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The map label for this gene is ilvC

Identifier: 50842854

GI number: 50842854

Start: 1493821

End: 1494849

Strand: Reverse

Name: ilvC

Synonym: PPA1372

Alternate gene names: 50842854

Gene position: 1494849-1493821 (Counterclockwise)

Preceding gene: 50842855

Following gene: 50842852

Centisome position: 58.39

GC content: 58.5

Gene sequence:

>1029_bases
ATGGCAAAGATCTACTACGACGATGACGCCGATCTGTCCATCATCCAAAACCGTCAGGTTGCCGTCATCGGTTACGGTTC
CCAAGGTCATGCTCACGCTCTCAACCTGCGCGACTCCGGTGTCGATGTGCGTGTCGGTCTGCGTGACGGCTCCTCGTCTA
TCGCCAAGGCTGAGGCTCAGGGGCTGCGGGTGCTGTCCATCGAGGATGCCTGCGAAGAGGCCGACTTAATTATGGTGCTC
GTTCCCGACCAAAACCAGCGCCAGCTCTATGCTGAGCACATTGCCCCGCACCTCAAGGACGGTGACGCTCTCTTCTTCGC
TCACGGCTTCAACGTCCACTTCGGCTACATCAAAGCTCCCCAGGGCGTCGACGTCTGTATGGTTGCCCCGAAGGGTCCCG
GTCACATCGTGCGTCGGGAGTACTCTGATGGTCGCGGAGTCCCGGTGCTGGTGTGCGTCGAGCAGGATGCCTCTGGCATC
GCCTGGGACCTCACGAGGTCTTACGCCAAGGCCCTCGGCGGTTTGCGCGCCGGCGGCATTGAAACGAGCTTCCGTGAGGA
GACCGAGACCGATCTTTTCGGTGAGCAAGCGGTGCTGTGCGGTGGCCTGTCCCACCTCATCCAGGCCGGTTTTGAGACTC
TCGTTACCGCCGGTTACCAGCCGGAGATGGCCTATTTTGAGGTTTGTCACGAGATGAAGATGATCGTCGACCTCATCATC
GAAGGCGGTATCTCCAAGCTGCGTTGGTCAATTTCCGATACTGCTGAGTATGGCGACTACGTGTCTGGCCCGCGTGTGAT
CGACGACCACGTCAAAAAGAATATGAAGGCGGTCCTAGACGACATCCAAAATGGCGCCTTCGCTAAGCGTTTCATCGCCG
ATCAGGATGCCGGTGCTCCACAGTCCAAGAAATTTCGCGAGGGTGAGGCAAAGCATCCGATCGAGGCCACCGGTAAAGAG
CTTCGCAAGATGTACTCCTGGCTGGCAGCTGCTGATGACGACTACACCGAAGGCAGCGTGGCTCGTTGA

Upstream 100 bases:

>100_bases
CCCTCAACCGTGGTGTGGCTGTTCTCGGGGCGAAACGCCCCGGGTGACGTTCCCTAGATCCCAAGACAACCCAGACCCCC
AACAAGGAGAGAAATACGCT

Downstream 100 bases:

>100_bases
GCCTGCTGGCCTGACGTTGAGGGCCCGTAGGTACCGCGGGCCCTCAATTCTGTATCCTCTGCCTCGTCAGCCTCGAGCAG
ATAGCCGACAGGCAACGATG

Product: ketol-acid reductoisomerase

Products: NA

Alternate protein names: Acetohydroxy-acid isomeroreductase; Alpha-keto-beta-hydroxylacil reductoisomerase

Number of amino acids: Translated: 342; Mature: 341

Protein sequence:

>342_residues
MAKIYYDDDADLSIIQNRQVAVIGYGSQGHAHALNLRDSGVDVRVGLRDGSSSIAKAEAQGLRVLSIEDACEEADLIMVL
VPDQNQRQLYAEHIAPHLKDGDALFFAHGFNVHFGYIKAPQGVDVCMVAPKGPGHIVRREYSDGRGVPVLVCVEQDASGI
AWDLTRSYAKALGGLRAGGIETSFREETETDLFGEQAVLCGGLSHLIQAGFETLVTAGYQPEMAYFEVCHEMKMIVDLII
EGGISKLRWSISDTAEYGDYVSGPRVIDDHVKKNMKAVLDDIQNGAFAKRFIADQDAGAPQSKKFREGEAKHPIEATGKE
LRKMYSWLAAADDDYTEGSVAR

Sequences:

>Translated_342_residues
MAKIYYDDDADLSIIQNRQVAVIGYGSQGHAHALNLRDSGVDVRVGLRDGSSSIAKAEAQGLRVLSIEDACEEADLIMVL
VPDQNQRQLYAEHIAPHLKDGDALFFAHGFNVHFGYIKAPQGVDVCMVAPKGPGHIVRREYSDGRGVPVLVCVEQDASGI
AWDLTRSYAKALGGLRAGGIETSFREETETDLFGEQAVLCGGLSHLIQAGFETLVTAGYQPEMAYFEVCHEMKMIVDLII
EGGISKLRWSISDTAEYGDYVSGPRVIDDHVKKNMKAVLDDIQNGAFAKRFIADQDAGAPQSKKFREGEAKHPIEATGKE
LRKMYSWLAAADDDYTEGSVAR
>Mature_341_residues
AKIYYDDDADLSIIQNRQVAVIGYGSQGHAHALNLRDSGVDVRVGLRDGSSSIAKAEAQGLRVLSIEDACEEADLIMVLV
PDQNQRQLYAEHIAPHLKDGDALFFAHGFNVHFGYIKAPQGVDVCMVAPKGPGHIVRREYSDGRGVPVLVCVEQDASGIA
WDLTRSYAKALGGLRAGGIETSFREETETDLFGEQAVLCGGLSHLIQAGFETLVTAGYQPEMAYFEVCHEMKMIVDLIIE
GGISKLRWSISDTAEYGDYVSGPRVIDDHVKKNMKAVLDDIQNGAFAKRFIADQDAGAPQSKKFREGEAKHPIEATGKEL
RKMYSWLAAADDDYTEGSVAR

Specific function: Valine and isoleucine biosynthesis; second step. [C]

COG id: COG0059

COG function: function code EH; Ketol-acid reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketol-acid reductoisomerase family

Homologues:

Organism=Escherichia coli, GI1790210, Length=319, Percent_Identity=33.5423197492163, Blast_Score=153, Evalue=2e-38,
Organism=Saccharomyces cerevisiae, GI6323387, Length=324, Percent_Identity=31.4814814814815, Blast_Score=128, Evalue=1e-30,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1420 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): ILVC_PROAC (Q6A7Z2)

Other databases:

- EMBL:   AE017283
- RefSeq:   YP_056081.1
- ProteinModelPortal:   Q6A7Z2
- SMR:   Q6A7Z2
- GeneID:   2931623
- GenomeReviews:   AE017283_GR
- KEGG:   pac:PPA1372
- NMPDR:   fig|267747.1.peg.1358
- HOGENOM:   HBG286525
- OMA:   MAYAKGI
- ProtClustDB:   PRK05479
- BioCyc:   PACN267747:PPA1372-MONOMER
- BRENDA:   1.1.1.86
- HAMAP:   MF_00435
- InterPro:   IPR008927
- InterPro:   IPR013023
- InterPro:   IPR000506
- InterPro:   IPR013328
- InterPro:   IPR013116
- Gene3D:   G3DSA:1.10.1040.10
- PANTHER:   PTHR21371
- TIGRFAMs:   TIGR00465

Pfam domain/function: PF01450 IlvC; PF07991 IlvN; SSF48179 6DGDH_C_like

EC number: =1.1.1.86

Molecular weight: Translated: 37367; Mature: 37236

Theoretical pI: Translated: 4.87; Mature: 4.87

Prosite motif: NA

Important sites: ACT_SITE 108-108

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKIYYDDDADLSIIQNRQVAVIGYGSQGHAHALNLRDSGVDVRVGLRDGSSSIAKAEAQ
CCEEEECCCCCEEEECCCEEEEEEECCCCCEEEEEECCCCCEEEEEECCCCCHHHHHHHC
GLRVLSIEDACEEADLIMVLVPDQNQRQLYAEHIAPHLKDGDALFFAHGFNVHFGYIKAP
CEEEEEEHHHCCCCCEEEEEECCCCHHHHHHHHCCCCCCCCCEEEEEECCEEEEEEEECC
QGVDVCMVAPKGPGHIVRREYSDGRGVPVLVCVEQDASGIAWDLTRSYAKALGGLRAGGI
CCCCEEEECCCCCCCEEEEECCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHCCCCCCCC
ETSFREETETDLFGEQAVLCGGLSHLIQAGFETLVTAGYQPEMAYFEVCHEMKMIVDLII
CCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
EGGISKLRWSISDTAEYGDYVSGPRVIDDHVKKNMKAVLDDIQNGAFAKRFIADQDAGAP
HCCHHHEEEECCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCC
QSKKFREGEAKHPIEATGKELRKMYSWLAAADDDYTEGSVAR
CCCHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCC
>Mature Secondary Structure 
AKIYYDDDADLSIIQNRQVAVIGYGSQGHAHALNLRDSGVDVRVGLRDGSSSIAKAEAQ
CEEEECCCCCEEEECCCEEEEEEECCCCCEEEEEECCCCCEEEEEECCCCCHHHHHHHC
GLRVLSIEDACEEADLIMVLVPDQNQRQLYAEHIAPHLKDGDALFFAHGFNVHFGYIKAP
CEEEEEEHHHCCCCCEEEEEECCCCHHHHHHHHCCCCCCCCCEEEEEECCEEEEEEEECC
QGVDVCMVAPKGPGHIVRREYSDGRGVPVLVCVEQDASGIAWDLTRSYAKALGGLRAGGI
CCCCEEEECCCCCCCEEEEECCCCCCCEEEEEEECCCCCCCHHHHHHHHHHHCCCCCCCC
ETSFREETETDLFGEQAVLCGGLSHLIQAGFETLVTAGYQPEMAYFEVCHEMKMIVDLII
CCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHH
EGGISKLRWSISDTAEYGDYVSGPRVIDDHVKKNMKAVLDDIQNGAFAKRFIADQDAGAP
HCCHHHEEEECCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCC
QSKKFREGEAKHPIEATGKELRKMYSWLAAADDDYTEGSVAR
CCCHHCCCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA