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The map label for this gene is relA [H]

Identifier: 50842646

GI number: 50842646

Start: 1266496

End: 1268820

Strand: Direct

Name: relA [H]

Synonym: PPA1166

Alternate gene names: 50842646

Gene position: 1266496-1268820 (Clockwise)

Preceding gene: 50842645

Following gene: 50842648

Centisome position: 49.47

GC content: 57.46

Gene sequence:

>2325_bases
ATGACCGACGATAGCGTCTATGGCCCGTACGGTTCGGGCAAGGGAACCCTGGGCAAGCCGAAGCCCGGCCAACAGCGTCC
CCAGCCCCGTATGCGGATGCGCGAGCGCATTGTCCGGTGGGGGACGCCGAAACCACCAGCACCGACGCAAAGCGTCACGG
ATCCCTTAATTTCGGTAGTGCTGGCCAACCACCCCAAGGCCGACACCGCTATCATCGAGCGGGCATATCGCACTGCTGAG
CATTACCACCGCGGACAGTCTCGTAAGTCTGGTGACCCCTACATCACACATCCACTTGCGGTGACGATGATCCTCGCTGA
GCTTGGCATGGACGAGCGGACTCTATGCGCCGGCCTCCTGCACGACACCGTCGAAGACACGTCCTACACCAACGAACAGC
TCACTGCTGATTTCGGTGAAGAAATCGCCCTTCTCGTCGATGGGGTCACTAAGCTCGACAAAGTCCAATATGGGGATTCT
GCGAAAGCTGAGACCATTCGCAAGATGGTCATCGCGATGAGCCGAGATATTCGGGTTCTCGTCATCAAGCTGGCAGATCG
GCTGCATAATATGCGCACGTTAGGGTTTCTACGTCCCGATAAGCAAAACCGTATTGCCAAGGAAACCCTCGAGATTTTCG
CCCCGCTAGCTCACCGCCTTGGGATGAATGCCATCAAGTGGGAGCTGGAAGACCTGTGCTTCTCCACCCTTAACCCGAAG
CTCTACGACGAGATCGTCCATATGGTTGCGGAGCGGGCTCCGCAACGGGAAGCCCAACTCAAAGATGTCATCACAATCGT
TCGTCAGGACCTTGACGAAGCAGGCATCAAGGCCATCGTCTACGGACGACCGAAGCATTACTACTCGATCTATCAAAAGA
TGGTGGTACGGGGCCGGGATTTCTCTGACATCTACGACCTCACCGGTCTGCGCATCCTTGTCGACACTCCACGCGATTGT
TACGCAGCCCTCGGTGTCATGCACGTGCGATGGAACCCTCTTCCGGGTCGGTTTAAGGACTACATCGCGATGCCCAAGTA
CAACATGTACCAGTCTTTGCACACCACGGTGTTGGGGCCGGGCGGCCAGCCGGTCGAGTTGCAGATCCGCACTCACGAGA
TGCACCGGCGTGCTGAGTATGGTGTAGCAGCCCACTGGAAGTATAAGGAAAACCCCAATGCTGTCGGTCGGGGGATTCAG
CCTGATGGCACAGATCTTTCGTGGGTGCAGTCTCTCAACCAGTGGTCCAAGGAGGAATCTGATCCCAGCGAGTTCCTGGA
CTCGCTGCGCTTCGAGATTAACTCTCGCGAGGTGTATGTCTTTACCCCCAAGGGCGATGTTATGAGCCTTCCTCAGGGCG
CCACTCCGGTTGACTTCGCCTATGCCGTCCATACCGAGGTTGGTCACCGCTGTATTGGCGCCAGGGTGAACGGCAAACTT
GTCACCCTCGATACCAAACTTAACAACGGCGACGTCATCGATATCCTCACGTCGAACGCGCCTGATGCGGGTCCCAGTCG
GGACTGGCTGGGGTTCATCGCTTCTCCCCGTGCTCGTTCCAAGATTAAGTCTTACTTCACTAAGGAGCGCCGCGAGGAGT
CCATTGAAGCCGGCAAGGACGCTATCGCAAAGCAGCTACGTCAAGCCGGTGTGCCGTTACAGTCGTTGCTAACTGTCGAA
TACCTCACCGCGGTGGCCGACGACCTCCGGGTGCCCGGCATCAACGCCTTGTATGCGGCGGTAGGAGAGCACAACGCCAG
CGCCCAGTCCGTCGTCGAGAAGCTCATCGCGTTGGGTGGCGGCCCGGAAGAGGCTACCGCTGACGTCGAGGAAGAACTGG
CAGTTGGCGTCAAGGCGCCGCGTCGTCGTCGCAGTAGCGAAACTGGGGTTATGGTCGACGGCGATCCGGATATGCTTGTG
AAGCTGGCTCGGTGCTGTACCCCGCTGCCCGGCGATCCCATCATGGGGTTCGTGACGCGCTATGACGGGGTTTCAGTACA
TCGAACGGATTGCTCCAATGCCAAGAATCTTCTTGAGCACCCGGAGCGCATCGTTTCGGTGTCGTGGTCTGATGATCGGC
AAGAGAGCTATCAGGTCACTATCCAGGTGGAAGGCCTTGATCGTGCCGGTTTGTTGGTCGATACCTTTCGGGTTTTCGCC
GAGCAGGGGGTAAGCGTCATTTCAGCCAATATGAGTACGTCAAAGTCTCATCTCGCTCGATTGCGGCTTACCTTCGAAGC
CCCCGATCCGACTCACCTCAAGCACCTTACTGAGTCGATTCGTCGAATCTCGGGGGTTTACGACGTCTTCCGTGTGAAGT
CTTGA

Upstream 100 bases:

>100_bases
CAGCGCTGGTTGCACCTAGCCCTCGGGCAGCACACTCAACCGACACTGAGACGCGGCATACCACTAGAATGAGAGGTCTA
GCTTGCCAGGAGGTGACGCG

Downstream 100 bases:

>100_bases
AGGTTGCCTAGAACGCCAACGGCCCCGGGTCTGGGAAGTGTTCCGAGGCCGTCAGCGGTGACCATCAGGCGCTAAATTCG
TCGAGTGCCTTCTGAGCCTC

Product: GTP pyrophosphokinase

Products: NA

Alternate protein names: (p)ppGpp synthase; ATP:GTP 3'-pyrophosphotransferase; ppGpp synthase I [H]

Number of amino acids: Translated: 774; Mature: 773

Protein sequence:

>774_residues
MTDDSVYGPYGSGKGTLGKPKPGQQRPQPRMRMRERIVRWGTPKPPAPTQSVTDPLISVVLANHPKADTAIIERAYRTAE
HYHRGQSRKSGDPYITHPLAVTMILAELGMDERTLCAGLLHDTVEDTSYTNEQLTADFGEEIALLVDGVTKLDKVQYGDS
AKAETIRKMVIAMSRDIRVLVIKLADRLHNMRTLGFLRPDKQNRIAKETLEIFAPLAHRLGMNAIKWELEDLCFSTLNPK
LYDEIVHMVAERAPQREAQLKDVITIVRQDLDEAGIKAIVYGRPKHYYSIYQKMVVRGRDFSDIYDLTGLRILVDTPRDC
YAALGVMHVRWNPLPGRFKDYIAMPKYNMYQSLHTTVLGPGGQPVELQIRTHEMHRRAEYGVAAHWKYKENPNAVGRGIQ
PDGTDLSWVQSLNQWSKEESDPSEFLDSLRFEINSREVYVFTPKGDVMSLPQGATPVDFAYAVHTEVGHRCIGARVNGKL
VTLDTKLNNGDVIDILTSNAPDAGPSRDWLGFIASPRARSKIKSYFTKERREESIEAGKDAIAKQLRQAGVPLQSLLTVE
YLTAVADDLRVPGINALYAAVGEHNASAQSVVEKLIALGGGPEEATADVEEELAVGVKAPRRRRSSETGVMVDGDPDMLV
KLARCCTPLPGDPIMGFVTRYDGVSVHRTDCSNAKNLLEHPERIVSVSWSDDRQESYQVTIQVEGLDRAGLLVDTFRVFA
EQGVSVISANMSTSKSHLARLRLTFEAPDPTHLKHLTESIRRISGVYDVFRVKS

Sequences:

>Translated_774_residues
MTDDSVYGPYGSGKGTLGKPKPGQQRPQPRMRMRERIVRWGTPKPPAPTQSVTDPLISVVLANHPKADTAIIERAYRTAE
HYHRGQSRKSGDPYITHPLAVTMILAELGMDERTLCAGLLHDTVEDTSYTNEQLTADFGEEIALLVDGVTKLDKVQYGDS
AKAETIRKMVIAMSRDIRVLVIKLADRLHNMRTLGFLRPDKQNRIAKETLEIFAPLAHRLGMNAIKWELEDLCFSTLNPK
LYDEIVHMVAERAPQREAQLKDVITIVRQDLDEAGIKAIVYGRPKHYYSIYQKMVVRGRDFSDIYDLTGLRILVDTPRDC
YAALGVMHVRWNPLPGRFKDYIAMPKYNMYQSLHTTVLGPGGQPVELQIRTHEMHRRAEYGVAAHWKYKENPNAVGRGIQ
PDGTDLSWVQSLNQWSKEESDPSEFLDSLRFEINSREVYVFTPKGDVMSLPQGATPVDFAYAVHTEVGHRCIGARVNGKL
VTLDTKLNNGDVIDILTSNAPDAGPSRDWLGFIASPRARSKIKSYFTKERREESIEAGKDAIAKQLRQAGVPLQSLLTVE
YLTAVADDLRVPGINALYAAVGEHNASAQSVVEKLIALGGGPEEATADVEEELAVGVKAPRRRRSSETGVMVDGDPDMLV
KLARCCTPLPGDPIMGFVTRYDGVSVHRTDCSNAKNLLEHPERIVSVSWSDDRQESYQVTIQVEGLDRAGLLVDTFRVFA
EQGVSVISANMSTSKSHLARLRLTFEAPDPTHLKHLTESIRRISGVYDVFRVKS
>Mature_773_residues
TDDSVYGPYGSGKGTLGKPKPGQQRPQPRMRMRERIVRWGTPKPPAPTQSVTDPLISVVLANHPKADTAIIERAYRTAEH
YHRGQSRKSGDPYITHPLAVTMILAELGMDERTLCAGLLHDTVEDTSYTNEQLTADFGEEIALLVDGVTKLDKVQYGDSA
KAETIRKMVIAMSRDIRVLVIKLADRLHNMRTLGFLRPDKQNRIAKETLEIFAPLAHRLGMNAIKWELEDLCFSTLNPKL
YDEIVHMVAERAPQREAQLKDVITIVRQDLDEAGIKAIVYGRPKHYYSIYQKMVVRGRDFSDIYDLTGLRILVDTPRDCY
AALGVMHVRWNPLPGRFKDYIAMPKYNMYQSLHTTVLGPGGQPVELQIRTHEMHRRAEYGVAAHWKYKENPNAVGRGIQP
DGTDLSWVQSLNQWSKEESDPSEFLDSLRFEINSREVYVFTPKGDVMSLPQGATPVDFAYAVHTEVGHRCIGARVNGKLV
TLDTKLNNGDVIDILTSNAPDAGPSRDWLGFIASPRARSKIKSYFTKERREESIEAGKDAIAKQLRQAGVPLQSLLTVEY
LTAVADDLRVPGINALYAAVGEHNASAQSVVEKLIALGGGPEEATADVEEELAVGVKAPRRRRSSETGVMVDGDPDMLVK
LARCCTPLPGDPIMGFVTRYDGVSVHRTDCSNAKNLLEHPERIVSVSWSDDRQESYQVTIQVEGLDRAGLLVDTFRVFAE
QGVSVISANMSTSKSHLARLRLTFEAPDPTHLKHLTESIRRISGVYDVFRVKS

Specific function: In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which i

COG id: COG0317

COG function: function code TK; Guanosine polyphosphate pyrophosphohydrolases/synthetases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HD domain [H]

Homologues:

Organism=Escherichia coli, GI1790082, Length=710, Percent_Identity=39.2957746478873, Blast_Score=513, Evalue=1e-146,
Organism=Escherichia coli, GI1789147, Length=686, Percent_Identity=38.3381924198251, Blast_Score=474, Evalue=1e-135,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR012675
- InterPro:   IPR003607
- InterPro:   IPR007685
- InterPro:   IPR004811
- InterPro:   IPR004095
- InterPro:   IPR012676 [H]

Pfam domain/function: PF01842 ACT; PF04607 RelA_SpoT; PF02824 TGS [H]

EC number: =2.7.6.5 [H]

Molecular weight: Translated: 86399; Mature: 86267

Theoretical pI: Translated: 7.38; Mature: 7.38

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTDDSVYGPYGSGKGTLGKPKPGQQRPQPRMRMRERIVRWGTPKPPAPTQSVTDPLISVV
CCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHH
LANHPKADTAIIERAYRTAEHYHRGQSRKSGDPYITHPLAVTMILAELGMDERTLCAGLL
HCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEHHHHHHHHHHHHCCCHHHHHHHHH
HDTVEDTSYTNEQLTADFGEEIALLVDGVTKLDKVQYGDSAKAETIRKMVIAMSRDIRVL
HHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCHHHH
VIKLADRLHNMRTLGFLRPDKQNRIAKETLEIFAPLAHRLGMNAIKWELEDLCFSTLNPK
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCHH
LYDEIVHMVAERAPQREAQLKDVITIVRQDLDEAGIKAIVYGRPKHYYSIYQKMVVRGRD
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHCCCC
FSDIYDLTGLRILVDTPRDCYAALGVMHVRWNPLPGRFKDYIAMPKYNMYQSLHTTVLGP
HHHHHHHCCCEEEEECCHHHHHHHCEEEEEECCCCCHHHHHHCCCCHHHHHHHHHHEECC
GGQPVELQIRTHEMHRRAEYGVAAHWKYKENPNAVGRGIQPDGTDLSWVQSLNQWSKEES
CCCCEEEEEEHHHHHHHHHCCCEEEEEECCCCCHHCCCCCCCCCCHHHHHHHHHHHCCCC
DPSEFLDSLRFEINSREVYVFTPKGDVMSLPQGATPVDFAYAVHTEVGHRCIGARVNGKL
CHHHHHHHHHEEECCCEEEEECCCCCEEECCCCCCCCHHHHHHHHHHCCCEECEEECCEE
VTLDTKLNNGDVIDILTSNAPDAGPSRDWLGFIASPRARSKIKSYFTKERREESIEAGKD
EEEEEECCCCCEEEEEECCCCCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
AIAKQLRQAGVPLQSLLTVEYLTAVADDLRVPGINALYAAVGEHNASAQSVVEKLIALGG
HHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCHHHHHHHHHHHCCC
GPEEATADVEEELAVGVKAPRRRRSSETGVMVDGDPDMLVKLARCCTPLPGDPIMGFVTR
CCCHHHHHHHHHHHHCCCCHHHHCCCCCCEEECCCHHHHHHHHHHCCCCCCCCHHHHHHH
YDGVSVHRTDCSNAKNLLEHPERIVSVSWSDDRQESYQVTIQVEGLDRAGLLVDTFRVFA
CCCCEEECCCHHHHHHHHHCCHHEEEECCCCCCCCCEEEEEEEECCCCCCHHHHHHHHHH
EQGVSVISANMSTSKSHLARLRLTFEAPDPTHLKHLTESIRRISGVYDVFRVKS
HCCCCEEECCCCCCHHHHEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TDDSVYGPYGSGKGTLGKPKPGQQRPQPRMRMRERIVRWGTPKPPAPTQSVTDPLISVV
CCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHH
LANHPKADTAIIERAYRTAEHYHRGQSRKSGDPYITHPLAVTMILAELGMDERTLCAGLL
HCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEHHHHHHHHHHHHCCCHHHHHHHHH
HDTVEDTSYTNEQLTADFGEEIALLVDGVTKLDKVQYGDSAKAETIRKMVIAMSRDIRVL
HHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCHHHH
VIKLADRLHNMRTLGFLRPDKQNRIAKETLEIFAPLAHRLGMNAIKWELEDLCFSTLNPK
HHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHCCHH
LYDEIVHMVAERAPQREAQLKDVITIVRQDLDEAGIKAIVYGRPKHYYSIYQKMVVRGRD
HHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCEEEEECCCHHHHHHHHHHHHCCCC
FSDIYDLTGLRILVDTPRDCYAALGVMHVRWNPLPGRFKDYIAMPKYNMYQSLHTTVLGP
HHHHHHHCCCEEEEECCHHHHHHHCEEEEEECCCCCHHHHHHCCCCHHHHHHHHHHEECC
GGQPVELQIRTHEMHRRAEYGVAAHWKYKENPNAVGRGIQPDGTDLSWVQSLNQWSKEES
CCCCEEEEEEHHHHHHHHHCCCEEEEEECCCCCHHCCCCCCCCCCHHHHHHHHHHHCCCC
DPSEFLDSLRFEINSREVYVFTPKGDVMSLPQGATPVDFAYAVHTEVGHRCIGARVNGKL
CHHHHHHHHHEEECCCEEEEECCCCCEEECCCCCCCCHHHHHHHHHHCCCEECEEECCEE
VTLDTKLNNGDVIDILTSNAPDAGPSRDWLGFIASPRARSKIKSYFTKERREESIEAGKD
EEEEEECCCCCEEEEEECCCCCCCCCCHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHH
AIAKQLRQAGVPLQSLLTVEYLTAVADDLRVPGINALYAAVGEHNASAQSVVEKLIALGG
HHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCHHHHHHHHHHHCCC
GPEEATADVEEELAVGVKAPRRRRSSETGVMVDGDPDMLVKLARCCTPLPGDPIMGFVTR
CCCHHHHHHHHHHHHCCCCHHHHCCCCCCEEECCCHHHHHHHHHHCCCCCCCCHHHHHHH
YDGVSVHRTDCSNAKNLLEHPERIVSVSWSDDRQESYQVTIQVEGLDRAGLLVDTFRVFA
CCCCEEECCCHHHHHHHHHCCHHEEEECCCCCCCCCEEEEEEEECCCCCCHHHHHHHHHH
EQGVSVISANMSTSKSHLARLRLTFEAPDPTHLKHLTESIRRISGVYDVFRVKS
HCCCCEEECCCCCCHHHHEEEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8825780; 8631867; 12000953 [H]