| Definition | Propionibacterium acnes KPA171202, complete genome. |
|---|---|
| Accession | NC_006085 |
| Length | 2,560,265 |
Click here to switch to the map view.
The map label for this gene is gyrA [H]
Identifier: 50841504
GI number: 50841504
Start: 11847
End: 14522
Strand: Direct
Name: gyrA [H]
Synonym: PPA0010
Alternate gene names: 50841504
Gene position: 11847-14522 (Clockwise)
Preceding gene: 50841503
Following gene: 50841505
Centisome position: 0.46
GC content: 61.02
Gene sequence:
>2676_bases ATGGCTGACGACGAGAAGCCCGACGAGCAGAACCAGGCCGACCGTCAAGGATTGGTGACCGGCCGTCACGTCGGAATCCA GCCGGTCGAGATTCGTGACGAGATCCAGAACGCGTACCTCGACTACGCGATGAGCGTCATCGTCGGGCGTGCCCTGCCCG ATGTGCGCGACGGCCTCAAACCGGTACACCGTCGGGTCATCTACGCGATGTACGACGGCGGTTACCGCCCCGACCGCGGC TGGAACAAGTGCTCCCGCGTCGTCGGTGACGTCATGGGTAAGTACCACCCTCACGGCGACTCGGCCATTTACGACACCTT GGTGCGTTTGGCTCAGCCATGGGCCATGCGATACAAGCTTGTCCAGGGTCAGGGTAACTTCGGGTCCCAGGGCAACGACG GTGCGGCTGCCATGCGATACACCGAGTGCAAGATGGCGCCGCTGGCCATGGAGATGGTGCGCGACATCGACCAGGACACT GTCGATTTCCAGCCCAACTATGACAACAAGGAGACCGAACCGGTCGTCTTGCCGTCGAGGTTCCCCAACCTGCTTGTCAA TGGTTCTTCAGGTATCGCGGTGGGCATGGCCACCAACATCCCGACCCATAATCTGCGCGAGGTCAACGAGGCCGTGCAGT GGTCTTTGGCTCACCCCAATGCTTCCCACGAGGAACTGCTCGAGGCGTGCATGGAGCGCATTAAGGGTCCGGATTTCCCC GGCGGCGCCCTCATTGTGGGTCGGCAGGGCATCGAGGACGCCTACCGCACCGGCCGCGGTTCGGTGACGATGCGTGCCGT CATCGACATGGAAGAGGACAAGAAGGGACGCCAGTGCCTGGTCGTCACCGAGTTGCCTTATATGTGCAACCCGGACAACC TCGCCACCAAGATCGCCGACCTGGTGAACTCCGGTCGCATCAACGGTATCGCCGACATCCGTGACGACTCCTCAGCCCGT ACTGGTCAGCGTTTAGTCATCGTCCTCAAGCGTGACGCTCAGCCGCGTGTCGTCATGAACAACCTGTACAAGCACACGGC TTTGCAGGACACCTTCGGCTGCAACATGCTGGCTCTGGTGGACAACGTGCCGCGCACCTTGCGTCTGGACCAATTTATCA GCTACTGGATTGACCACCAGATGGAGGTCATCCGCAGGCGTACCGAGTACCGCCTGGCTCAGGCCGAAAAAGACGCCCAC ATCCAGCGGGCTCTCGTCAAGGCCCTCGATATGCTCGACGAGGTCATCGCGCTCATCCGTCGCTCCCCGAACACTGAGGC CGCCAGCACCGGCCTACAGGAACTGCTTGATATCGACGAGATTCAGGCTCGCGCCATCCTCGATATGCAGTTGCGTCGTC TGGCTGCCCTGGAGCGTCAAAAGATCATCGACCGACTTGAAGAACTCGAGCGCCTCATCGCTGATTACAAAGCAATTCTG GCTAGCGAGGACCGCCAGCGCGAGATCATCTCTACCGAGCTTGCCGAGATCGTCGATAAGTATGGTGACGAGCGTCGCAC CCGCATTATCGCCGCCGATGGGGACTTTTCCGAGGAAGACTTCATCCCCGACGATGACGTCGTCGTCACCATTACCCGGG GCGGCTACGCCAAGCGCACCCGCACTGACCTGTACCGGGTCCAGAAACGCGGTGGCAAGGGTGTTCGCGGCGCCAGCCTG CGCGCTGACGACGAGATGGCACAGCTATTCACTACCACGAACCACCAGTGGATCCTCTTCTTCACAAATATGGGTCGGGT GTATCGCACCAAGGTATGGCAGCTGCCGGAGGCTGGTCGTGACGCCAGGGGGGGTCACGTCGCTGGGTTGCTGAGCTTCC TGCCCGACGAGAAGATCGCCCAAGTCATGACCCTACGGTCCTACGACGGCGCCGAGTACCTCCTCCTGGCCACTCGTAAG GGTATGGTCAAGAAGACGGCGCTCAAGGCTTATGACTCGTCTCGTCAGGCCGGCGTTATCGCCGTTAATTTCCGTACCGA GGACGATGAGCTCATCGGCGCCGAGCAGTGCTCCGCCGCTGACGACGTGCTGCTTATCAGCCGTAAGGGGCAAGCGATCC GGTTCTCTGCCGGCGACGACCAGCTGCGCCCGATGGGGCGTGCGACTTCGGGCGTTACCGGCATGAAGTTCCGTGGTGAT GACGAGTTGCTGTCAATGTCGATCATCCACTCCGACATGCCTGAGGATGATCGGTTCGTTTTCACAGCAACCGGTGGCGG CTACGCCAAGCGCACTGCTGTGTCGGAGTACCGTCAGCAGGGGCGTGGGGGAGTCGGCATCAAAGCGATGGCCCTCAGTG AGGAGCGCGGCTCCCTGGTTGGTGGCCTGGTGGTCAGCGAGGCTGACGAAATCATCGCGATTAAGACGTCAGGTCAGATC ACCCGATCGGCCGTGTCTGAGGTGCCCGCCAAGGGACGCTCCACGATGGGGGTCAAGTTCGTCTCCGTACGAGGTGGCGA CGCTGTCTCAATCATCGCTGTCAACCCCGAACATACCGTCGAGGAGGAAGTCGCTGACGAATCAGTGGAAACTGTTGAAG GCGATGCCACGCAGGCCCAATCGGGAGGTGTGGTTCGGCGAAGCGATACTGTGGACGACGACCGTGCCGTCGATACGGCG GGAAACGACATGAAGCCGGAGGACAACGGTGAGTGA
Upstream 100 bases:
>100_bases AACAGCGCCGATCGTTCATTCAGCGCAATGCCAAGGACGTCCGCTTCCTCGACATCTGAGCACCCATTCCCTCATCCCCT GATTATTCAAAGGACACTCC
Downstream 100 bases:
>100_bases CGAGAAGAAGGTGACGCATCCCGGTCCCGACGACCCGGAGGCAATCCACTGGACCGCCGGTGATGCCCGCCGTACCTTCC ACGAGAAGGGCGAGGAGCGC
Product: DNA gyrase subunit A
Products: NA
Alternate protein names: NA
Number of amino acids: Translated: 891; Mature: 890
Protein sequence:
>891_residues MADDEKPDEQNQADRQGLVTGRHVGIQPVEIRDEIQNAYLDYAMSVIVGRALPDVRDGLKPVHRRVIYAMYDGGYRPDRG WNKCSRVVGDVMGKYHPHGDSAIYDTLVRLAQPWAMRYKLVQGQGNFGSQGNDGAAAMRYTECKMAPLAMEMVRDIDQDT VDFQPNYDNKETEPVVLPSRFPNLLVNGSSGIAVGMATNIPTHNLREVNEAVQWSLAHPNASHEELLEACMERIKGPDFP GGALIVGRQGIEDAYRTGRGSVTMRAVIDMEEDKKGRQCLVVTELPYMCNPDNLATKIADLVNSGRINGIADIRDDSSAR TGQRLVIVLKRDAQPRVVMNNLYKHTALQDTFGCNMLALVDNVPRTLRLDQFISYWIDHQMEVIRRRTEYRLAQAEKDAH IQRALVKALDMLDEVIALIRRSPNTEAASTGLQELLDIDEIQARAILDMQLRRLAALERQKIIDRLEELERLIADYKAIL ASEDRQREIISTELAEIVDKYGDERRTRIIAADGDFSEEDFIPDDDVVVTITRGGYAKRTRTDLYRVQKRGGKGVRGASL RADDEMAQLFTTTNHQWILFFTNMGRVYRTKVWQLPEAGRDARGGHVAGLLSFLPDEKIAQVMTLRSYDGAEYLLLATRK GMVKKTALKAYDSSRQAGVIAVNFRTEDDELIGAEQCSAADDVLLISRKGQAIRFSAGDDQLRPMGRATSGVTGMKFRGD DELLSMSIIHSDMPEDDRFVFTATGGGYAKRTAVSEYRQQGRGGVGIKAMALSEERGSLVGGLVVSEADEIIAIKTSGQI TRSAVSEVPAKGRSTMGVKFVSVRGGDAVSIIAVNPEHTVEEEVADESVETVEGDATQAQSGGVVRRSDTVDDDRAVDTA GNDMKPEDNGE
Sequences:
>Translated_891_residues MADDEKPDEQNQADRQGLVTGRHVGIQPVEIRDEIQNAYLDYAMSVIVGRALPDVRDGLKPVHRRVIYAMYDGGYRPDRG WNKCSRVVGDVMGKYHPHGDSAIYDTLVRLAQPWAMRYKLVQGQGNFGSQGNDGAAAMRYTECKMAPLAMEMVRDIDQDT VDFQPNYDNKETEPVVLPSRFPNLLVNGSSGIAVGMATNIPTHNLREVNEAVQWSLAHPNASHEELLEACMERIKGPDFP GGALIVGRQGIEDAYRTGRGSVTMRAVIDMEEDKKGRQCLVVTELPYMCNPDNLATKIADLVNSGRINGIADIRDDSSAR TGQRLVIVLKRDAQPRVVMNNLYKHTALQDTFGCNMLALVDNVPRTLRLDQFISYWIDHQMEVIRRRTEYRLAQAEKDAH IQRALVKALDMLDEVIALIRRSPNTEAASTGLQELLDIDEIQARAILDMQLRRLAALERQKIIDRLEELERLIADYKAIL ASEDRQREIISTELAEIVDKYGDERRTRIIAADGDFSEEDFIPDDDVVVTITRGGYAKRTRTDLYRVQKRGGKGVRGASL RADDEMAQLFTTTNHQWILFFTNMGRVYRTKVWQLPEAGRDARGGHVAGLLSFLPDEKIAQVMTLRSYDGAEYLLLATRK GMVKKTALKAYDSSRQAGVIAVNFRTEDDELIGAEQCSAADDVLLISRKGQAIRFSAGDDQLRPMGRATSGVTGMKFRGD DELLSMSIIHSDMPEDDRFVFTATGGGYAKRTAVSEYRQQGRGGVGIKAMALSEERGSLVGGLVVSEADEIIAIKTSGQI TRSAVSEVPAKGRSTMGVKFVSVRGGDAVSIIAVNPEHTVEEEVADESVETVEGDATQAQSGGVVRRSDTVDDDRAVDTA GNDMKPEDNGE >Mature_890_residues ADDEKPDEQNQADRQGLVTGRHVGIQPVEIRDEIQNAYLDYAMSVIVGRALPDVRDGLKPVHRRVIYAMYDGGYRPDRGW NKCSRVVGDVMGKYHPHGDSAIYDTLVRLAQPWAMRYKLVQGQGNFGSQGNDGAAAMRYTECKMAPLAMEMVRDIDQDTV DFQPNYDNKETEPVVLPSRFPNLLVNGSSGIAVGMATNIPTHNLREVNEAVQWSLAHPNASHEELLEACMERIKGPDFPG GALIVGRQGIEDAYRTGRGSVTMRAVIDMEEDKKGRQCLVVTELPYMCNPDNLATKIADLVNSGRINGIADIRDDSSART GQRLVIVLKRDAQPRVVMNNLYKHTALQDTFGCNMLALVDNVPRTLRLDQFISYWIDHQMEVIRRRTEYRLAQAEKDAHI QRALVKALDMLDEVIALIRRSPNTEAASTGLQELLDIDEIQARAILDMQLRRLAALERQKIIDRLEELERLIADYKAILA SEDRQREIISTELAEIVDKYGDERRTRIIAADGDFSEEDFIPDDDVVVTITRGGYAKRTRTDLYRVQKRGGKGVRGASLR ADDEMAQLFTTTNHQWILFFTNMGRVYRTKVWQLPEAGRDARGGHVAGLLSFLPDEKIAQVMTLRSYDGAEYLLLATRKG MVKKTALKAYDSSRQAGVIAVNFRTEDDELIGAEQCSAADDVLLISRKGQAIRFSAGDDQLRPMGRATSGVTGMKFRGDD ELLSMSIIHSDMPEDDRFVFTATGGGYAKRTAVSEYRQQGRGGVGIKAMALSEERGSLVGGLVVSEADEIIAIKTSGQIT RSAVSEVPAKGRSTMGVKFVSVRGGDAVSIIAVNPEHTVEEEVADESVETVEGDATQAQSGGVVRRSDTVDDDRAVDTAG NDMKPEDNGE
Specific function: DNA gyrase negatively supercoils closed circular double- stranded DNA in an ATP-dependent manner and also catalyzes the interconversion of other topological isomers of double-stranded DNA rings, including catenanes and knotted rings [H]
COG id: COG0188
COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]
Homologues:
Organism=Homo sapiens, GI19913408, Length=328, Percent_Identity=24.390243902439, Blast_Score=84, Evalue=5e-16, Organism=Homo sapiens, GI19913406, Length=165, Percent_Identity=31.5151515151515, Blast_Score=79, Evalue=2e-14, Organism=Escherichia coli, GI1788562, Length=868, Percent_Identity=43.6635944700461, Blast_Score=683, Evalue=0.0, Organism=Escherichia coli, GI1789396, Length=679, Percent_Identity=34.9042709867452, Blast_Score=359, Evalue=1e-100, Organism=Caenorhabditis elegans, GI17535065, Length=165, Percent_Identity=32.1212121212121, Blast_Score=82, Evalue=1e-15, Organism=Caenorhabditis elegans, GI115534553, Length=161, Percent_Identity=31.6770186335404, Blast_Score=73, Evalue=8e-13, Organism=Caenorhabditis elegans, GI212645845, Length=212, Percent_Identity=27.8301886792453, Blast_Score=72, Evalue=1e-12, Organism=Caenorhabditis elegans, GI212645657, Length=212, Percent_Identity=26.8867924528302, Blast_Score=71, Evalue=2e-12, Organism=Saccharomyces cerevisiae, GI6324241, Length=187, Percent_Identity=27.2727272727273, Blast_Score=72, Evalue=5e-13, Organism=Drosophila melanogaster, GI17136538, Length=165, Percent_Identity=33.3333333333333, Blast_Score=85, Evalue=2e-16,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR020899 - InterPro: IPR005743 - InterPro: IPR006691 - InterPro: IPR002205 - InterPro: IPR013758 - InterPro: IPR013757 - InterPro: IPR013760 [H]
Pfam domain/function: PF03989 DNA_gyraseA_C; PF00521 DNA_topoisoIV [H]
EC number: =5.99.1.3 [H]
Molecular weight: Translated: 98692; Mature: 98561
Theoretical pI: Translated: 5.04; Mature: 5.04
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.8 %Cys (Translated Protein) 3.4 %Met (Translated Protein) 4.2 %Cys+Met (Translated Protein) 0.8 %Cys (Mature Protein) 3.3 %Met (Mature Protein) 4.0 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MADDEKPDEQNQADRQGLVTGRHVGIQPVEIRDEIQNAYLDYAMSVIVGRALPDVRDGLK CCCCCCCCCCCHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH PVHRRVIYAMYDGGYRPDRGWNKCSRVVGDVMGKYHPHGDSAIYDTLVRLAQPWAMRYKL HHHHHEEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCHHHEEEE VQGQGNFGSQGNDGAAAMRYTECKMAPLAMEMVRDIDQDTVDFQPNYDNKETEPVVLPSR EECCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEECCCC FPNLLVNGSSGIAVGMATNIPTHNLREVNEAVQWSLAHPNASHEELLEACMERIKGPDFP CCCEEEECCCCEEEEEECCCCCCHHHHHHHHHEEEECCCCCCHHHHHHHHHHHHCCCCCC GGALIVGRQGIEDAYRTGRGSVTMRAVIDMEEDKKGRQCLVVTELPYMCNPDNLATKIAD CCEEEEECCCHHHHHHCCCCCEEEEEEEECCCCCCCCEEEEEECCCCCCCCHHHHHHHHH LVNSGRINGIADIRDDSSARTGQRLVIVLKRDAQPRVVMNNLYKHTALQDTFGCNMLALV HHHCCCCCCEEECCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCEEEHH DNVPRTLRLDQFISYWIDHQMEVIRRRTEYRLAQAEKDAHIQRALVKALDMLDEVIALIR HCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH RSPNTEAASTGLQELLDIDEIQARAILDMQLRRLAALERQKIIDRLEELERLIADYKAIL CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH ASEDRQREIISTELAEIVDKYGDERRTRIIAADGDFSEEDFIPDDDVVVTITRGGYAKRT CCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCEEEEEECCCCCHHH RTDLYRVQKRGGKGVRGASLRADDEMAQLFTTTNHQWILFFTNMGRVYRTKVWQLPEAGR HHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHCCCCEEEEEEECCCCHHHHHHHCCCCCCC DARGGHVAGLLSFLPDEKIAQVMTLRSYDGAEYLLLATRKGMVKKTALKAYDSSRQAGVI CCCCCHHHHHHHHCCCHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHCCCCCCCEE AVNFRTEDDELIGAEQCSAADDVLLISRKGQAIRFSAGDDQLRPMGRATSGVTGMKFRGD EEEEECCCCHHCCHHHCCCCCCEEEEECCCCEEEEECCCCHHCCCCCCCCCCCCEEECCC DELLSMSIIHSDMPEDDRFVFTATGGGYAKRTAVSEYRQQGRGGVGIKAMALSEERGSLV HHHHHHHHHHCCCCCCCCEEEEECCCCCHHHHHHHHHHHCCCCCCCEEEEEECCCCCCEE GGLVVSEADEIIAIKTSGQITRSAVSEVPAKGRSTMGVKFVSVRGGDAVSIIAVNPEHTV CCEEEECCCCEEEEECCCCHHHHHHHHCCCCCCCCCCEEEEEECCCCEEEEEEECCCHHH EEEVADESVETVEGDATQAQSGGVVRRSDTVDDDRAVDTAGNDMKPEDNGE HHHHHHHHHHHHCCCCCHHCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCC >Mature Secondary Structure ADDEKPDEQNQADRQGLVTGRHVGIQPVEIRDEIQNAYLDYAMSVIVGRALPDVRDGLK CCCCCCCCCCHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHH PVHRRVIYAMYDGGYRPDRGWNKCSRVVGDVMGKYHPHGDSAIYDTLVRLAQPWAMRYKL HHHHHEEEEEECCCCCCCCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCHHHEEEE VQGQGNFGSQGNDGAAAMRYTECKMAPLAMEMVRDIDQDTVDFQPNYDNKETEPVVLPSR EECCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCEECCCC FPNLLVNGSSGIAVGMATNIPTHNLREVNEAVQWSLAHPNASHEELLEACMERIKGPDFP CCCEEEECCCCEEEEEECCCCCCHHHHHHHHHEEEECCCCCCHHHHHHHHHHHHCCCCCC GGALIVGRQGIEDAYRTGRGSVTMRAVIDMEEDKKGRQCLVVTELPYMCNPDNLATKIAD CCEEEEECCCHHHHHHCCCCCEEEEEEEECCCCCCCCEEEEEECCCCCCCCHHHHHHHHH LVNSGRINGIADIRDDSSARTGQRLVIVLKRDAQPRVVMNNLYKHTALQDTFGCNMLALV HHHCCCCCCEEECCCCCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCEEEHH DNVPRTLRLDQFISYWIDHQMEVIRRRTEYRLAQAEKDAHIQRALVKALDMLDEVIALIR HCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH RSPNTEAASTGLQELLDIDEIQARAILDMQLRRLAALERQKIIDRLEELERLIADYKAIL CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH ASEDRQREIISTELAEIVDKYGDERRTRIIAADGDFSEEDFIPDDDVVVTITRGGYAKRT CCCHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCCCCCCCCEEEEEECCCCCHHH RTDLYRVQKRGGKGVRGASLRADDEMAQLFTTTNHQWILFFTNMGRVYRTKVWQLPEAGR HHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHCCCCEEEEEEECCCCHHHHHHHCCCCCCC DARGGHVAGLLSFLPDEKIAQVMTLRSYDGAEYLLLATRKGMVKKTALKAYDSSRQAGVI CCCCCHHHHHHHHCCCHHHHHHHHHHCCCCCCEEEEECCCCHHHHHHHHHHCCCCCCCEE AVNFRTEDDELIGAEQCSAADDVLLISRKGQAIRFSAGDDQLRPMGRATSGVTGMKFRGD EEEEECCCCHHCCHHHCCCCCCEEEEECCCCEEEEECCCCHHCCCCCCCCCCCCEEECCC DELLSMSIIHSDMPEDDRFVFTATGGGYAKRTAVSEYRQQGRGGVGIKAMALSEERGSLV HHHHHHHHHHCCCCCCCCEEEEECCCCCHHHHHHHHHHHCCCCCCCEEEEEECCCCCCEE GGLVVSEADEIIAIKTSGQITRSAVSEVPAKGRSTMGVKFVSVRGGDAVSIIAVNPEHTV CCEEEECCCCEEEEECCCCHHHHHHHHCCCCCCCCCCEEEEEECCCCEEEEEEECCCHHH EEEVADESVETVEGDATQAQSGGVVRRSDTVDDDRAVDTAGNDMKPEDNGE HHHHHHHHHHHHCCCCCHHCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: 7828880; 12000953 [H]