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The map label for this gene is frlA [H]

Identifier: 50365421

GI number: 50365421

Start: 709256

End: 710644

Strand: Reverse

Name: frlA [H]

Synonym: Mfl605

Alternate gene names: 50365421

Gene position: 710644-709256 (Counterclockwise)

Preceding gene: 50365422

Following gene: 50365420

Centisome position: 89.59

GC content: 26.93

Gene sequence:

>1389_bases
ATGAAACTAAATAAAAAATATGGATTTTGAACAGTATTAGCATCTACATTAGCTGCAATAGTAGGTTCAAGCATTATAAT
TTCTTTTAATATGGTATTTGCTTTATCTGAAGCAAATCCTCTTTTAATGATATTGGCGTGAGTTTTTGGAGCTTTAATAG
TTCTACCTGATGCATTTATTGTTATTGAACCTTCAATAGGTTATGGAGAAAGTGGTAGTGGTTATAGTTGAATTAGAAAA
TGTAATTGAAGAATATTAGCATTTTGATTTGGTTGAGTTTTAATTTTATTTGTTTCAGCAACATCTTTGGCTAGTTGTTG
TTCTGCAATGAGTTCTATGATAACTCAAATCTTAGAATTAAATCCTGAAGAAATAGCAGTTGAAACATTACAAAAAAGCT
TAGCAATATTTATCTTGATATTTTTGGCTGGGATTCAAATAATGATTAAAAATAGTAGTAAATACACACAGTTATTCTTT
TTATTTGTTAAAACATTACCAATCATATTAGTTTTTATTTTAGCAATAATGTATGGTTCAAAAGATGGTTTACTTTCAAA
TTCAGAAATGAATAAGAATTTAGGGCATGCATATATTTCATCTGCTATGTTGATTCCAGCAATAACATATACAGGGTTTG
CATATTCTGGTCATGAATTCCCAACATACATTACAGAAGAAATTGAAAATCCTAAAAAAACAATTCCATGAGTCATCATT
AGTGCTGTATTAATAGTTTTAGTTATATACGTTTGTTATGGTATTGCTCTTTTATCATTAGCAACACCTGACTCAAATGG
AAATTGAATAAATCCAGGAGGAACAACGTCATCAATTTTTGCTCAGCATAGATGGGCTGTTTTAACTTTTAATATTTTTG
CAATATTTTTATTTATTGGTTCTGTAAACTCTTTATTATTTTTTCAATCAAGACTAATACATAAATTATCTGAAACTGGA
GATGTTCATTCTGTTTTTGGAAAAGTGCATAAAAAAACAAATCAACCTTATATGGCAATTATCTTGTTATGTTGTGTTGC
AGTATTTTATATTTTATTTAGTTCTATTTCTGAAATCATTTCTTCATTTGCGTTAGCTACAAGTGTTTTAAAAATTTTAT
TAAACTCATCGATAATAAAATTAAGACTGAAAGATCCAGAATATAAAAAAATATATGGAAATAAAACTTTCTGAACACTA
ATGATTTTAAGTTTAGTTACATGTGCTCTTACATTTATAGGTTCAATTTATTTAATGGTTATAATGCCCCATCAACAAAC
AGGTGCAAGTACATTCTCAATCTTGTGAAAACCTATTTTAATGGTTCTTATCGCATTCTTAGTTTACTTGTTTGGAATTT
TTAAATTTAATAATATAAAAATCAAATAA

Upstream 100 bases:

>100_bases
ATTTGAACACCCGAAGGCTCAGAGCATGTAAATACAATTAAGACTTATAATGATGATTACATTCTTAAAACAATAAATTT
TGCTAGAAAGTGAGAAGTAA

Downstream 100 bases:

>100_bases
CTTTTAAGTTATTTTTTTTATTAAGTGTTATCTTATATATATGAACTACTAAAGTTCATTTATTTAAAAGGAGACATATG
ATAGACATTATCAAAGGTTT

Product: putative amino acid/amine (lysine) APC transporter

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 462; Mature: 462

Protein sequence:

>462_residues
MKLNKKYGFWTVLASTLAAIVGSSIIISFNMVFALSEANPLLMILAWVFGALIVLPDAFIVIEPSIGYGESGSGYSWIRK
CNWRILAFWFGWVLILFVSATSLASCCSAMSSMITQILELNPEEIAVETLQKSLAIFILIFLAGIQIMIKNSSKYTQLFF
LFVKTLPIILVFILAIMYGSKDGLLSNSEMNKNLGHAYISSAMLIPAITYTGFAYSGHEFPTYITEEIENPKKTIPWVII
SAVLIVLVIYVCYGIALLSLATPDSNGNWINPGGTTSSIFAQHRWAVLTFNIFAIFLFIGSVNSLLFFQSRLIHKLSETG
DVHSVFGKVHKKTNQPYMAIILLCCVAVFYILFSSISEIISSFALATSVLKILLNSSIIKLRLKDPEYKKIYGNKTFWTL
MILSLVTCALTFIGSIYLMVIMPHQQTGASTFSILWKPILMVLIAFLVYLFGIFKFNNIKIK

Sequences:

>Translated_462_residues
MKLNKKYGF*TVLASTLAAIVGSSIIISFNMVFALSEANPLLMILA*VFGALIVLPDAFIVIEPSIGYGESGSGYS*IRK
CN*RILAF*FG*VLILFVSATSLASCCSAMSSMITQILELNPEEIAVETLQKSLAIFILIFLAGIQIMIKNSSKYTQLFF
LFVKTLPIILVFILAIMYGSKDGLLSNSEMNKNLGHAYISSAMLIPAITYTGFAYSGHEFPTYITEEIENPKKTIP*VII
SAVLIVLVIYVCYGIALLSLATPDSNGN*INPGGTTSSIFAQHRWAVLTFNIFAIFLFIGSVNSLLFFQSRLIHKLSETG
DVHSVFGKVHKKTNQPYMAIILLCCVAVFYILFSSISEIISSFALATSVLKILLNSSIIKLRLKDPEYKKIYGNKTF*TL
MILSLVTCALTFIGSIYLMVIMPHQQTGASTFSIL*KPILMVLIAFLVYLFGIFKFNNIKIK
>Mature_462_residues
MKLNKKYGF*TVLASTLAAIVGSSIIISFNMVFALSEANPLLMILA*VFGALIVLPDAFIVIEPSIGYGESGSGYS*IRK
CN*RILAF*FG*VLILFVSATSLASCCSAMSSMITQILELNPEEIAVETLQKSLAIFILIFLAGIQIMIKNSSKYTQLFF
LFVKTLPIILVFILAIMYGSKDGLLSNSEMNKNLGHAYISSAMLIPAITYTGFAYSGHEFPTYITEEIENPKKTIP*VII
SAVLIVLVIYVCYGIALLSLATPDSNGN*INPGGTTSSIFAQHRWAVLTFNIFAIFLFIGSVNSLLFFQSRLIHKLSETG
DVHSVFGKVHKKTNQPYMAIILLCCVAVFYILFSSISEIISSFALATSVLKILLNSSIIKLRLKDPEYKKIYGNKTF*TL
MILSLVTCALTFIGSIYLMVIMPHQQTGASTFSIL*KPILMVLIAFLVYLFGIFKFNNIKIK

Specific function: May be involved in fructoselysine transport [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily [H]

Homologues:

Organism=Escherichia coli, GI87082250, Length=431, Percent_Identity=27.1461716937355, Blast_Score=104, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17540018, Length=147, Percent_Identity=31.2925170068027, Blast_Score=68, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17568033, Length=331, Percent_Identity=24.773413897281, Blast_Score=65, Evalue=6e-11,
Organism=Drosophila melanogaster, GI45550968, Length=285, Percent_Identity=26.3157894736842, Blast_Score=65, Evalue=1e-10,
Organism=Drosophila melanogaster, GI19921172, Length=285, Percent_Identity=26.3157894736842, Blast_Score=65, Evalue=1e-10,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 49499; Mature: 49499

Theoretical pI: Translated: 9.41; Mature: 9.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLNKKYGFTVLASTLAAIVGSSIIISFNMVFALSEANPLLMILAVFGALIVLPDAFIVI
CCCCCCCCHHHHHHHHHHHHCCHHHEEEHHHEEECCCCHHHHHHHHHHHHHHCCCCEEEE
EPSIGYGESGSGYSIRKCNRILAFFGVLILFVSATSLASCCSAMSSMITQILELNPEEIA
ECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
VETLQKSLAIFILIFLAGIQIMIKNSSKYTQLFFLFVKTLPIILVFILAIMYGSKDGLLS
HHHHHHHHHHHHHHHHHHHEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
NSEMNKNLGHAYISSAMLIPAITYTGFAYSGHEFPTYITEEIENPKKTIPVIISAVLIVL
CCHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCHHHHHHHCCCHHHHHHHHHHHHHHH
VIYVCYGIALLSLATPDSNGNINPGGTTSSIFAQHRWAVLTFNIFAIFLFIGSVNSLLFF
HHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QSRLIHKLSETGDVHSVFGKVHKKTNQPYMAIILLCCVAVFYILFSSISEIISSFALATS
HHHHHHHHHCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VLKILLNSSIIKLRLKDPEYKKIYGNKTFTLMILSLVTCALTFIGSIYLMVIMPHQQTGA
HHHHHHCCCEEEEEECCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCC
STFSILKPILMVLIAFLVYLFGIFKFNNIKIK
HHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEC
>Mature Secondary Structure
MKLNKKYGFTVLASTLAAIVGSSIIISFNMVFALSEANPLLMILAVFGALIVLPDAFIVI
CCCCCCCCHHHHHHHHHHHHCCHHHEEEHHHEEECCCCHHHHHHHHHHHHHHCCCCEEEE
EPSIGYGESGSGYSIRKCNRILAFFGVLILFVSATSLASCCSAMSSMITQILELNPEEIA
ECCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHH
VETLQKSLAIFILIFLAGIQIMIKNSSKYTQLFFLFVKTLPIILVFILAIMYGSKDGLLS
HHHHHHHHHHHHHHHHHHHEEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
NSEMNKNLGHAYISSAMLIPAITYTGFAYSGHEFPTYITEEIENPKKTIPVIISAVLIVL
CCHHHHHHHHHHHHHHHHHHHHHHCCCEECCCCCCHHHHHHHCCCHHHHHHHHHHHHHHH
VIYVCYGIALLSLATPDSNGNINPGGTTSSIFAQHRWAVLTFNIFAIFLFIGSVNSLLFF
HHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
QSRLIHKLSETGDVHSVFGKVHKKTNQPYMAIILLCCVAVFYILFSSISEIISSFALATS
HHHHHHHHHCCCCHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
VLKILLNSSIIKLRLKDPEYKKIYGNKTFTLMILSLVTCALTFIGSIYLMVIMPHQQTGA
HHHHHHCCCEEEEEECCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCC
STFSILKPILMVLIAFLVYLFGIFKFNNIKIK
HHHHHHHHHHHHHHHHHHHHHHHHHHCCEEEC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]