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The map label for this gene is gcvT

Identifier: 50842231

GI number: 50842231

Start: 816646

End: 817761

Strand: Reverse

Name: gcvT

Synonym: PPA0744

Alternate gene names: 50842231

Gene position: 817761-816646 (Counterclockwise)

Preceding gene: 50842232

Following gene: 50842230

Centisome position: 31.94

GC content: 61.29

Gene sequence:

>1116_bases
ATGACTACGCTTCGACGTACACCACTGGCGGCCGTACACGAGAGCCTCGGAGCATCCTTCACCGATTTCGCGGGCTGGAA
CATGCCCGTGCGGTACTCCTCCGACCTGGCCGAACACCACGCCGTCCGCAAGAATGCCGGCATCTTCGACCTATCCCACA
TGGGAGAGATCAGGATCTCTGGCCCTGATTCTGGAGCTGCCCTCGATTACGCCTTGGCCGGTAAGCTCTCCGCTGTGGCG
GAAGGCCGTGCGAAGTATTCCCTCCTACTCACAGACGAGGGGGGTGTCGTTGATGACCTCGTGACCTACCATCTGCCTGA
CGGTGACTACCTCGTCGTTGCCAATGCTGCCAATGCCGAAACTGATCTCGCGGAATTCACCAAGCGCTGCGCACGGTTCG
ACGTCACCGTCACAGACGAGTCAGCCCAGACCGCCCTCGTCGCCGTGCAAGGCCCCACAGCCGTGAAGATCGTGCTGGCG
GCCCTCCAGAAGGCTAATACCACCCTCGACTCCGACGAGGTCCGCGACGTCAAGTACTACCGCTGCCTCACCGGAGAACT
GGATGGTTTCCCCGTACTCGTTGCTCGCACCGGTTACACCGGAGAGGACGGCTACGAGCTATACGTTCCGGCCAAAGCCG
CCGCGCATCTGTGGCAGCTCCTCATGGACGCTGGCGGCGAAGATCTCACACCGTGTGGTCTCGCCTGCCGTGACACTTTG
CGCCTGGAAGCTGGGATGCCTCTCTACGGACACGAGTTGGGCACCGACATCCATCCCTCTCAAGCCGGGCTTGGGCGAGT
CGTCAATTTCAAGAAGGAGGGCGACTTTGTCGGTCGCTGTGCCCTCGAGAACCGCGATACCACTGCCGATCGTGTGCTAG
TCGGGCTGACCGGGGAAGGACGCCGAGCCGGGCGTGCCGGATATGCTGTCGTGAACGAAGACAAAACGGTCGGAGCCATC
ACCTCCGGCATCCTCTCCCCCACTCTGGGCCATCCCATCGCAATGGCTTTCGTTGATCCTGACGTCGCCAAGATCGGCAC
CTCGCTTAGCGTTGATGTGCGGGGCAAAGCCCTCAACACTACCGTCGTCGAATTACCGTTCTACAAGCGGTCCTGA

Upstream 100 bases:

>100_bases
GAGCTCGCTGGAATGGACTCCGTCGTACGCCGCTCAGTCTACTTCTTCAGTTCTCCCTACGAGCAAGCACACGGTCCCTC
GTCATGCCATACTTCGAATC

Downstream 100 bases:

>100_bases
CCCCAACCACAATCCCCACACAAATACCTAGGAGCAGACATGGAACTGTCCGAACTTAAGTACTCCGCCGAGCATGAGTG
GGTCGCCGTTGATGGTGACA

Product: glycine cleavage system aminomethyltransferase T

Products: NA

Alternate protein names: Glycine cleavage system T protein

Number of amino acids: Translated: 371; Mature: 370

Protein sequence:

>371_residues
MTTLRRTPLAAVHESLGASFTDFAGWNMPVRYSSDLAEHHAVRKNAGIFDLSHMGEIRISGPDSGAALDYALAGKLSAVA
EGRAKYSLLLTDEGGVVDDLVTYHLPDGDYLVVANAANAETDLAEFTKRCARFDVTVTDESAQTALVAVQGPTAVKIVLA
ALQKANTTLDSDEVRDVKYYRCLTGELDGFPVLVARTGYTGEDGYELYVPAKAAAHLWQLLMDAGGEDLTPCGLACRDTL
RLEAGMPLYGHELGTDIHPSQAGLGRVVNFKKEGDFVGRCALENRDTTADRVLVGLTGEGRRAGRAGYAVVNEDKTVGAI
TSGILSPTLGHPIAMAFVDPDVAKIGTSLSVDVRGKALNTTVVELPFYKRS

Sequences:

>Translated_371_residues
MTTLRRTPLAAVHESLGASFTDFAGWNMPVRYSSDLAEHHAVRKNAGIFDLSHMGEIRISGPDSGAALDYALAGKLSAVA
EGRAKYSLLLTDEGGVVDDLVTYHLPDGDYLVVANAANAETDLAEFTKRCARFDVTVTDESAQTALVAVQGPTAVKIVLA
ALQKANTTLDSDEVRDVKYYRCLTGELDGFPVLVARTGYTGEDGYELYVPAKAAAHLWQLLMDAGGEDLTPCGLACRDTL
RLEAGMPLYGHELGTDIHPSQAGLGRVVNFKKEGDFVGRCALENRDTTADRVLVGLTGEGRRAGRAGYAVVNEDKTVGAI
TSGILSPTLGHPIAMAFVDPDVAKIGTSLSVDVRGKALNTTVVELPFYKRS
>Mature_370_residues
TTLRRTPLAAVHESLGASFTDFAGWNMPVRYSSDLAEHHAVRKNAGIFDLSHMGEIRISGPDSGAALDYALAGKLSAVAE
GRAKYSLLLTDEGGVVDDLVTYHLPDGDYLVVANAANAETDLAEFTKRCARFDVTVTDESAQTALVAVQGPTAVKIVLAA
LQKANTTLDSDEVRDVKYYRCLTGELDGFPVLVARTGYTGEDGYELYVPAKAAAHLWQLLMDAGGEDLTPCGLACRDTLR
LEAGMPLYGHELGTDIHPSQAGLGRVVNFKKEGDFVGRCALENRDTTADRVLVGLTGEGRRAGRAGYAVVNEDKTVGAIT
SGILSPTLGHPIAMAFVDPDVAKIGTSLSVDVRGKALNTTVVELPFYKRS

Specific function: The glycine cleavage system catalyzes the degradation of glycine

COG id: COG0404

COG function: function code E; Glycine cleavage system T protein (aminomethyltransferase)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gcvT family

Homologues:

Organism=Homo sapiens, GI44662838, Length=373, Percent_Identity=32.7077747989276, Blast_Score=179, Evalue=4e-45,
Organism=Homo sapiens, GI257796258, Length=359, Percent_Identity=32.3119777158774, Blast_Score=167, Evalue=1e-41,
Organism=Homo sapiens, GI257796254, Length=371, Percent_Identity=30.7277628032345, Blast_Score=137, Evalue=1e-32,
Organism=Homo sapiens, GI257796256, Length=320, Percent_Identity=30.9375, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI24797151, Length=336, Percent_Identity=28.5714285714286, Blast_Score=127, Evalue=1e-29,
Organism=Homo sapiens, GI197927446, Length=332, Percent_Identity=25.3012048192771, Blast_Score=80, Evalue=3e-15,
Organism=Homo sapiens, GI21361378, Length=332, Percent_Identity=25.3012048192771, Blast_Score=80, Evalue=3e-15,
Organism=Escherichia coli, GI1789272, Length=375, Percent_Identity=37.6, Blast_Score=218, Evalue=6e-58,
Organism=Caenorhabditis elegans, GI17560118, Length=377, Percent_Identity=31.8302387267904, Blast_Score=164, Evalue=6e-41,
Organism=Caenorhabditis elegans, GI71994045, Length=377, Percent_Identity=31.8302387267904, Blast_Score=130, Evalue=9e-31,
Organism=Caenorhabditis elegans, GI71994052, Length=377, Percent_Identity=31.8302387267904, Blast_Score=130, Evalue=1e-30,
Organism=Caenorhabditis elegans, GI32563613, Length=362, Percent_Identity=23.7569060773481, Blast_Score=78, Evalue=8e-15,
Organism=Saccharomyces cerevisiae, GI6320222, Length=393, Percent_Identity=33.8422391857506, Blast_Score=174, Evalue=3e-44,
Organism=Drosophila melanogaster, GI20129441, Length=388, Percent_Identity=32.4742268041237, Blast_Score=178, Evalue=4e-45,
Organism=Drosophila melanogaster, GI20130091, Length=342, Percent_Identity=27.4853801169591, Blast_Score=92, Evalue=7e-19,
Organism=Drosophila melanogaster, GI28571104, Length=275, Percent_Identity=26.5454545454545, Blast_Score=74, Evalue=1e-13,

Paralogues:

None

Copy number: 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): GCST_PROAC (Q6A9R6)

Other databases:

- EMBL:   AE017283
- RefSeq:   YP_055458.1
- ProteinModelPortal:   Q6A9R6
- SMR:   Q6A9R6
- GeneID:   2930895
- GenomeReviews:   AE017283_GR
- KEGG:   pac:PPA0744
- NMPDR:   fig|267747.1.peg.735
- HOGENOM:   HBG299834
- OMA:   KALYGGM
- ProtClustDB:   PRK00389
- BioCyc:   PACN267747:PPA0744-MONOMER
- BRENDA:   2.1.2.10
- GO:   GO:0005737
- HAMAP:   MF_00259
- InterPro:   IPR013977
- InterPro:   IPR006222
- InterPro:   IPR006223
- InterPro:   IPR022903
- PIRSF:   PIRSF006487
- TIGRFAMs:   TIGR00528

Pfam domain/function: PF01571 GCV_T; PF08669 GCV_T_C

EC number: =2.1.2.10

Molecular weight: Translated: 39520; Mature: 39389

Theoretical pI: Translated: 5.01; Mature: 5.01

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTLRRTPLAAVHESLGASFTDFAGWNMPVRYSSDLAEHHAVRKNAGIFDLSHMGEIRIS
CCCCCCCCHHHHHHHHCCCCHHCCCCCCCEEECHHHHHHHHHHHCCCEEEECCCCEEEEE
GPDSGAALDYALAGKLSAVAEGRAKYSLLLTDEGGVVDDLVTYHLPDGDYLVVANAANAE
CCCCCCEEEHHHHCCHHHHHCCCCEEEEEEECCCCCEEEEEEEECCCCCEEEEEECCCCC
TDLAEFTKRCARFDVTVTDESAQTALVAVQGPTAVKIVLAALQKANTTLDSDEVRDVKYY
HHHHHHHHHHHHEEEEEECCCCCEEEEEEECCHHHHHHHHHHHHCCCCCCCCHHHHEEEE
RCLTGELDGFPVLVARTGYTGEDGYELYVPAKAAAHLWQLLMDAGGEDLTPCGLACRDTL
EEECCCCCCCEEEEEECCCCCCCCEEEEECHHHHHHHHHHHHHCCCCCCCCCCHHHHHHE
RLEAGMPLYGHELGTDIHPSQAGLGRVVNFKKEGDFVGRCALENRDTTADRVLVGLTGEG
EEECCCCCCCHHCCCCCCCCCCCCCCEEEEECCCCEEEEEEECCCCCCCCEEEEEECCCC
RRAGRAGYAVVNEDKTVGAITSGILSPTLGHPIAMAFVDPDVAKIGTSLSVDVRGKALNT
CCCCCCCEEEEECCCCHHHHHHHHCCCCCCCCEEEEEECCCHHHHCCEEEEEECCCEECE
TVVELPFYKRS
EEEEECCCCCC
>Mature Secondary Structure 
TTLRRTPLAAVHESLGASFTDFAGWNMPVRYSSDLAEHHAVRKNAGIFDLSHMGEIRIS
CCCCCCCHHHHHHHHCCCCHHCCCCCCCEEECHHHHHHHHHHHCCCEEEECCCCEEEEE
GPDSGAALDYALAGKLSAVAEGRAKYSLLLTDEGGVVDDLVTYHLPDGDYLVVANAANAE
CCCCCCEEEHHHHCCHHHHHCCCCEEEEEEECCCCCEEEEEEEECCCCCEEEEEECCCCC
TDLAEFTKRCARFDVTVTDESAQTALVAVQGPTAVKIVLAALQKANTTLDSDEVRDVKYY
HHHHHHHHHHHHEEEEEECCCCCEEEEEEECCHHHHHHHHHHHHCCCCCCCCHHHHEEEE
RCLTGELDGFPVLVARTGYTGEDGYELYVPAKAAAHLWQLLMDAGGEDLTPCGLACRDTL
EEECCCCCCCEEEEEECCCCCCCCEEEEECHHHHHHHHHHHHHCCCCCCCCCCHHHHHHE
RLEAGMPLYGHELGTDIHPSQAGLGRVVNFKKEGDFVGRCALENRDTTADRVLVGLTGEG
EEECCCCCCCHHCCCCCCCCCCCCCCEEEEECCCCEEEEEEECCCCCCCCEEEEEECCCC
RRAGRAGYAVVNEDKTVGAITSGILSPTLGHPIAMAFVDPDVAKIGTSLSVDVRGKALNT
CCCCCCCEEEEECCCCHHHHHHHHCCCCCCCCEEEEEECCCHHHHCCEEEEEECCCEECE
TVVELPFYKRS
EEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA