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The map label for this gene is uvrB

Identifier: 50842290

GI number: 50842290

Start: 881422

End: 883527

Strand: Direct

Name: uvrB

Synonym: PPA0803

Alternate gene names: 50842290

Gene position: 881422-883527 (Clockwise)

Preceding gene: 50842283

Following gene: 50842291

Centisome position: 34.43

GC content: 58.12

Gene sequence:

>2106_bases
ATGCGCCCTGTCACTGACATCACTCGCCGCGTAGCCCCTTTTCACGTCGTCAGTGAGTTTCAGCCTTCTGGTGACCAGCC
ACAGGCCATTGCGGAGTTGGAGAAGAGGGTTAACAGTGGTGAACAGGACGTTGTTCTGCTCGGCGCCACCGGTACTGGCA
AGACGGCCACGGTGGCGTGGCTGGCGGAGAGGCTGCAGCGCCCGATGCTCGTCATGCAGCCCAACAAGACGTTGGCCGCC
CAGTTTGCCCAGGAACTACGTACCTTCTTCCCTGACAATGCCGTCGAGTACTTCGTCTCTTACTACGATTACTACCAACC
TGAGGCGTACATCCCACAGACGGATACCTACATCGAGAAAGATTCCAGCCTCAACGAGGAAGTTGAAAGGTTGCGCCACT
CCGCGACGAACTCCCTGCTCACCCGTCGCGACGTCATCGTGGTGTCAACCGTTTCAGCTATCTATGGCCTGGGCACGCCA
CAGGAATACGTAGACCGGATGATTCCACTGGAGGTCGGCCAGGAGTGGGATCGCGATGAGTTGCTGCGCGACCTCGTCAC
CAACCAGTACGTCCGTAACGACATATCGGGGGAGCGCGGCACCTTCCGGGTGCGCGGGGACACCCTCGAGATTTTCCCGG
TTTATGAGGAGAATGCGCTGCGTGTCGAGTTTTTCGGCGACGAAATTGAGGCCCTCACGACGATGCACCCACTCACCGGG
GAGATCATCAGCGAGGACGAGCAGGTCTACGTGTTCCCGGCTACCCACTATGTCGCCGGCCCGGAACGTATGGAGCGGGC
CATAGCGTCCATCCAGCAGGAGCTCGAGGAGCGCCTGGCCGTTCTAGAGCGTGATGGGAAACTGTTGGAGGCCCAACGGT
TACGTATGCGTACTACCTACGATATCGAGATGATGCAGCAGGTCGGTGCCTGTGCTGGCATCGAAAACTATTCGCGGCAC
ATCGACGGACGCGCTCCCGGCTCAGCCCCGAACTGTCTGCTTGACTACTTTCCGGAAGATTTTGTGCTCGTCATTGATGA
ATCCCACGTGACCGTCCCGCAGATTGGCGGGATGTATGAGGGGGACATGAGCCGCAAGCGGACATTGGTAGAACATGGTT
TCCGACTGCCCAGCGCGATGGACAACCGTCCTCTCAAATTCGATGAGTTCACCCAGCGGATCGGCCAGACTGTCTACCTG
TCCGCCACGCCCGGTTCGTACGAGACCGAACGAGCTCACGGCGTCGTCGAACAAATCATTCGTCCGACAGGTCTGGTGGA
TCCGGAGATTATCGTCAAGCCTACGCGTGGCCAGATTGACGACCTTATGGGTGAAATTCGTACCCGAGTGGACCGTGGCG
ACGGTGTCTTGGTGACGACTCTGACGAAGAAGATGGCCGAAGACCTCACCGACTACCTCATGGAGCACGGGATTCGCACC
CGTTACCTGCACTCGGAGATCGACACACTCAAACGCATCGAGCTGCTCAAGGAGTTGCGCATGGGCGAGTTCGATGTGCT
TGTCGGTATCAACCTGCTACGAGAGGGACTCGACCTCCCGGAGGTTTCCTTGGTGGCGATCCTCGACGCCGACAAGGAAG
GCTTTTTGCGTTCTGAACGGTCCCTTATCCAGACCGTCGGCCGCGCTGCTCGTAACGTCAACGGTCAGGTCATCATGTAC
GCCGACCAGATCACTGATTCCATGCAGGTCGCCATCGACGAGACAAATCGTCGTCGCGATATCCAGATGGCGTACAACAA
GGAGCACGGGATCGATCCACAGCCGTTGCGCAAGAAGATCGGCGACATCACTGAGATGCTGGCTCGCGAAGGTGCCGATA
CTGACGAGCTCGTCGAGAAGTTCAACTATGGGAAAGGCCAACGCGGCTACAATTCGATGATCACTGACGAGCAGCGAGCC
GCCCAAGGCAGGCGACTCGACGTCTCGAAGATGGCCGAAGAGGATCTAGGCAAGCTCATCGTCGACCTCACCACCGAAAT
GCGTTCTGCGGCTGGCGAACTCAAGTTTGAAGTCGCTGCCCGGCTACGTGACGAAATCGCCGATCTTAAGAAAGAGTTGC
GCCAGATGGTGGAGGCCAACCGGTAG

Upstream 100 bases:

>100_bases
CATCGGGACCGGAGATGCAGGCTTTCAGATCTGACGTCCCGAACCCGGTCGCATGCTTTTAGCTAATCCTATCGCGGGTG
GCTTGAACTAGGGTGGAGCT

Downstream 100 bases:

>100_bases
ACAGGGGCGGGAGTCGCGGTCGAGGCCCCGGTGTGCGAGTATGGAACTCCTTGGAGGGGAGTACTCCTGAGAAAAGTGTG
GTCGTCATCACGATCGTGCC

Product: excinuclease ABC subunit B

Products: NA

Alternate protein names: Protein uvrB; Excinuclease ABC subunit B

Number of amino acids: Translated: 701; Mature: 701

Protein sequence:

>701_residues
MRPVTDITRRVAPFHVVSEFQPSGDQPQAIAELEKRVNSGEQDVVLLGATGTGKTATVAWLAERLQRPMLVMQPNKTLAA
QFAQELRTFFPDNAVEYFVSYYDYYQPEAYIPQTDTYIEKDSSLNEEVERLRHSATNSLLTRRDVIVVSTVSAIYGLGTP
QEYVDRMIPLEVGQEWDRDELLRDLVTNQYVRNDISGERGTFRVRGDTLEIFPVYEENALRVEFFGDEIEALTTMHPLTG
EIISEDEQVYVFPATHYVAGPERMERAIASIQQELEERLAVLERDGKLLEAQRLRMRTTYDIEMMQQVGACAGIENYSRH
IDGRAPGSAPNCLLDYFPEDFVLVIDESHVTVPQIGGMYEGDMSRKRTLVEHGFRLPSAMDNRPLKFDEFTQRIGQTVYL
SATPGSYETERAHGVVEQIIRPTGLVDPEIIVKPTRGQIDDLMGEIRTRVDRGDGVLVTTLTKKMAEDLTDYLMEHGIRT
RYLHSEIDTLKRIELLKELRMGEFDVLVGINLLREGLDLPEVSLVAILDADKEGFLRSERSLIQTVGRAARNVNGQVIMY
ADQITDSMQVAIDETNRRRDIQMAYNKEHGIDPQPLRKKIGDITEMLAREGADTDELVEKFNYGKGQRGYNSMITDEQRA
AQGRRLDVSKMAEEDLGKLIVDLTTEMRSAAGELKFEVAARLRDEIADLKKELRQMVEANR

Sequences:

>Translated_701_residues
MRPVTDITRRVAPFHVVSEFQPSGDQPQAIAELEKRVNSGEQDVVLLGATGTGKTATVAWLAERLQRPMLVMQPNKTLAA
QFAQELRTFFPDNAVEYFVSYYDYYQPEAYIPQTDTYIEKDSSLNEEVERLRHSATNSLLTRRDVIVVSTVSAIYGLGTP
QEYVDRMIPLEVGQEWDRDELLRDLVTNQYVRNDISGERGTFRVRGDTLEIFPVYEENALRVEFFGDEIEALTTMHPLTG
EIISEDEQVYVFPATHYVAGPERMERAIASIQQELEERLAVLERDGKLLEAQRLRMRTTYDIEMMQQVGACAGIENYSRH
IDGRAPGSAPNCLLDYFPEDFVLVIDESHVTVPQIGGMYEGDMSRKRTLVEHGFRLPSAMDNRPLKFDEFTQRIGQTVYL
SATPGSYETERAHGVVEQIIRPTGLVDPEIIVKPTRGQIDDLMGEIRTRVDRGDGVLVTTLTKKMAEDLTDYLMEHGIRT
RYLHSEIDTLKRIELLKELRMGEFDVLVGINLLREGLDLPEVSLVAILDADKEGFLRSERSLIQTVGRAARNVNGQVIMY
ADQITDSMQVAIDETNRRRDIQMAYNKEHGIDPQPLRKKIGDITEMLAREGADTDELVEKFNYGKGQRGYNSMITDEQRA
AQGRRLDVSKMAEEDLGKLIVDLTTEMRSAAGELKFEVAARLRDEIADLKKELRQMVEANR
>Mature_701_residues
MRPVTDITRRVAPFHVVSEFQPSGDQPQAIAELEKRVNSGEQDVVLLGATGTGKTATVAWLAERLQRPMLVMQPNKTLAA
QFAQELRTFFPDNAVEYFVSYYDYYQPEAYIPQTDTYIEKDSSLNEEVERLRHSATNSLLTRRDVIVVSTVSAIYGLGTP
QEYVDRMIPLEVGQEWDRDELLRDLVTNQYVRNDISGERGTFRVRGDTLEIFPVYEENALRVEFFGDEIEALTTMHPLTG
EIISEDEQVYVFPATHYVAGPERMERAIASIQQELEERLAVLERDGKLLEAQRLRMRTTYDIEMMQQVGACAGIENYSRH
IDGRAPGSAPNCLLDYFPEDFVLVIDESHVTVPQIGGMYEGDMSRKRTLVEHGFRLPSAMDNRPLKFDEFTQRIGQTVYL
SATPGSYETERAHGVVEQIIRPTGLVDPEIIVKPTRGQIDDLMGEIRTRVDRGDGVLVTTLTKKMAEDLTDYLMEHGIRT
RYLHSEIDTLKRIELLKELRMGEFDVLVGINLLREGLDLPEVSLVAILDADKEGFLRSERSLIQTVGRAARNVNGQVIMY
ADQITDSMQVAIDETNRRRDIQMAYNKEHGIDPQPLRKKIGDITEMLAREGADTDELVEKFNYGKGQRGYNSMITDEQRA
AQGRRLDVSKMAEEDLGKLIVDLTTEMRSAAGELKFEVAARLRDEIADLKKELRQMVEANR

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. Upon binding of the uvrA(2)B(2) complex to a putative damaged site, the DNA

COG id: COG0556

COG function: function code L; Helicase subunit of the DNA excision repair complex

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain

Homologues:

Organism=Escherichia coli, GI1786996, Length=681, Percent_Identity=56.5345080763583, Blast_Score=729, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UVRB_PROAC (Q6A9K7)

Other databases:

- EMBL:   AE017283
- RefSeq:   YP_055517.1
- ProteinModelPortal:   Q6A9K7
- GeneID:   2932368
- GenomeReviews:   AE017283_GR
- KEGG:   pac:PPA0803
- NMPDR:   fig|267747.1.peg.794
- HOGENOM:   HBG703949
- OMA:   AAQLCNE
- ProtClustDB:   PRK05298
- BioCyc:   PACN267747:PPA0803-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00204
- InterPro:   IPR014001
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR006935
- InterPro:   IPR001943
- InterPro:   IPR004807
- InterPro:   IPR009055
- SMART:   SM00487
- SMART:   SM00490
- TIGRFAMs:   TIGR00631

Pfam domain/function: PF00271 Helicase_C; PF04851 ResIII; PF02151 UVR; SSF46600 UvrB_C

EC number: NA

Molecular weight: Translated: 79704; Mature: 79704

Theoretical pI: Translated: 4.61; Mature: 4.61

Prosite motif: PS51192 HELICASE_ATP_BIND_1; PS51194 HELICASE_CTER; PS50151 UVR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRPVTDITRRVAPFHVVSEFQPSGDQPQAIAELEKRVNSGEQDVVLLGATGTGKTATVAW
CCCHHHHHHHHCHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHH
LAERLQRPMLVMQPNKTLAAQFAQELRTFFPDNAVEYFVSYYDYYQPEAYIPQTDTYIEK
HHHHHHCCEEEECCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCHHCC
DSSLNEEVERLRHSATNSLLTRRDVIVVSTVSAIYGLGTPQEYVDRMIPLEVGQEWDRDE
CCCHHHHHHHHHHHHHHHHHHHCCEEEEEHHHHHHCCCCCHHHHHHHCCHHHCCCCCHHH
LLRDLVTNQYVRNDISGERGTFRVRGDTLEIFPVYEENALRVEFFGDEIEALTTMHPLTG
HHHHHHHHHHHHHCCCCCCCEEEEECCEEEEEEEECCCEEEEEECCCHHHHHHHCCCCCH
EIISEDEQVYVFPATHYVAGPERMERAIASIQQELEERLAVLERDGKLLEAQRLRMRTTY
HHHCCCCEEEEEECHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCHH
DIEMMQQVGACAGIENYSRHIDGRAPGSAPNCLLDYFPEDFVLVIDESHVTVPQIGGMYE
HHHHHHHHHHHCCHHHHHHHCCCCCCCCCCCHHHHCCCCCEEEEEECCCCCCCCCCCCCC
GDMSRKRTLVEHGFRLPSAMDNRPLKFDEFTQRIGQTVYLSATPGSYETERAHGVVEQII
CCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHCCEEEEEECCCCCCHHHHHHHHHHHH
RPTGLVDPEIIVKPTRGQIDDLMGEIRTRVDRGDGVLVTTLTKKMAEDLTDYLMEHGIRT
CCCCCCCCCEEEECCCCCHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHCCCHH
RYLHSEIDTLKRIELLKELRMGEFDVLVGINLLREGLDLPEVSLVAILDADKEGFLRSER
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCEEEEEEEECCCHHHHHHHH
SLIQTVGRAARNVNGQVIMYADQITDSMQVAIDETNRRRDIQMAYNKEHGIDPQPLRKKI
HHHHHHHHHHHCCCCCEEEEEHHCCCCHHEEECCCCCCCHHHHHCCCCCCCCHHHHHHHH
GDITEMLAREGADTDELVEKFNYGKGQRGYNSMITDEQRAAQGRRLDVSKMAEEDLGKLI
HHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCCCCHHHHHCCCCCCHHHHHHHHHHHHH
VDLTTEMRSAAGELKFEVAARLRDEIADLKKELRQMVEANR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MRPVTDITRRVAPFHVVSEFQPSGDQPQAIAELEKRVNSGEQDVVLLGATGTGKTATVAW
CCCHHHHHHHHCHHHHHHCCCCCCCCCHHHHHHHHHHCCCCCCEEEEECCCCCCHHHHHH
LAERLQRPMLVMQPNKTLAAQFAQELRTFFPDNAVEYFVSYYDYYQPEAYIPQTDTYIEK
HHHHHHCCEEEECCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCCCCCCCCCHHCC
DSSLNEEVERLRHSATNSLLTRRDVIVVSTVSAIYGLGTPQEYVDRMIPLEVGQEWDRDE
CCCHHHHHHHHHHHHHHHHHHHCCEEEEEHHHHHHCCCCCHHHHHHHCCHHHCCCCCHHH
LLRDLVTNQYVRNDISGERGTFRVRGDTLEIFPVYEENALRVEFFGDEIEALTTMHPLTG
HHHHHHHHHHHHHCCCCCCCEEEEECCEEEEEEEECCCEEEEEECCCHHHHHHHCCCCCH
EIISEDEQVYVFPATHYVAGPERMERAIASIQQELEERLAVLERDGKLLEAQRLRMRTTY
HHHCCCCEEEEEECHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCHH
DIEMMQQVGACAGIENYSRHIDGRAPGSAPNCLLDYFPEDFVLVIDESHVTVPQIGGMYE
HHHHHHHHHHHCCHHHHHHHCCCCCCCCCCCHHHHCCCCCEEEEEECCCCCCCCCCCCCC
GDMSRKRTLVEHGFRLPSAMDNRPLKFDEFTQRIGQTVYLSATPGSYETERAHGVVEQII
CCHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHCCEEEEEECCCCCCHHHHHHHHHHHH
RPTGLVDPEIIVKPTRGQIDDLMGEIRTRVDRGDGVLVTTLTKKMAEDLTDYLMEHGIRT
CCCCCCCCCEEEECCCCCHHHHHHHHHHHHCCCCCEEEHHHHHHHHHHHHHHHHHCCCHH
RYLHSEIDTLKRIELLKELRMGEFDVLVGINLLREGLDLPEVSLVAILDADKEGFLRSER
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCCEEEEEEEECCCHHHHHHHH
SLIQTVGRAARNVNGQVIMYADQITDSMQVAIDETNRRRDIQMAYNKEHGIDPQPLRKKI
HHHHHHHHHHHCCCCCEEEEEHHCCCCHHEEECCCCCCCHHHHHCCCCCCCCHHHHHHHH
GDITEMLAREGADTDELVEKFNYGKGQRGYNSMITDEQRAAQGRRLDVSKMAEEDLGKLI
HHHHHHHHHCCCCHHHHHHHHCCCCCCCCCCCCCCCHHHHHCCCCCCHHHHHHHHHHHHH
VDLTTEMRSAAGELKFEVAARLRDEIADLKKELRQMVEANR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA