGATCCGACAACGAGGATTTCCCGTCCTCGCGAGCTTTACGATGGTCCGGTATC
GACTCCGTGGGTGCCACGCGGCGAGCGCTGA

Upstream 100 bases:

>100_bases
TCGACTTTATCAGTCTCTTCCACGGAGTCGACGAGAGAGTCCCCGTCAGATCCCTCGTTTTCGGTGCCAAGGTCGTCGAT
CACATACTGCAGGAGGCCTG

Downstream 100 bases:

>100_bases
GCTATTTGACCCTAGGCTTCTTCGCGGGCGAGGTTTGGCCCGCCGGTGATGTCGTCGAGGGCTGAGGTGATCTCCTTAGG
AAGACTGACCTCGTCAGCTC

Product: citrate synthase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 436; Mature: 436

Protein sequence:

>436_residues
MMSVPNKKPEGGPTATLILDGQEYTLPVIAGTTGDRVIDISNLRQLTGGVTTFDPAFANTASCRSAISWIDGEEGVLTYR
GLPIETLAKERVSFVETAWLLIFGHLPTEAQRDDFRNRLTEYSALHRSMNLHFNAFPPNGHPMAIMSSMINAMSTHDRPR
ITDEESFTDAAAKLMSKVRTIAAASYKASIGEPAIYPRYDLKYVENFMHMMFSLPYRAYEPDPVAARALNLFFVLHADHG
QNCSTSTVRMVGSSGANLFTSCSAGVCALWGDRHGGANVNAVLALQRIRNSGLTPRQYLAKAKDSGERISGFGHRVYRNW
DPRARIFRSVVGPLLDTMHKPDPLLDVAMELEEAVLADDYFIERRLYPNVDFYSGIVLRALGIPLNMFTVMFAIGRMAGW
IAHWKEVFEDPTTRISRPRELYDGPVSTPWVPRGER

Sequences:

>Translated_436_residues
MMSVPNKKPEGGPTATLILDGQEYTLPVIAGTTGDRVIDISNLRQLTGGVTTFDPAFANTASCRSAISWIDGEEGVLTYR
GLPIETLAKERVSFVETAWLLIFGHLPTEAQRDDFRNRLTEYSALHRSMNLHFNAFPPNGHPMAIMSSMINAMSTHDRPR
ITDEESFTDAAAKLMSKVRTIAAASYKASIGEPAIYPRYDLKYVENFMHMMFSLPYRAYEPDPVAARALNLFFVLHADHG
QNCSTSTVRMVGSSGANLFTSCSAGVCALWGDRHGGANVNAVLALQRIRNSGLTPRQYLAKAKDSGERISGFGHRVYRNW
DPRARIFRSVVGPLLDTMHKPDPLLDVAMELEEAVLADDYFIERRLYPNVDFYSGIVLRALGIPLNMFTVMFAIGRMAGW
IAHWKEVFEDPTTRISRPRELYDGPVSTPWVPRGER
>Mature_436_residues
MMSVPNKKPEGGPTATLILDGQEYTLPVIAGTTGDRVIDISNLRQLTGGVTTFDPAFANTASCRSAISWIDGEEGVLTYR
GLPIETLAKERVSFVETAWLLIFGHLPTEAQRDDFRNRLTEYSALHRSMNLHFNAFPPNGHPMAIMSSMINAMSTHDRPR
ITDEESFTDAAAKLMSKVRTIAAASYKASIGEPAIYPRYDLKYVENFMHMMFSLPYRAYEPDPVAARALNLFFVLHADHG
QNCSTSTVRMVGSSGANLFTSCSAGVCALWGDRHGGANVNAVLALQRIRNSGLTPRQYLAKAKDSGERISGFGHRVYRNW
DPRARIFRSVVGPLLDTMHKPDPLLDVAMELEEAVLADDYFIERRLYPNVDFYSGIVLRALGIPLNMFTVMFAIGRMAGW
IAHWKEVFEDPTTRISRPRELYDGPVSTPWVPRGER

Specific function: Tricarboxylic acid cycle. [C]

COG id: COG0372

COG function: function code C; Citrate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the citrate synthase family [H]

Homologues:

Organism=Homo sapiens, GI38327625, Length=349, Percent_Identity=26.647564469914, Blast_Score=109, Evalue=6e-24,
Organism=Escherichia coli, GI1786939, Length=415, Percent_Identity=47.4698795180723, Blast_Score=387, Evalue=1e-109,
Organism=Escherichia coli, GI1786527, Length=389, Percent_Identity=29.8200514138817, Blast_Score=144, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI17555174, Length=408, Percent_Identity=26.2254901960784, Blast_Score=105, Evalue=4e-23,
Organism=Saccharomyces cerevisiae, GI6319850, Length=370, Percent_Identity=28.1081081081081, Blast_Score=100, Evalue=4e-22,
Organism=Saccharomyces cerevisiae, GI6324328, Length=364, Percent_Identity=26.6483516483516, Blast_Score=97, Evalue=7e-21,
Organism=Saccharomyces cerevisiae, GI6325257, Length=396, Percent_Identity=25.2525252525253, Blast_Score=70, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24640126, Length=461, Percent_Identity=25.8134490238612, Blast_Score=115, Evalue=6e-26,
Organism=Drosophila melanogaster, GI24640124, Length=463, Percent_Identity=25.7019438444924, Blast_Score=114, Evalue=1e-25,
Organism=Drosophila melanogaster, GI21356863, Length=434, Percent_Identity=24.4239631336406, Blast_Score=95, Evalue=1e-19,

Paralogues:

None

Copy number: 624 Molecules/Cell In: Growth Phase, Glucose-minimal MOPS Media. 2,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR016142
- InterPro:   IPR016143
- InterPro:   IPR002020
- InterPro:   IPR016141
- InterPro:   IPR019810
- InterPro:   IPR010953 [H]

Pfam domain/function: PF00285 Citrate_synt [H]

EC number: =2.3.3.1 [H]

Molecular weight: Translated: 48627; Mature: 48627

Theoretical pI: Translated: 7.39; Mature: 7.39

Prosite motif: PS00480 CITRATE_SYNTHASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMSVPNKKPEGGPTATLILDGQEYTLPVIAGTTGDRVIDISNLRQLTGGVTTFDPAFANT
CCCCCCCCCCCCCEEEEEECCCCEEEEEEECCCCCCEEEHHHHHHHHCCCCCCCCHHCCH
ASCRSAISWIDGEEGVLTYRGLPIETLAKERVSFVETAWLLIFGHLPTEAQRDDFRNRLT
HHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHH
EYSALHRSMNLHFNAFPPNGHPMAIMSSMINAMSTHDRPRITDEESFTDAAAKLMSKVRT
HHHHHHHHHCCEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHH
IAAASYKASIGEPAIYPRYDLKYVENFMHMMFSLPYRAYEPDPVAARALNLFFVLHADHG
HHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHEEEEEEEECCCC
QNCSTSTVRMVGSSGANLFTSCSAGVCALWGDRHGGANVNAVLALQRIRNSGLTPRQYLA
CCCCCHHHEEECCCCCCHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCHHHHHH
KAKDSGERISGFGHRVYRNWDPRARIFRSVVGPLLDTMHKPDPLLDVAMELEEAVLADDY
HHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
FIERRLYPNVDFYSGIVLRALGIPLNMFTVMFAIGRMAGWIAHWKEVFEDPTTRISRPRE
HHHHHCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCHH
LYDGPVSTPWVPRGER
HHCCCCCCCCCCCCCC
>Mature Secondary Structure
MMSVPNKKPEGGPTATLILDGQEYTLPVIAGTTGDRVIDISNLRQLTGGVTTFDPAFANT
CCCCCCCCCCCCCEEEEEECCCCEEEEEEECCCCCCEEEHHHHHHHHCCCCCCCCHHCCH
ASCRSAISWIDGEEGVLTYRGLPIETLAKERVSFVETAWLLIFGHLPTEAQRDDFRNRLT
HHHHHHHHHCCCCCCEEEECCCCHHHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHHHHH
EYSALHRSMNLHFNAFPPNGHPMAIMSSMINAMSTHDRPRITDEESFTDAAAKLMSKVRT
HHHHHHHHHCCEEEEECCCCCHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHH
IAAASYKASIGEPAIYPRYDLKYVENFMHMMFSLPYRAYEPDPVAARALNLFFVLHADHG
HHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHEEEEEEEECCCC
QNCSTSTVRMVGSSGANLFTSCSAGVCALWGDRHGGANVNAVLALQRIRNSGLTPRQYLA
CCCCCHHHEEECCCCCCHHHHCCCCEEEEECCCCCCCCHHHHHHHHHHHHCCCCHHHHHH
KAKDSGERISGFGHRVYRNWDPRARIFRSVVGPLLDTMHKPDPLLDVAMELEEAVLADDY
HHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
FIERRLYPNVDFYSGIVLRALGIPLNMFTVMFAIGRMAGWIAHWKEVFEDPTTRISRPRE
HHHHHCCCCCCHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCHH
LYDGPVSTPWVPRGER
HHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12597275 [H]