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The map label for this gene is mtrB [H]

Identifier: 50842817

GI number: 50842817

Start: 1458558

End: 1460306

Strand: Reverse

Name: mtrB [H]

Synonym: PPA1337

Alternate gene names: 50842817

Gene position: 1460306-1458558 (Counterclockwise)

Preceding gene: 50842818

Following gene: 50842816

Centisome position: 57.04

GC content: 60.89

Gene sequence:

>1749_bases
ATGGGGATACACCAACATCACCGATACTCGGTTGGTCAACGTCCATGTGCAGAGACTGCGTTCCAAGGTGGAGCGCAACG
CGGACCACCCCCAGATGATCGTCACTGTTCGTGGCATCGGTTACCGCATCAACACCCCTGGGGAGGAAAGCTGATCACCC
TGGCGGGGCGCGCCGGTCGTGGTTGGCGGCCGGGTTGGTGCCCATCGTGGCTGACCGGACCTCGACGGCTGTGGTGGTCT
TCCCTGCCGCTGCGCACGGTTACTGTCACTTTGTCGAGTAGCCTCGTCATTCTCATTGTTGGTGGCTTCTTCCTCGTTCG
TCAGGCCACCGCGGGCATCGTTGAAGCTAAGCGCACCTCAGCCGTCGCCGAGACGACCGCGACCATCAATCGGATTCAGG
GACAACTGCGCGACACCGATCTGCGTACGGCATCTTTCTATGAGCGGCTCAACCTTCTTGCCGACGACGCCGCGAGCCAG
TCCGACCAATACCACGTCCTCATTCAGGGACCGGTTTCCGGCCTCATCTCCCAAGGCGTGTCCCCAGATTCGGTCCCGAC
GGACCTGACAGCGACGGTGGGGGAGTCCAACGGCATGTGGACTGCCCCCACGACGGTGCACTACACCGACCATGTCCGTC
CAGATGTCCCCGGAATCGTCGTTGGGTCGACGCTGTGGTCGCCAGAGGCCAGCCAATCCATCCCGGTATATTTCATCTTT
CCCGAGACTCAGGAGGTTGCTGCCGTCGAGCTATTGCGTCGCAGTGTCATTAGCGTCGGTGCTCTCATGGCCTTGGCTAT
TGCAGTTACGACCTATCTGGCGACTCGTCATATTTCCTTGCCGATTCGCCAAGCGTCCATTACTGCTTCAAAACTGGCCA
AAGGCGCCCTTGACGAGCGGATGGTGGTGCGCGGGACCGACGATCTGGCGACCCTAGCATCGTCCATGAACGACATGGCT
GCGCAGCTGGACCTACGCATCGGTGAGCTCGAGAAGTTGTCGAGTCTGCAACAGCAGTTCGTTTCTGACGTATCCCACGA
GTTACGCACGCCGATGACGACGATGCGGATGGCCTCGGAAATGGTCGAGGCTAACCCGGACGATCCGGTGCAAGTGCGAT
CCGTGGAGCTCATGCGCGCCCAGATGGAGCGGCTAGAACTGCTTCTCGCCGACCTGTTGGAGATCTCGCGGTTTGACGCC
GGTGCTGCCCAACTCAGCCTAGAAGACTGTGACATTGTTGACTTGGTGCGGTCCGAGATCAGCGACGTCACACCGTTGGC
CGATCGTCTAGGAGTATCGATCGTGCTCGTTGCCGAGGCTGCTCAGACCGCAGAGGTAGATCCGCGTCGTATCAGCCGCA
TCGTCCGAAACCTGGTATCCAACGCCGTCGAGCACGCCGAGGGCAAGACCGTTGAGGTTACGGTGGTGGGCAATGACTGT
GCGGTGGGAGTCGCTGTGCGTGATCACGGTGTCGGGTTTGAGGCATGGCAAGCTGAGAAGGTCTTCGGACGATTCTGGCG
AGGCGACCCATCACGGGTGCGTACTGTGGGCGGCAGTGGCCTAGGGCTGGCGATCTCGCGTCAGGATGCGAACCTTCATC
ATGGCTGGCTGACAGCCTGGGGACGCCCGAACCAGGGGGCCTACTTCCGATTGGTGGTTCCCAGACAGCCCGGCGGAGTC
ATCGTCAAGTCCCCGCTCCCCGCATCTCCGACCGATGCCGACCGCTCTGACGACGAGGAAGAACGATGA

Upstream 100 bases:

>100_bases
GCGAGGAGATCTCACTCACTCCGTTGGAATACTCCCTGCTCGTTACGATGGCCCAATACCCCAATAGGGTATTTAGCAGG
GAGACCCTGTTGCGTGAGGT

Downstream 100 bases:

>100_bases
CCCTACGCCCTTCCCGGCGTGCTGTGCTGTCAGCTGCTGCTGTTTTGCTCACCGGATGCTCCGAAGTACCATCCCAGGGC
CCAGTGAAGCGAGCTGATGG

Product: signal transduction histidine kinase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 582; Mature: 581

Protein sequence:

>582_residues
MGIHQHHRYSVGQRPCAETAFQGGAQRGPPPDDRHCSWHRLPHQHPWGGKLITLAGRAGRGWRPGWCPSWLTGPRRLWWS
SLPLRTVTVTLSSSLVILIVGGFFLVRQATAGIVEAKRTSAVAETTATINRIQGQLRDTDLRTASFYERLNLLADDAASQ
SDQYHVLIQGPVSGLISQGVSPDSVPTDLTATVGESNGMWTAPTTVHYTDHVRPDVPGIVVGSTLWSPEASQSIPVYFIF
PETQEVAAVELLRRSVISVGALMALAIAVTTYLATRHISLPIRQASITASKLAKGALDERMVVRGTDDLATLASSMNDMA
AQLDLRIGELEKLSSLQQQFVSDVSHELRTPMTTMRMASEMVEANPDDPVQVRSVELMRAQMERLELLLADLLEISRFDA
GAAQLSLEDCDIVDLVRSEISDVTPLADRLGVSIVLVAEAAQTAEVDPRRISRIVRNLVSNAVEHAEGKTVEVTVVGNDC
AVGVAVRDHGVGFEAWQAEKVFGRFWRGDPSRVRTVGGSGLGLAISRQDANLHHGWLTAWGRPNQGAYFRLVVPRQPGGV
IVKSPLPASPTDADRSDDEEER

Sequences:

>Translated_582_residues
MGIHQHHRYSVGQRPCAETAFQGGAQRGPPPDDRHCSWHRLPHQHPWGGKLITLAGRAGRGWRPGWCPSWLTGPRRLWWS
SLPLRTVTVTLSSSLVILIVGGFFLVRQATAGIVEAKRTSAVAETTATINRIQGQLRDTDLRTASFYERLNLLADDAASQ
SDQYHVLIQGPVSGLISQGVSPDSVPTDLTATVGESNGMWTAPTTVHYTDHVRPDVPGIVVGSTLWSPEASQSIPVYFIF
PETQEVAAVELLRRSVISVGALMALAIAVTTYLATRHISLPIRQASITASKLAKGALDERMVVRGTDDLATLASSMNDMA
AQLDLRIGELEKLSSLQQQFVSDVSHELRTPMTTMRMASEMVEANPDDPVQVRSVELMRAQMERLELLLADLLEISRFDA
GAAQLSLEDCDIVDLVRSEISDVTPLADRLGVSIVLVAEAAQTAEVDPRRISRIVRNLVSNAVEHAEGKTVEVTVVGNDC
AVGVAVRDHGVGFEAWQAEKVFGRFWRGDPSRVRTVGGSGLGLAISRQDANLHHGWLTAWGRPNQGAYFRLVVPRQPGGV
IVKSPLPASPTDADRSDDEEER
>Mature_581_residues
GIHQHHRYSVGQRPCAETAFQGGAQRGPPPDDRHCSWHRLPHQHPWGGKLITLAGRAGRGWRPGWCPSWLTGPRRLWWSS
LPLRTVTVTLSSSLVILIVGGFFLVRQATAGIVEAKRTSAVAETTATINRIQGQLRDTDLRTASFYERLNLLADDAASQS
DQYHVLIQGPVSGLISQGVSPDSVPTDLTATVGESNGMWTAPTTVHYTDHVRPDVPGIVVGSTLWSPEASQSIPVYFIFP
ETQEVAAVELLRRSVISVGALMALAIAVTTYLATRHISLPIRQASITASKLAKGALDERMVVRGTDDLATLASSMNDMAA
QLDLRIGELEKLSSLQQQFVSDVSHELRTPMTTMRMASEMVEANPDDPVQVRSVELMRAQMERLELLLADLLEISRFDAG
AAQLSLEDCDIVDLVRSEISDVTPLADRLGVSIVLVAEAAQTAEVDPRRISRIVRNLVSNAVEHAEGKTVEVTVVGNDCA
VGVAVRDHGVGFEAWQAEKVFGRFWRGDPSRVRTVGGSGLGLAISRQDANLHHGWLTAWGRPNQGAYFRLVVPRQPGGVI
VKSPLPASPTDADRSDDEEER

Specific function: Member of the two-component regulatory system mtrA/mtrB. Seems to function as a membrane-associated protein kinase that phosphorylates mtrA in response to environmental signals [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1786600, Length=288, Percent_Identity=27.4305555555556, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI1788393, Length=283, Percent_Identity=27.208480565371, Blast_Score=99, Evalue=8e-22,
Organism=Escherichia coli, GI1787894, Length=269, Percent_Identity=26.3940520446097, Blast_Score=97, Evalue=2e-21,
Organism=Escherichia coli, GI1790346, Length=276, Percent_Identity=27.8985507246377, Blast_Score=97, Evalue=4e-21,
Organism=Escherichia coli, GI1786783, Length=305, Percent_Identity=25.5737704918033, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1789149, Length=336, Percent_Identity=24.1071428571429, Blast_Score=93, Evalue=5e-20,
Organism=Escherichia coli, GI1786912, Length=288, Percent_Identity=26.0416666666667, Blast_Score=87, Evalue=4e-18,
Organism=Escherichia coli, GI1788713, Length=245, Percent_Identity=23.265306122449, Blast_Score=81, Evalue=2e-16,
Organism=Escherichia coli, GI145693157, Length=226, Percent_Identity=23.8938053097345, Blast_Score=79, Evalue=6e-16,
Organism=Escherichia coli, GI1789403, Length=216, Percent_Identity=31.0185185185185, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI87082128, Length=298, Percent_Identity=25.8389261744966, Blast_Score=78, Evalue=2e-15,
Organism=Escherichia coli, GI1788279, Length=258, Percent_Identity=25.968992248062, Blast_Score=77, Evalue=3e-15,
Organism=Escherichia coli, GI1788549, Length=237, Percent_Identity=25.7383966244726, Blast_Score=77, Evalue=4e-15,
Organism=Escherichia coli, GI87081816, Length=258, Percent_Identity=27.5193798449612, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI1790551, Length=294, Percent_Identity=24.1496598639456, Blast_Score=69, Evalue=6e-13,
Organism=Escherichia coli, GI1790436, Length=227, Percent_Identity=24.2290748898678, Blast_Score=67, Evalue=3e-12,
Organism=Escherichia coli, GI1790861, Length=237, Percent_Identity=26.1603375527426, Blast_Score=64, Evalue=4e-11,
Organism=Escherichia coli, GI48994928, Length=229, Percent_Identity=24.4541484716157, Blast_Score=63, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 63377; Mature: 63245

Theoretical pI: Translated: 6.31; Mature: 6.31

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGIHQHHRYSVGQRPCAETAFQGGAQRGPPPDDRHCSWHRLPHQHPWGGKLITLAGRAGR
CCCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCHHCCCCCCCCCCEEEEEECCCCC
GWRPGWCPSWLTGPRRLWWSSLPLRTVTVTLSSSLVILIVGGFFLVRQATAGIVEAKRTS
CCCCCCCCCCCCCCHHHHHCCCCCEEEEEEECCCEEEEHHHHHHHHHHHHHHHHHHHHHH
AVAETTATINRIQGQLRDTDLRTASFYERLNLLADDAASQSDQYHVLIQGPVSGLISQGV
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEECCHHHHHHCCC
SPDSVPTDLTATVGESNGMWTAPTTVHYTDHVRPDVPGIVVGSTLWSPEASQSIPVYFIF
CCCCCCCCCEEEECCCCCEEECCCEEEECCCCCCCCCCEEEECCCCCCCCCCCCCEEEEC
PETQEVAAVELLRRSVISVGALMALAIAVTTYLATRHISLPIRQASITASKLAKGALDER
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCHHHHHHHHHHHHHCCCCC
MVVRGTDDLATLASSMNDMAAQLDLRIGELEKLSSLQQQFVSDVSHELRTPMTTMRMASE
EEEECCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
MVEANPDDPVQVRSVELMRAQMERLELLLADLLEISRFDAGAAQLSLEDCDIVDLVRSEI
HHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCHHHHHHHHHH
SDVTPLADRLGVSIVLVAEAAQTAEVDPRRISRIVRNLVSNAVEHAEGKTVEVTVVGNDC
HHCCHHHHHCCCEEEEEECCCHHCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCE
AVGVAVRDHGVGFEAWQAEKVFGRFWRGDPSRVRTVGGSGLGLAISRQDANLHHGWLTAW
EEEEEEECCCCCCHHHHHHHHHHHHHCCCHHHEEEECCCCCEEEEECCCCCCCCCEEEEC
GRPNQGAYFRLVVPRQPGGVIVKSPLPASPTDADRSDDEEER
CCCCCCCEEEEEEECCCCCEEEECCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure 
GIHQHHRYSVGQRPCAETAFQGGAQRGPPPDDRHCSWHRLPHQHPWGGKLITLAGRAGR
CCCCCCCCCCCCCCHHHHHHCCCCCCCCCCCCCCCCHHCCCCCCCCCCEEEEEECCCCC
GWRPGWCPSWLTGPRRLWWSSLPLRTVTVTLSSSLVILIVGGFFLVRQATAGIVEAKRTS
CCCCCCCCCCCCCCHHHHHCCCCCEEEEEEECCCEEEEHHHHHHHHHHHHHHHHHHHHHH
AVAETTATINRIQGQLRDTDLRTASFYERLNLLADDAASQSDQYHVLIQGPVSGLISQGV
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHCCCCCCCEEEEEECCHHHHHHCCC
SPDSVPTDLTATVGESNGMWTAPTTVHYTDHVRPDVPGIVVGSTLWSPEASQSIPVYFIF
CCCCCCCCCEEEECCCCCEEECCCEEEECCCCCCCCCCEEEECCCCCCCCCCCCCEEEEC
PETQEVAAVELLRRSVISVGALMALAIAVTTYLATRHISLPIRQASITASKLAKGALDER
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCHHHHHHHHHHHHHCCCCC
MVVRGTDDLATLASSMNDMAAQLDLRIGELEKLSSLQQQFVSDVSHELRTPMTTMRMASE
EEEECCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHH
MVEANPDDPVQVRSVELMRAQMERLELLLADLLEISRFDAGAAQLSLEDCDIVDLVRSEI
HHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCCHHHHHHHHHH
SDVTPLADRLGVSIVLVAEAAQTAEVDPRRISRIVRNLVSNAVEHAEGKTVEVTVVGNDC
HHCCHHHHHCCCEEEEEECCCHHCCCCHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCCE
AVGVAVRDHGVGFEAWQAEKVFGRFWRGDPSRVRTVGGSGLGLAISRQDANLHHGWLTAW
EEEEEEECCCCCCHHHHHHHHHHHHHCCCHHHEEEECCCCCEEEEECCCCCCCCCEEEEC
GRPNQGAYFRLVVPRQPGGVIVKSPLPASPTDADRSDDEEER
CCCCCCCEEEEEEECCCCCEEEECCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA