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The map label for this gene is dxs [H]

Identifier: 50842544

GI number: 50842544

Start: 1156678

End: 1158582

Strand: Direct

Name: dxs [H]

Synonym: PPA1062

Alternate gene names: 50842544

Gene position: 1156678-1158582 (Clockwise)

Preceding gene: 50842543

Following gene: 50842550

Centisome position: 45.18

GC content: 58.43

Gene sequence:

>1905_bases
GTGACAGCGGTAGGTCCTAAGATGCCACGTATGGCTCTTCTCGACGACATCGGCTGTCCCGACGACGTGAGGAAACTCAC
CACTAAGCAGGCCGAGGATCTCGCCGAGGAAATTCGTGCCTTCCTTATCGACAAAGTATCGCGTACCGGTGGTCACCTCG
GGCCGAATCTCGGCGTCGTTGAGTTGACGATCGCCTTGCACCGGGTGTTCGACTCACCCCACGACCCCATCATCTTTGAC
ACCGGTCACCAGAGCTACGTCCATAAGATCCTTACCGGGCGCGCGAACGGTTTTGAGAAGCTGCGCCAGCGTGGGGGACT
TTCCGGGTATCCCAGTCGCGCGGAATCTGTCCATGATTGGGTGGAAAACTCCCACGCTTCGGCCTCGTTGTCTTGGGCCG
AGGGCATGGCCAAGGGATTTCTTTCTCAGGGCGAGGATCGCACCGTCGTCGCCGTCATTGGTGACGGAGCGTTGACGGGT
GGAATGGCATGGGAGGCGCTGAACTCCATCGCCGACCAGCAGGGCCTTCGTCTAGTCATTGTCGTTAACGACAATGGCCG
TTCCTACACCCCGACAGTGGGGGGTTTGGCGAACCAACTTGCCATTATCCGCACTGATCCTCACTACGAGGAAGCTCTCG
ACCGGATGAAGCGGCATGTCACCGACAAGCCACTCGGCAAGCAGGTTTTCGGTCTCATGCATGCCGCTAAGGCCGGTGTT
AAAGACGCCCTCATCGGCAATGGGATTTTCTCCGATTTGGGTATCAAGTACCTCGGCCCGGTTGATGGCCACGATGTCCT
CTCTGTCGAACGAGCCCTCGAGCTTGCTAAGCGCTATGGGCATCCCGTCATCGTCCATGTCATGACGACCAAGGGCAAGG
GATTTGCTGCTGCTGAGGCTAATGAGGAGGATCATTTTCACGCTGTCGGAAGGATTGACCCAGTCACTGGTGCATCTCTT
AAGGCTTCCGGTGGTGCTTCGTGGACCCAGGCTTTTGCTGGCGCCATGGTTGAGTTGGGGGAGAGGCGCCCCGATATTGT
CGGGGTGACCGCCGCCATGCTTCACCCCGTCGGTCTCGCACCGTTCGCAGCCCGACACCCGGATCGGGTTCTCGATGTCG
GTATCGCCGAGCAGCATGCGGTGACATCTGCTGCTGGCATGGCCGCCGCAGGGTTACACCCCGTTGTGGCTCTCTACTCG
ACCTTCCTTAATCGTGCTTTTGACCAGCTCCTTATGGATGCCGGGTTGCACCATGCGGGTGTGACTATCGTGCTGGATCG
GGCTGGTATCACAGGTACTGACGGCGCATCTCACAACGGTATGTGGGATATGGCTATGTGCGGGATTGTTCCTGGTCTGA
TGCTGTCGGCCCCACGTGACCGTCAGCACCTCGTGTCCGTGCTCAATGAAGCCGTCGACATTGACGACCGTCCTACAGTC
ATCCGGTATTCCAAGGACCCCATACCTGACGACATCCGCATTGTGACCTCCCATGACGGTCTCGACGTGTTGTGTGATGG
TCCTGAGGATGGGATTCTTCTCGTCGCCCACGGTCAGCTTTGTGCAGAGGCTCTCGCTGCAGTAGATCAACTCGACTCCC
CGGTTCGCGTCGTCAGCCCCAGGTGGTCTCTCCCCGTGTGTGGCGGGCTTATTGAGGAAGCTGCAAGAGCTCGCGCAGTC
GTTAGTGTTGAAGACGGGCTAGTCGTTTCCGGGCTCGGATCTCATTTGGCTGATGCGTTGTCGCAGCGGGGTATGTGGCG
ACCGATACGTAGCCTCGGCATTCCGCAGCGCTACCTCGATCACGACTCGCGTTCGGCAATCATGGCTGAGCTTGGTTTAG
ATTCTCGAGGTATCGCTGATGCCGTCAGCCAACTGGTTGCCCAACTTGATGGTGAGTACTCGTGA

Upstream 100 bases:

>100_bases
CGCGGCGGTCTTTGGCCCCATCCGCGCGGGCCCACTCCATCTCTGAGAAGGAGACGAGATAGTGAGCGTGAGGCGAAATG
GAGCGCTAAGGAGGCACAGT

Downstream 100 bases:

>100_bases
AGGGGATGCCGGGATTCACAGCGTGGCCATAACCGCGCTTAGCGGCCCCGAGAGAATCTCCCGTTGCCACGGCCGTGCGC
CGAGCCCCTCCAGGAAAACG

Product: 1-deoxy-D-xylulose-5-phosphate synthase

Products: NA

Alternate protein names: 1-deoxyxylulose-5-phosphate synthase; DXP synthase; DXPS [H]

Number of amino acids: Translated: 634; Mature: 633

Protein sequence:

>634_residues
MTAVGPKMPRMALLDDIGCPDDVRKLTTKQAEDLAEEIRAFLIDKVSRTGGHLGPNLGVVELTIALHRVFDSPHDPIIFD
TGHQSYVHKILTGRANGFEKLRQRGGLSGYPSRAESVHDWVENSHASASLSWAEGMAKGFLSQGEDRTVVAVIGDGALTG
GMAWEALNSIADQQGLRLVIVVNDNGRSYTPTVGGLANQLAIIRTDPHYEEALDRMKRHVTDKPLGKQVFGLMHAAKAGV
KDALIGNGIFSDLGIKYLGPVDGHDVLSVERALELAKRYGHPVIVHVMTTKGKGFAAAEANEEDHFHAVGRIDPVTGASL
KASGGASWTQAFAGAMVELGERRPDIVGVTAAMLHPVGLAPFAARHPDRVLDVGIAEQHAVTSAAGMAAAGLHPVVALYS
TFLNRAFDQLLMDAGLHHAGVTIVLDRAGITGTDGASHNGMWDMAMCGIVPGLMLSAPRDRQHLVSVLNEAVDIDDRPTV
IRYSKDPIPDDIRIVTSHDGLDVLCDGPEDGILLVAHGQLCAEALAAVDQLDSPVRVVSPRWSLPVCGGLIEEAARARAV
VSVEDGLVVSGLGSHLADALSQRGMWRPIRSLGIPQRYLDHDSRSAIMAELGLDSRGIADAVSQLVAQLDGEYS

Sequences:

>Translated_634_residues
MTAVGPKMPRMALLDDIGCPDDVRKLTTKQAEDLAEEIRAFLIDKVSRTGGHLGPNLGVVELTIALHRVFDSPHDPIIFD
TGHQSYVHKILTGRANGFEKLRQRGGLSGYPSRAESVHDWVENSHASASLSWAEGMAKGFLSQGEDRTVVAVIGDGALTG
GMAWEALNSIADQQGLRLVIVVNDNGRSYTPTVGGLANQLAIIRTDPHYEEALDRMKRHVTDKPLGKQVFGLMHAAKAGV
KDALIGNGIFSDLGIKYLGPVDGHDVLSVERALELAKRYGHPVIVHVMTTKGKGFAAAEANEEDHFHAVGRIDPVTGASL
KASGGASWTQAFAGAMVELGERRPDIVGVTAAMLHPVGLAPFAARHPDRVLDVGIAEQHAVTSAAGMAAAGLHPVVALYS
TFLNRAFDQLLMDAGLHHAGVTIVLDRAGITGTDGASHNGMWDMAMCGIVPGLMLSAPRDRQHLVSVLNEAVDIDDRPTV
IRYSKDPIPDDIRIVTSHDGLDVLCDGPEDGILLVAHGQLCAEALAAVDQLDSPVRVVSPRWSLPVCGGLIEEAARARAV
VSVEDGLVVSGLGSHLADALSQRGMWRPIRSLGIPQRYLDHDSRSAIMAELGLDSRGIADAVSQLVAQLDGEYS
>Mature_633_residues
TAVGPKMPRMALLDDIGCPDDVRKLTTKQAEDLAEEIRAFLIDKVSRTGGHLGPNLGVVELTIALHRVFDSPHDPIIFDT
GHQSYVHKILTGRANGFEKLRQRGGLSGYPSRAESVHDWVENSHASASLSWAEGMAKGFLSQGEDRTVVAVIGDGALTGG
MAWEALNSIADQQGLRLVIVVNDNGRSYTPTVGGLANQLAIIRTDPHYEEALDRMKRHVTDKPLGKQVFGLMHAAKAGVK
DALIGNGIFSDLGIKYLGPVDGHDVLSVERALELAKRYGHPVIVHVMTTKGKGFAAAEANEEDHFHAVGRIDPVTGASLK
ASGGASWTQAFAGAMVELGERRPDIVGVTAAMLHPVGLAPFAARHPDRVLDVGIAEQHAVTSAAGMAAAGLHPVVALYST
FLNRAFDQLLMDAGLHHAGVTIVLDRAGITGTDGASHNGMWDMAMCGIVPGLMLSAPRDRQHLVSVLNEAVDIDDRPTVI
RYSKDPIPDDIRIVTSHDGLDVLCDGPEDGILLVAHGQLCAEALAAVDQLDSPVRVVSPRWSLPVCGGLIEEAARARAVV
SVEDGLVVSGLGSHLADALSQRGMWRPIRSLGIPQRYLDHDSRSAIMAELGLDSRGIADAVSQLVAQLDGEYS

Specific function: Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) [H]

COG id: COG1154

COG function: function code HI; Deoxyxylulose-5-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family. DXPS subfamily [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=553, Percent_Identity=23.869801084991, Blast_Score=86, Evalue=1e-16,
Organism=Homo sapiens, GI4507521, Length=553, Percent_Identity=23.869801084991, Blast_Score=86, Evalue=1e-16,
Organism=Homo sapiens, GI225637463, Length=235, Percent_Identity=28.0851063829787, Blast_Score=71, Evalue=4e-12,
Organism=Homo sapiens, GI225637461, Length=235, Percent_Identity=28.0851063829787, Blast_Score=71, Evalue=4e-12,
Organism=Homo sapiens, GI225637459, Length=235, Percent_Identity=28.0851063829787, Blast_Score=70, Evalue=4e-12,
Organism=Homo sapiens, GI133778974, Length=414, Percent_Identity=24.1545893719807, Blast_Score=69, Evalue=2e-11,
Organism=Escherichia coli, GI1786622, Length=627, Percent_Identity=35.5661881977671, Blast_Score=375, Evalue=1e-105,
Organism=Caenorhabditis elegans, GI17539652, Length=395, Percent_Identity=24.8101265822785, Blast_Score=73, Evalue=4e-13,
Organism=Drosophila melanogaster, GI24666278, Length=674, Percent_Identity=24.3323442136499, Blast_Score=92, Evalue=8e-19,
Organism=Drosophila melanogaster, GI45551847, Length=674, Percent_Identity=23.5905044510386, Blast_Score=82, Evalue=8e-16,
Organism=Drosophila melanogaster, GI45550715, Length=674, Percent_Identity=23.5905044510386, Blast_Score=82, Evalue=8e-16,
Organism=Drosophila melanogaster, GI24645119, Length=550, Percent_Identity=24.3636363636364, Blast_Score=80, Evalue=3e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005477
- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C [H]

EC number: =2.2.1.7 [H]

Molecular weight: Translated: 67468; Mature: 67336

Theoretical pI: Translated: 5.94; Mature: 5.94

Prosite motif: PS00801 TRANSKETOLASE_1 ; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAVGPKMPRMALLDDIGCPDDVRKLTTKQAEDLAEEIRAFLIDKVSRTGGHLGPNLGVV
CCCCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHH
ELTIALHRVFDSPHDPIIFDTGHQSYVHKILTGRANGFEKLRQRGGLSGYPSRAESVHDW
HHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHCCCCHHHHHHHCCCCCCCCHHHHHHHHH
VENSHASASLSWAEGMAKGFLSQGEDRTVVAVIGDGALTGGMAWEALNSIADQQGLRLVI
HHCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHCCCCEEEE
VVNDNGRSYTPTVGGLANQLAIIRTDPHYEEALDRMKRHVTDKPLGKQVFGLMHAAKAGV
EEECCCCEECCCHHHHHHCEEEEECCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCC
KDALIGNGIFSDLGIKYLGPVDGHDVLSVERALELAKRYGHPVIVHVMTTKGKGFAAAEA
HHHHHCCCHHHHCCCEEECCCCCCHHHHHHHHHHHHHHCCCCEEEEEEEECCCCEEECCC
NEEDHFHAVGRIDPVTGASLKASGGASWTQAFAGAMVELGERRPDIVGVTAAMLHPVGLA
CCCCCEEECCCCCCCCCCCEECCCCCHHHHHHHHHHHHHHCCCCCEEEHHHHHHCCCCCC
PFAARHPDRVLDVGIAEQHAVTSAAGMAAAGLHPVVALYSTFLNRAFDQLLMDAGLHHAG
CHHHCCCCHHEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
VTIVLDRAGITGTDGASHNGMWDMAMCGIVPGLMLSAPRDRQHLVSVLNEAVDIDDRPTV
EEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCE
IRYSKDPIPDDIRIVTSHDGLDVLCDGPEDGILLVAHGQLCAEALAAVDQLDSPVRVVSP
EEECCCCCCCCEEEEEECCCCEEEECCCCCCEEEEECCHHHHHHHHHHHHCCCCCEEECC
RWSLPVCGGLIEEAARARAVVSVEDGLVVSGLGSHLADALSQRGMWRPIRSLGIPQRYLD
CCCCCHHHHHHHHHHHHHEEEEECCCEEEEHHHHHHHHHHHHCCCCHHHHHCCCCHHHHC
HDSRSAIMAELGLDSRGIADAVSQLVAQLDGEYS
CCCHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
TAVGPKMPRMALLDDIGCPDDVRKLTTKQAEDLAEEIRAFLIDKVSRTGGHLGPNLGVV
CCCCCCCCHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHH
ELTIALHRVFDSPHDPIIFDTGHQSYVHKILTGRANGFEKLRQRGGLSGYPSRAESVHDW
HHHHHHHHHHCCCCCCEEEECCCHHHHHHHHHCCCCHHHHHHHCCCCCCCCHHHHHHHHH
VENSHASASLSWAEGMAKGFLSQGEDRTVVAVIGDGALTGGMAWEALNSIADQQGLRLVI
HHCCCCCCCHHHHHHHHHHHHCCCCCCEEEEEECCCCCCCHHHHHHHHHHHHCCCCEEEE
VVNDNGRSYTPTVGGLANQLAIIRTDPHYEEALDRMKRHVTDKPLGKQVFGLMHAAKAGV
EEECCCCEECCCHHHHHHCEEEEECCCCHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCC
KDALIGNGIFSDLGIKYLGPVDGHDVLSVERALELAKRYGHPVIVHVMTTKGKGFAAAEA
HHHHHCCCHHHHCCCEEECCCCCCHHHHHHHHHHHHHHCCCCEEEEEEEECCCCEEECCC
NEEDHFHAVGRIDPVTGASLKASGGASWTQAFAGAMVELGERRPDIVGVTAAMLHPVGLA
CCCCCEEECCCCCCCCCCCEECCCCCHHHHHHHHHHHHHHCCCCCEEEHHHHHHCCCCCC
PFAARHPDRVLDVGIAEQHAVTSAAGMAAAGLHPVVALYSTFLNRAFDQLLMDAGLHHAG
CHHHCCCCHHEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
VTIVLDRAGITGTDGASHNGMWDMAMCGIVPGLMLSAPRDRQHLVSVLNEAVDIDDRPTV
EEEEEECCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCCCCE
IRYSKDPIPDDIRIVTSHDGLDVLCDGPEDGILLVAHGQLCAEALAAVDQLDSPVRVVSP
EEECCCCCCCCEEEEEECCCCEEEECCCCCCEEEEECCHHHHHHHHHHHHCCCCCEEECC
RWSLPVCGGLIEEAARARAVVSVEDGLVVSGLGSHLADALSQRGMWRPIRSLGIPQRYLD
CCCCCHHHHHHHHHHHHHEEEEECCCEEEEHHHHHHHHHHHHCCCCHHHHHCCCCHHHHC
HDSRSAIMAELGLDSRGIADAVSQLVAQLDGEYS
CCCHHHHHHHHCCCCCCHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA