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The map label for this gene is dnaX [H]

Identifier: 50365493

GI number: 50365493

Start: 787650

End: 789545

Strand: Reverse

Name: dnaX [H]

Synonym: Mfl678

Alternate gene names: 50365493

Gene position: 789545-787650 (Counterclockwise)

Preceding gene: 50365494

Following gene: 50365492

Centisome position: 99.54

GC content: 24.16

Gene sequence:

>1896_bases
ATGGAACAAAATAAAGCTTTATATAGAAAATATAGACCAAGTAATTTTGGTGATATAGCAGGGCACCAAAATGTTGTTGA
AATATTAAAGAACGAATTAAAAAATAATAAAATAAGTCACTCATTTCTTTTTGCTGGTCAAAGAGGAACTGGAAAAACAT
CAATAGCAAGAATTTTAGCCAAAAGTGTTAACTGTTTAAATATTAAAGATGGACTTGCTTGTGAAGTTTGTGAAAGTTGT
ATAGCTTCAAATGAACAAAGAAATCCTGACATTATAGAAATGGACGCTGCATCTAATAATGGTGTTGATGAAATTAGAGA
AATAAAAAATAATATTAATTCATTACCATTTATAGGTAAATACAAAATTTACATAATAGATGAAGTTCATATGTTAACAA
AAGCGGCTTTTAATGCATTACTTAAAACACTTGAAGAACCTCCTGTTCATGCAATATTTATTTTAGCAACAACTGAATAT
GCAAAAATACCAGCAACAATACTTTCAAGATGTCAGATATTTAATTTTAAAAAAATAGACAGAATATCATTGATGAATAG
ATTAAGTTTCATTTGTGAAAATGAAGGATATAAAATTGATAAAGCTGTACTTGAAGAAATAGCAATTATTTCAGAAGGAT
CACTAAGAGATGCATCAAACGTAATTGAACAATTAATGACTGTAACTTCAGATCACATAACAGTTGAAGATTTAAAATCA
GTTTTCTATGTTGCAACAAAAAATGAAAAAATGAAAATATTAACTAATATCTTAAATAATGATCCAGCAACAATAATAAA
TTATTTTGAAAAAGCTAATAATCAAGGAATGGATTTTGATGTTTTCACTTTAAGCTTAATAGAAATAGTAAAAGAAATAA
TTGAGTTCAAATTTACAAATGACGAAAATGTTTTAAATATATTAGACAAATCTGATTTAAATGAATTTGCTCAAGTAAAT
GTAAAGTCATTATTTGAAGTGGCTGATAATTTAAGTGAAGCATATGCAAAAACAAAAGGTACAAATATTAATTTTAATTA
TTTATTAATTAGCTTATTAAAAACTTTAAAAGAACCAACTGAACATAAAATAAAAATTGAAGAAAGTGTTTTAACAATTC
AAGAAAACATAATTGTAAAAGAAGTCATTGCTGAACCAGTTCATATACAAGAACCAGAAAAACAAATTTTAATTGAAAAA
GTTGAAGAAATAAAAGAAGAAGTTATAGAACAACCAATAAAAACATTTGAAGAAAAAATTACACAAGTAAAAGATATTGA
AATAAAAGAAGAAAGCGTTTCAATAGATGATGATTATGAATTAAAAACATTAACAAATTTAAAAATACAGTTAAATAAAA
ATTTAGTTGATAACGAAGAAAAGAAAACTTATAAAGTCGAAATTAATGAAGTTATAAACTTATTAGTTGGAGCCAATAAA
AATAAAAGAGAGGATATTGAAAATAAAATAAATAGCTTCTTTAAAGTGGATGAACAAGATAATTTATTAAATCCTGATTT
AGCAAAAAAATATATTAATTTTTTCAACTTTAAAGTTATAGCTGCATCTCAAAATGAAATCCTTTTAAGAGCTGATGATT
TTGAAAATGTAAATAACCTATTAGTATTTTTACAAAATGAAGAATATAGAGAGTCTATTCAAAAAGAATTTGGAAAAGCT
TTATTTTTACCAATTGATGAAACTCTTTGAAATGAAGTTAAAATATCATTTAAGAGACTTAAAGAAAATAATCAATTGCC
AAGTTATGAAGAAATAAATTATGATTCATATTTTGACAAGAAAAAGCAATCTATGGTGCTAAGTCATTTTGATGATAAAA
CAATTGAGGCAGCATCAAGATTATTTAATATAGATGAATTAGAAATAGAGGATTAG

Upstream 100 bases:

>100_bases
ATTAGTATTGATTTATATATTAATTACACACAAGAGGTTTATAACAACACTCAAAAATGTTAAAATTAATAATAAATATA
ATTTATTAGTTGGAGGATTC

Downstream 100 bases:

>100_bases
ATATGAATAATGAATTGTTTGAAGAAATTATAAATAATATAAATAAAAACAATGGACTTACTAAAAAGACAAGTGAGAGA
TTGGTAAATAATTTGATTAT

Product: DNA polymerase III gamma and tau subunits

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 631; Mature: 631

Protein sequence:

>631_residues
MEQNKALYRKYRPSNFGDIAGHQNVVEILKNELKNNKISHSFLFAGQRGTGKTSIARILAKSVNCLNIKDGLACEVCESC
IASNEQRNPDIIEMDAASNNGVDEIREIKNNINSLPFIGKYKIYIIDEVHMLTKAAFNALLKTLEEPPVHAIFILATTEY
AKIPATILSRCQIFNFKKIDRISLMNRLSFICENEGYKIDKAVLEEIAIISEGSLRDASNVIEQLMTVTSDHITVEDLKS
VFYVATKNEKMKILTNILNNDPATIINYFEKANNQGMDFDVFTLSLIEIVKEIIEFKFTNDENVLNILDKSDLNEFAQVN
VKSLFEVADNLSEAYAKTKGTNINFNYLLISLLKTLKEPTEHKIKIEESVLTIQENIIVKEVIAEPVHIQEPEKQILIEK
VEEIKEEVIEQPIKTFEEKITQVKDIEIKEESVSIDDDYELKTLTNLKIQLNKNLVDNEEKKTYKVEINEVINLLVGANK
NKREDIENKINSFFKVDEQDNLLNPDLAKKYINFFNFKVIAASQNEILLRADDFENVNNLLVFLQNEEYRESIQKEFGKA
LFLPIDETLWNEVKISFKRLKENNQLPSYEEINYDSYFDKKKQSMVLSHFDDKTIEAASRLFNIDELEIED

Sequences:

>Translated_631_residues
MEQNKALYRKYRPSNFGDIAGHQNVVEILKNELKNNKISHSFLFAGQRGTGKTSIARILAKSVNCLNIKDGLACEVCESC
IASNEQRNPDIIEMDAASNNGVDEIREIKNNINSLPFIGKYKIYIIDEVHMLTKAAFNALLKTLEEPPVHAIFILATTEY
AKIPATILSRCQIFNFKKIDRISLMNRLSFICENEGYKIDKAVLEEIAIISEGSLRDASNVIEQLMTVTSDHITVEDLKS
VFYVATKNEKMKILTNILNNDPATIINYFEKANNQGMDFDVFTLSLIEIVKEIIEFKFTNDENVLNILDKSDLNEFAQVN
VKSLFEVADNLSEAYAKTKGTNINFNYLLISLLKTLKEPTEHKIKIEESVLTIQENIIVKEVIAEPVHIQEPEKQILIEK
VEEIKEEVIEQPIKTFEEKITQVKDIEIKEESVSIDDDYELKTLTNLKIQLNKNLVDNEEKKTYKVEINEVINLLVGANK
NKREDIENKINSFFKVDEQDNLLNPDLAKKYINFFNFKVIAASQNEILLRADDFENVNNLLVFLQNEEYRESIQKEFGKA
LFLPIDETL*NEVKISFKRLKENNQLPSYEEINYDSYFDKKKQSMVLSHFDDKTIEAASRLFNIDELEIED
>Mature_631_residues
MEQNKALYRKYRPSNFGDIAGHQNVVEILKNELKNNKISHSFLFAGQRGTGKTSIARILAKSVNCLNIKDGLACEVCESC
IASNEQRNPDIIEMDAASNNGVDEIREIKNNINSLPFIGKYKIYIIDEVHMLTKAAFNALLKTLEEPPVHAIFILATTEY
AKIPATILSRCQIFNFKKIDRISLMNRLSFICENEGYKIDKAVLEEIAIISEGSLRDASNVIEQLMTVTSDHITVEDLKS
VFYVATKNEKMKILTNILNNDPATIINYFEKANNQGMDFDVFTLSLIEIVKEIIEFKFTNDENVLNILDKSDLNEFAQVN
VKSLFEVADNLSEAYAKTKGTNINFNYLLISLLKTLKEPTEHKIKIEESVLTIQENIIVKEVIAEPVHIQEPEKQILIEK
VEEIKEEVIEQPIKTFEEKITQVKDIEIKEESVSIDDDYELKTLTNLKIQLNKNLVDNEEKKTYKVEINEVINLLVGANK
NKREDIENKINSFFKVDEQDNLLNPDLAKKYINFFNFKVIAASQNEILLRADDFENVNNLLVFLQNEEYRESIQKEFGKA
LFLPIDETL*NEVKISFKRLKENNQLPSYEEINYDSYFDKKKQSMVLSHFDDKTIEAASRLFNIDELEIED

Specific function: DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria [H]

COG id: COG2812

COG function: function code L; DNA polymerase III, gamma/tau subunits

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI6677723, Length=264, Percent_Identity=26.1363636363636, Blast_Score=83, Evalue=6e-16,
Organism=Homo sapiens, GI194306571, Length=257, Percent_Identity=26.4591439688716, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI194306567, Length=257, Percent_Identity=26.4591439688716, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI4506491, Length=300, Percent_Identity=27.3333333333333, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI31881687, Length=300, Percent_Identity=27.3333333333333, Blast_Score=78, Evalue=2e-14,
Organism=Homo sapiens, GI31563534, Length=218, Percent_Identity=27.9816513761468, Blast_Score=73, Evalue=8e-13,
Organism=Escherichia coli, GI1786676, Length=293, Percent_Identity=34.8122866894198, Blast_Score=219, Evalue=4e-58,
Organism=Escherichia coli, GI1787341, Length=143, Percent_Identity=30.7692307692308, Blast_Score=63, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI71986063, Length=337, Percent_Identity=25.2225519287834, Blast_Score=89, Evalue=8e-18,
Organism=Caenorhabditis elegans, GI17554730, Length=226, Percent_Identity=27.4336283185841, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17541988, Length=223, Percent_Identity=28.2511210762332, Blast_Score=84, Evalue=3e-16,
Organism=Saccharomyces cerevisiae, GI6322528, Length=232, Percent_Identity=31.0344827586207, Blast_Score=95, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6324039, Length=317, Percent_Identity=23.3438485804416, Blast_Score=81, Evalue=4e-16,
Organism=Saccharomyces cerevisiae, GI6324478, Length=215, Percent_Identity=30.6976744186047, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI18859927, Length=236, Percent_Identity=31.3559322033898, Blast_Score=90, Evalue=6e-18,
Organism=Drosophila melanogaster, GI19921076, Length=216, Percent_Identity=27.3148148148148, Blast_Score=80, Evalue=5e-15,
Organism=Drosophila melanogaster, GI17647857, Length=236, Percent_Identity=26.271186440678, Blast_Score=69, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR003959
- InterPro:   IPR001270
- InterPro:   IPR008921
- InterPro:   IPR022754
- InterPro:   IPR012763 [H]

Pfam domain/function: PF00004 AAA; PF12169 DNA_pol3_gamma3 [H]

EC number: =2.7.7.7 [H]

Molecular weight: Translated: 72459; Mature: 72459

Theoretical pI: Translated: 4.63; Mature: 4.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEQNKALYRKYRPSNFGDIAGHQNVVEILKNELKNNKISHSFLFAGQRGTGKTSIARILA
CCCCHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEECCCCCCHHHHHHHHH
KSVNCLNIKDGLACEVCESCIASNEQRNPDIIEMDAASNNGVDEIREIKNNINSLPFIGK
HCCCEEECCCCCHHHHHHHHHHCCCCCCCCEEEECCCCCCCHHHHHHHHHHHCCCCCCCC
YKIYIIDEVHMLTKAAFNALLKTLEEPPVHAIFILATTEYAKIPATILSRCQIFNFKKID
EEEEEEEHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCHHHCHHHHHHHHHHCCCHHHH
RISLMNRLSFICENEGYKIDKAVLEEIAIISEGSLRDASNVIEQLMTVTSDHITVEDLKS
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCHHHHHH
VFYVATKNEKMKILTNILNNDPATIINYFEKANNQGMDFDVFTLSLIEIVKEIIEFKFTN
HEEEEECCCHHHHHHHHHCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHEECCC
DENVLNILDKSDLNEFAQVNVKSLFEVADNLSEAYAKTKGTNINFNYLLISLLKTLKEPT
CCCHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCC
EHKIKIEESVLTIQENIIVKEVIAEPVHIQEPEKQILIEKVEEIKEEVIEQPIKTFEEKI
CCEEEEHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TQVKDIEIKEESVSIDDDYELKTLTNLKIQLNKNLVDNEEKKTYKVEINEVINLLVGANK
HHHHCCEEECCCCCCCCCCCEEEEEEEEEEECCCCCCCCCCCEEEEEHHHHHHHHHCCCC
NKREDIENKINSFFKVDEQDNLLNPDLAKKYINFFNFKVIAASQNEILLRADDFENVNNL
CHHHHHHHHHHHHEECCCCCCCCCHHHHHHHHHHHCEEEEEECCCCEEEEECCCCCCCCE
LVFLQNEEYRESIQKEFGKALFLPIDETLNEVKISFKRLKENNQLPSYEEINYDSYFDKK
EEEEECHHHHHHHHHHHCCEEEEEHHHHHHHHHHHHHHHHCCCCCCCHHCCCCHHHHHHH
KQSMVLSHFDDKTIEAASRLFNIDELEIED
HHHHHHHHCCCHHHHHHHHHCCCCCEEECC
>Mature Secondary Structure
MEQNKALYRKYRPSNFGDIAGHQNVVEILKNELKNNKISHSFLFAGQRGTGKTSIARILA
CCCCHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEECCCCCCHHHHHHHHH
KSVNCLNIKDGLACEVCESCIASNEQRNPDIIEMDAASNNGVDEIREIKNNINSLPFIGK
HCCCEEECCCCCHHHHHHHHHHCCCCCCCCEEEECCCCCCCHHHHHHHHHHHCCCCCCCC
YKIYIIDEVHMLTKAAFNALLKTLEEPPVHAIFILATTEYAKIPATILSRCQIFNFKKID
EEEEEEEHHHHHHHHHHHHHHHHHCCCCCEEEEEEEECCHHHCHHHHHHHHHHCCCHHHH
RISLMNRLSFICENEGYKIDKAVLEEIAIISEGSLRDASNVIEQLMTVTSDHITVEDLKS
HHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCHHHHHH
VFYVATKNEKMKILTNILNNDPATIINYFEKANNQGMDFDVFTLSLIEIVKEIIEFKFTN
HEEEEECCCHHHHHHHHHCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHEECCC
DENVLNILDKSDLNEFAQVNVKSLFEVADNLSEAYAKTKGTNINFNYLLISLLKTLKEPT
CCCHHHHHCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCC
EHKIKIEESVLTIQENIIVKEVIAEPVHIQEPEKQILIEKVEEIKEEVIEQPIKTFEEKI
CCEEEEHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
TQVKDIEIKEESVSIDDDYELKTLTNLKIQLNKNLVDNEEKKTYKVEINEVINLLVGANK
HHHHCCEEECCCCCCCCCCCEEEEEEEEEEECCCCCCCCCCCEEEEEHHHHHHHHHCCCC
NKREDIENKINSFFKVDEQDNLLNPDLAKKYINFFNFKVIAASQNEILLRADDFENVNNL
CHHHHHHHHHHHHEECCCCCCCCCHHHHHHHHHHHCEEEEEECCCCEEEEECCCCCCCCE
LVFLQNEEYRESIQKEFGKALFLPIDETLNEVKISFKRLKENNQLPSYEEINYDSYFDKK
EEEEECHHHHHHHHHHHCCEEEEEHHHHHHHHHHHHHHHHCCCCCCCHHCCCCHHHHHHH
KQSMVLSHFDDKTIEAASRLFNIDELEIED
HHHHHHHHCCCHHHHHHHHHCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2124672; 7584024; 9384377; 2452406; 2468993; 1698458 [H]