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The map label for this gene is engA

Identifier: 50842690

GI number: 50842690

Start: 1317706

End: 1319076

Strand: Direct

Name: engA

Synonym: PPA1210

Alternate gene names: 50842690

Gene position: 1317706-1319076 (Clockwise)

Preceding gene: 50842689

Following gene: 50842697

Centisome position: 51.47

GC content: 60.69

Gene sequence:

>1371_bases
ATGTCTGACTCGCCCGAGTTTCGCAACGACCCCAGCGACGACATCGAGGAGGCTCTTCCCAAGCCTGTTGTTGCCGTCGT
CGGTCGGCCCAATGTCGGTAAATCCACCCTCGTCAATCGCATCCTTGGCCGCAGAGCAGCTGTCGTACAGGATGTCCCGG
GAGTGACCCGTGACCGAGTGTCTTATGACGCGGAGTGGTCTGGTCGCCAGTTCGTCCTCGTCGATACCGGCGGTTGGGCC
TCCGATGCCTCTGGCATGGCGGCCATGATCGCCGAGCAGGCCGAATTGGCTATCTCAACTGCTGACGCCGTTCTCTTCGT
CGTTGACGCGAACGTGGGCACCACCGACGAAGATGAGGCCGTTGTCCAGGTACTGAGGCAGTCTCGTAAGCCCGTCGTGG
TAGCTGCCAACAAGGTCGACAATGCACGCGGCGAGTCTGAAGCAGCGACAATGTGGAACCTAGGACTGGGGGAGCCCCAC
CCCGTTTCCGCCATGCACGGACGCGGTTCAGGTGACCTTCTTGATGCGCTCATTGCGGTACTGCCGAAGGAGCAGGCTAG
CTACGAGTCATCGGACGGACCGCGTCGGGTCGCCATTGTGGGCAAGCCGAATGTCGGCAAGTCGTCTCTTCTGAACCGTA
TAGCGCGTCAGAACCGCGTAGTCGTCTCGGATATTTCCGGGACGACGGTTGATCCCGTTGATGAGTTAGTCACCGTTGGT
GGCACCGTCTATCAGTTCATTGACACCGCTGGTTTGCGCAAGAGGGTCAAGGAGGCCTCCGGGCACGAGTACTACGCTTC
ACTGCGCACCCAGGCTGCCATCGAGCGTGCCGAGGTCTGCGTGGTCGTCATTGATGCCTCGGAGTCGATCAGCGACCAGG
ACCTTCGCATCCTCACGATGGTCGAGAATGCGGGTCGGGCGATGGTCATCGCCTACAACAAGTGGGATTTGACCGATGAA
GAGCGACGCCGCTATTTAGAGCGCGAGATCGAGCGCGACGTTCAGGCCTATTCGTGGGCGCCGCGGGTCAACATCTCTGC
GCTCAACGGCCGGAATGTCGACAAGCTCGAGAAGGCTATTGAGACGGCCGCAGAAGGCTGGGAGACGCGCATTTCGACCG
GCAAGCTCAACGCATTCCTTGGACGTCTTGCAGCTGCCCACCCACACCCGGTGCGGGGAGGGAAACAACCGAGGATCCTC
TTCGGGACCCAAGCCCACAACTGTCCGCCGACGTTCGCCCTGTTCACATCGGGGGTATTCGACCAAGGATATGTGCGGTT
CATCATCAGGCGGCTGCGTGAAGACTTCGGCTTCGCCGGTTCACCCGTCCATGTGGAGATCCGACCTCGGGCGAAGCGGC
AGAGGAAGTGA

Upstream 100 bases:

>100_bases
GCTGTCATTGATCTGGTGCCCGTCACGCTGCGCTGAGCAGTATTTTTCCTAGCGCCACACCGTGTACCGTGGTTTAGTCC
CCTAGCAGGAGCGTGCCTTC

Downstream 100 bases:

>100_bases
ACAGTTTTGTCGGCGGAACGGAAGTACGCTAATGTACTTCTTCGGGTCACCGAGTGATCCAAACGGGCTGTGGCGCAGTT
TGGTAGCGCACTTGACTGGG

Product: GTP-binding protein EngA

Products: NA

Alternate protein names: GTP-binding protein EngA [H]

Number of amino acids: Translated: 456; Mature: 455

Protein sequence:

>456_residues
MSDSPEFRNDPSDDIEEALPKPVVAVVGRPNVGKSTLVNRILGRRAAVVQDVPGVTRDRVSYDAEWSGRQFVLVDTGGWA
SDASGMAAMIAEQAELAISTADAVLFVVDANVGTTDEDEAVVQVLRQSRKPVVVAANKVDNARGESEAATMWNLGLGEPH
PVSAMHGRGSGDLLDALIAVLPKEQASYESSDGPRRVAIVGKPNVGKSSLLNRIARQNRVVVSDISGTTVDPVDELVTVG
GTVYQFIDTAGLRKRVKEASGHEYYASLRTQAAIERAEVCVVVIDASESISDQDLRILTMVENAGRAMVIAYNKWDLTDE
ERRRYLEREIERDVQAYSWAPRVNISALNGRNVDKLEKAIETAAEGWETRISTGKLNAFLGRLAAAHPHPVRGGKQPRIL
FGTQAHNCPPTFALFTSGVFDQGYVRFIIRRLREDFGFAGSPVHVEIRPRAKRQRK

Sequences:

>Translated_456_residues
MSDSPEFRNDPSDDIEEALPKPVVAVVGRPNVGKSTLVNRILGRRAAVVQDVPGVTRDRVSYDAEWSGRQFVLVDTGGWA
SDASGMAAMIAEQAELAISTADAVLFVVDANVGTTDEDEAVVQVLRQSRKPVVVAANKVDNARGESEAATMWNLGLGEPH
PVSAMHGRGSGDLLDALIAVLPKEQASYESSDGPRRVAIVGKPNVGKSSLLNRIARQNRVVVSDISGTTVDPVDELVTVG
GTVYQFIDTAGLRKRVKEASGHEYYASLRTQAAIERAEVCVVVIDASESISDQDLRILTMVENAGRAMVIAYNKWDLTDE
ERRRYLEREIERDVQAYSWAPRVNISALNGRNVDKLEKAIETAAEGWETRISTGKLNAFLGRLAAAHPHPVRGGKQPRIL
FGTQAHNCPPTFALFTSGVFDQGYVRFIIRRLREDFGFAGSPVHVEIRPRAKRQRK
>Mature_455_residues
SDSPEFRNDPSDDIEEALPKPVVAVVGRPNVGKSTLVNRILGRRAAVVQDVPGVTRDRVSYDAEWSGRQFVLVDTGGWAS
DASGMAAMIAEQAELAISTADAVLFVVDANVGTTDEDEAVVQVLRQSRKPVVVAANKVDNARGESEAATMWNLGLGEPHP
VSAMHGRGSGDLLDALIAVLPKEQASYESSDGPRRVAIVGKPNVGKSSLLNRIARQNRVVVSDISGTTVDPVDELVTVGG
TVYQFIDTAGLRKRVKEASGHEYYASLRTQAAIERAEVCVVVIDASESISDQDLRILTMVENAGRAMVIAYNKWDLTDEE
RRRYLEREIERDVQAYSWAPRVNISALNGRNVDKLEKAIETAAEGWETRISTGKLNAFLGRLAAAHPHPVRGGKQPRILF
GTQAHNCPPTFALFTSGVFDQGYVRFIIRRLREDFGFAGSPVHVEIRPRAKRQRK

Specific function: GTPase that plays an essential role in the late steps of ribosome biogenesis [H]

COG id: COG1160

COG function: function code R; Predicted GTPases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 KH-like domain [H]

Homologues:

Organism=Escherichia coli, GI87082120, Length=456, Percent_Identity=36.6228070175439, Blast_Score=280, Evalue=2e-76,
Organism=Escherichia coli, GI1788919, Length=125, Percent_Identity=35.2, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI2367268, Length=123, Percent_Identity=34.1463414634146, Blast_Score=63, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17507259, Length=128, Percent_Identity=35.9375, Blast_Score=69, Evalue=7e-12,
Organism=Saccharomyces cerevisiae, GI6323665, Length=201, Percent_Identity=27.8606965174129, Blast_Score=70, Evalue=6e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR016484
- InterPro:   IPR006073
- InterPro:   IPR015946
- InterPro:   IPR002917
- InterPro:   IPR005225 [H]

Pfam domain/function: PF01926 MMR_HSR1 [H]

EC number: NA

Molecular weight: Translated: 49819; Mature: 49688

Theoretical pI: Translated: 6.65; Mature: 6.65

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDSPEFRNDPSDDIEEALPKPVVAVVGRPNVGKSTLVNRILGRRAAVVQDVPGVTRDRV
CCCCCCCCCCCCHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHC
SYDAEWSGRQFVLVDTGGWASDASGMAAMIAEQAELAISTADAVLFVVDANVGTTDEDEA
CCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHEEEECCEEEEEEECCCCCCCCHHH
VVQVLRQSRKPVVVAANKVDNARGESEAATMWNLGLGEPHPVSAMHGRGSGDLLDALIAV
HHHHHHHCCCCEEEEECCCCCCCCCCHHHEEEECCCCCCCCCHHCCCCCCHHHHHHHHHH
LPKEQASYESSDGPRRVAIVGKPNVGKSSLLNRIARQNRVVVSDISGTTVDPVDELVTVG
CCCHHHCCCCCCCCEEEEEEECCCCCHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHCC
GTVYQFIDTAGLRKRVKEASGHEYYASLRTQAAIERAEVCVVVIDASESISDQDLRILTM
CHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCEEEEEE
VENAGRAMVIAYNKWDLTDEERRRYLEREIERDVQAYSWAPRVNISALNGRNVDKLEKAI
EECCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHH
ETAAEGWETRISTGKLNAFLGRLAAAHPHPVRGGKQPRILFGTQAHNCPPTFALFTSGVF
HHHHCCHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCCCCCCHHHHHCCCC
DQGYVRFIIRRLREDFGFAGSPVHVEIRPRAKRQRK
CCHHHHHHHHHHHHHHCCCCCCEEEEECCCHHCCCC
>Mature Secondary Structure 
SDSPEFRNDPSDDIEEALPKPVVAVVGRPNVGKSTLVNRILGRRAAVVQDVPGVTRDRV
CCCCCCCCCCCHHHHHHCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHC
SYDAEWSGRQFVLVDTGGWASDASGMAAMIAEQAELAISTADAVLFVVDANVGTTDEDEA
CCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHEEEECCEEEEEEECCCCCCCCHHH
VVQVLRQSRKPVVVAANKVDNARGESEAATMWNLGLGEPHPVSAMHGRGSGDLLDALIAV
HHHHHHHCCCCEEEEECCCCCCCCCCHHHEEEECCCCCCCCCHHCCCCCCHHHHHHHHHH
LPKEQASYESSDGPRRVAIVGKPNVGKSSLLNRIARQNRVVVSDISGTTVDPVDELVTVG
CCCHHHCCCCCCCCEEEEEEECCCCCHHHHHHHHHHCCCEEEEECCCCCCCCHHHHHHCC
GTVYQFIDTAGLRKRVKEASGHEYYASLRTQAAIERAEVCVVVIDASESISDQDLRILTM
CHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCEEEEEEECCCCCCCCCEEEEEE
VENAGRAMVIAYNKWDLTDEERRRYLEREIERDVQAYSWAPRVNISALNGRNVDKLEKAI
EECCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCEEEECCCCCHHHHHHHH
ETAAEGWETRISTGKLNAFLGRLAAAHPHPVRGGKQPRILFGTQAHNCPPTFALFTSGVF
HHHHCCHHHHCCCCHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCCCCCCHHHHHCCCC
DQGYVRFIIRRLREDFGFAGSPVHVEIRPRAKRQRK
CCHHHHHHHHHHHHHHCCCCCCEEEEECCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11572948; 12692562 [H]