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The map label for this gene is fhs [H]

Identifier: 50841539

GI number: 50841539

Start: 47426

End: 49135

Strand: Direct

Name: fhs [H]

Synonym: PPA0049

Alternate gene names: 50841539

Gene position: 47426-49135 (Clockwise)

Preceding gene: 50841537

Following gene: 50841540

Centisome position: 1.85

GC content: 60.82

Gene sequence:

>1710_bases
ATGATTGGAGCTATGACAATGAAGTCGGATCTTGAAATTGCCCGCGAGGCCCACCTTGACCCCATCGAGAAGGTTGCAGC
CCGGGCAGGCATTGATGAGAAATACCTGGAGCCCTATGGGCGCGGCGTCGCGAAGGTGGACCTCGATGTCGTCACACACA
ACAGGGATCATTCTTGCGGTAAATACGTCGTCGTCACGGCCATGACTCCCACGCCTCTTGGTGAGGGCAAAACGACCACC
GCTGTTGGTCTAGCCCAGGGCCTAGAGAAGATCGGCAAACATAGCGTGCTGGCCCTACGCCAGCCGTCGATGGGCCCAAC
TTTCGGAATCAAGGGCGGTGCCGCTGGCGCTGGATACTCCCAGGTGCTGCCGATGGAGAAGCTCAATTTGCACCTGACTG
GTGACTTCCATGCCATTGGAGCGGCCCACAACCTGCTTGCCGCCATGATCGACAACCATCTGCACCAGGGCAACGAGCTC
GACATTGAACCTCACTCGATCTCGTGGCGTCGCGTCGTCGATATCAATGACCGTGCCCTGCGCAACACCATTGTTGGTCT
TGGATCGAGGGTCGACGGCGTCCCCCGCGAGACCGGATTCGATATCACCGCGGCTAGCGAGGTTGGCGTCATCCTGTCCT
TGGCCACCTCCTTGTCCGACCTGCGTGCTCGCCTGGGGCGTATCGTCATCGGCTATAACCGCTCCAAAGAGCCAGTCAGC
GCCGAGGATCTGCACGCCGCCGGATCGATGGCCGTCATTCTTAAAGACGCCCTCAAGCCAAACCTATTACAAACTACCGA
GAACAGCCCGGTGCTCGTTCACGCCGGCCCCTTTGGCAATATCGCCACCGGTAACTCCTCGGTCATCGCAGACCGCGTCG
GTATCGGTTGCGGCGATTACTTGCTCACCGAGGCCGGATTCGGTGCTGACATGGGAGCTGAGCGGTTCTTCAACATCAAA
TGCCGCATCGGTGGGATGCGCCCCGACGCTGCCGTCCTCGTCGCCACCGTGCGTGCCCTCAAAACCCACGCCGGTCGCTA
CAAAGTCATCCCCGGAAAGCCCCTGCCCCCGGCAATGCTGGAGGACAACCCTGACGACGTGCTCGCTGGTGCTGCCAATC
TGCGCAAACACATCGAGATTGTGCGTGAGTTCGGCGTCTCCCCGATTGTGGCTCTCAACGTTTTCCCGACCGATCACCCC
GATGAGATCGATGCCGTCCGTAAAGTCGCTGAGGCCGCCGGAGCCCATTTCGCCTCTTCGACCCATGTCGTCGATGGCGG
TGACGGTGCCGTCGACCTGGCTCACGCGGTCGTGGCAGCCTGTGACCACAAGGCCGACTTCCGCTACACCTACGACCTTG
AGGACTCTCTAGTCGAGAAACTGACCAAGGTTGCTACCAAGGTTTATGGGGCTGACGGAATCGACATCGCCCCAGCGGCA
GCCAAGGAGCTGGCCCACTTCGAGGATCTCGGCTACGGCACATTCCCGGTTGTCATCGCGAAGACCCACCTATCCCTGTC
CCATGACCCATCCCTCAAGGGCGCCCCGACCGGATGGCGGTTGCCTGTGCGCGAGGTGAGGGCCGCCGTCGGAGCTGGAT
ACATCTACGCGATCTGCGGCGACATGCGCACCATGCCGGGCTTGGGCCGTCACCCGGCCGCCGAGAGGATAGATATCGAC
GATAACGGCGAAACCATCGGACTGTTCTGA

Upstream 100 bases:

>100_bases
GGCAGCGGAACGCTACGCTGCTGTGGCGTCAGGTGAGCGTTGGTAACGGTCCGGGCCGGCCATGATGCGCACAGGTATGC
AAAGAGGTGTCCAACACGTC

Downstream 100 bases:

>100_bases
CGTCAACGGTTCGGGGGCGCGCAGTGGTGCCGCGTCCCCAAGCTGGTTCCAACCATCGGCGTTGTGTAACGCCTCCGGAC
AACACAGTTCAGGCTTGTTG

Product: formate--tetrahydrofolate ligase

Products: NA

Alternate protein names: Formyltetrahydrofolate synthetase; FHS; FTHFS [H]

Number of amino acids: Translated: 569; Mature: 569

Protein sequence:

>569_residues
MIGAMTMKSDLEIAREAHLDPIEKVAARAGIDEKYLEPYGRGVAKVDLDVVTHNRDHSCGKYVVVTAMTPTPLGEGKTTT
AVGLAQGLEKIGKHSVLALRQPSMGPTFGIKGGAAGAGYSQVLPMEKLNLHLTGDFHAIGAAHNLLAAMIDNHLHQGNEL
DIEPHSISWRRVVDINDRALRNTIVGLGSRVDGVPRETGFDITAASEVGVILSLATSLSDLRARLGRIVIGYNRSKEPVS
AEDLHAAGSMAVILKDALKPNLLQTTENSPVLVHAGPFGNIATGNSSVIADRVGIGCGDYLLTEAGFGADMGAERFFNIK
CRIGGMRPDAAVLVATVRALKTHAGRYKVIPGKPLPPAMLEDNPDDVLAGAANLRKHIEIVREFGVSPIVALNVFPTDHP
DEIDAVRKVAEAAGAHFASSTHVVDGGDGAVDLAHAVVAACDHKADFRYTYDLEDSLVEKLTKVATKVYGADGIDIAPAA
AKELAHFEDLGYGTFPVVIAKTHLSLSHDPSLKGAPTGWRLPVREVRAAVGAGYIYAICGDMRTMPGLGRHPAAERIDID
DNGETIGLF

Sequences:

>Translated_569_residues
MIGAMTMKSDLEIAREAHLDPIEKVAARAGIDEKYLEPYGRGVAKVDLDVVTHNRDHSCGKYVVVTAMTPTPLGEGKTTT
AVGLAQGLEKIGKHSVLALRQPSMGPTFGIKGGAAGAGYSQVLPMEKLNLHLTGDFHAIGAAHNLLAAMIDNHLHQGNEL
DIEPHSISWRRVVDINDRALRNTIVGLGSRVDGVPRETGFDITAASEVGVILSLATSLSDLRARLGRIVIGYNRSKEPVS
AEDLHAAGSMAVILKDALKPNLLQTTENSPVLVHAGPFGNIATGNSSVIADRVGIGCGDYLLTEAGFGADMGAERFFNIK
CRIGGMRPDAAVLVATVRALKTHAGRYKVIPGKPLPPAMLEDNPDDVLAGAANLRKHIEIVREFGVSPIVALNVFPTDHP
DEIDAVRKVAEAAGAHFASSTHVVDGGDGAVDLAHAVVAACDHKADFRYTYDLEDSLVEKLTKVATKVYGADGIDIAPAA
AKELAHFEDLGYGTFPVVIAKTHLSLSHDPSLKGAPTGWRLPVREVRAAVGAGYIYAICGDMRTMPGLGRHPAAERIDID
DNGETIGLF
>Mature_569_residues
MIGAMTMKSDLEIAREAHLDPIEKVAARAGIDEKYLEPYGRGVAKVDLDVVTHNRDHSCGKYVVVTAMTPTPLGEGKTTT
AVGLAQGLEKIGKHSVLALRQPSMGPTFGIKGGAAGAGYSQVLPMEKLNLHLTGDFHAIGAAHNLLAAMIDNHLHQGNEL
DIEPHSISWRRVVDINDRALRNTIVGLGSRVDGVPRETGFDITAASEVGVILSLATSLSDLRARLGRIVIGYNRSKEPVS
AEDLHAAGSMAVILKDALKPNLLQTTENSPVLVHAGPFGNIATGNSSVIADRVGIGCGDYLLTEAGFGADMGAERFFNIK
CRIGGMRPDAAVLVATVRALKTHAGRYKVIPGKPLPPAMLEDNPDDVLAGAANLRKHIEIVREFGVSPIVALNVFPTDHP
DEIDAVRKVAEAAGAHFASSTHVVDGGDGAVDLAHAVVAACDHKADFRYTYDLEDSLVEKLTKVATKVYGADGIDIAPAA
AKELAHFEDLGYGTFPVVIAKTHLSLSHDPSLKGAPTGWRLPVREVRAAVGAGYIYAICGDMRTMPGLGRHPAAERIDID
DNGETIGLF

Specific function: Unknown

COG id: COG2759

COG function: function code F; Formyltetrahydrofolate synthetase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the formate--tetrahydrofolate ligase family [H]

Homologues:

Organism=Homo sapiens, GI222136639, Length=618, Percent_Identity=45.7928802588997, Blast_Score=502, Evalue=1e-142,
Organism=Homo sapiens, GI36796743, Length=618, Percent_Identity=45.4692556634304, Blast_Score=494, Evalue=1e-140,
Organism=Homo sapiens, GI310124614, Length=84, Percent_Identity=42.8571428571429, Blast_Score=84, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17568737, Length=622, Percent_Identity=46.4630225080386, Blast_Score=491, Evalue=1e-139,
Organism=Caenorhabditis elegans, GI17568739, Length=622, Percent_Identity=46.4630225080386, Blast_Score=491, Evalue=1e-139,
Organism=Saccharomyces cerevisiae, GI6321643, Length=625, Percent_Identity=45.12, Blast_Score=503, Evalue=1e-143,
Organism=Saccharomyces cerevisiae, GI6319558, Length=630, Percent_Identity=44.4444444444444, Blast_Score=501, Evalue=1e-142,
Organism=Drosophila melanogaster, GI62472483, Length=619, Percent_Identity=44.5880452342488, Blast_Score=488, Evalue=1e-138,
Organism=Drosophila melanogaster, GI45551871, Length=619, Percent_Identity=44.5880452342488, Blast_Score=488, Evalue=1e-138,
Organism=Drosophila melanogaster, GI24645718, Length=619, Percent_Identity=44.5880452342488, Blast_Score=486, Evalue=1e-137,
Organism=Drosophila melanogaster, GI17137370, Length=619, Percent_Identity=44.5880452342488, Blast_Score=486, Evalue=1e-137,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000559
- InterPro:   IPR020628 [H]

Pfam domain/function: PF01268 FTHFS [H]

EC number: =6.3.4.3 [H]

Molecular weight: Translated: 60266; Mature: 60266

Theoretical pI: Translated: 6.40; Mature: 6.40

Prosite motif: PS00237 G_PROTEIN_RECEP_F1_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIGAMTMKSDLEIAREAHLDPIEKVAARAGIDEKYLEPYGRGVAKVDLDVVTHNRDHSCG
CCCCEECHHHHHHHHHHCCCHHHHHHHHCCCCHHHHHHHCCCEEEEEEEEEECCCCCCCC
KYVVVTAMTPTPLGEGKTTTAVGLAQGLEKIGKHSVLALRQPSMGPTFGIKGGAAGAGYS
CEEEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCCHH
QVLPMEKLNLHLTGDFHAIGAAHNLLAAMIDNHLHQGNELDIEPHSISWRRVVDINDRAL
HCCCHHHCEEEEECCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCHHHH
RNTIVGLGSRVDGVPRETGFDITAASEVGVILSLATSLSDLRARLGRIVIGYNRSKEPVS
HHHHHHCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHCEEEEEECCCCCCCC
AEDLHAAGSMAVILKDALKPNLLQTTENSPVLVHAGPFGNIATGNSSVIADRVGIGCGDY
HHHHHCCCCHHEEEHHHCCCCCEEECCCCCEEEECCCCCCCCCCCCCEEEHHHCCCCCHH
LLTEAGFGADMGAERFFNIKCRIGGMRPDAAVLVATVRALKTHAGRYKVIPGKPLPPAML
HHHCCCCCCCCCCCEEEEEEEEECCCCCCHHHHHHHHHHHHHCCCCEEECCCCCCCCHHC
EDNPDDVLAGAANLRKHIEIVREFGVSPIVALNVFPTDHPDEIDAVRKVAEAAGAHFASS
CCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCC
THVVDGGDGAVDLAHAVVAACDHKADFRYTYDLEDSLVEKLTKVATKVYGADGIDIAPAA
CEEEECCCCHHHHHHHHHHHHCCCCCCEEEECCHHHHHHHHHHHHHHHCCCCCCCCCHHH
AKELAHFEDLGYGTFPVVIAKTHLSLSHDPSLKGAPTGWRLPVREVRAAVGAGYIYAICG
HHHHHHHHHCCCCCEEEEEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHCCCEEEEEEC
DMRTMPGLGRHPAAERIDIDDNGETIGLF
CHHCCCCCCCCCCCCEEEECCCCCEEECC
>Mature Secondary Structure
MIGAMTMKSDLEIAREAHLDPIEKVAARAGIDEKYLEPYGRGVAKVDLDVVTHNRDHSCG
CCCCEECHHHHHHHHHHCCCHHHHHHHHCCCCHHHHHHHCCCEEEEEEEEEECCCCCCCC
KYVVVTAMTPTPLGEGKTTTAVGLAQGLEKIGKHSVLALRQPSMGPTFGIKGGAAGAGYS
CEEEEEEECCCCCCCCCCHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCCCCHH
QVLPMEKLNLHLTGDFHAIGAAHNLLAAMIDNHLHQGNELDIEPHSISWRRVVDINDRAL
HCCCHHHCEEEEECCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCEEEEEECCHHHH
RNTIVGLGSRVDGVPRETGFDITAASEVGVILSLATSLSDLRARLGRIVIGYNRSKEPVS
HHHHHHCCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHHHCEEEEEECCCCCCCC
AEDLHAAGSMAVILKDALKPNLLQTTENSPVLVHAGPFGNIATGNSSVIADRVGIGCGDY
HHHHHCCCCHHEEEHHHCCCCCEEECCCCCEEEECCCCCCCCCCCCCEEEHHHCCCCCHH
LLTEAGFGADMGAERFFNIKCRIGGMRPDAAVLVATVRALKTHAGRYKVIPGKPLPPAML
HHHCCCCCCCCCCCEEEEEEEEECCCCCCHHHHHHHHHHHHHCCCCEEECCCCCCCCHHC
EDNPDDVLAGAANLRKHIEIVREFGVSPIVALNVFPTDHPDEIDAVRKVAEAAGAHFASS
CCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCC
THVVDGGDGAVDLAHAVVAACDHKADFRYTYDLEDSLVEKLTKVATKVYGADGIDIAPAA
CEEEECCCCHHHHHHHHHHHHCCCCCCEEEECCHHHHHHHHHHHHHHHCCCCCCCCCHHH
AKELAHFEDLGYGTFPVVIAKTHLSLSHDPSLKGAPTGWRLPVREVRAAVGAGYIYAICG
HHHHHHHHHCCCCCEEEEEEEEEECCCCCCCCCCCCCCCCCCHHHHHHHHCCCEEEEEEC
DMRTMPGLGRHPAAERIDIDDNGETIGLF
CHHCCCCCCCCCCCCEEEECCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA