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The map label for this gene is serA [H]

Identifier: 50842751

GI number: 50842751

Start: 1379370

End: 1380623

Strand: Reverse

Name: serA [H]

Synonym: PPA1272

Alternate gene names: 50842751

Gene position: 1380623-1379370 (Counterclockwise)

Preceding gene: 50842752

Following gene: 50842749

Centisome position: 53.93

GC content: 55.26

Gene sequence:

>1254_bases
ATGATTCCACCCATTGAGACGCCCGCAACGGGTCGCGCTTGCCCCCTCCATAAACTGGCGGTTATGAAGGCGCTGCTACT
CGAAAACATCCATGACGAAGCGGTCCGAACACTGAAAAAGGCCGGATACGAGGTCGAGCGGGTAAGTGAGGCCCTTGACG
AGGATGACCTCATCAGCGCCCTTGACGGAGTTGACCTGTTGGGCATCAGATCACGTACCCGCGTTACTCGTCGGGTCGTT
GAGGCCTGCGGCGACAAGCTCCATGCGGTTGGCGCTTTTTGTATTGGCACTAATCAGATGGATCTTGATGCGTTAGCCGA
GGCTGGCGTTCCCGCTTTTAATGCTCCTTATTCCAATACCCGTTCAGTCGTTGAGCTTGTCATGGCAGAGATCATCGCTC
TAGCTCGTCGTTTAGGCGATCGCAATACTCAAATGCACAACGGTGTGTGGCGTAAGTCCGCAATTGGGTCGCACGAGATT
CGTGGACGTCGACTAGGCATTATCGGCTACGGCAATATTGGCCAGCAGCTGTCGGTCGTGGCAGAGGCCATGGGCATGCA
GGTGTTTTTCTATGACATCGCTGATGTTTTACCTATGGGCAACGCTCACAAGTGTGATTCCATGGAAGAGCTGCTTGGTA
GCGTCGAGACGGTGTCTCTTCATATCGATGGACGCCCCAGCAACACCGATCTTATCGGGGATCGCGAATTCGCCATGATG
CGACCGAGGTCCCTCTTTCTAAACTTGTCGCGAGGCAAGGTCGTCGACATCAATGCTCTGGTGGACAACCTACGTACTGG
ACACATCGCTGGCGCAGGAGTGGACGTGTATCCCGAAGAGCCGGCCTCCGGAAAAGAGCCCTTTATCTCTCCGTTGCGCG
AGATGGACAATGTTATTCTGACCCCGCATATCGGCGGGTCCACCCAAGAGGCTCAAGTTGATATCGGTCGTTACGTCGCC
GGGAAACTTATCGACTATGTAGATAACGGCGCGACCGGAATGAGTGTTAACATTCCTGAGATCACCCCATCGCCTCGCAC
GGGTGCTCGCATCGGCCATCTACATCGCAATGTCCCAGGTGTCATGGCGACCCTGAACCGACTCGTTGCTGATCAGGGGG
GAAACGTCACTTACCAGGCTCTGGCGACGAAGGGCGAGCTCGGTTACTGCATTCTCGACATTGCGGAGACTGACAGTGGG
CTGCTCGCCAATGTCACCGTTCTTGAGGGGACAATTCGGGCTCGTATCCTCTAA

Upstream 100 bases:

>100_bases
GGGCGGATCGTCGAGCGGGGTAAGCTCGCGGACGTGTACCGTGACCCGCAGCACGTGGTTACTCAGGAGCTACTAAGAGC
GATTCCACGCATTCGCGTCG

Downstream 100 bases:

>100_bases
CTGGCGATGCGCAGCGGGGACAGGGGCGTCCGGCGACCGGTGCTCACTCCTGGGGCTGGACCATGGCTAGGGCCTGGTCA
TGAAGGAAACCATTCGACGC

Product: D-3-phosphoglycerate dehydrogenase

Products: NA

Alternate protein names: PGDH [H]

Number of amino acids: Translated: 417; Mature: 417

Protein sequence:

>417_residues
MIPPIETPATGRACPLHKLAVMKALLLENIHDEAVRTLKKAGYEVERVSEALDEDDLISALDGVDLLGIRSRTRVTRRVV
EACGDKLHAVGAFCIGTNQMDLDALAEAGVPAFNAPYSNTRSVVELVMAEIIALARRLGDRNTQMHNGVWRKSAIGSHEI
RGRRLGIIGYGNIGQQLSVVAEAMGMQVFFYDIADVLPMGNAHKCDSMEELLGSVETVSLHIDGRPSNTDLIGDREFAMM
RPRSLFLNLSRGKVVDINALVDNLRTGHIAGAGVDVYPEEPASGKEPFISPLREMDNVILTPHIGGSTQEAQVDIGRYVA
GKLIDYVDNGATGMSVNIPEITPSPRTGARIGHLHRNVPGVMATLNRLVADQGGNVTYQALATKGELGYCILDIAETDSG
LLANVTVLEGTIRARIL

Sequences:

>Translated_417_residues
MIPPIETPATGRACPLHKLAVMKALLLENIHDEAVRTLKKAGYEVERVSEALDEDDLISALDGVDLLGIRSRTRVTRRVV
EACGDKLHAVGAFCIGTNQMDLDALAEAGVPAFNAPYSNTRSVVELVMAEIIALARRLGDRNTQMHNGVWRKSAIGSHEI
RGRRLGIIGYGNIGQQLSVVAEAMGMQVFFYDIADVLPMGNAHKCDSMEELLGSVETVSLHIDGRPSNTDLIGDREFAMM
RPRSLFLNLSRGKVVDINALVDNLRTGHIAGAGVDVYPEEPASGKEPFISPLREMDNVILTPHIGGSTQEAQVDIGRYVA
GKLIDYVDNGATGMSVNIPEITPSPRTGARIGHLHRNVPGVMATLNRLVADQGGNVTYQALATKGELGYCILDIAETDSG
LLANVTVLEGTIRARIL
>Mature_417_residues
MIPPIETPATGRACPLHKLAVMKALLLENIHDEAVRTLKKAGYEVERVSEALDEDDLISALDGVDLLGIRSRTRVTRRVV
EACGDKLHAVGAFCIGTNQMDLDALAEAGVPAFNAPYSNTRSVVELVMAEIIALARRLGDRNTQMHNGVWRKSAIGSHEI
RGRRLGIIGYGNIGQQLSVVAEAMGMQVFFYDIADVLPMGNAHKCDSMEELLGSVETVSLHIDGRPSNTDLIGDREFAMM
RPRSLFLNLSRGKVVDINALVDNLRTGHIAGAGVDVYPEEPASGKEPFISPLREMDNVILTPHIGGSTQEAQVDIGRYVA
GKLIDYVDNGATGMSVNIPEITPSPRTGARIGHLHRNVPGVMATLNRLVADQGGNVTYQALATKGELGYCILDIAETDSG
LLANVTVLEGTIRARIL

Specific function: Serine biosynthesis; first step. [C]

COG id: COG0111

COG function: function code HE; Phosphoglycerate dehydrogenase and related dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 ACT domain [H]

Homologues:

Organism=Homo sapiens, GI23308577, Length=339, Percent_Identity=31.5634218289086, Blast_Score=161, Evalue=1e-39,
Organism=Homo sapiens, GI61743967, Length=252, Percent_Identity=28.968253968254, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI4557497, Length=252, Percent_Identity=28.968253968254, Blast_Score=111, Evalue=1e-24,
Organism=Homo sapiens, GI145580578, Length=256, Percent_Identity=29.6875, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI4557499, Length=256, Percent_Identity=29.6875, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI145580575, Length=256, Percent_Identity=29.6875, Blast_Score=107, Evalue=1e-23,
Organism=Homo sapiens, GI6912396, Length=313, Percent_Identity=26.1980830670927, Blast_Score=102, Evalue=9e-22,
Organism=Escherichia coli, GI1789279, Length=401, Percent_Identity=49.8753117206983, Blast_Score=400, Evalue=1e-112,
Organism=Escherichia coli, GI87082289, Length=260, Percent_Identity=30.7692307692308, Blast_Score=111, Evalue=8e-26,
Organism=Escherichia coli, GI1787645, Length=291, Percent_Identity=25.4295532646048, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI1788660, Length=318, Percent_Identity=27.3584905660377, Blast_Score=65, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17532191, Length=313, Percent_Identity=29.3929712460064, Blast_Score=149, Evalue=4e-36,
Organism=Caenorhabditis elegans, GI25147481, Length=250, Percent_Identity=26, Blast_Score=77, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6320925, Length=397, Percent_Identity=42.3173803526448, Blast_Score=334, Evalue=1e-92,
Organism=Saccharomyces cerevisiae, GI6322116, Length=397, Percent_Identity=42.3173803526448, Blast_Score=334, Evalue=2e-92,
Organism=Saccharomyces cerevisiae, GI6324055, Length=224, Percent_Identity=27.2321428571429, Blast_Score=85, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6324964, Length=269, Percent_Identity=24.907063197026, Blast_Score=74, Evalue=6e-14,
Organism=Saccharomyces cerevisiae, GI6321253, Length=158, Percent_Identity=27.2151898734177, Blast_Score=64, Evalue=4e-11,
Organism=Drosophila melanogaster, GI19921140, Length=308, Percent_Identity=29.2207792207792, Blast_Score=135, Evalue=6e-32,
Organism=Drosophila melanogaster, GI28571528, Length=316, Percent_Identity=26.5822784810127, Blast_Score=111, Evalue=8e-25,
Organism=Drosophila melanogaster, GI24646446, Length=254, Percent_Identity=30.7086614173228, Blast_Score=99, Evalue=4e-21,
Organism=Drosophila melanogaster, GI24646448, Length=254, Percent_Identity=30.7086614173228, Blast_Score=99, Evalue=4e-21,
Organism=Drosophila melanogaster, GI24646452, Length=254, Percent_Identity=30.7086614173228, Blast_Score=99, Evalue=4e-21,
Organism=Drosophila melanogaster, GI24646450, Length=254, Percent_Identity=30.7086614173228, Blast_Score=99, Evalue=4e-21,
Organism=Drosophila melanogaster, GI62472511, Length=254, Percent_Identity=30.7086614173228, Blast_Score=99, Evalue=4e-21,
Organism=Drosophila melanogaster, GI28574286, Length=244, Percent_Identity=27.0491803278689, Blast_Score=99, Evalue=5e-21,
Organism=Drosophila melanogaster, GI24585516, Length=313, Percent_Identity=23.3226837060703, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI45551003, Length=303, Percent_Identity=22.4422442244224, Blast_Score=90, Evalue=3e-18,
Organism=Drosophila melanogaster, GI24585514, Length=300, Percent_Identity=22.6666666666667, Blast_Score=90, Evalue=3e-18,
Organism=Drosophila melanogaster, GI28574282, Length=300, Percent_Identity=22.6666666666667, Blast_Score=90, Evalue=3e-18,
Organism=Drosophila melanogaster, GI28574284, Length=299, Percent_Identity=22.742474916388, Blast_Score=90, Evalue=3e-18,
Organism=Drosophila melanogaster, GI45552429, Length=300, Percent_Identity=22.6666666666667, Blast_Score=89, Evalue=4e-18,

Paralogues:

None

Copy number: 380 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR006139
- InterPro:   IPR006140
- InterPro:   IPR010771
- InterPro:   IPR016040
- ProDom:   PD147088 [H]

Pfam domain/function: PF00389 2-Hacid_dh; PF02826 2-Hacid_dh_C; PF01842 ACT [H]

EC number: =1.1.1.95 [H]

Molecular weight: Translated: 44943; Mature: 44943

Theoretical pI: Translated: 5.61; Mature: 5.61

Prosite motif: PS00065 D_2_HYDROXYACID_DH_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIPPIETPATGRACPLHKLAVMKALLLENIHDEAVRTLKKAGYEVERVSEALDEDDLISA
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHH
LDGVDLLGIRSRTRVTRRVVEACGDKLHAVGAFCIGTNQMDLDALAEAGVPAFNAPYSNT
HCCCCEECCCHHHHHHHHHHHHHCCHHHHHEEEEECCCCCCHHHHHHCCCCCCCCCCCCH
RSVVELVMAEIIALARRLGDRNTQMHNGVWRKSAIGSHEIRGRRLGIIGYGNIGQQLSVV
HHHHHHHHHHHHHHHHHHCCCCCHHHCCCHHHHCCCCCCCCCCEEEEEECCCCCHHHHHH
AEAMGMQVFFYDIADVLPMGNAHKCDSMEELLGSVETVSLHIDGRPSNTDLIGDREFAMM
HHHHCCEEEEEHHHHHHCCCCCCCCCHHHHHHCCEEEEEEEECCCCCCCCCCCCCHHHHC
RPRSLFLNLSRGKVVDINALVDNLRTGHIAGAGVDVYPEEPASGKEPFISPLREMDNVIL
CCHHHEEECCCCCEEEHHHHHHCCCCCCEECCCCCCCCCCCCCCCCHHHHHHHHHCCEEE
TPHIGGSTQEAQVDIGRYVAGKLIDYVDNGATGMSVNIPEITPSPRTGARIGHLHRNVPG
ECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCCCHHHHHHCCCCH
VMATLNRLVADQGGNVTYQALATKGELGYCILDIAETDSGLLANVTVLEGTIRARIL
HHHHHHHHHHCCCCCEEEEEEECCCCCCEEEEEEECCCCCCEEEEEEEECCCCEECC
>Mature Secondary Structure
MIPPIETPATGRACPLHKLAVMKALLLENIHDEAVRTLKKAGYEVERVSEALDEDDLISA
CCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHH
LDGVDLLGIRSRTRVTRRVVEACGDKLHAVGAFCIGTNQMDLDALAEAGVPAFNAPYSNT
HCCCCEECCCHHHHHHHHHHHHHCCHHHHHEEEEECCCCCCHHHHHHCCCCCCCCCCCCH
RSVVELVMAEIIALARRLGDRNTQMHNGVWRKSAIGSHEIRGRRLGIIGYGNIGQQLSVV
HHHHHHHHHHHHHHHHHHCCCCCHHHCCCHHHHCCCCCCCCCCEEEEEECCCCCHHHHHH
AEAMGMQVFFYDIADVLPMGNAHKCDSMEELLGSVETVSLHIDGRPSNTDLIGDREFAMM
HHHHCCEEEEEHHHHHHCCCCCCCCCHHHHHHCCEEEEEEEECCCCCCCCCCCCCHHHHC
RPRSLFLNLSRGKVVDINALVDNLRTGHIAGAGVDVYPEEPASGKEPFISPLREMDNVIL
CCHHHEEECCCCCEEEHHHHHHCCCCCCEECCCCCCCCCCCCCCCCHHHHHHHHHCCEEE
TPHIGGSTQEAQVDIGRYVAGKLIDYVDNGATGMSVNIPEITPSPRTGARIGHLHRNVPG
ECCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCEEECCCCCCCCCCCCHHHHHHCCCCH
VMATLNRLVADQGGNVTYQALATKGELGYCILDIAETDSGLLANVTVLEGTIRARIL
HHHHHHHHHHCCCCCEEEEEEECCCCCCEEEEEEECCCCCCEEEEEEEECCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]