Click here to switch to the map view.

The map label for this gene is hisI

Identifier: 50842605

GI number: 50842605

Start: 1224834

End: 1225211

Strand: Direct

Name: hisI

Synonym: PPA1126

Alternate gene names: 50842605

Gene position: 1224834-1225211 (Clockwise)

Preceding gene: 50842603

Following gene: 50842606

Centisome position: 47.84

GC content: 60.05

Gene sequence:

>378_bases
ATGAGGCGCGTGCAGACTGAAGAACCAACCCTGGCCCCCGCAATCGCGGCAAGGTTGCGCCGTAATGACGCTGGGCTGGT
GCCCGCCGTGGTGCAAGACGCTGCGACCGGGGACGTCCTCATGATGGCGTGGATGGATGACGTTGCTTTGGCCCGCACCT
TAGCAACCCGACGGGCCACTTATTGGTCCCGTTCTCGTCAGGAGTACTGGGTCAAGGGGGAAACCTCTGGTCACACTCAG
CATGTGTGTTCGGTGAGACTCGACTGTGACGGAGATACGCTCCTGCTGCGCGTCGACCAGGTCGATGGTGCCTGCCACAC
TGGTGATCACACCTGTTTTGATGCTGATGTTTTGCTAGCCGAGGAGGTCGAGTCATGA

Upstream 100 bases:

>100_bases
GGCAATGGACATCCGGGTCCTCCTTCGGGCTATGGGTCCATCTTGCCAGTACCGGTCCGAAACGCGGCGTCGGTCCAAGG
TGTCGGTGGTCCGGTGTTCA

Downstream 100 bases:

>100_bases
TCGACGTCGCCTCTTCGCGTGAAGAGTTCGTGGCTCGTGCTGTCAATCACACGGTCGTGCCGGTGCGAACCGCGCTGGTG
AGTGATGATGACACTCCTGT

Product: phosphoribosyl-AMP cyclohydrolase

Products: NA

Alternate protein names: PRA-CH

Number of amino acids: Translated: 125; Mature: 125

Protein sequence:

>125_residues
MRRVQTEEPTLAPAIAARLRRNDAGLVPAVVQDAATGDVLMMAWMDDVALARTLATRRATYWSRSRQEYWVKGETSGHTQ
HVCSVRLDCDGDTLLLRVDQVDGACHTGDHTCFDADVLLAEEVES

Sequences:

>Translated_125_residues
MRRVQTEEPTLAPAIAARLRRNDAGLVPAVVQDAATGDVLMMAWMDDVALARTLATRRATYWSRSRQEYWVKGETSGHTQ
HVCSVRLDCDGDTLLLRVDQVDGACHTGDHTCFDADVLLAEEVES
>Mature_125_residues
MRRVQTEEPTLAPAIAARLRRNDAGLVPAVVQDAATGDVLMMAWMDDVALARTLATRRATYWSRSRQEYWVKGETSGHTQ
HVCSVRLDCDGDTLLLRVDQVDGACHTGDHTCFDADVLLAEEVES

Specific function: Histidine biosynthesis; second step. Histidine biosynthesis; third step. [C]

COG id: COG0139

COG function: function code E; Phosphoribosyl-AMP cyclohydrolase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PRA-CH family

Homologues:

Organism=Escherichia coli, GI2367128, Length=89, Percent_Identity=44.9438202247191, Blast_Score=96, Evalue=8e-22,
Organism=Saccharomyces cerevisiae, GI6319819, Length=75, Percent_Identity=38.6666666666667, Blast_Score=64, Evalue=9e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HIS3_PROAC (Q6A8P2)

Other databases:

- EMBL:   AE017283
- RefSeq:   YP_055832.1
- ProteinModelPortal:   Q6A8P2
- SMR:   Q6A8P2
- GeneID:   2933005
- GenomeReviews:   AE017283_GR
- KEGG:   pac:PPA1126
- NMPDR:   fig|267747.1.peg.1109
- HOGENOM:   HBG294308
- OMA:   TQYVHEV
- ProtClustDB:   PRK00051
- BioCyc:   PACN267747:PPA1126-MONOMER
- BRENDA:   3.5.4.19
- GO:   GO:0005737
- HAMAP:   MF_01021
- InterPro:   IPR002496
- ProDom:   PD002610

Pfam domain/function: PF01502 PRA-CH

EC number: =3.5.4.19

Molecular weight: Translated: 13829; Mature: 13829

Theoretical pI: Translated: 4.73; Mature: 4.73

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.2 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
3.2 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
6.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRRVQTEEPTLAPAIAARLRRNDAGLVPAVVQDAATGDVLMMAWMDDVALARTLATRRAT
CCCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHHHH
YWSRSRQEYWVKGETSGHTQHVCSVRLDCDGDTLLLRVDQVDGACHTGDHTCFDADVLLA
HHHCCCCEEEEECCCCCCCEEEEEEEEECCCCEEEEEEECCCCCEECCCCCEECCCEEEE
EEVES
ECCCC
>Mature Secondary Structure
MRRVQTEEPTLAPAIAARLRRNDAGLVPAVVQDAATGDVLMMAWMDDVALARTLATRRAT
CCCCCCCCCCHHHHHHHHHHCCCCCCCHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHHHH
YWSRSRQEYWVKGETSGHTQHVCSVRLDCDGDTLLLRVDQVDGACHTGDHTCFDADVLLA
HHHCCCCEEEEECCCCCCCEEEEEEEEECCCCEEEEEEECCCCCEECCCCCEECCCEEEE
EEVES
ECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA