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The map label for this gene is atpA [H]

Identifier: 50364928

GI number: 50364928

Start: 136424

End: 138001

Strand: Direct

Name: atpA [H]

Synonym: Mfl113

Alternate gene names: 50364928

Gene position: 136424-138001 (Clockwise)

Preceding gene: 50364927

Following gene: 50364929

Centisome position: 17.2

GC content: 31.12

Gene sequence:

>1578_bases
ATGGCATTAAATATTAAAGAAATCTCTGAAGTAATTGAAAAACAAATAAAAAACTATGGTAAAGATATTATTGAAGCTGA
GCAAGGTAGTGTTGTTACTATTGGGGATGGTGTTTCTTTAATTTACGGATTAGACAAAGCTTTAATGGGTGAATTGTTAA
TTTTCCCTAATGATGTTTATGGTATGGTTTTAAGTCTTGAAGAAGGAGCTGTTGGAGCTGTTATTCTTGGAGATTATAAA
CTTATCAAAGAAGGTGACATTGTTAAACGTACAGGTAAAGTTGTTGAAACACCTGTTGGTGATGCAATGATTGGTAGAGT
TGTTAATGCATTGGGACAACCAATTGACAATAATGGACCAATCAAAACTAAAAAATCTAAACCAGTTGAAAGAATAGCAA
CAGGAGTTATGGCTCGTAAATCAGTTAGTCAACCTCTAGAAACAGGTATTCTTGGAATTGATGCATCTATTCCAATTGGA
AAAGGACAACGTGAGTTAATCATTGGAGATCGTCAAACTGGTAAAACAGCTGTAGCAATTGATACAATCATTAACCAAAA
AGGTAAAAATGTTAAATGTATTTATGTATCAATTGGACAAAAAGATTCAACAATTGCACAAGTTGTTGAAAAACTTAAAA
AATTTGGTGCAATGGAATATACTACTGTTGTTAATGCAGGAGCTAGTGATTCAGCACCATTACAATATTTAGCACCATAT
ACTGGTGTAACTATTGGTGAAGAATGAATGGAAAATGGAGAAGACGTTTTAATTGTTTATGATGACTTATCAAAACATGC
GGTTGCTTATCGTGAAATGTCTCTTCTATTAAGAAGACCACCAGGTCGTGAAGCTTATCCTGGTGATGTATTCTACTTAC
ACTCACGTCTTTTAGAAAGAGCAGCTAGAGTTAATGAAAAATTTGGTGGTGGTTCAATTACTGCTTTACCAATTATTGAA
ACTCAAGCAAGTGATATTTCAGCATATATTCCAACAAACGTAATTTCAATTACCGATGGTCAAATTTTCTTATCAAGTGA
TTTATTCATGGCAGGTATTAGACCAGCTATTAATATTGGTCCTTCAGTATCTAGAGTTGGTTCATCAGCGCAAATCAAAG
CTGTTAAACAAGTTTCAGGAACATTGAAATTAGAATTAGCTCAATATTATGAACTAGAAGCTTTCTCAAAATTTGGTTCA
GATTTAGATGAATCAACAAAAGCAACTTTAGATCATGGGGCAAGAATTATCCAAATGTTAGTTCAACGTCAATATTCACC
TTTAAATCAAATTGATGAAGCAATTATTTTATTTGCTATTAAATCTCACTTAATTAAATGAATTCCTTTAGAAAACATTA
GAGATTTTAAAACTGAAATAATTACATTCTTTAATAATGAAAAAGATGCAAAAGCTTTAAAAGCTGAATTAACTAAAAAA
CTTGAATGAAATGCTGATCTTGAAAGTGGAATTCAAAAAGAAATTGAAAAATTAGTTGTTAAATTCACTTCTACTTTAAA
AAACTACAACCCAACTATTTTTGGGGATGAAAAAGAATTTAAAAAATTAGGTAAGTAA

Upstream 100 bases:

>100_bases
TCAAGTAGTTGTTCATAACAAAGTTTATGATGGCTCATTAAGAAGTAAACTTGATGAAATGAAATATCAAGTATTGAAAG
AAAAATAGGAGGTTTAATAT

Downstream 100 bases:

>100_bases
TGGCAAATTTAAGTAATTTAAAAACACAAATTTCTAATACACAAGATATCGGTAAAATTACTAACGCTATGCAATTAGTT
GCTAGTGCAAAATTACGTCG

Product: F0F1 ATP synthase subunit alpha

Products: NA

Alternate protein names: ATP synthase F1 sector subunit alpha; F-ATPase subunit alpha [H]

Number of amino acids: Translated: 525; Mature: 524

Protein sequence:

>525_residues
MALNIKEISEVIEKQIKNYGKDIIEAEQGSVVTIGDGVSLIYGLDKALMGELLIFPNDVYGMVLSLEEGAVGAVILGDYK
LIKEGDIVKRTGKVVETPVGDAMIGRVVNALGQPIDNNGPIKTKKSKPVERIATGVMARKSVSQPLETGILGIDASIPIG
KGQRELIIGDRQTGKTAVAIDTIINQKGKNVKCIYVSIGQKDSTIAQVVEKLKKFGAMEYTTVVNAGASDSAPLQYLAPY
TGVTIGEEWMENGEDVLIVYDDLSKHAVAYREMSLLLRRPPGREAYPGDVFYLHSRLLERAARVNEKFGGGSITALPIIE
TQASDISAYIPTNVISITDGQIFLSSDLFMAGIRPAINIGPSVSRVGSSAQIKAVKQVSGTLKLELAQYYELEAFSKFGS
DLDESTKATLDHGARIIQMLVQRQYSPLNQIDEAIILFAIKSHLIKWIPLENIRDFKTEIITFFNNEKDAKALKAELTKK
LEWNADLESGIQKEIEKLVVKFTSTLKNYNPTIFGDEKEFKKLGK

Sequences:

>Translated_525_residues
MALNIKEISEVIEKQIKNYGKDIIEAEQGSVVTIGDGVSLIYGLDKALMGELLIFPNDVYGMVLSLEEGAVGAVILGDYK
LIKEGDIVKRTGKVVETPVGDAMIGRVVNALGQPIDNNGPIKTKKSKPVERIATGVMARKSVSQPLETGILGIDASIPIG
KGQRELIIGDRQTGKTAVAIDTIINQKGKNVKCIYVSIGQKDSTIAQVVEKLKKFGAMEYTTVVNAGASDSAPLQYLAPY
TGVTIGEE*MENGEDVLIVYDDLSKHAVAYREMSLLLRRPPGREAYPGDVFYLHSRLLERAARVNEKFGGGSITALPIIE
TQASDISAYIPTNVISITDGQIFLSSDLFMAGIRPAINIGPSVSRVGSSAQIKAVKQVSGTLKLELAQYYELEAFSKFGS
DLDESTKATLDHGARIIQMLVQRQYSPLNQIDEAIILFAIKSHLIK*IPLENIRDFKTEIITFFNNEKDAKALKAELTKK
LE*NADLESGIQKEIEKLVVKFTSTLKNYNPTIFGDEKEFKKLGK
>Mature_524_residues
ALNIKEISEVIEKQIKNYGKDIIEAEQGSVVTIGDGVSLIYGLDKALMGELLIFPNDVYGMVLSLEEGAVGAVILGDYKL
IKEGDIVKRTGKVVETPVGDAMIGRVVNALGQPIDNNGPIKTKKSKPVERIATGVMARKSVSQPLETGILGIDASIPIGK
GQRELIIGDRQTGKTAVAIDTIINQKGKNVKCIYVSIGQKDSTIAQVVEKLKKFGAMEYTTVVNAGASDSAPLQYLAPYT
GVTIGEE*MENGEDVLIVYDDLSKHAVAYREMSLLLRRPPGREAYPGDVFYLHSRLLERAARVNEKFGGGSITALPIIET
QASDISAYIPTNVISITDGQIFLSSDLFMAGIRPAINIGPSVSRVGSSAQIKAVKQVSGTLKLELAQYYELEAFSKFGSD
LDESTKATLDHGARIIQMLVQRQYSPLNQIDEAIILFAIKSHLIK*IPLENIRDFKTEIITFFNNEKDAKALKAELTKKL
E*NADLESGIQKEIEKLVVKFTSTLKNYNPTIFGDEKEFKKLGK

Specific function: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit [H]

COG id: COG0056

COG function: function code C; F0F1-type ATP synthase, alpha subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATPase alpha/beta chains family [H]

Homologues:

Organism=Homo sapiens, GI50345984, Length=472, Percent_Identity=56.1440677966102, Blast_Score=533, Evalue=1e-151,
Organism=Homo sapiens, GI4757810, Length=472, Percent_Identity=56.1440677966102, Blast_Score=533, Evalue=1e-151,
Organism=Homo sapiens, GI19913428, Length=294, Percent_Identity=28.2312925170068, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI19913426, Length=392, Percent_Identity=25.5102040816327, Blast_Score=107, Evalue=4e-23,
Organism=Homo sapiens, GI32189394, Length=309, Percent_Identity=26.2135922330097, Blast_Score=90, Evalue=6e-18,
Organism=Escherichia coli, GI1790172, Length=490, Percent_Identity=53.265306122449, Blast_Score=519, Evalue=1e-148,
Organism=Escherichia coli, GI1788251, Length=297, Percent_Identity=28.2828282828283, Blast_Score=96, Evalue=6e-21,
Organism=Escherichia coli, GI1790170, Length=301, Percent_Identity=26.2458471760797, Blast_Score=94, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI71988063, Length=508, Percent_Identity=53.1496062992126, Blast_Score=538, Evalue=1e-153,
Organism=Caenorhabditis elegans, GI71988080, Length=508, Percent_Identity=53.1496062992126, Blast_Score=537, Evalue=1e-153,
Organism=Caenorhabditis elegans, GI71988074, Length=508, Percent_Identity=48.8188976377953, Blast_Score=474, Evalue=1e-134,
Organism=Caenorhabditis elegans, GI17570191, Length=323, Percent_Identity=28.7925696594427, Blast_Score=115, Evalue=4e-26,
Organism=Caenorhabditis elegans, GI17510931, Length=291, Percent_Identity=27.8350515463918, Blast_Score=108, Evalue=7e-24,
Organism=Caenorhabditis elegans, GI25144756, Length=290, Percent_Identity=25.1724137931034, Blast_Score=81, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6319370, Length=504, Percent_Identity=53.3730158730159, Blast_Score=536, Evalue=1e-153,
Organism=Saccharomyces cerevisiae, GI6319603, Length=297, Percent_Identity=29.2929292929293, Blast_Score=115, Evalue=2e-26,
Organism=Saccharomyces cerevisiae, GI6322581, Length=368, Percent_Identity=26.9021739130435, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24658560, Length=508, Percent_Identity=53.740157480315, Blast_Score=531, Evalue=1e-151,
Organism=Drosophila melanogaster, GI281361666, Length=315, Percent_Identity=27.9365079365079, Blast_Score=120, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24646341, Length=315, Percent_Identity=27.9365079365079, Blast_Score=120, Evalue=3e-27,
Organism=Drosophila melanogaster, GI17136796, Length=315, Percent_Identity=27.9365079365079, Blast_Score=120, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24638766, Length=319, Percent_Identity=25.0783699059561, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI28574560, Length=304, Percent_Identity=26.6447368421053, Blast_Score=74, Evalue=3e-13,

Paralogues:

None

Copy number: 9,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020003
- InterPro:   IPR000194
- InterPro:   IPR005294
- InterPro:   IPR017458
- InterPro:   IPR018118
- InterPro:   IPR000793
- InterPro:   IPR004100 [H]

Pfam domain/function: PF00006 ATP-synt_ab; PF00306 ATP-synt_ab_C; PF02874 ATP-synt_ab_N [H]

EC number: =3.6.3.14 [H]

Molecular weight: Translated: 56888; Mature: 56757

Theoretical pI: Translated: 6.23; Mature: 6.23

Prosite motif: PS00152 ATPASE_ALPHA_BETA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALNIKEISEVIEKQIKNYGKDIIEAEQGSVVTIGDGVSLIYGLDKALMGELLIFPNDVY
CCCCHHHHHHHHHHHHHHHCHHHHCCCCCCEEEECCCHHHHHHHHHHHHCCEEECCCCCE
GMVLSLEEGAVGAVILGDYKLIKEGDIVKRTGKVVETPVGDAMIGRVVNALGQPIDNNGP
EEEEEECCCCEEEEEECCEEEECCCCHHHHCCCEEECCCCHHHHHHHHHHHCCCCCCCCC
IKTKKSKPVERIATGVMARKSVSQPLETGILGIDASIPIGKGQRELIIGDRQTGKTAVAI
CCCCCCCCHHHHHHHHHHHHHHCCHHHHCEEEECCCCCCCCCCCEEEEECCCCCCEEEEH
DTIINQKGKNVKCIYVSIGQKDSTIAQVVEKLKKFGAMEYTTVVNAGASDSAPLQYLAPY
HHHHCCCCCCEEEEEEEECCCCHHHHHHHHHHHHCCCCEEEHEEECCCCCCCCHHEECCC
TGVTIGEEMENGEDVLIVYDDLSKHAVAYREMSLLLRRPPGREAYPGDVFYLHSRLLERA
CCCEECCCCCCCCEEEEEECCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHH
ARVNEKFGGGSITALPIIETQASDISAYIPTNVISITDGQIFLSSDLFMAGIRPAINIGP
HHHHHCCCCCCEEEEEEEECCCCCCEEECCCCEEEEECCEEEEECCHHHHCCCCCCCCCC
SVSRVGSSAQIKAVKQVSGTLKLELAQYYELEAFSKFGSDLDESTKATLDHGARIIQMLV
CHHHCCCCHHHHHHHHHCCCEEEEHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
QRQYSPLNQIDEAIILFAIKSHLIKIPLENIRDFKTEIITFFNNEKDAKALKAELTKKLE
HHHCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
NADLESGIQKEIEKLVVKFTSTLKNYNPTIFGDEKEFKKLGK
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCEECCHHHHHHHCC
>Mature Secondary Structure 
ALNIKEISEVIEKQIKNYGKDIIEAEQGSVVTIGDGVSLIYGLDKALMGELLIFPNDVY
CCCHHHHHHHHHHHHHHHCHHHHCCCCCCEEEECCCHHHHHHHHHHHHCCEEECCCCCE
GMVLSLEEGAVGAVILGDYKLIKEGDIVKRTGKVVETPVGDAMIGRVVNALGQPIDNNGP
EEEEEECCCCEEEEEECCEEEECCCCHHHHCCCEEECCCCHHHHHHHHHHHCCCCCCCCC
IKTKKSKPVERIATGVMARKSVSQPLETGILGIDASIPIGKGQRELIIGDRQTGKTAVAI
CCCCCCCCHHHHHHHHHHHHHHCCHHHHCEEEECCCCCCCCCCCEEEEECCCCCCEEEEH
DTIINQKGKNVKCIYVSIGQKDSTIAQVVEKLKKFGAMEYTTVVNAGASDSAPLQYLAPY
HHHHCCCCCCEEEEEEEECCCCHHHHHHHHHHHHCCCCEEEHEEECCCCCCCCHHEECCC
TGVTIGEEMENGEDVLIVYDDLSKHAVAYREMSLLLRRPPGREAYPGDVFYLHSRLLERA
CCCEECCCCCCCCEEEEEECCCCHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHH
ARVNEKFGGGSITALPIIETQASDISAYIPTNVISITDGQIFLSSDLFMAGIRPAINIGP
HHHHHCCCCCCEEEEEEEECCCCCCEEECCCCEEEEECCEEEEECCHHHHCCCCCCCCCC
SVSRVGSSAQIKAVKQVSGTLKLELAQYYELEAFSKFGSDLDESTKATLDHGARIIQMLV
CHHHCCCCHHHHHHHHHCCCEEEEHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHH
QRQYSPLNQIDEAIILFAIKSHLIKIPLENIRDFKTEIITFFNNEKDAKALKAELTKKLE
HHHCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
NADLESGIQKEIEKLVVKFTSTLKNYNPTIFGDEKEFKKLGK
CCCHHHHHHHHHHHHHHHHHHHHHCCCCCEECCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA