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The map label for this gene is pepPI [H]

Identifier: 50842137

GI number: 50842137

Start: 714480

End: 715976

Strand: Reverse

Name: pepPI [H]

Synonym: PPA0650

Alternate gene names: 50842137

Gene position: 715976-714480 (Counterclockwise)

Preceding gene: 50842140

Following gene: 50842134

Centisome position: 27.96

GC content: 62.06

Gene sequence:

>1497_bases
ATGACCGAGACGAGGTCCACAGAGCTCAACGAACAACTGCGGCAAGCCGAAAAACAAAGGATCCCCAAGCGTCAGACCCC
GTTCTCAAAAGCCTTCGTCGAGTTCATCCCTACCGACTGGGCCCCCTATCCCGACGAGCTGCCCGAACCGCTCAGCTCGG
CGCCTTCGGCTACCGCACACCGTGATGCCTTAGCCGCCCGCTTCGATAGCGATCGCCTCGTCATCCCCGCTGGCCATCTC
ATGCGTCGCAACAACGACTGCGATTACCCTTTCCGCCCCAACACCGCCTTCGCCTACTACTCGGGCTTAGGCACCGACAG
GGAGCCCAACGCGGTCCTAGTCGTCGATACGACCGCGGAAACTCGCGATGTGCTGTACTTCAAGCCGCGTGCGCCCCGCA
CCGACCGCGAGTTCTATGCTGATCCAACCTACGGTGAGATGTGGGTTGGCCAGCGAGAGTCCCTTGAGGAAATGGCGGCC
ATGACGGGACTCGTCTGCCGTGACATCTCCCAACTCGACGACGCCCTGTCGACCGGAGACGCCACAGTGCGCGTTATTCG
CGACGCCGACGAGACTGTCACCGCCACCGTCGACTCATTGCGTCCTCGGGGCTCTGAAGACGCCGACGACGAGTTCTACG
AGTTTTCCTCAGCCGCCCGCTTCTGCAAAGACGATTGGGAGGTCGAGCAACTGCGGGATGCCTGCCGCAAATCCAAGGTG
GGTTTTGAATCCATGATCGCTGAGATCCCGGAAGCCGTCCGCAAGGGGCGAGGCGAGCGTTGGATGGAAGGCACCTTCGG
ACGTGTCGCTCGTCATCTTGGCAATGAGGTGGGCTACGGCTCGATCTGCGCAGCCGGCGACCACGCCAACACGCTGCACT
GGGTACGCAACGACGGCGACCTGCGCCCCGGCGAACTTATCCTTATCGACGCTGGGATCGAGGTCGACTCCCTTTACACC
GCCGACATCACCCGCACCCTACCGATCTCGGGAACCTTCTCTCCCGCCCAGCGTCGCGTCTACCAGGCCGTCCTTGAGGC
TCAGGACGCGGCAGCTGCCGTCGCGAAAGTTGGCCACGACCATGCCGAGATCCATCAGGCCGCCATTCGCGTCATCTGCG
AGTATCTGCACGAGTGGGGCATCCTTCCAGTCAGCGTCGAGGAGTCGCTGTCCCCCGAAGGCGGGCAGCACCGCCGGTGG
ATGGTTCACGGCACGTCGCACCACCTCGGTCTAGATGTCCACGACTGTAACCAGGCACGTCGTCAGGATTACTCCGGACC
GCTCAAGAAGGGTATGTGCGTCTCCGACGAGCCGGGTATCTACTTCAAACAAACCGACCTACTGGTCCCCGAGGAGTTCC
GCGGTATCGGTGTACGCATTGAGGACGACCTGTGCATCACTGACGGTGAGCCTGAGTGGCTATCCAAGGATTGCCCGCGT
CAGGTCGACGAGATCGAGGCCTGGATGCAAGAGATCTGGGGACGCGCTTGCCACTGA

Upstream 100 bases:

>100_bases
GCGTCTGTGCGGCCCCATAAAAGCCCTCTGGACCCCAAGACTTCCGTGTCACCGAGACCTACACTAGAGGGGATACTCAA
CAATCAGCGGAGGTCCGAAT

Downstream 100 bases:

>100_bases
TCCAGTGTCGATGCGCGGTGTCCAGACTTCTCAGCCTCTGGCACTGCGCATCGTCGCCGTCATGGTCAGGCACAGGATGA
GCACGGCGGGGATCGCGTGC

Product: Xaa-Pro aminopeptidase I

Products: NA

Alternate protein names: Aminoacylproline aminopeptidase I; Aminopeptidase P I; APP; PEPP I; X-Pro aminopeptidase I; Xaa-Pro aminopeptidase I [H]

Number of amino acids: Translated: 498; Mature: 497

Protein sequence:

>498_residues
MTETRSTELNEQLRQAEKQRIPKRQTPFSKAFVEFIPTDWAPYPDELPEPLSSAPSATAHRDALAARFDSDRLVIPAGHL
MRRNNDCDYPFRPNTAFAYYSGLGTDREPNAVLVVDTTAETRDVLYFKPRAPRTDREFYADPTYGEMWVGQRESLEEMAA
MTGLVCRDISQLDDALSTGDATVRVIRDADETVTATVDSLRPRGSEDADDEFYEFSSAARFCKDDWEVEQLRDACRKSKV
GFESMIAEIPEAVRKGRGERWMEGTFGRVARHLGNEVGYGSICAAGDHANTLHWVRNDGDLRPGELILIDAGIEVDSLYT
ADITRTLPISGTFSPAQRRVYQAVLEAQDAAAAVAKVGHDHAEIHQAAIRVICEYLHEWGILPVSVEESLSPEGGQHRRW
MVHGTSHHLGLDVHDCNQARRQDYSGPLKKGMCVSDEPGIYFKQTDLLVPEEFRGIGVRIEDDLCITDGEPEWLSKDCPR
QVDEIEAWMQEIWGRACH

Sequences:

>Translated_498_residues
MTETRSTELNEQLRQAEKQRIPKRQTPFSKAFVEFIPTDWAPYPDELPEPLSSAPSATAHRDALAARFDSDRLVIPAGHL
MRRNNDCDYPFRPNTAFAYYSGLGTDREPNAVLVVDTTAETRDVLYFKPRAPRTDREFYADPTYGEMWVGQRESLEEMAA
MTGLVCRDISQLDDALSTGDATVRVIRDADETVTATVDSLRPRGSEDADDEFYEFSSAARFCKDDWEVEQLRDACRKSKV
GFESMIAEIPEAVRKGRGERWMEGTFGRVARHLGNEVGYGSICAAGDHANTLHWVRNDGDLRPGELILIDAGIEVDSLYT
ADITRTLPISGTFSPAQRRVYQAVLEAQDAAAAVAKVGHDHAEIHQAAIRVICEYLHEWGILPVSVEESLSPEGGQHRRW
MVHGTSHHLGLDVHDCNQARRQDYSGPLKKGMCVSDEPGIYFKQTDLLVPEEFRGIGVRIEDDLCITDGEPEWLSKDCPR
QVDEIEAWMQEIWGRACH
>Mature_497_residues
TETRSTELNEQLRQAEKQRIPKRQTPFSKAFVEFIPTDWAPYPDELPEPLSSAPSATAHRDALAARFDSDRLVIPAGHLM
RRNNDCDYPFRPNTAFAYYSGLGTDREPNAVLVVDTTAETRDVLYFKPRAPRTDREFYADPTYGEMWVGQRESLEEMAAM
TGLVCRDISQLDDALSTGDATVRVIRDADETVTATVDSLRPRGSEDADDEFYEFSSAARFCKDDWEVEQLRDACRKSKVG
FESMIAEIPEAVRKGRGERWMEGTFGRVARHLGNEVGYGSICAAGDHANTLHWVRNDGDLRPGELILIDAGIEVDSLYTA
DITRTLPISGTFSPAQRRVYQAVLEAQDAAAAVAKVGHDHAEIHQAAIRVICEYLHEWGILPVSVEESLSPEGGQHRRWM
VHGTSHHLGLDVHDCNQARRQDYSGPLKKGMCVSDEPGIYFKQTDLLVPEEFRGIGVRIEDDLCITDGEPEWLSKDCPRQ
VDEIEAWMQEIWGRACH

Specific function: Unknown

COG id: COG0006

COG function: function code E; Xaa-Pro aminopeptidase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M24B family [H]

Homologues:

Organism=Homo sapiens, GI11559925, Length=426, Percent_Identity=29.5774647887324, Blast_Score=177, Evalue=3e-44,
Organism=Homo sapiens, GI149589008, Length=449, Percent_Identity=28.5077951002227, Blast_Score=116, Evalue=4e-26,
Organism=Homo sapiens, GI260593665, Length=304, Percent_Identity=33.2236842105263, Blast_Score=115, Evalue=1e-25,
Organism=Homo sapiens, GI260593663, Length=243, Percent_Identity=34.5679012345679, Blast_Score=106, Evalue=5e-23,
Organism=Escherichia coli, GI1789275, Length=423, Percent_Identity=32.1513002364066, Blast_Score=179, Evalue=5e-46,
Organism=Escherichia coli, GI1790282, Length=453, Percent_Identity=26.4900662251656, Blast_Score=92, Evalue=6e-20,
Organism=Escherichia coli, GI1788728, Length=260, Percent_Identity=28.4615384615385, Blast_Score=70, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17508215, Length=478, Percent_Identity=28.6610878661088, Blast_Score=125, Evalue=4e-29,
Organism=Caenorhabditis elegans, GI71989583, Length=286, Percent_Identity=31.4685314685315, Blast_Score=114, Evalue=2e-25,
Organism=Saccharomyces cerevisiae, GI6321118, Length=450, Percent_Identity=28.8888888888889, Blast_Score=136, Evalue=8e-33,
Organism=Saccharomyces cerevisiae, GI6320922, Length=428, Percent_Identity=26.4018691588785, Blast_Score=134, Evalue=3e-32,
Organism=Drosophila melanogaster, GI19920384, Length=428, Percent_Identity=30.8411214953271, Blast_Score=152, Evalue=4e-37,
Organism=Drosophila melanogaster, GI21357079, Length=450, Percent_Identity=30.2222222222222, Blast_Score=137, Evalue=2e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000994
- InterPro:   IPR007865
- InterPro:   IPR001131 [H]

Pfam domain/function: PF05195 AMP_N; PF00557 Peptidase_M24 [H]

EC number: =3.4.11.9 [H]

Molecular weight: Translated: 56019; Mature: 55888

Theoretical pI: Translated: 4.65; Mature: 4.65

Prosite motif: PS00491 PROLINE_PEPTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTETRSTELNEQLRQAEKQRIPKRQTPFSKAFVEFIPTDWAPYPDELPEPLSSAPSATAH
CCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCHHCCCHHHCCCCCHHH
RDALAARFDSDRLVIPAGHLMRRNNDCDYPFRPNTAFAYYSGLGTDREPNAVLVVDTTAE
HHHHHHHCCCCCEEECCHHHHHCCCCCCCCCCCCCCEEEEECCCCCCCCCEEEEEECCCC
TRDVLYFKPRAPRTDREFYADPTYGEMWVGQRESLEEMAAMTGLVCRDISQLDDALSTGD
CCCEEEECCCCCCCCCCEECCCCCCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
ATVRVIRDADETVTATVDSLRPRGSEDADDEFYEFSSAARFCKDDWEVEQLRDACRKSKV
CEEEEEECCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCC
GFESMIAEIPEAVRKGRGERWMEGTFGRVARHLGNEVGYGSICAAGDHANTLHWVRNDGD
CHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCEEECCCCCCCEEEECCCCC
LRPGELILIDAGIEVDSLYTADITRTLPISGTFSPAQRRVYQAVLEAQDAAAAVAKVGHD
CCCCCEEEEECCCCCCCEEECCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCH
HAEIHQAAIRVICEYLHEWGILPVSVEESLSPEGGQHRRWMVHGTSHHLGLDVHDCNQAR
HHHHHHHHHHHHHHHHHHCCCEEEEHHHCCCCCCCCCCEEEEECCCCCCCCCHHHHHHHH
RQDYSGPLKKGMCVSDEPGIYFKQTDLLVPEEFRGIGVRIEDDLCITDGEPEWLSKDCPR
HHCCCCCHHCCCCCCCCCCEEEEECCCCCCHHHCCCCEEEECCEEEECCCCHHHCCCCCH
QVDEIEAWMQEIWGRACH
HHHHHHHHHHHHHHCCCC
>Mature Secondary Structure 
TETRSTELNEQLRQAEKQRIPKRQTPFSKAFVEFIPTDWAPYPDELPEPLSSAPSATAH
CCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCHHCCCHHHCCCCCHHH
RDALAARFDSDRLVIPAGHLMRRNNDCDYPFRPNTAFAYYSGLGTDREPNAVLVVDTTAE
HHHHHHHCCCCCEEECCHHHHHCCCCCCCCCCCCCCEEEEECCCCCCCCCEEEEEECCCC
TRDVLYFKPRAPRTDREFYADPTYGEMWVGQRESLEEMAAMTGLVCRDISQLDDALSTGD
CCCEEEECCCCCCCCCCEECCCCCCHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
ATVRVIRDADETVTATVDSLRPRGSEDADDEFYEFSSAARFCKDDWEVEQLRDACRKSKV
CEEEEEECCCCHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHHHHHHHHHCC
GFESMIAEIPEAVRKGRGERWMEGTFGRVARHLGNEVGYGSICAAGDHANTLHWVRNDGD
CHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCCCCCCCCEEECCCCCCCEEEECCCCC
LRPGELILIDAGIEVDSLYTADITRTLPISGTFSPAQRRVYQAVLEAQDAAAAVAKVGHD
CCCCCEEEEECCCCCCCEEECCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHCCH
HAEIHQAAIRVICEYLHEWGILPVSVEESLSPEGGQHRRWMVHGTSHHLGLDVHDCNQAR
HHHHHHHHHHHHHHHHHHCCCEEEEHHHCCCCCCCCCCEEEEECCCCCCCCCHHHHHHHH
RQDYSGPLKKGMCVSDEPGIYFKQTDLLVPEEFRGIGVRIEDDLCITDGEPEWLSKDCPR
HHCCCCCHHCCCCCCCCCCEEEEECCCCCCHHHCCCCEEEECCEEEECCCCHHHCCCCCH
QVDEIEAWMQEIWGRACH
HHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12000953 [H]