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The map label for this gene is kasA [H]

Identifier: 50842465

GI number: 50842465

Start: 1064239

End: 1065510

Strand: Reverse

Name: kasA [H]

Synonym: PPA0980

Alternate gene names: 50842465

Gene position: 1065510-1064239 (Counterclockwise)

Preceding gene: 50842466

Following gene: 50842458

Centisome position: 41.62

GC content: 61.32

Gene sequence:

>1272_bases
ATGAGCGACGTCGTCATCACTGGTTTCGGGACCACCACACCGTTGGGACCCGACGCCCCTAGCACCTGGCAGGGGCTGCT
GGAAGGGCGAAACGGGGTACACACCCTCGACTTCGACTGGATTGACGACGTTCCCGTCAAATTCGCCGCACCGGCGGTCG
ATGATCCGGCCAACCACCTGCCCCGTCCACAGGCTCGCCGTCTAGACCGCTCAAGCCAGCTGGCCCTTGTCGCTGCCAAG
GAGGCCTGGGCCGACGCCGGCCTGGAGCTTCCCGAAGCCGACGACAACTCCGGTTCCAACGGCATCGACCCCGAACGCTT
GGTGGTGTGCTGCGCTACCGGTATTGGTGGCCTGCACTCTTTGCTCGGCCAGTGGGACATTCAGAAAGACAAGGGCTTCA
AACGGGTTAGTCCCTTTACCGTCCCGATGCTAATGGCCAATGCACCGGCGGCCAATATTGGCTTGATGGTGCATGCCAAG
GCCGGCGTCCATACCCCCGTTTCGGCTTGCGCTTCATCTTCCGAAGCAATCTCGCTCGGCCTGGATCAGCTTCATCTGGG
GCGAGCCGATATTGCCGTCGTCGGCGGCGCCGAGGCCATCATCCATCCGTTGCCGGTGGCCGCTTTCGCCCAAATGAAAG
CCTTGTCGACTCGCAACGACGATCCTGAGCACGCTTCACGTCCATGGGACGTTGATCGTGACGGCTTCGTCATCGGCGAG
GGAGCGGCGATCATGGTCATTGAGACACTCGAGCATGCTCAAGCCCGCGGGGCAAAGATCTACGGCACTCTTGCCGGATC
CGGTATTTCGGCTGATTCGCACGATATCGTTCAGCCAGATCCCACTGGTTCCGGCCAGGCATCCGCGATGCACAAGGCTC
TTGCATCCGCCGGGCTATCCCCCTCCGACGTCAACCACGTCAACGCCCACGCCACCTCGACCCCACTCGGTGACACTGCG
GAGGCCCACTCCATCGCCGCGGTCCTAGAGAAAGCCACTGACCAGGTGCTTGTCAACGGCACCAAGTCGATGACGGGACA
CCTGTTAGGTGGAGCTGGGGCTTTGGAATCCTTCGCAGCGGTGATGGCCCTACTGAAGCGTCAGGTGCCTGGCACCATCA
ACGTCGAACACCTCGAAGAGGGCTTGGAAATCAACGTCGTCACCGAGACGACCGACCTACCCGACGGTGATCTGGCTGCT
CTTAATAACTCTTTCGGGTTCGGAGGGCACAACGTCACCTTGGCGTTCACTAACACCAACGCCACTCGCTGA

Upstream 100 bases:

>100_bases
AACTACATCATCGAGCACCAGGGCTGACTTCCACGGCGTCCGGGGCTCGCCGGCCCCGGACTGCGGCCCACATAACCCAT
CCACCGATACTGGAGAACTC

Downstream 100 bases:

>100_bases
CATCCATGGGATGAGGGGGCTGGTCATCGTGATCAGCCCCCTCTCATGGTTCCTCGTCCTTGGACTCCCGACCGAGCAGC
CCCTGTTACCCGGCAGACAG

Product: 3-oxoacyl-[acyl-carrier-protein] synthase 1

Products: NA

Alternate protein names: Beta-ketoacyl-ACP synthase 1; KAS 1 [H]

Number of amino acids: Translated: 423; Mature: 422

Protein sequence:

>423_residues
MSDVVITGFGTTTPLGPDAPSTWQGLLEGRNGVHTLDFDWIDDVPVKFAAPAVDDPANHLPRPQARRLDRSSQLALVAAK
EAWADAGLELPEADDNSGSNGIDPERLVVCCATGIGGLHSLLGQWDIQKDKGFKRVSPFTVPMLMANAPAANIGLMVHAK
AGVHTPVSACASSSEAISLGLDQLHLGRADIAVVGGAEAIIHPLPVAAFAQMKALSTRNDDPEHASRPWDVDRDGFVIGE
GAAIMVIETLEHAQARGAKIYGTLAGSGISADSHDIVQPDPTGSGQASAMHKALASAGLSPSDVNHVNAHATSTPLGDTA
EAHSIAAVLEKATDQVLVNGTKSMTGHLLGGAGALESFAAVMALLKRQVPGTINVEHLEEGLEINVVTETTDLPDGDLAA
LNNSFGFGGHNVTLAFTNTNATR

Sequences:

>Translated_423_residues
MSDVVITGFGTTTPLGPDAPSTWQGLLEGRNGVHTLDFDWIDDVPVKFAAPAVDDPANHLPRPQARRLDRSSQLALVAAK
EAWADAGLELPEADDNSGSNGIDPERLVVCCATGIGGLHSLLGQWDIQKDKGFKRVSPFTVPMLMANAPAANIGLMVHAK
AGVHTPVSACASSSEAISLGLDQLHLGRADIAVVGGAEAIIHPLPVAAFAQMKALSTRNDDPEHASRPWDVDRDGFVIGE
GAAIMVIETLEHAQARGAKIYGTLAGSGISADSHDIVQPDPTGSGQASAMHKALASAGLSPSDVNHVNAHATSTPLGDTA
EAHSIAAVLEKATDQVLVNGTKSMTGHLLGGAGALESFAAVMALLKRQVPGTINVEHLEEGLEINVVTETTDLPDGDLAA
LNNSFGFGGHNVTLAFTNTNATR
>Mature_422_residues
SDVVITGFGTTTPLGPDAPSTWQGLLEGRNGVHTLDFDWIDDVPVKFAAPAVDDPANHLPRPQARRLDRSSQLALVAAKE
AWADAGLELPEADDNSGSNGIDPERLVVCCATGIGGLHSLLGQWDIQKDKGFKRVSPFTVPMLMANAPAANIGLMVHAKA
GVHTPVSACASSSEAISLGLDQLHLGRADIAVVGGAEAIIHPLPVAAFAQMKALSTRNDDPEHASRPWDVDRDGFVIGEG
AAIMVIETLEHAQARGAKIYGTLAGSGISADSHDIVQPDPTGSGQASAMHKALASAGLSPSDVNHVNAHATSTPLGDTAE
AHSIAAVLEKATDQVLVNGTKSMTGHLLGGAGALESFAAVMALLKRQVPGTINVEHLEEGLEINVVTETTDLPDGDLAAL
NNSFGFGGHNVTLAFTNTNATR

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP [H]

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=423, Percent_Identity=34.9881796690307, Blast_Score=239, Evalue=5e-63,
Organism=Homo sapiens, GI223972627, Length=146, Percent_Identity=39.7260273972603, Blast_Score=105, Evalue=5e-23,
Organism=Homo sapiens, GI41872631, Length=263, Percent_Identity=26.9961977186312, Blast_Score=77, Evalue=4e-14,
Organism=Escherichia coli, GI1787337, Length=414, Percent_Identity=39.3719806763285, Blast_Score=265, Evalue=3e-72,
Organism=Escherichia coli, GI1788663, Length=421, Percent_Identity=35.1543942992874, Blast_Score=201, Evalue=9e-53,
Organism=Caenorhabditis elegans, GI71983541, Length=420, Percent_Identity=33.8095238095238, Blast_Score=223, Evalue=1e-58,
Organism=Caenorhabditis elegans, GI71983535, Length=259, Percent_Identity=37.4517374517375, Blast_Score=174, Evalue=5e-44,
Organism=Caenorhabditis elegans, GI212642053, Length=424, Percent_Identity=25.7075471698113, Blast_Score=113, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17550940, Length=254, Percent_Identity=24.0157480314961, Blast_Score=69, Evalue=4e-12,
Organism=Saccharomyces cerevisiae, GI6320904, Length=439, Percent_Identity=32.3462414578588, Blast_Score=224, Evalue=3e-59,
Organism=Saccharomyces cerevisiae, GI6325025, Length=206, Percent_Identity=29.126213592233, Blast_Score=72, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24644341, Length=421, Percent_Identity=38.9548693586698, Blast_Score=285, Evalue=4e-77,
Organism=Drosophila melanogaster, GI221330659, Length=273, Percent_Identity=26.3736263736264, Blast_Score=83, Evalue=4e-16,
Organism=Drosophila melanogaster, GI19920632, Length=273, Percent_Identity=26.3736263736264, Blast_Score=83, Evalue=5e-16,
Organism=Drosophila melanogaster, GI24581345, Length=257, Percent_Identity=24.9027237354086, Blast_Score=73, Evalue=4e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000794
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.41 [H]

Molecular weight: Translated: 43784; Mature: 43653

Theoretical pI: Translated: 4.76; Mature: 4.76

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDVVITGFGTTTPLGPDAPSTWQGLLEGRNGVHTLDFDWIDDVPVKFAAPAVDDPANHL
CCCEEEECCCCCCCCCCCCCHHHHHHHCCCCCCEEECCCCCCCCCCEEECCCCCCCHHHC
PRPQARRLDRSSQLALVAAKEAWADAGLELPEADDNSGSNGIDPERLVVCCATGIGGLHS
CCCHHHHCCCCCCEEEEEEHHHHHHCCCCCCCCCCCCCCCCCCHHHEEEEECCCCCHHHH
LLGQWDIQKDKGFKRVSPFTVPMLMANAPAANIGLMVHAKAGVHTPVSACASSSEAISLG
HHHCCCCCCCCCCCCCCCCEEEHEEECCCCCCEEEEEEECCCCCCCHHHHCCCCCEEEEC
LDQLHLGRADIAVVGGAEAIIHPLPVAAFAQMKALSTRNDDPEHASRPWDVDRDGFVIGE
HHHHCCCCCCEEEECCCHHHHCCCCHHHHHHHHHHHCCCCCHHHCCCCCCCCCCCEEEEC
GAAIMVIETLEHAQARGAKIYGTLAGSGISADSHDIVQPDPTGSGQASAMHKALASAGLS
CCEEEEEEHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCC
PSDVNHVNAHATSTPLGDTAEAHSIAAVLEKATDQVLVNGTKSMTGHLLGGAGALESFAA
CCCCCCEECCCCCCCCCCCHHHHHHHHHHHHHCCCEEECCCHHHCCEEECCHHHHHHHHH
VMALLKRQVPGTINVEHLEEGLEINVVTETTDLPDGDLAALNNSFGFGGHNVTLAFTNTN
HHHHHHHCCCCCEEHHHHHCCCEEEEEEECCCCCCCCHHHCCCCCCCCCCEEEEEEECCC
ATR
CCC
>Mature Secondary Structure 
SDVVITGFGTTTPLGPDAPSTWQGLLEGRNGVHTLDFDWIDDVPVKFAAPAVDDPANHL
CCEEEECCCCCCCCCCCCCHHHHHHHCCCCCCEEECCCCCCCCCCEEECCCCCCCHHHC
PRPQARRLDRSSQLALVAAKEAWADAGLELPEADDNSGSNGIDPERLVVCCATGIGGLHS
CCCHHHHCCCCCCEEEEEEHHHHHHCCCCCCCCCCCCCCCCCCHHHEEEEECCCCCHHHH
LLGQWDIQKDKGFKRVSPFTVPMLMANAPAANIGLMVHAKAGVHTPVSACASSSEAISLG
HHHCCCCCCCCCCCCCCCCEEEHEEECCCCCCEEEEEEECCCCCCCHHHHCCCCCEEEEC
LDQLHLGRADIAVVGGAEAIIHPLPVAAFAQMKALSTRNDDPEHASRPWDVDRDGFVIGE
HHHHCCCCCCEEEECCCHHHHCCCCHHHHHHHHHHHCCCCCHHHCCCCCCCCCCCEEEEC
GAAIMVIETLEHAQARGAKIYGTLAGSGISADSHDIVQPDPTGSGQASAMHKALASAGLS
CCEEEEEEHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCC
PSDVNHVNAHATSTPLGDTAEAHSIAAVLEKATDQVLVNGTKSMTGHLLGGAGALESFAA
CCCCCCEECCCCCCCCCCCHHHHHHHHHHHHHCCCEEECCCHHHCCEEECCHHHHHHHHH
VMALLKRQVPGTINVEHLEEGLEINVVTETTDLPDGDLAALNNSFGFGGHNVTLAFTNTN
HHHHHHHCCCCCEEHHHHHCCCEEEEEEECCCCCCCCHHHCCCCCCCCCCEEEEEEECCC
ATR
CCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12788972 [H]