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The map label for this gene is ndk [H]

Identifier: 50842310

GI number: 50842310

Start: 903470

End: 903898

Strand: Direct

Name: ndk [H]

Synonym: PPA0823

Alternate gene names: 50842310

Gene position: 903470-903898 (Clockwise)

Preceding gene: 50842309

Following gene: 50842311

Centisome position: 35.29

GC content: 58.28

Gene sequence:

>429_bases
ATGTTGGGGCTCATGAGTGACGAGGAACGCACCTTGGTCCTGTTAAAGCCGGATGCCGTGAAGCGCCGTCTTATGGGTGA
GATCATCGGTAGGTATGAGGCCAAAGGTTTGACCGTGCGGGCGATGGAACTGAGCACGATCGACACTAAGATTGCCCGTA
AGCACTATGCCGAGCATGTGGGCCGGGACTATTACGCGGCGTTGGAGGAGTTCATTACCTCGGGTCCGCTCGTCGCCATG
GTGCTTGAAGGGCGCAGGGCTATCTCGGTTGTCCGTGCTATGAACGGGACAACGGACTGCGCTGAGGCTCTGCCTGGAAC
AATCCGCGGCGATTTCGGCACGGAGAAGAACCATAACCTTGTCCATGCCTCCGATTGTCTCGAATCCGCTGAGCGCGAGA
TCGGCCTCTGGTTCCCCCACCTGGTGTGA

Upstream 100 bases:

>100_bases
CGGGATCATCTTCGCGGCCATCTGGGTATCAATTATGGTGCTAGGAAAGCGTATCGACGGAAGCCCCGAGGTGTGGTGAG
GTGTCGATCCTGGCTGCGAT

Downstream 100 bases:

>100_bases
TGTGTGATTCCATGATCTGGCTCTGACCACCTAGCATGGCCGTTCGTGAATACCCAGGATCTTCTTGGACGGATTGAACC
GCTGCTGTCCCGAGTTAATA

Product: nucleoside diphosphate kinase

Products: NA

Alternate protein names: NDK; NDP kinase; Nucleoside-2-P kinase [H]

Number of amino acids: Translated: 142; Mature: 142

Protein sequence:

>142_residues
MLGLMSDEERTLVLLKPDAVKRRLMGEIIGRYEAKGLTVRAMELSTIDTKIARKHYAEHVGRDYYAALEEFITSGPLVAM
VLEGRRAISVVRAMNGTTDCAEALPGTIRGDFGTEKNHNLVHASDCLESAEREIGLWFPHLV

Sequences:

>Translated_142_residues
MLGLMSDEERTLVLLKPDAVKRRLMGEIIGRYEAKGLTVRAMELSTIDTKIARKHYAEHVGRDYYAALEEFITSGPLVAM
VLEGRRAISVVRAMNGTTDCAEALPGTIRGDFGTEKNHNLVHASDCLESAEREIGLWFPHLV
>Mature_142_residues
MLGLMSDEERTLVLLKPDAVKRRLMGEIIGRYEAKGLTVRAMELSTIDTKIARKHYAEHVGRDYYAALEEFITSGPLVAM
VLEGRRAISVVRAMNGTTDCAEALPGTIRGDFGTEKNHNLVHASDCLESAEREIGLWFPHLV

Specific function: Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate [H]

COG id: COG0105

COG function: function code F; Nucleoside diphosphate kinase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the NDK family [H]

Homologues:

Organism=Homo sapiens, GI4826862, Length=130, Percent_Identity=48.4615384615385, Blast_Score=134, Evalue=2e-32,
Organism=Homo sapiens, GI37693993, Length=130, Percent_Identity=49.2307692307692, Blast_Score=132, Evalue=9e-32,
Organism=Homo sapiens, GI38045913, Length=136, Percent_Identity=44.1176470588235, Blast_Score=130, Evalue=3e-31,
Organism=Homo sapiens, GI4557797, Length=134, Percent_Identity=44.0298507462687, Blast_Score=129, Evalue=1e-30,
Organism=Homo sapiens, GI66392227, Length=134, Percent_Identity=43.2835820895522, Blast_Score=125, Evalue=2e-29,
Organism=Homo sapiens, GI66392205, Length=134, Percent_Identity=43.2835820895522, Blast_Score=125, Evalue=2e-29,
Organism=Homo sapiens, GI4505409, Length=134, Percent_Identity=43.2835820895522, Blast_Score=125, Evalue=2e-29,
Organism=Homo sapiens, GI66392192, Length=134, Percent_Identity=43.2835820895522, Blast_Score=125, Evalue=2e-29,
Organism=Homo sapiens, GI66392203, Length=134, Percent_Identity=43.2835820895522, Blast_Score=125, Evalue=2e-29,
Organism=Homo sapiens, GI5031951, Length=134, Percent_Identity=39.5522388059701, Blast_Score=82, Evalue=2e-16,
Organism=Homo sapiens, GI37574614, Length=143, Percent_Identity=33.5664335664336, Blast_Score=79, Evalue=1e-15,
Organism=Homo sapiens, GI7019465, Length=143, Percent_Identity=33.5664335664336, Blast_Score=79, Evalue=1e-15,
Organism=Homo sapiens, GI4505413, Length=138, Percent_Identity=31.8840579710145, Blast_Score=72, Evalue=2e-13,
Organism=Escherichia coli, GI1788866, Length=130, Percent_Identity=41.5384615384615, Blast_Score=111, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17506807, Length=134, Percent_Identity=40.2985074626866, Blast_Score=114, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6322783, Length=135, Percent_Identity=43.7037037037037, Blast_Score=131, Evalue=4e-32,
Organism=Drosophila melanogaster, GI45549037, Length=135, Percent_Identity=42.962962962963, Blast_Score=134, Evalue=3e-32,
Organism=Drosophila melanogaster, GI18860097, Length=136, Percent_Identity=30.8823529411765, Blast_Score=73, Evalue=5e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001564 [H]

Pfam domain/function: PF00334 NDK [H]

EC number: =2.7.4.6 [H]

Molecular weight: Translated: 15784; Mature: 15784

Theoretical pI: Translated: 6.35; Mature: 6.35

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
5.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLGLMSDEERTLVLLKPDAVKRRLMGEIIGRYEAKGLTVRAMELSTIDTKIARKHYAEHV
CCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHCCCCEEEEEEEHHHHHHHHHHHHHHHHH
GRDYYAALEEFITSGPLVAMVLEGRRAISVVRAMNGTTDCAEALPGTIRGDFGTEKNHNL
CCHHHHHHHHHHCCCCCEEEHHCCHHHHHHHHHHCCCCHHHHHCCCCCCCCCCCCCCCCE
VHASDCLESAEREIGLWFPHLV
EEHHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure
MLGLMSDEERTLVLLKPDAVKRRLMGEIIGRYEAKGLTVRAMELSTIDTKIARKHYAEHV
CCCCCCCCCCEEEEECCHHHHHHHHHHHHHHHCCCCEEEEEEEHHHHHHHHHHHHHHHHH
GRDYYAALEEFITSGPLVAMVLEGRRAISVVRAMNGTTDCAEALPGTIRGDFGTEKNHNL
CCHHHHHHHHHHCCCCCEEEHHCCHHHHHHHHHHCCCCHHHHHCCCCCCCCCCCCCCCCE
VHASDCLESAEREIGLWFPHLV
EEHHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA