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The map label for this gene is adhA [H]

Identifier: 50842552

GI number: 50842552

Start: 1168051

End: 1169112

Strand: Direct

Name: adhA [H]

Synonym: PPA1072

Alternate gene names: 50842552

Gene position: 1168051-1169112 (Clockwise)

Preceding gene: 50842551

Following gene: 50842553

Centisome position: 45.62

GC content: 58.0

Gene sequence:

>1062_bases
ATGCCCATCATCGTCAAGGCGCTTCAGAAGGATGGACCGGACCGGCCTTTCAAAGTTGTCGAGATTGAACGACGAGACCC
GCGTCCCGACGACGTCGTCATCGACATTAAAGCTGCTGGAATCTGTCATTCTGACATTCACACCATTCGCAACGAGTGGG
GCCAGGCGCACTTCCCGCTGACCGTCGGTCATGAGATTGCCGGAATCGTTGAGGCTGTTGGTTCCGAGGTCACGAAGTAC
AAACCTGGAGACCGAGTAGGCGTCGGATGTCTGGTCAACTCGTGCGGACACTGTGAGCAGTGCGAGGCCGGGGAGGAGCA
GGCGTGTCTCAACGGGCCGGTCGGTACTTACAACGCCCATGATGTCGACGGAAGTATCACCCAGGGCGGCTACTCTCAGA
AAATCGTCGTCAACGAGAGGTTTGTTTGCCGCATCCCCGATTCCCTGGACTTCGTAGAGGCAGCTCCGCTGCTGTGCGCC
GGCATCACCACCTATTCGCCGATCGCCCAGTGGAACGTCGGACCTGGCCAGAAGGTAGCCGTGCTGGGGCTCGGCGGACT
GGGCCATATGGGGGTCCAGATTGCCGCTGCTAAAGGAGCGGATGTTACGGTGCTCTCACGTAGCCTGCGCAAGGAGAAAT
TCGCCGAAAAGCTCGCGGCCACGCGGACCCTTGCTACCAGCGACGACAACTTCTTCCGTGATCACCGGGGAGAGTTCGAT
TTCATACTCAACACCATTAGTGCTCTGATTGACGTGTCGGCTTACCTTAAGCTACTCAAGCCGCGTGGCGTCATGGCTTG
TGTCGGTCTGCCACCTGAGGAACTTGGACTGCAGGTTGGTTCTCTCATCAACGGTTCCAAGGTGCTTGCCGGTTCAAATA
TCGGTGGCATCCCCCAGACCCAGGATATGCTCGATTTCTGCGCCGAGCATCGCCTCGGGGCATGGGTGGAAAAGATCGGG
GTTGACGAGGTCGACGCGGCATATGACCGGGTGGTTGCGGGCGATGTGAGATTCCGCTTCGTTATTGACACTGCAACTTT
CAGAGCAGTCGGAGCTGGATGA

Upstream 100 bases:

>100_bases
GGACTGATTCCATAGTTAGCCCCGTGTCATAGGCAAATCCGCAATATTGTGGCTACGTCAGTGCCGGGAGATAGACATTA
GGGATCAAGGAGGCTCATTC

Downstream 100 bases:

>100_bases
GCGATGAGCCGATGCCACCGCGAATTGGCGTGAAATTGATACCGACGGGTTGGCTGTCGTCCACTCCATCTTCCCGAGAC
ACCTTGGCATCGGTGTACGA

Product: Zn-dependent alcohol dehydrogenase

Products: aldehyde; NADPH; H+

Alternate protein names: NA

Number of amino acids: Translated: 353; Mature: 352

Protein sequence:

>353_residues
MPIIVKALQKDGPDRPFKVVEIERRDPRPDDVVIDIKAAGICHSDIHTIRNEWGQAHFPLTVGHEIAGIVEAVGSEVTKY
KPGDRVGVGCLVNSCGHCEQCEAGEEQACLNGPVGTYNAHDVDGSITQGGYSQKIVVNERFVCRIPDSLDFVEAAPLLCA
GITTYSPIAQWNVGPGQKVAVLGLGGLGHMGVQIAAAKGADVTVLSRSLRKEKFAEKLAATRTLATSDDNFFRDHRGEFD
FILNTISALIDVSAYLKLLKPRGVMACVGLPPEELGLQVGSLINGSKVLAGSNIGGIPQTQDMLDFCAEHRLGAWVEKIG
VDEVDAAYDRVVAGDVRFRFVIDTATFRAVGAG

Sequences:

>Translated_353_residues
MPIIVKALQKDGPDRPFKVVEIERRDPRPDDVVIDIKAAGICHSDIHTIRNEWGQAHFPLTVGHEIAGIVEAVGSEVTKY
KPGDRVGVGCLVNSCGHCEQCEAGEEQACLNGPVGTYNAHDVDGSITQGGYSQKIVVNERFVCRIPDSLDFVEAAPLLCA
GITTYSPIAQWNVGPGQKVAVLGLGGLGHMGVQIAAAKGADVTVLSRSLRKEKFAEKLAATRTLATSDDNFFRDHRGEFD
FILNTISALIDVSAYLKLLKPRGVMACVGLPPEELGLQVGSLINGSKVLAGSNIGGIPQTQDMLDFCAEHRLGAWVEKIG
VDEVDAAYDRVVAGDVRFRFVIDTATFRAVGAG
>Mature_352_residues
PIIVKALQKDGPDRPFKVVEIERRDPRPDDVVIDIKAAGICHSDIHTIRNEWGQAHFPLTVGHEIAGIVEAVGSEVTKYK
PGDRVGVGCLVNSCGHCEQCEAGEEQACLNGPVGTYNAHDVDGSITQGGYSQKIVVNERFVCRIPDSLDFVEAAPLLCAG
ITTYSPIAQWNVGPGQKVAVLGLGGLGHMGVQIAAAKGADVTVLSRSLRKEKFAEKLAATRTLATSDDNFFRDHRGEFDF
ILNTISALIDVSAYLKLLKPRGVMACVGLPPEELGLQVGSLINGSKVLAGSNIGGIPQTQDMLDFCAEHRLGAWVEKIGV
DEVDAAYDRVVAGDVRFRFVIDTATFRAVGAG

Specific function: Functions in the protection against aldehyde-stress [H]

COG id: COG1064

COG function: function code R; Zn-dependent alcohol dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the zinc-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4501933, Length=351, Percent_Identity=30.1994301994302, Blast_Score=108, Evalue=7e-24,
Organism=Homo sapiens, GI34577061, Length=293, Percent_Identity=30.7167235494881, Blast_Score=106, Evalue=3e-23,
Organism=Homo sapiens, GI4501929, Length=312, Percent_Identity=29.8076923076923, Blast_Score=102, Evalue=5e-22,
Organism=Homo sapiens, GI156523966, Length=334, Percent_Identity=29.0419161676647, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI4501939, Length=334, Percent_Identity=29.0419161676647, Blast_Score=101, Evalue=1e-21,
Organism=Homo sapiens, GI71743840, Length=320, Percent_Identity=26.5625, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI262073058, Length=320, Percent_Identity=26.5625, Blast_Score=95, Evalue=1e-19,
Organism=Homo sapiens, GI71565152, Length=321, Percent_Identity=29.2834890965732, Blast_Score=89, Evalue=6e-18,
Organism=Homo sapiens, GI71565154, Length=234, Percent_Identity=31.1965811965812, Blast_Score=85, Evalue=8e-17,
Organism=Escherichia coli, GI1786518, Length=346, Percent_Identity=47.6878612716763, Blast_Score=293, Evalue=1e-80,
Organism=Escherichia coli, GI87082401, Length=328, Percent_Identity=31.7073170731707, Blast_Score=169, Evalue=2e-43,
Organism=Escherichia coli, GI87081918, Length=323, Percent_Identity=27.2445820433437, Blast_Score=119, Evalue=2e-28,
Organism=Escherichia coli, GI1788073, Length=273, Percent_Identity=30.4029304029304, Blast_Score=100, Evalue=2e-22,
Organism=Escherichia coli, GI1788075, Length=298, Percent_Identity=28.8590604026846, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1790045, Length=290, Percent_Identity=27.2413793103448, Blast_Score=86, Evalue=4e-18,
Organism=Escherichia coli, GI1786552, Length=353, Percent_Identity=26.9121813031161, Blast_Score=84, Evalue=1e-17,
Organism=Escherichia coli, GI1788407, Length=262, Percent_Identity=27.8625954198473, Blast_Score=83, Evalue=3e-17,
Organism=Escherichia coli, GI87082125, Length=241, Percent_Identity=27.3858921161826, Blast_Score=82, Evalue=4e-17,
Organism=Escherichia coli, GI1787863, Length=138, Percent_Identity=34.0579710144928, Blast_Score=78, Evalue=1e-15,
Organism=Escherichia coli, GI226510992, Length=230, Percent_Identity=29.5652173913043, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71988145, Length=350, Percent_Identity=27.7142857142857, Blast_Score=127, Evalue=1e-29,
Organism=Caenorhabditis elegans, GI17562584, Length=336, Percent_Identity=28.2738095238095, Blast_Score=120, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI17562582, Length=351, Percent_Identity=26.7806267806268, Blast_Score=114, Evalue=6e-26,
Organism=Caenorhabditis elegans, GI25146526, Length=361, Percent_Identity=24.9307479224377, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17562878, Length=202, Percent_Identity=29.2079207920792, Blast_Score=78, Evalue=6e-15,
Organism=Caenorhabditis elegans, GI71997431, Length=363, Percent_Identity=24.7933884297521, Blast_Score=76, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17562876, Length=206, Percent_Identity=30.0970873786408, Blast_Score=75, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17565904, Length=342, Percent_Identity=25.4385964912281, Blast_Score=70, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6323980, Length=328, Percent_Identity=37.5, Blast_Score=187, Evalue=2e-48,
Organism=Saccharomyces cerevisiae, GI6319949, Length=331, Percent_Identity=35.3474320241692, Blast_Score=162, Evalue=7e-41,
Organism=Saccharomyces cerevisiae, GI6323729, Length=328, Percent_Identity=30.4878048780488, Blast_Score=154, Evalue=2e-38,
Organism=Saccharomyces cerevisiae, GI6319621, Length=355, Percent_Identity=28.7323943661972, Blast_Score=150, Evalue=2e-37,
Organism=Saccharomyces cerevisiae, GI6323961, Length=338, Percent_Identity=28.1065088757396, Blast_Score=142, Evalue=8e-35,
Organism=Saccharomyces cerevisiae, GI6324486, Length=338, Percent_Identity=27.2189349112426, Blast_Score=137, Evalue=3e-33,
Organism=Saccharomyces cerevisiae, GI6320033, Length=356, Percent_Identity=27.5280898876405, Blast_Score=96, Evalue=9e-21,
Organism=Saccharomyces cerevisiae, GI6319258, Length=308, Percent_Identity=25.3246753246753, Blast_Score=75, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6319257, Length=268, Percent_Identity=26.1194029850746, Blast_Score=67, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6323099, Length=284, Percent_Identity=26.4084507042254, Blast_Score=65, Evalue=2e-11,
Organism=Saccharomyces cerevisiae, GI6319955, Length=326, Percent_Identity=25.4601226993865, Blast_Score=63, Evalue=9e-11,
Organism=Saccharomyces cerevisiae, GI6322619, Length=326, Percent_Identity=25.4601226993865, Blast_Score=63, Evalue=9e-11,
Organism=Drosophila melanogaster, GI17737895, Length=316, Percent_Identity=25.6329113924051, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI17737897, Length=221, Percent_Identity=28.9592760180996, Blast_Score=72, Evalue=4e-13,
Organism=Drosophila melanogaster, GI17137530, Length=234, Percent_Identity=28.6324786324786, Blast_Score=70, Evalue=2e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013149
- InterPro:   IPR013154
- InterPro:   IPR002085
- InterPro:   IPR002328
- InterPro:   IPR011032
- InterPro:   IPR016040 [H]

Pfam domain/function: PF08240 ADH_N; PF00107 ADH_zinc_N [H]

EC number: 1.1.1.2

Molecular weight: Translated: 37761; Mature: 37629

Theoretical pI: Translated: 5.41; Mature: 5.41

Prosite motif: PS00059 ADH_ZINC

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
1.1 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
0.9 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPIIVKALQKDGPDRPFKVVEIERRDPRPDDVVIDIKAAGICHSDIHTIRNEWGQAHFPL
CCEEEEEHHCCCCCCCEEEEEEECCCCCCCCEEEEEEECCCCHHHHHHHHHHCCCCCCCE
TVGHEIAGIVEAVGSEVTKYKPGDRVGVGCLVNSCGHCEQCEAGEEQACLNGPVGTYNAH
EECHHHHHHHHHHCCHHHCCCCCCCCCHHHHHHCCCCCCCCCCCCCCHHCCCCCCCCCCC
DVDGSITQGGYSQKIVVNERFVCRIPDSLDFVEAAPLLCAGITTYSPIAQWNVGPGQKVA
CCCCCCCCCCCCCEEEECCEEEEECCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCEEE
VLGLGGLGHMGVQIAAAKGADVTVLSRSLRKEKFAEKLAATRTLATSDDNFFRDHRGEFD
EEEECCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHEECCCCCHHHHCCCCHH
FILNTISALIDVSAYLKLLKPRGVMACVGLPPEELGLQVGSLINGSKVLAGSNIGGIPQT
HHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHCHHHHCCCCCCEEEECCCCCCCCCH
QDMLDFCAEHRLGAWVEKIGVDEVDAAYDRVVAGDVRFRFVIDTATFRAVGAG
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHEEECCEEEEEEEECCEEEEECCC
>Mature Secondary Structure 
PIIVKALQKDGPDRPFKVVEIERRDPRPDDVVIDIKAAGICHSDIHTIRNEWGQAHFPL
CEEEEEHHCCCCCCCEEEEEEECCCCCCCCEEEEEEECCCCHHHHHHHHHHCCCCCCCE
TVGHEIAGIVEAVGSEVTKYKPGDRVGVGCLVNSCGHCEQCEAGEEQACLNGPVGTYNAH
EECHHHHHHHHHHCCHHHCCCCCCCCCHHHHHHCCCCCCCCCCCCCCHHCCCCCCCCCCC
DVDGSITQGGYSQKIVVNERFVCRIPDSLDFVEAAPLLCAGITTYSPIAQWNVGPGQKVA
CCCCCCCCCCCCCEEEECCEEEEECCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCEEE
VLGLGGLGHMGVQIAAAKGADVTVLSRSLRKEKFAEKLAATRTLATSDDNFFRDHRGEFD
EEEECCCCCCCEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHEECCCCCHHHHCCCCHH
FILNTISALIDVSAYLKLLKPRGVMACVGLPPEELGLQVGSLINGSKVLAGSNIGGIPQT
HHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHHHCHHHHCCCCCCEEEECCCCCCCCCH
QDMLDFCAEHRLGAWVEKIGVDEVDAAYDRVVAGDVRFRFVIDTATFRAVGAG
HHHHHHHHHHHHHHHHHHHCCCHHHHHHHHEEECCEEEEEEEECCEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: alcohol; NADP+

Specific reaction: an alcohol + NADP+ = an aldehyde + NADPH + H+

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9141695; 9384377 [H]