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The map label for this gene is lysN [H]

Identifier: 50842361

GI number: 50842361

Start: 949848

End: 951236

Strand: Direct

Name: lysN [H]

Synonym: PPA0875

Alternate gene names: 50842361

Gene position: 949848-951236 (Clockwise)

Preceding gene: 50842352

Following gene: 50842362

Centisome position: 37.1

GC content: 58.32

Gene sequence:

>1389_bases
GTGGTTGTCAAGGTTGACCCTGCAAGTCTGAGCCGGATGCTGGGGGAGTGGAGCCAGCCCGGAGAAGCGCTTCCGGAAGC
GTTGGCGGACGCATTGCTGGATCTCATTGACGCTGGTTTTGTGCCCGCTGGTGCGGTTCTTCCACCCCAACGAGCATGCG
CCGCGACACTGCAAGTATCTCGGCAAACCGTGGCGGAGGCATTTGGGATTCTTGAAGCCGCAGGCCACATTGCGGCGTTG
GTTGGGTCAGGGACGCGGGTTAGATCAGGCCGCGCTGCAGTGAGTACTGATGGCAGGTTGTTCTCGTTCAGCGAGGCTGC
ACCTGGCCTGATCGACCTGTCAACGGGGGCGCTACCTGCGTCAGAGGTGGTGCGAAGAGTGCGGCTAGAAGACCACGTCG
ACTTGGATGAGTATTTCGATACCGACGGATATTTCCCGGCTGGACTACCTATATTGCGTGCAGCCATCGCGGAACGGCTC
ACTCGAGATGGAGTTCCCACAGTCCCGCAGCAGATCGTTGTTACCAACGGCGCTCAGCATGCGAGTTATCTTGCCTCTCA
GCTCCTGGTCTCGGCTGGTGACACCGTGTTGGTGGAGGAGCCGACATATCGGGGTGAGCTCGCAGAGCTGCGACTGATGG
GCGCCCGTGTGAAGAGTGTCCCGCTGACTGCCGCAGGTCTGGCTCTTGATCTCGTTGACCGTGGTTTGCGACGTGCGCCA
GCGATGTTCTATTGCCAGACGAGTATCCACAATCCGACTGGTTTGACGATGGCTCCCGGTTATCGCAAAGCTCTTGCTGC
CTTGCTTGATCACCATGGTGTTCCCGTTGTCGAGGATTGCTGCTCGTACGACCTCACTACATCGGGATTACCCGCTCCCA
TGTTGGCAGGAGAGATGGGCGATGATCTGGTACTCACGATCGGAACACTGTCGAAACTGTTTTGGGGTGGTCTGAGAATC
GGATGGTTGAGAGCCAGTTCGACACGCATTCGGCAACTGATCGAGCGTCGTAAAGCGGAGGATCTTGCCAGCCCCATATC
AACCCAGGTGGTTGCCACCAACCTGATGACGCATATGGGGGAAGCGCGTCAAGAGCGACGAGCGCTGCTTCAAGCCGGCC
GGGGGGCAACATGTGAGGTTGTTAGTGACGTGTTTCTGGCGTGGGTGTGGACCGCATCACAAAGTGGGACTGGTTTGTGG
GTCGATACTCACAATGACTCCTCAGCTTTGGCTGAAGCTGCGAAACGAGTGGGGGTTCGACTGGCTCCGGGGCCGGGATA
TTCGGCTTATGACGGGCAGCGGACAATGTTGCGGCTTCCTGTCTGGCATGAACCGGAGTCGCTCGAGAAAGCATTGAGAA
TGCTGCGCCGAGCCATCTCTGATAGGTGA

Upstream 100 bases:

>100_bases
TCATGACCGTAGTTCGGTGATTCTGCCTACACCATGCCGTTTGAGACGAATTGGCCTGTACGTTGTATCGCTGGTTGTGA
AGAAGGGCAATACTTCAGGT

Downstream 100 bases:

>100_bases
TGACGCCGGCTGATTCGGGCGTGCCCGCTCGATGCCGGATCGATTACGAATCTCGTTGTCCGCACGAGCGGAACATGAGT
GCGATCAAAACTGGCAGTCG

Product: GntR family regulatory protein

Products: NA

Alternate protein names: 2-aminoadipate aminotransferase; Alpha-aminoadipate aminotransferase; AAA-AT; AadAT [H]

Number of amino acids: Translated: 462; Mature: 462

Protein sequence:

>462_residues
MVVKVDPASLSRMLGEWSQPGEALPEALADALLDLIDAGFVPAGAVLPPQRACAATLQVSRQTVAEAFGILEAAGHIAAL
VGSGTRVRSGRAAVSTDGRLFSFSEAAPGLIDLSTGALPASEVVRRVRLEDHVDLDEYFDTDGYFPAGLPILRAAIAERL
TRDGVPTVPQQIVVTNGAQHASYLASQLLVSAGDTVLVEEPTYRGELAELRLMGARVKSVPLTAAGLALDLVDRGLRRAP
AMFYCQTSIHNPTGLTMAPGYRKALAALLDHHGVPVVEDCCSYDLTTSGLPAPMLAGEMGDDLVLTIGTLSKLFWGGLRI
GWLRASSTRIRQLIERRKAEDLASPISTQVVATNLMTHMGEARQERRALLQAGRGATCEVVSDVFLAWVWTASQSGTGLW
VDTHNDSSALAEAAKRVGVRLAPGPGYSAYDGQRTMLRLPVWHEPESLEKALRMLRRAISDR

Sequences:

>Translated_462_residues
MVVKVDPASLSRMLGEWSQPGEALPEALADALLDLIDAGFVPAGAVLPPQRACAATLQVSRQTVAEAFGILEAAGHIAAL
VGSGTRVRSGRAAVSTDGRLFSFSEAAPGLIDLSTGALPASEVVRRVRLEDHVDLDEYFDTDGYFPAGLPILRAAIAERL
TRDGVPTVPQQIVVTNGAQHASYLASQLLVSAGDTVLVEEPTYRGELAELRLMGARVKSVPLTAAGLALDLVDRGLRRAP
AMFYCQTSIHNPTGLTMAPGYRKALAALLDHHGVPVVEDCCSYDLTTSGLPAPMLAGEMGDDLVLTIGTLSKLFWGGLRI
GWLRASSTRIRQLIERRKAEDLASPISTQVVATNLMTHMGEARQERRALLQAGRGATCEVVSDVFLAWVWTASQSGTGLW
VDTHNDSSALAEAAKRVGVRLAPGPGYSAYDGQRTMLRLPVWHEPESLEKALRMLRRAISDR
>Mature_462_residues
MVVKVDPASLSRMLGEWSQPGEALPEALADALLDLIDAGFVPAGAVLPPQRACAATLQVSRQTVAEAFGILEAAGHIAAL
VGSGTRVRSGRAAVSTDGRLFSFSEAAPGLIDLSTGALPASEVVRRVRLEDHVDLDEYFDTDGYFPAGLPILRAAIAERL
TRDGVPTVPQQIVVTNGAQHASYLASQLLVSAGDTVLVEEPTYRGELAELRLMGARVKSVPLTAAGLALDLVDRGLRRAP
AMFYCQTSIHNPTGLTMAPGYRKALAALLDHHGVPVVEDCCSYDLTTSGLPAPMLAGEMGDDLVLTIGTLSKLFWGGLRI
GWLRASSTRIRQLIERRKAEDLASPISTQVVATNLMTHMGEARQERRALLQAGRGATCEVVSDVFLAWVWTASQSGTGLW
VDTHNDSSALAEAAKRVGVRLAPGPGYSAYDGQRTMLRLPVWHEPESLEKALRMLRRAISDR

Specific function: Catalyzes the transfer of an amino group between 2- oxoadipate (2-OA) and glutamate (Glu) to yield alpha-aminodipate (AAA). It can also transaminate glutamate, leucine, and aromatic amino acids. It also conbtributes in the biosynthesis of other amino acid

COG id: COG1167

COG function: function code KE; Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI7705897, Length=310, Percent_Identity=24.1935483870968, Blast_Score=84, Evalue=3e-16,
Organism=Homo sapiens, GI33469970, Length=310, Percent_Identity=24.1935483870968, Blast_Score=84, Evalue=3e-16,
Organism=Escherichia coli, GI1787710, Length=467, Percent_Identity=26.7665952890792, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1790797, Length=450, Percent_Identity=24.6666666666667, Blast_Score=85, Evalue=1e-17,
Organism=Escherichia coli, GI1788722, Length=340, Percent_Identity=25.5882352941176, Blast_Score=69, Evalue=5e-13,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.6.1.39 [H]

Molecular weight: Translated: 49414; Mature: 49414

Theoretical pI: Translated: 6.25; Mature: 6.25

Prosite motif: PS50949 HTH_GNTR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVVKVDPASLSRMLGEWSQPGEALPEALADALLDLIDAGFVPAGAVLPPQRACAATLQVS
CEEEECHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHH
RQTVAEAFGILEAAGHIAALVGSGTRVRSGRAAVSTDGRLFSFSEAAPGLIDLSTGALPA
HHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCEECCCCCEEEECCCCCCEEECCCCCCCH
SEVVRRVRLEDHVDLDEYFDTDGYFPAGLPILRAAIAERLTRDGVPTVPQQIVVTNGAQH
HHHHHHHHHHCCCCHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEECCCHH
ASYLASQLLVSAGDTVLVEEPTYRGELAELRLMGARVKSVPLTAAGLALDLVDRGLRRAP
HHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCC
AMFYCQTSIHNPTGLTMAPGYRKALAALLDHHGVPVVEDCCSYDLTTSGLPAPMLAGEMG
CEEEEECCCCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHCCCCCCCCCCCCHHHHCCCC
DDLVLTIGTLSKLFWGGLRIGWLRASSTRIRQLIERRKAEDLASPISTQVVATNLMTHMG
CCEEEEHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EARQERRALLQAGRGATCEVVSDVFLAWVWTASQSGTGLWVDTHNDSSALAEAAKRVGVR
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHCCCE
LAPGPGYSAYDGQRTMLRLPVWHEPESLEKALRMLRRAISDR
ECCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MVVKVDPASLSRMLGEWSQPGEALPEALADALLDLIDAGFVPAGAVLPPQRACAATLQVS
CEEEECHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHH
RQTVAEAFGILEAAGHIAALVGSGTRVRSGRAAVSTDGRLFSFSEAAPGLIDLSTGALPA
HHHHHHHHHHHHHHHHHHHHHCCCCEECCCCCEECCCCCEEEECCCCCCEEECCCCCCCH
SEVVRRVRLEDHVDLDEYFDTDGYFPAGLPILRAAIAERLTRDGVPTVPQQIVVTNGAQH
HHHHHHHHHHCCCCHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCEEEEECCCHH
ASYLASQLLVSAGDTVLVEEPTYRGELAELRLMGARVKSVPLTAAGLALDLVDRGLRRAP
HHHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCC
AMFYCQTSIHNPTGLTMAPGYRKALAALLDHHGVPVVEDCCSYDLTTSGLPAPMLAGEMG
CEEEEECCCCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHHCCCCCCCCCCCCHHHHCCCC
DDLVLTIGTLSKLFWGGLRIGWLRASSTRIRQLIERRKAEDLASPISTQVVATNLMTHMG
CCEEEEHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
EARQERRALLQAGRGATCEVVSDVFLAWVWTASQSGTGLWVDTHNDSSALAEAAKRVGVR
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCCCCCEEEEECCCCHHHHHHHHHHCCCE
LAPGPGYSAYDGQRTMLRLPVWHEPESLEKALRMLRRAISDR
ECCCCCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA