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The map label for this gene is tmk [H]

Identifier: 50365491

GI number: 50365491

Start: 786420

End: 787055

Strand: Reverse

Name: tmk [H]

Synonym: Mfl676

Alternate gene names: 50365491

Gene position: 787055-786420 (Counterclockwise)

Preceding gene: 50365492

Following gene: 50365490

Centisome position: 99.22

GC content: 30.97

Gene sequence:

>636_bases
ATGTTCATAACAATTGAAGGAATGGATGGTAGTGGAAAAACAACTGCACTACAAAGAGTAAAACAATATTTAGAAGATTT
GAATTATAAAGTAGTTATGACTAGAGAACCTGGTGGACTACCGCTATCTGAAAAAATTAGAGAACTAATTTTAAATAAAG
ATGGTGTAGGAATGGAACCTTGAACAGAGGCGTTGCTTTTTATTGCTGCAAGAAAAGAACATCTTGAAAAAGTTATCAAA
CCTTATCTTAAAAAAGGATATATAGTTATATCTGACAGATTTATGGATTCAACAACCGCATATCAAGGTGGAGCTAGAGG
GCTTGGGGTTGATTACTTAAATGAGTTACAAAAAAATATTCTTGAAGGTTTTCTTCCTGATCTAACTTTATATTTTGAAT
TAAGTTTTGAGGATGCTGAAAAAAGACTTTCTGCAAGACCTGAAGAAAAGAATAGATTAGATGAAGAAGGAAGAAAGTTT
AAAGAAGCAGTAAAATTAGCTTTCGAAGAATTAGTGGTTAAAGAACCAAATAGAATAACTGTCATTGATGCTTCAAAATC
ACCTGAAGAAGTTTTTGAAGAAACTAAAAAAGTTATCTTAGAAAAGATTGAATTATGAAAAAAAGAGAAGCGTTAG

Upstream 100 bases:

>100_bases
AGAATAGCAAAAGGTATACCAATGGGTGGTAGCCTTGATTATATGGATGAAACAACACTTGAAAGCGCATTTAAAAATAG
AAAGAAATACGAGGTTTAAT

Downstream 100 bases:

>100_bases
AAAAATTTGTTGAGCAATTAAAAAATAAAAAGATGTTTAGCTCTATATTAATTTCAAACGATAATCAAGAAACTTTAAAT
GATTTTGCAAACAATTTATC

Product: thymidylate kinase

Products: NA

Alternate protein names: dTMP kinase [H]

Number of amino acids: Translated: 211; Mature: 211

Protein sequence:

>211_residues
MFITIEGMDGSGKTTALQRVKQYLEDLNYKVVMTREPGGLPLSEKIRELILNKDGVGMEPWTEALLFIAARKEHLEKVIK
PYLKKGYIVISDRFMDSTTAYQGGARGLGVDYLNELQKNILEGFLPDLTLYFELSFEDAEKRLSARPEEKNRLDEEGRKF
KEAVKLAFEELVVKEPNRITVIDASKSPEEVFEETKKVILEKIELWKKEKR

Sequences:

>Translated_211_residues
MFITIEGMDGSGKTTALQRVKQYLEDLNYKVVMTREPGGLPLSEKIRELILNKDGVGMEP*TEALLFIAARKEHLEKVIK
PYLKKGYIVISDRFMDSTTAYQGGARGLGVDYLNELQKNILEGFLPDLTLYFELSFEDAEKRLSARPEEKNRLDEEGRKF
KEAVKLAFEELVVKEPNRITVIDASKSPEEVFEETKKVILEKIEL*KKEKR
>Mature_211_residues
MFITIEGMDGSGKTTALQRVKQYLEDLNYKVVMTREPGGLPLSEKIRELILNKDGVGMEP*TEALLFIAARKEHLEKVIK
PYLKKGYIVISDRFMDSTTAYQGGARGLGVDYLNELQKNILEGFLPDLTLYFELSFEDAEKRLSARPEEKNRLDEEGRKF
KEAVKLAFEELVVKEPNRITVIDASKSPEEVFEETKKVILEKIEL*KKEKR

Specific function: Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis [H]

COG id: COG0125

COG function: function code F; Thymidylate kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the thymidylate kinase family [H]

Homologues:

Organism=Escherichia coli, GI1787340, Length=206, Percent_Identity=39.8058252427184, Blast_Score=131, Evalue=3e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR018095
- InterPro:   IPR018094 [H]

Pfam domain/function: PF02223 Thymidylate_kin [H]

EC number: =2.7.4.9 [H]

Molecular weight: Translated: 23939; Mature: 23939

Theoretical pI: Translated: 5.31; Mature: 5.31

Prosite motif: PS01331 THYMIDYLATE_KINASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFITIEGMDGSGKTTALQRVKQYLEDLNYKVVMTREPGGLPLSEKIRELILNKDGVGMEP
CEEEEECCCCCCHHHHHHHHHHHHHHCCEEEEEEECCCCCCHHHHHHHHHHCCCCCCCCH
TEALLFIAARKEHLEKVIKPYLKKGYIVISDRFMDSTTAYQGGARGLGVDYLNELQKNIL
HHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCHHHHCCCCCCCCHHHHHHHHHHHH
EGFLPDLTLYFELSFEDAEKRLSARPEEKNRLDEEGRKFKEAVKLAFEELVVKEPNRITV
HHHCCCEEEEEEECHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEE
IDASKSPEEVFEETKKVILEKIELKKEKR
EECCCCHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MFITIEGMDGSGKTTALQRVKQYLEDLNYKVVMTREPGGLPLSEKIRELILNKDGVGMEP
CEEEEECCCCCCHHHHHHHHHHHHHHCCEEEEEEECCCCCCHHHHHHHHHHCCCCCCCCH
TEALLFIAARKEHLEKVIKPYLKKGYIVISDRFMDSTTAYQGGARGLGVDYLNELQKNIL
HHHHHHHHHHHHHHHHHHHHHHHCCEEEEECCCCCCHHHHCCCCCCCCHHHHHHHHHHHH
EGFLPDLTLYFELSFEDAEKRLSARPEEKNRLDEEGRKFKEAVKLAFEELVVKEPNRITV
HHHCCCEEEEEEECHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEE
IDASKSPEEVFEETKKVILEKIELKKEKR
EECCCCHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA