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The map label for this gene is trpA [H]

Identifier: 50842611

GI number: 50842611

Start: 1228622

End: 1229119

Strand: Direct

Name: trpA [H]

Synonym: PPA1132

Alternate gene names: 50842611

Gene position: 1228622-1229119 (Clockwise)

Preceding gene: 50842610

Following gene: 50842612

Centisome position: 47.99

GC content: 63.05

Gene sequence:

>498_bases
ATGACCGGTAGCGCCAGTGTCTACCTCAGGGCCCACCAAGAGAACCGCCCGGCCCTCGTCGGTTACTTCCCGGTGGGACA
CCCGTCAGTTCCTCACTCGATCGATGCTATGAAGGCACTGACTACGGGCACTACTGGGACCGGTGTCGACCTCGTCGTGA
TCGGAATGCCTTACTCCGACCCGATGATGGACGGCACCGTCATTCAGCACGTCACTACCGGGGCTCTAGAGCGCGGGGTA
CGCACTCGCGACACCCTATTGGCCACAGAGGCCGTGGCCGGGACCGGAACTCCGTGCGTGATTATGACCTATTGGAACCT
TGTCGAGCACTACGGTGTCGACGCTTATGCTCGCGATCTGGCATCCGCGGGTGGCTCAGGGCTCACCACCCCCGATGAGG
CTGAGGATCGGGGGGACTCAGTGACGGTAGGAATTGACCGGATGTGCGCCATCGTCGACGACCTGGCGGCCGGAGTACGG
CGGGCGGAACGCCAGTGA

Upstream 100 bases:

>100_bases
TCATCGTCACGGTGTCGGGTCGCGGGGATAAAGATGTTGACACTGCCCTGGAGTGGTTTGCCATGGACGGCAGCGTCGAC
GCCACTACGGGAGGTATGGA

Downstream 100 bases:

>100_bases
GTCAGCTATCGATCCCTAGCCCATCAATCGAAGCGTTTCATCTTGGACCGCTAACCATCCACATCTACGCCCTATGCATC
CTCGCGGGCATCGTCGTCGC

Product: tryptophan synthase alpha chain

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 165; Mature: 164

Protein sequence:

>165_residues
MTGSASVYLRAHQENRPALVGYFPVGHPSVPHSIDAMKALTTGTTGTGVDLVVIGMPYSDPMMDGTVIQHVTTGALERGV
RTRDTLLATEAVAGTGTPCVIMTYWNLVEHYGVDAYARDLASAGGSGLTTPDEAEDRGDSVTVGIDRMCAIVDDLAAGVR
RAERQ

Sequences:

>Translated_165_residues
MTGSASVYLRAHQENRPALVGYFPVGHPSVPHSIDAMKALTTGTTGTGVDLVVIGMPYSDPMMDGTVIQHVTTGALERGV
RTRDTLLATEAVAGTGTPCVIMTYWNLVEHYGVDAYARDLASAGGSGLTTPDEAEDRGDSVTVGIDRMCAIVDDLAAGVR
RAERQ
>Mature_164_residues
TGSASVYLRAHQENRPALVGYFPVGHPSVPHSIDAMKALTTGTTGTGVDLVVIGMPYSDPMMDGTVIQHVTTGALERGVR
TRDTLLATEAVAGTGTPCVIMTYWNLVEHYGVDAYARDLASAGGSGLTTPDEAEDRGDSVTVGIDRMCAIVDDLAAGVRR
AERQ

Specific function: The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3- phosphate [H]

COG id: COG0159

COG function: function code E; Tryptophan synthase alpha chain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpA family [H]

Homologues:

Organism=Saccharomyces cerevisiae, GI6321412, Length=133, Percent_Identity=35.3383458646617, Blast_Score=85, Evalue=6e-18,

Paralogues:

None

Copy number: 280 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR011060
- InterPro:   IPR018204
- InterPro:   IPR002028 [H]

Pfam domain/function: PF00290 Trp_syntA [H]

EC number: =4.2.1.20 [H]

Molecular weight: Translated: 17365; Mature: 17234

Theoretical pI: Translated: 4.73; Mature: 4.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
3.7 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTGSASVYLRAHQENRPALVGYFPVGHPSVPHSIDAMKALTTGTTGTGVDLVVIGMPYSD
CCCCCEEEEEECCCCCCEEEEEECCCCCCCCCHHHHHHHHHCCCCCCCCEEEEEECCCCC
PMMDGTVIQHVTTGALERGVRTRDTLLATEAVAGTGTPCVIMTYWNLVEHYGVDAYARDL
CCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCEEEHHHHHHHHHCCCCHHHHHH
ASAGGSGLTTPDEAEDRGDSVTVGIDRMCAIVDDLAAGVRRAERQ
HHCCCCCCCCCCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TGSASVYLRAHQENRPALVGYFPVGHPSVPHSIDAMKALTTGTTGTGVDLVVIGMPYSD
CCCCEEEEEECCCCCCEEEEEECCCCCCCCCHHHHHHHHHCCCCCCCCEEEEEECCCCC
PMMDGTVIQHVTTGALERGVRTRDTLLATEAVAGTGTPCVIMTYWNLVEHYGVDAYARDL
CCCCCHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCEEEHHHHHHHHHCCCCHHHHHH
ASAGGSGLTTPDEAEDRGDSVTVGIDRMCAIVDDLAAGVRRAERQ
HHCCCCCCCCCCCCCCCCCEEEECHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]