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The map label for this gene is aroP [H]

Identifier: 50842551

GI number: 50842551

Start: 1164465

End: 1165919

Strand: Direct

Name: aroP [H]

Synonym: PPA1069

Alternate gene names: 50842551

Gene position: 1164465-1165919 (Clockwise)

Preceding gene: 50842550

Following gene: 50842552

Centisome position: 45.48

GC content: 57.25

Gene sequence:

>1455_bases
ATGTCCACCCGGCTGGGAGGCTCTTCCCCGGCCGCTGGGTGCCCCGCCGTACCGTCACGCTTCGGTGCGGCGGGATCCGG
AGCGCCGAGTGGAACAGAGCAGGAGCAAGGACTTCAACGGGGGCTGAAGAACCGGCACATCCAGTTTATCGCCCTGGGCG
GGGCGATCGGAACGGGCTTGTTCTATGGCGCAGCTGAGTCTATCGAGCAGGCGGGGCCCGCCATCATGGTGTGCTATCTG
ATCGGCGGAGCTGTGATCTTTCTCATCATGCGAGCCTTGGGAGAGATGAGCGTTGAGCACCCAACTTCAGGGGCTTTCAG
CTATTACGCCTACCGCAACTGGAGCCCACGCGCTGGATTCGTCTCTGGTTACAACTACTGGTTTAACTACATCGCCGTCT
CCATGGCTGAGCTTACGGTGGTGGGAAAATACGTCAACTTCTGGTTCCCACAGATACCTGAGTGGTTGTCCGCAGGGGCC
TTTCTCGTGCTCATTACTATTATCAACCTCACGGCAGTGAGAGCCTACGGAGAATTCGAGTTCTGGTTCGCTGTCATCAA
AGTCGTCGCGATTCTTGCGATGATCGTGCTGGGTGTCCTTATCATTGCAACTGGCCTGGGTGGTGGCCCTCCGACCGGGA
TAGGTAACCTGTGGCGACACGGAGGATTCTTTCCAACCGGCATCAGCGGGATGCTGTGCGGTTTTGTCGTGGTGATGTTC
AGCTTTGGAGGGGTCGAGCTCATCGGGATTACGGCAGGGGAGGCTGACGATCCGCGTCGGTCTATTCCGCGAGCGATCAA
TCAAGTCGTGTATCGGATCCTCATTTTCTACATCGGTGCAATTTCGGTCATGTTGTGTCTTTTTCCATGGAACCAGATCG
GCAAGGCAGGCAGCCCCTTCGTGACGATCTTCGACAAAATCGGAGTCGCAGGTGCGGCGAATATCCTCAATGTTGTGGTG
CTTACCGCTTCCATGTCGGCCTACAACTCGGGCCTATACTCCAACGGGCGGATGCTTTACAGCTTGGCCGCTCAGCACAA
CGCTCCCGGGATCTTCTGGAAGACGAATCGGCTGGGGGCGCCGTGGGTGGGAGTGCTCGCCTCCTCGGTGGTGACGGCAA
CGGCGGTGCTGCTGACGTACTTGATTCCTGGAAAGGTGTTTTTGTACATCATCTCGATCGCCTTGATCTCTGGGGTCATC
AATTGGACGATGATCATCATCACCAACCTAAAGTTTCGGCGAAGGATCGGTCCTGAAGGTGTCGCAGCGTTGGAATTTCG
GATGCCCGGTAATCCCGTCACCAGTTACGTGGTGTTGGTTTTTCTGGCGCTCGTGGTGGTCATCATGGCGATGATGCCGA
GCTACCGAGTGGCACTCGTTGTTGGTCCCGTCTGGTTGGCGTTGCTGTGGGTGGGTTATGACGTGTCCTGCCTGGTGCGA
CGCCGTCATGCCTGA

Upstream 100 bases:

>100_bases
ATTGCCCGGGAGCCTGAAAAAGTACCCGGATACCGCATTACATGGGAGCCTCCGGTCTTGCGCCATTTCACAAGTCGACT
CGAACCAATTCGGTGATGAG

Downstream 100 bases:

>100_bases
GGGGACGAGCGTACTGCCCCGGTAGCGGGGAGAACAGAGCCTAGAGCGCGTGCGGGCCCGGCGCGATTCCCCATGTGGGT
TATTGATCCGGGCTGTGCAC

Product: aromatic amino acid transport protein

Products: L-tryptophan [Cytoplasm]; Proton [Cytoplasm]; Proton [Cytoplasm]; L-tyrosine [Cytoplasm]; Proton [Cytoplasm]; L-phenylalanine [Cytoplasm] [C]

Alternate protein names: General aromatic amino acid permease [H]

Number of amino acids: Translated: 484; Mature: 483

Protein sequence:

>484_residues
MSTRLGGSSPAAGCPAVPSRFGAAGSGAPSGTEQEQGLQRGLKNRHIQFIALGGAIGTGLFYGAAESIEQAGPAIMVCYL
IGGAVIFLIMRALGEMSVEHPTSGAFSYYAYRNWSPRAGFVSGYNYWFNYIAVSMAELTVVGKYVNFWFPQIPEWLSAGA
FLVLITIINLTAVRAYGEFEFWFAVIKVVAILAMIVLGVLIIATGLGGGPPTGIGNLWRHGGFFPTGISGMLCGFVVVMF
SFGGVELIGITAGEADDPRRSIPRAINQVVYRILIFYIGAISVMLCLFPWNQIGKAGSPFVTIFDKIGVAGAANILNVVV
LTASMSAYNSGLYSNGRMLYSLAAQHNAPGIFWKTNRLGAPWVGVLASSVVTATAVLLTYLIPGKVFLYIISIALISGVI
NWTMIIITNLKFRRRIGPEGVAALEFRMPGNPVTSYVVLVFLALVVVIMAMMPSYRVALVVGPVWLALLWVGYDVSCLVR
RRHA

Sequences:

>Translated_484_residues
MSTRLGGSSPAAGCPAVPSRFGAAGSGAPSGTEQEQGLQRGLKNRHIQFIALGGAIGTGLFYGAAESIEQAGPAIMVCYL
IGGAVIFLIMRALGEMSVEHPTSGAFSYYAYRNWSPRAGFVSGYNYWFNYIAVSMAELTVVGKYVNFWFPQIPEWLSAGA
FLVLITIINLTAVRAYGEFEFWFAVIKVVAILAMIVLGVLIIATGLGGGPPTGIGNLWRHGGFFPTGISGMLCGFVVVMF
SFGGVELIGITAGEADDPRRSIPRAINQVVYRILIFYIGAISVMLCLFPWNQIGKAGSPFVTIFDKIGVAGAANILNVVV
LTASMSAYNSGLYSNGRMLYSLAAQHNAPGIFWKTNRLGAPWVGVLASSVVTATAVLLTYLIPGKVFLYIISIALISGVI
NWTMIIITNLKFRRRIGPEGVAALEFRMPGNPVTSYVVLVFLALVVVIMAMMPSYRVALVVGPVWLALLWVGYDVSCLVR
RRHA
>Mature_483_residues
STRLGGSSPAAGCPAVPSRFGAAGSGAPSGTEQEQGLQRGLKNRHIQFIALGGAIGTGLFYGAAESIEQAGPAIMVCYLI
GGAVIFLIMRALGEMSVEHPTSGAFSYYAYRNWSPRAGFVSGYNYWFNYIAVSMAELTVVGKYVNFWFPQIPEWLSAGAF
LVLITIINLTAVRAYGEFEFWFAVIKVVAILAMIVLGVLIIATGLGGGPPTGIGNLWRHGGFFPTGISGMLCGFVVVMFS
FGGVELIGITAGEADDPRRSIPRAINQVVYRILIFYIGAISVMLCLFPWNQIGKAGSPFVTIFDKIGVAGAANILNVVVL
TASMSAYNSGLYSNGRMLYSLAAQHNAPGIFWKTNRLGAPWVGVLASSVVTATAVLLTYLIPGKVFLYIISIALISGVIN
WTMIIITNLKFRRRIGPEGVAALEFRMPGNPVTSYVVLVFLALVVVIMAMMPSYRVALVVGPVWLALLWVGYDVSCLVRR
RHA

Specific function: Permease that is involved in the transport across the cytoplasmic membrane of the aromatic amino acids (phenylalanine, tyrosine, and tryptophan) [H]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Homo sapiens, GI110347453, Length=364, Percent_Identity=24.7252747252747, Blast_Score=80, Evalue=4e-15,
Organism=Homo sapiens, GI258614003, Length=408, Percent_Identity=21.8137254901961, Blast_Score=70, Evalue=4e-12,
Organism=Homo sapiens, GI258614005, Length=408, Percent_Identity=21.8137254901961, Blast_Score=70, Evalue=6e-12,
Organism=Homo sapiens, GI114326544, Length=348, Percent_Identity=22.9885057471264, Blast_Score=69, Evalue=8e-12,
Organism=Homo sapiens, GI114326550, Length=348, Percent_Identity=22.9885057471264, Blast_Score=69, Evalue=8e-12,
Organism=Homo sapiens, GI258645169, Length=403, Percent_Identity=21.3399503722084, Blast_Score=69, Evalue=1e-11,
Organism=Escherichia coli, GI1786302, Length=446, Percent_Identity=50.6726457399103, Blast_Score=455, Evalue=1e-129,
Organism=Escherichia coli, GI1786789, Length=464, Percent_Identity=46.551724137931, Blast_Score=436, Evalue=1e-123,
Organism=Escherichia coli, GI1786602, Length=452, Percent_Identity=47.787610619469, Blast_Score=409, Evalue=1e-115,
Organism=Escherichia coli, GI48994972, Length=455, Percent_Identity=44.8351648351648, Blast_Score=369, Evalue=1e-103,
Organism=Escherichia coli, GI1790653, Length=456, Percent_Identity=38.3771929824561, Blast_Score=337, Evalue=8e-94,
Organism=Escherichia coli, GI87081915, Length=406, Percent_Identity=39.4088669950739, Blast_Score=315, Evalue=4e-87,
Organism=Escherichia coli, GI87081708, Length=448, Percent_Identity=37.2767857142857, Blast_Score=286, Evalue=2e-78,
Organism=Escherichia coli, GI1789017, Length=430, Percent_Identity=36.046511627907, Blast_Score=282, Evalue=3e-77,
Organism=Escherichia coli, GI1788480, Length=431, Percent_Identity=35.7308584686775, Blast_Score=270, Evalue=1e-73,
Organism=Escherichia coli, GI87081869, Length=317, Percent_Identity=24.2902208201893, Blast_Score=87, Evalue=2e-18,
Organism=Escherichia coli, GI87082023, Length=317, Percent_Identity=25.2365930599369, Blast_Score=68, Evalue=2e-12,
Organism=Escherichia coli, GI87082250, Length=325, Percent_Identity=24, Blast_Score=63, Evalue=5e-11,
Organism=Saccharomyces cerevisiae, GI6320772, Length=442, Percent_Identity=35.5203619909502, Blast_Score=250, Evalue=4e-67,
Organism=Saccharomyces cerevisiae, GI6324061, Length=437, Percent_Identity=34.324942791762, Blast_Score=248, Evalue=2e-66,
Organism=Saccharomyces cerevisiae, GI6324059, Length=500, Percent_Identity=33.2, Blast_Score=219, Evalue=7e-58,
Organism=Saccharomyces cerevisiae, GI6324924, Length=491, Percent_Identity=31.9755600814664, Blast_Score=219, Evalue=1e-57,
Organism=Saccharomyces cerevisiae, GI6324990, Length=447, Percent_Identity=33.1096196868009, Blast_Score=216, Evalue=5e-57,
Organism=Saccharomyces cerevisiae, GI6322892, Length=429, Percent_Identity=33.7995337995338, Blast_Score=211, Evalue=2e-55,
Organism=Saccharomyces cerevisiae, GI6319824, Length=409, Percent_Identity=29.8288508557457, Blast_Score=189, Evalue=7e-49,
Organism=Saccharomyces cerevisiae, GI6324553, Length=408, Percent_Identity=32.1078431372549, Blast_Score=189, Evalue=7e-49,
Organism=Saccharomyces cerevisiae, GI6320717, Length=409, Percent_Identity=29.0953545232274, Blast_Score=182, Evalue=7e-47,
Organism=Saccharomyces cerevisiae, GI6321053, Length=470, Percent_Identity=28.2978723404255, Blast_Score=178, Evalue=2e-45,
Organism=Saccharomyces cerevisiae, GI6321629, Length=418, Percent_Identity=25.8373205741627, Blast_Score=167, Evalue=3e-42,
Organism=Saccharomyces cerevisiae, GI6322967, Length=402, Percent_Identity=30.5970149253731, Blast_Score=166, Evalue=1e-41,
Organism=Saccharomyces cerevisiae, GI6319542, Length=501, Percent_Identity=28.5429141716567, Blast_Score=164, Evalue=3e-41,
Organism=Saccharomyces cerevisiae, GI6320251, Length=414, Percent_Identity=29.7101449275362, Blast_Score=161, Evalue=2e-40,
Organism=Saccharomyces cerevisiae, GI6319608, Length=439, Percent_Identity=27.5626423690205, Blast_Score=159, Evalue=9e-40,
Organism=Saccharomyces cerevisiae, GI6319543, Length=405, Percent_Identity=28.8888888888889, Blast_Score=159, Evalue=9e-40,
Organism=Saccharomyces cerevisiae, GI6324981, Length=417, Percent_Identity=30.9352517985612, Blast_Score=156, Evalue=7e-39,
Organism=Saccharomyces cerevisiae, GI6320364, Length=497, Percent_Identity=24.9496981891348, Blast_Score=111, Evalue=3e-25,
Organism=Drosophila melanogaster, GI24666159, Length=306, Percent_Identity=23.5294117647059, Blast_Score=74, Evalue=2e-13,
Organism=Drosophila melanogaster, GI221512776, Length=306, Percent_Identity=23.5294117647059, Blast_Score=74, Evalue=3e-13,
Organism=Drosophila melanogaster, GI24668806, Length=304, Percent_Identity=24.0131578947368, Blast_Score=73, Evalue=5e-13,
Organism=Drosophila melanogaster, GI21356285, Length=304, Percent_Identity=24.0131578947368, Blast_Score=73, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24668802, Length=304, Percent_Identity=24.0131578947368, Blast_Score=73, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24667468, Length=365, Percent_Identity=21.9178082191781, Blast_Score=70, Evalue=3e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 51912; Mature: 51781

Theoretical pI: Translated: 9.79; Mature: 9.79

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTRLGGSSPAAGCPAVPSRFGAAGSGAPSGTEQEQGLQRGLKNRHIQFIALGGAIGTGL
CCCCCCCCCCCCCCCCCCHHCCCCCCCCCCCCHHHHHHHHHHHHCCEEEEEECCHHHHHH
FYGAAESIEQAGPAIMVCYLIGGAVIFLIMRALGEMSVEHPTSGAFSYYAYRNWSPRAGF
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCCC
VSGYNYWFNYIAVSMAELTVVGKYVNFWFPQIPEWLSAGAFLVLITIINLTAVRAYGEFE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCHHHHHHHHHHHHHHHHCCCHH
FWFAVIKVVAILAMIVLGVLIIATGLGGGPPTGIGNLWRHGGFFPTGISGMLCGFVVVMF
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHH
SFGGVELIGITAGEADDPRRSIPRAINQVVYRILIFYIGAISVMLCLFPWNQIGKAGSPF
HCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCH
VTIFDKIGVAGAANILNVVVLTASMSAYNSGLYSNGRMLYSLAAQHNAPGIFWKTNRLGA
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEHHCCCCCCEEEECCCCCC
PWVGVLASSVVTATAVLLTYLIPGKVFLYIISIALISGVINWTMIIITNLKFRRRIGPEG
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCC
VAALEFRMPGNPVTSYVVLVFLALVVVIMAMMPSYRVALVVGPVWLALLWVGYDVSCLVR
CEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCHHHHHH
RRHA
HCCC
>Mature Secondary Structure 
STRLGGSSPAAGCPAVPSRFGAAGSGAPSGTEQEQGLQRGLKNRHIQFIALGGAIGTGL
CCCCCCCCCCCCCCCCCHHCCCCCCCCCCCCHHHHHHHHHHHHCCEEEEEECCHHHHHH
FYGAAESIEQAGPAIMVCYLIGGAVIFLIMRALGEMSVEHPTSGAFSYYAYRNWSPRAGF
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCCC
VSGYNYWFNYIAVSMAELTVVGKYVNFWFPQIPEWLSAGAFLVLITIINLTAVRAYGEFE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCHHHHHHHHHHHHHHHHCCCHH
FWFAVIKVVAILAMIVLGVLIIATGLGGGPPTGIGNLWRHGGFFPTGISGMLCGFVVVMF
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHCCCCCCCCHHHHHHHHHHHHH
SFGGVELIGITAGEADDPRRSIPRAINQVVYRILIFYIGAISVMLCLFPWNQIGKAGSPF
HCCCEEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCH
VTIFDKIGVAGAANILNVVVLTASMSAYNSGLYSNGRMLYSLAAQHNAPGIFWKTNRLGA
HHHHHHHCCCHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEEHHCCCCCCEEEECCCCCC
PWVGVLASSVVTATAVLLTYLIPGKVFLYIISIALISGVINWTMIIITNLKFRRRIGPEG
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHCCCCC
VAALEFRMPGNPVTSYVVLVFLALVVVIMAMMPSYRVALVVGPVWLALLWVGYDVSCLVR
CEEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCHHHHHH
RRHA
HCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-tryptophan [Periplasm]; Proton [Periplasm]; Proton [Periplasm]; L-tyrosine [Periplasm]; Proton [Periplasm]; L-phenylalanine [Periplasm] [C]

Specific reaction: L-tryptophan [Periplasm] + Proton [Periplasm] = L-tryptophan [Cytoplasm] + Proton [Cytoplasm] Proton [Periplasm] + L-tyrosine [Periplasm] = Proton [Cytoplasm] + L-tyrosine [Cytoplasm] Proton [Periplasm] + L-phenylalanine [Periplasm] = Proton [Cytoplasm] +

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]