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The map label for this gene is pat

Identifier: 50841527

GI number: 50841527

Start: 33561

End: 34619

Strand: Direct

Name: pat

Synonym: PPA0034

Alternate gene names: 50841527

Gene position: 33561-34619 (Clockwise)

Preceding gene: 50841524

Following gene: 50841528

Centisome position: 1.31

GC content: 62.42

Gene sequence:

>1059_bases
GTGAGTCAGGACCGACGCGATGTTGTTCGAGGACTACCGCTCTACAAGCAAGGGGCAAGTCACGGCGAGAACGCTGTGAA
GCTGTCATCCAACGAGAACCCTTTCGAACCACTGCCGAGTGTGGTCGAGGCCGTCACCCGCACACTGCCGAGGTTCAACC
GTTACCCATTAATGAGTGCCGAGGAAGTACGCTCGACCATCGCCGGTCACTTCGGCGTCGACGTGAGCCAGGTGGCGGTG
GGGGCTGGATCGACGGAGGTAGCCAGTCAGCTCATGCATGCCTTGGCTGGTGCCGGTGACGAGATCATCTTTCCGTGGCG
GTCCTTCGAGGCCTACCCGATCCTCACCAAAGTTGCCGGGGCCACTCCGATCCCGGTGCCGCTGACCGTCGACTTGCGTC
ACGACCTTGACGCTATGGCTGACGCGATCACCGACCGTACCCGCGTGATCTTCCTATGTACCCCCAACAACCCGACTGGA
ACCGTCCTGCACACCGATGAGGTGGTGGAGTTCTTAGCGAGGGTGCCGGAGAACGTGGTCGTCGTCATGGACGAGGCTTA
CTGCCACTTCAACCGGGACGATGCCGCTGTGGATGGGCTCACTCTTCTCGAAGATCACCCCAACGTCGTCGTGCTGCGGA
CCTTCTCCAAGGCCTACGGGCTGGCCGGGCTGCGTATTGGTTTCGCCATCTCCACCCCCGAGATCAGCGACGACCTGCGA
CGTGTCGCCACTCCCTTCACGGTGACCACCCTGGCCCAGCAGGCCGCGATCGCTTCCTTGGCAGCCGAGGACGAGCTCAA
CGAGAGGGTTAACCGGATCGTCGCCGAGCGCACCCGGGTCTTTGACGAACTGACCCGCCAGGGCTGGAAGATCGTGCCGT
CCCAGGCGAACTTCCTGTGGTTGGCCACGGGTGACGACACCGATCGGATCGACGAGGTGATGGTTTCCCACGGCGTTTTC
GCACGCTGCTGGAGCGAGGAGGGGATTCGTCTGTCGATCGGGTTGGACGCGGAGAATGACCGAGCAATCGAGGCGCTATC
CCAGGCCGTCAAGGGCTGA

Upstream 100 bases:

>100_bases
TACAGCGTGGCTGGTCCGTGCCAGATGTGGTAGAGCATCGAGACAACGACTGTCGGGGGAGTGTGAAAGAGTTCTAGCGA
ACGTTGAATGGGAGGATGAC

Downstream 100 bases:

>100_bases
GGCTCAGACCCCCAGGAAGTCCCGCCACTGCGGCAGCTCAGCGTTCACCTGGGCCATCCCAAGAGCGTAGGCCTGACGTA
GCTTTGTGACGTTTCTTTCC

Product: putative aminotransferase

Products: 3-(imidazol-4-yl)-2-oxopropyl phosphate; L-glutamate

Alternate protein names: NA

Number of amino acids: Translated: 352; Mature: 351

Protein sequence:

>352_residues
MSQDRRDVVRGLPLYKQGASHGENAVKLSSNENPFEPLPSVVEAVTRTLPRFNRYPLMSAEEVRSTIAGHFGVDVSQVAV
GAGSTEVASQLMHALAGAGDEIIFPWRSFEAYPILTKVAGATPIPVPLTVDLRHDLDAMADAITDRTRVIFLCTPNNPTG
TVLHTDEVVEFLARVPENVVVVMDEAYCHFNRDDAAVDGLTLLEDHPNVVVLRTFSKAYGLAGLRIGFAISTPEISDDLR
RVATPFTVTTLAQQAAIASLAAEDELNERVNRIVAERTRVFDELTRQGWKIVPSQANFLWLATGDDTDRIDEVMVSHGVF
ARCWSEEGIRLSIGLDAENDRAIEALSQAVKG

Sequences:

>Translated_352_residues
MSQDRRDVVRGLPLYKQGASHGENAVKLSSNENPFEPLPSVVEAVTRTLPRFNRYPLMSAEEVRSTIAGHFGVDVSQVAV
GAGSTEVASQLMHALAGAGDEIIFPWRSFEAYPILTKVAGATPIPVPLTVDLRHDLDAMADAITDRTRVIFLCTPNNPTG
TVLHTDEVVEFLARVPENVVVVMDEAYCHFNRDDAAVDGLTLLEDHPNVVVLRTFSKAYGLAGLRIGFAISTPEISDDLR
RVATPFTVTTLAQQAAIASLAAEDELNERVNRIVAERTRVFDELTRQGWKIVPSQANFLWLATGDDTDRIDEVMVSHGVF
ARCWSEEGIRLSIGLDAENDRAIEALSQAVKG
>Mature_351_residues
SQDRRDVVRGLPLYKQGASHGENAVKLSSNENPFEPLPSVVEAVTRTLPRFNRYPLMSAEEVRSTIAGHFGVDVSQVAVG
AGSTEVASQLMHALAGAGDEIIFPWRSFEAYPILTKVAGATPIPVPLTVDLRHDLDAMADAITDRTRVIFLCTPNNPTGT
VLHTDEVVEFLARVPENVVVVMDEAYCHFNRDDAAVDGLTLLEDHPNVVVLRTFSKAYGLAGLRIGFAISTPEISDDLRR
VATPFTVTTLAQQAAIASLAAEDELNERVNRIVAERTRVFDELTRQGWKIVPSQANFLWLATGDDTDRIDEVMVSHGVFA
RCWSEEGIRLSIGLDAENDRAIEALSQAVKG

Specific function: May catalyze the transamination reaction in phenylalanine biosynthesis

COG id: COG0079

COG function: function code E; Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family

Homologues:

Organism=Escherichia coli, GI1788332, Length=352, Percent_Identity=28.9772727272727, Blast_Score=129, Evalue=4e-31,
Organism=Escherichia coli, GI1786816, Length=292, Percent_Identity=26.7123287671233, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1788627, Length=242, Percent_Identity=28.5123966942149, Blast_Score=71, Evalue=9e-14,
Organism=Escherichia coli, GI1788722, Length=239, Percent_Identity=27.6150627615063, Blast_Score=67, Evalue=1e-12,
Organism=Saccharomyces cerevisiae, GI6322075, Length=372, Percent_Identity=25, Blast_Score=96, Evalue=9e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): PATR_PROAC (Q6ABU3)

Other databases:

- EMBL:   AE017283
- RefSeq:   YP_054754.1
- ProteinModelPortal:   Q6ABU3
- SMR:   Q6ABU3
- GeneID:   2932997
- GenomeReviews:   AE017283_GR
- KEGG:   pac:PPA0034
- NMPDR:   fig|267747.1.peg.31
- HOGENOM:   HBG646350
- OMA:   ENTLIVI
- ProtClustDB:   PRK03321
- BioCyc:   PACN267747:PPA0034-MONOMER
- HAMAP:   MF_01513
- InterPro:   IPR001176
- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR005861
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422
- Gene3D:   G3DSA:3.40.640.10
- Gene3D:   G3DSA:3.90.1150.10
- PRINTS:   PR00753
- TIGRFAMs:   TIGR01141

Pfam domain/function: PF00155 Aminotran_1_2; SSF53383 PyrdxlP-dep_Trfase_major

EC number: 2.6.1.9

Molecular weight: Translated: 38490; Mature: 38359

Theoretical pI: Translated: 4.61; Mature: 4.61

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.4 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSQDRRDVVRGLPLYKQGASHGENAVKLSSNENPFEPLPSVVEAVTRTLPRFNRYPLMSA
CCCCHHHHHHCCCCHHCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCH
EEVRSTIAGHFGVDVSQVAVGAGSTEVASQLMHALAGAGDEIIFPWRSFEAYPILTKVAG
HHHHHHHHHHCCCCHHHHEECCCCHHHHHHHHHHHHCCCCCEEEECCCCCCCCHHHHHCC
ATPIPVPLTVDLRHDLDAMADAITDRTRVIFLCTPNNPTGTVLHTDEVVEFLARVPENVV
CCCCCCEEEEECHHHHHHHHHHHCCCCEEEEEECCCCCCCEEEEHHHHHHHHHHCCCCEE
VVMDEAYCHFNRDDAAVDGLTLLEDHPNVVVLRTFSKAYGLAGLRIGFAISTPEISDDLR
EEEECCEEECCCCCHHHCCEEEEECCCCEEEEEECHHHHCCCEEEEEEEECCCCHHHHHH
RVATPFTVTTLAQQAAIASLAAEDELNERVNRIVAERTRVFDELTRQGWKIVPSQANFLW
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCEEE
LATGDDTDRIDEVMVSHGVFARCWSEEGIRLSIGLDAENDRAIEALSQAVKG
EEECCCHHHHHHHHHHCCHHEEECCCCCEEEEEECCCCCCHHHHHHHHHHCC
>Mature Secondary Structure 
SQDRRDVVRGLPLYKQGASHGENAVKLSSNENPFEPLPSVVEAVTRTLPRFNRYPLMSA
CCCHHHHHHCCCCHHCCCCCCCCEEEECCCCCCCCHHHHHHHHHHHHHCCCCCCCCCCH
EEVRSTIAGHFGVDVSQVAVGAGSTEVASQLMHALAGAGDEIIFPWRSFEAYPILTKVAG
HHHHHHHHHHCCCCHHHHEECCCCHHHHHHHHHHHHCCCCCEEEECCCCCCCCHHHHHCC
ATPIPVPLTVDLRHDLDAMADAITDRTRVIFLCTPNNPTGTVLHTDEVVEFLARVPENVV
CCCCCCEEEEECHHHHHHHHHHHCCCCEEEEEECCCCCCCEEEEHHHHHHHHHHCCCCEE
VVMDEAYCHFNRDDAAVDGLTLLEDHPNVVVLRTFSKAYGLAGLRIGFAISTPEISDDLR
EEEECCEEECCCCCHHHCCEEEEECCCCEEEEEECHHHHCCCEEEEEEEECCCCHHHHHH
RVATPFTVTTLAQQAAIASLAAEDELNERVNRIVAERTRVFDELTRQGWKIVPSQANFLW
HHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCEEE
LATGDDTDRIDEVMVSHGVFARCWSEEGIRLSIGLDAENDRAIEALSQAVKG
EEECCCHHHHHHHHHHCCHHEEECCCCCEEEEEECCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: Pyridoxal Phosphate. [C]

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-histidinol phosphate; 2-oxoglutarate

Specific reaction: L-histidinol phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate

General reaction: Amino group transfer [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA