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The map label for this gene is pgcA [H]

Identifier: 50364935

GI number: 50364935

Start: 144340

End: 146025

Strand: Direct

Name: pgcA [H]

Synonym: Mfl120

Alternate gene names: 50364935

Gene position: 144340-146025 (Clockwise)

Preceding gene: 50364933

Following gene: 50364936

Centisome position: 18.2

GC content: 28.83

Gene sequence:

>1686_bases
ATGGTTTTTGATAAAAATAACAAAGTTTATAGTGAATGAATAAATAGCCAAAAATTGGATGATGAGTTGAAAAGCCTTTT
AGTAAATGCTACTGATGATGAATTGCATGCAGCATTTGAAGGAATAGAGTTAGAATTTGGAACAGCAGGTATAAGAGGTA
TTCTTGGAGCAGGACCTGGAAGATTTAACGTTTACACTGTTAAAAAAGTTACTATTGCATTTGCAGAATTATTAAAACAA
AATTACCCAAATAGGTTGAATGATGGAATAGTTGTTGGTCATGATAACCGTCATAATTCTAAACAGTTTGCAAAAGTTGT
AGCCGAAGTTTTATCAAGCTTTGGAATTAAAGCATATTTATTTAAAGAAAATGAAATGATGCCTACACCTGTTGTTTCAT
ATGCAACTAAATTTTTAAACTGTATTGGAGGTATTGTAATAACAGCATCACATAATCCTTCAGAATATAACGGTTATAAA
ATATATGATCCATACGGATGTCAATTGCAAGATGAACAAACAGCAATTATTGCAAAAAGAATGGATGAAATTACAGACAT
TTTAAATTGAGAATATAAAATAAATGATTCGCTAATAGAAACAGTTAGCGAAAATGTTATTAAAGAATATGTAGATATGA
TTAAAAATCTTGAATTCTACAAAAAAGAGCAAGAAGCTAAAAAAGATTTAAAAATTATTTTTAGCGCAGTTAATGGAACA
GGAACTAAATTTACCCCAAAAATATTACGTGAATCAGGATATAACGTTATTGAGGTTGAAGAGCATGCATTTGAAGATGA
AACATTTAAAAATGTTGTAAATCCAAATCCAGAATTTGATCCTGCATGAAAAATACCGCTTGAATATGGTATTAAACATG
ATGCAGATATTATTATTATGAATGACCCAGATGCTGACAGATTTGGAATGGCAATAAAACATGATGGTCATTTTGTAAGA
TTAGATGGAAATCAAACAGGACCAATTTTAATTGATTGAAAATTATCAAATCTAAAACGCTTAAATAGCATTCCAAAAAA
TCCGGCTCTATATTCAAGTTTTGTAACAAGTGATTTGGGTGATAGAATCGCTCATGAAAAATATGGAGTTAATATTGTAA
AAACTTTAACTGGATTTAAATGAATGGGTAGAGAAATTGCTAAAGAAGAAGATAACGGATTAAATTTTGTTTTTGCTTAT
GAAGAAAGTTATGGATATGTAATTGATGACTCAGCTAGAGATAAAGATGGAATACAAGCTTCTATATTAATAGCAGAGGC
TGCTTGATTTTATAAAAAACAAAATAAAACATTAGTAGACTATTTAGAAGATTTATTTAAAGAAATGGGTGCATATTACA
CTTTCACTTTAAACTTGAATTTTAAACCAGAAGAAAAGAAATTAAAAATTGAACCATTAATGAAATCATTGAGAGCAACA
CCCTTAACTCAAATTGCTGGACTTAAAGTTGTTAATGTTGAAGACTACATCGATGGAATGTATAATATGCCAGGACAAGA
CTTACTAAAATTTTATTTAGAAGATAAGTCATGATTTGCTGTTCGCCCAAGTGGAACTGAACCTAAACTAAAAATTTATT
TTATAGGTGTTGGTGAATCTGTTCAAAACGCTAAAGTTAAAGTAGACGAAATTATTAAAGAATTAAAATTAAAAATGAAT
ATATAG

Upstream 100 bases:

>100_bases
GTTCATAAGTCTCCTTTTGTAAGAGTGCACAATATTTACACCATTACTCTTTCTACTATATTATAATAGAATAGACATAT
AAAAAACATAAGGAGTACAA

Downstream 100 bases:

>100_bases
GAGAAAAAATGAAACTAAACAAATATATAGATCACACATTATTAAAACAAGATGCTACGAAAGCTGAAATTAAACAATTA
TGTGATGAAGCAATTGAATT

Product: phosphomannomutase/phosphoglucomutase-like protein

Products: NA

Alternate protein names: PGM; Alpha-phosphoglucomutase; Glucose phosphomutase [H]

Number of amino acids: Translated: 561; Mature: 561

Protein sequence:

>561_residues
MVFDKNNKVYSEWINSQKLDDELKSLLVNATDDELHAAFEGIELEFGTAGIRGILGAGPGRFNVYTVKKVTIAFAELLKQ
NYPNRLNDGIVVGHDNRHNSKQFAKVVAEVLSSFGIKAYLFKENEMMPTPVVSYATKFLNCIGGIVITASHNPSEYNGYK
IYDPYGCQLQDEQTAIIAKRMDEITDILNWEYKINDSLIETVSENVIKEYVDMIKNLEFYKKEQEAKKDLKIIFSAVNGT
GTKFTPKILRESGYNVIEVEEHAFEDETFKNVVNPNPEFDPAWKIPLEYGIKHDADIIIMNDPDADRFGMAIKHDGHFVR
LDGNQTGPILIDWKLSNLKRLNSIPKNPALYSSFVTSDLGDRIAHEKYGVNIVKTLTGFKWMGREIAKEEDNGLNFVFAY
EESYGYVIDDSARDKDGIQASILIAEAAWFYKKQNKTLVDYLEDLFKEMGAYYTFTLNLNFKPEEKKLKIEPLMKSLRAT
PLTQIAGLKVVNVEDYIDGMYNMPGQDLLKFYLEDKSWFAVRPSGTEPKLKIYFIGVGESVQNAKVKVDEIIKELKLKMN
I

Sequences:

>Translated_561_residues
MVFDKNNKVYSE*INSQKLDDELKSLLVNATDDELHAAFEGIELEFGTAGIRGILGAGPGRFNVYTVKKVTIAFAELLKQ
NYPNRLNDGIVVGHDNRHNSKQFAKVVAEVLSSFGIKAYLFKENEMMPTPVVSYATKFLNCIGGIVITASHNPSEYNGYK
IYDPYGCQLQDEQTAIIAKRMDEITDILN*EYKINDSLIETVSENVIKEYVDMIKNLEFYKKEQEAKKDLKIIFSAVNGT
GTKFTPKILRESGYNVIEVEEHAFEDETFKNVVNPNPEFDPA*KIPLEYGIKHDADIIIMNDPDADRFGMAIKHDGHFVR
LDGNQTGPILID*KLSNLKRLNSIPKNPALYSSFVTSDLGDRIAHEKYGVNIVKTLTGFK*MGREIAKEEDNGLNFVFAY
EESYGYVIDDSARDKDGIQASILIAEAA*FYKKQNKTLVDYLEDLFKEMGAYYTFTLNLNFKPEEKKLKIEPLMKSLRAT
PLTQIAGLKVVNVEDYIDGMYNMPGQDLLKFYLEDKS*FAVRPSGTEPKLKIYFIGVGESVQNAKVKVDEIIKELKLKMN
I
>Mature_561_residues
MVFDKNNKVYSE*INSQKLDDELKSLLVNATDDELHAAFEGIELEFGTAGIRGILGAGPGRFNVYTVKKVTIAFAELLKQ
NYPNRLNDGIVVGHDNRHNSKQFAKVVAEVLSSFGIKAYLFKENEMMPTPVVSYATKFLNCIGGIVITASHNPSEYNGYK
IYDPYGCQLQDEQTAIIAKRMDEITDILN*EYKINDSLIETVSENVIKEYVDMIKNLEFYKKEQEAKKDLKIIFSAVNGT
GTKFTPKILRESGYNVIEVEEHAFEDETFKNVVNPNPEFDPA*KIPLEYGIKHDADIIIMNDPDADRFGMAIKHDGHFVR
LDGNQTGPILID*KLSNLKRLNSIPKNPALYSSFVTSDLGDRIAHEKYGVNIVKTLTGFK*MGREIAKEEDNGLNFVFAY
EESYGYVIDDSARDKDGIQASILIAEAA*FYKKQNKTLVDYLEDLFKEMGAYYTFTLNLNFKPEEKKLKIEPLMKSLRAT
PLTQIAGLKVVNVEDYIDGMYNMPGQDLLKFYLEDKS*FAVRPSGTEPKLKIYFIGVGESVQNAKVKVDEIIKELKLKMN
I

Specific function: Catalyzes the interconversion between glucose-6- phosphate and alpha-glucose-1-phosphate. This is the first step in the biosynthesis of diglucosyl-diacylglycerol (Glc2-DAG), i.e. the predominant glycolipid found in B.subtilis membrane, which is also used

COG id: COG1109

COG function: function code G; Phosphomannomutase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphohexose mutase family [H]

Homologues:

Organism=Homo sapiens, GI31377548, Length=568, Percent_Identity=29.4014084507042, Blast_Score=200, Evalue=4e-51,
Organism=Homo sapiens, GI63055049, Length=548, Percent_Identity=30.1094890510949, Blast_Score=196, Evalue=5e-50,
Organism=Escherichia coli, GI1786904, Length=552, Percent_Identity=26.0869565217391, Blast_Score=84, Evalue=3e-17,
Organism=Escherichia coli, GI1789566, Length=418, Percent_Identity=25.5980861244019, Blast_Score=76, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI71993870, Length=576, Percent_Identity=32.2916666666667, Blast_Score=204, Evalue=8e-53,
Organism=Caenorhabditis elegans, GI71993878, Length=320, Percent_Identity=35, Blast_Score=156, Evalue=3e-38,
Organism=Saccharomyces cerevisiae, GI6323934, Length=460, Percent_Identity=32.3913043478261, Blast_Score=186, Evalue=7e-48,
Organism=Drosophila melanogaster, GI20129809, Length=527, Percent_Identity=29.4117647058824, Blast_Score=189, Evalue=4e-48,
Organism=Drosophila melanogaster, GI24651977, Length=430, Percent_Identity=31.1627906976744, Blast_Score=185, Evalue=8e-47,
Organism=Drosophila melanogaster, GI24653722, Length=476, Percent_Identity=28.5714285714286, Blast_Score=171, Evalue=1e-42,
Organism=Drosophila melanogaster, GI17864244, Length=438, Percent_Identity=24.8858447488584, Blast_Score=67, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005844
- InterPro:   IPR016055
- InterPro:   IPR005845
- InterPro:   IPR005846
- InterPro:   IPR005843
- InterPro:   IPR016066
- InterPro:   IPR005841 [H]

Pfam domain/function: PF02878 PGM_PMM_I; PF02879 PGM_PMM_II; PF02880 PGM_PMM_III; PF00408 PGM_PMM_IV [H]

EC number: =5.4.2.2 [H]

Molecular weight: Translated: 62492; Mature: 62492

Theoretical pI: Translated: 5.11; Mature: 5.11

Prosite motif: PS00710 PGM_PMM

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVFDKNNKVYSEINSQKLDDELKSLLVNATDDELHAAFEGIELEFGTAGIRGILGAGPGR
CEECCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCEEEEECCCCHHHHHCCCCCC
FNVYTVKKVTIAFAELLKQNYPNRLNDGIVVGHDNRHNSKQFAKVVAEVLSSFGIKAYLF
EEEEEHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHCCCEEEEE
KENEMMPTPVVSYATKFLNCIGGIVITASHNPSEYNGYKIYDPYGCQLQDEQTAIIAKRM
ECCCCCCCHHHHHHHHHHHHHCCEEEEECCCCCCCCCEEEECCCCCEECCCHHHHHHHHH
DEITDILNEYKINDSLIETVSENVIKEYVDMIKNLEFYKKEQEAKKDLKIIFSAVNGTGT
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCC
KFTPKILRESGYNVIEVEEHAFEDETFKNVVNPNPEFDPAKIPLEYGIKHDADIIIMNDP
CCCHHHHHHCCCCEEEEHHHHCCCHHHHHHCCCCCCCCCCCCCHHHCCCCCCCEEEECCC
DADRFGMAIKHDGHFVRLDGNQTGPILIDKLSNLKRLNSIPKNPALYSSFVTSDLGDRIA
CCHHHCEEEEECCEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
HEKYGVNIVKTLTGFKMGREIAKEEDNGLNFVFAYEESYGYVIDDSARDKDGIQASILIA
HHHCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCEEECCCCCCCCCCEEEEEEH
EAAFYKKQNKTLVDYLEDLFKEMGAYYTFTLNLNFKPEEKKLKIEPLMKSLRATPLTQIA
HHHHHHHCCCHHHHHHHHHHHHCCCEEEEEEEEEECCCHHCEEHHHHHHHHCCCCCHHHH
GLKVVNVEDYIDGMYNMPGQDLLKFYLEDKSFAVRPSGTEPKLKIYFIGVGESVQNAKVK
CEEEEEHHHHHHHHHCCCHHHHHHHHHCCCCEEECCCCCCCEEEEEEEEECCCCCCCEEE
VDEIIKELKLKMNI
HHHHHHHHHHHCCC
>Mature Secondary Structure
MVFDKNNKVYSEINSQKLDDELKSLLVNATDDELHAAFEGIELEFGTAGIRGILGAGPGR
CEECCCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHCCEEEEECCCCHHHHHCCCCCC
FNVYTVKKVTIAFAELLKQNYPNRLNDGIVVGHDNRHNSKQFAKVVAEVLSSFGIKAYLF
EEEEEHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHCCCEEEEE
KENEMMPTPVVSYATKFLNCIGGIVITASHNPSEYNGYKIYDPYGCQLQDEQTAIIAKRM
ECCCCCCCHHHHHHHHHHHHHCCEEEEECCCCCCCCCEEEECCCCCEECCCHHHHHHHHH
DEITDILNEYKINDSLIETVSENVIKEYVDMIKNLEFYKKEQEAKKDLKIIFSAVNGTGT
HHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECCCCCC
KFTPKILRESGYNVIEVEEHAFEDETFKNVVNPNPEFDPAKIPLEYGIKHDADIIIMNDP
CCCHHHHHHCCCCEEEEHHHHCCCHHHHHHCCCCCCCCCCCCCHHHCCCCCCCEEEECCC
DADRFGMAIKHDGHFVRLDGNQTGPILIDKLSNLKRLNSIPKNPALYSSFVTSDLGDRIA
CCHHHCEEEEECCEEEEECCCCCCCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHH
HEKYGVNIVKTLTGFKMGREIAKEEDNGLNFVFAYEESYGYVIDDSARDKDGIQASILIA
HHHCCCHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCEEECCCCCCCCCCEEEEEEH
EAAFYKKQNKTLVDYLEDLFKEMGAYYTFTLNLNFKPEEKKLKIEPLMKSLRATPLTQIA
HHHHHHHCCCHHHHHHHHHHHHCCCEEEEEEEEEECCCHHCEEHHHHHHHHCCCCCHHHH
GLKVVNVEDYIDGMYNMPGQDLLKFYLEDKSFAVRPSGTEPKLKIYFIGVGESVQNAKVK
CEEEEEHHHHHHHHHCCCHHHHHHHHHCCCCEEECCCCCCCEEEEEEEEECCCCCCCEEE
VDEIIKELKLKMNI
HHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377; 2127799 [H]