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The map label for this gene is proC [H]

Identifier: 50364860

GI number: 50364860

Start: 61126

End: 61926

Strand: Direct

Name: proC [H]

Synonym: Mfl045

Alternate gene names: 50364860

Gene position: 61126-61926 (Clockwise)

Preceding gene: 50364859

Following gene: 50364862

Centisome position: 7.71

GC content: 27.72

Gene sequence:

>801_bases
ATGAAAAGAGTATTATTTATAGGTTTAGGTCATATGGGTTCTTCACTTGTTAAGGGAGTTTTAAAAAATTCAAATAATAA
AATAGAAGTTTTTGGATACGATGTAATAAAAGAAGTTCAAGATAAAGCAATAAAAAATATTCAAGGGCTAAGACCTTTAA
AAGATATTTCAGAAATAGAACTTAAAAAAATAGATTATATTGTCATAGGGACAAGACCTATTGATGTTGAACCTTTATGT
AAAAATATGGATCAATTAAACATTGATGGAAAAACTATTATTTGTATGGCGAATGCAGTTACAATAGAAGATGTTCAGAA
TAATTTTGTAAAAAATAAGAAAGTTTCAGTAATTAGAATGATGCCAAACATGAATGCTTCTATACAAAAATCTGTGACAG
CTTTAGCAACTAAAAATGCATCAAATGAAACAATGAAATTTGTTTCTGAAATGTTTGAACTTTGTGGAATAGTGGAAAAT
ATTGATGAAGATAAATTTGGAACACTAACAGCTATTTCTGGTTGCTCACCATCTTATATAATTTCATTTTTTAAAGCTAT
GACTGATTATGCAATTGATAAAGGTTTCGAAAAAGAACAAGCCTTTAGAATAATAGAAGAGGCAATCATAGGAAGTGTTA
TGAATGCATCAAAATCAGAAGTAGAGTTAAGAACAATGGTCGATCAAATTTGTGTTCCAAATGGATCAACTATTGAAGGG
CAAAAAATTTTAGATAATAAAAACTTTGAAAAAATAATTCAAGAAGCACTGACAGCAGCAACTAAAAAAGCAACAAAATA
A

Upstream 100 bases:

>100_bases
AAAGATACAATCAATTTAACTAAATAGAATTAAAAATAACCATTAAGGTTATTTTTTTATCTTTTAAATTATAATTAATA
ATAAATAAATGAGGTGAAAC

Downstream 100 bases:

>100_bases
AAAAATCGGGGAAACCCGATTTTAATTTAAAATTTCTTAGCAGCAGCAATCAAATCAGAAGTTATTGATGAAACAATTTC
TTTTGGAGATTGAGTACTTA

Product: 1-pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR [H]

Number of amino acids: Translated: 266; Mature: 266

Protein sequence:

>266_residues
MKRVLFIGLGHMGSSLVKGVLKNSNNKIEVFGYDVIKEVQDKAIKNIQGLRPLKDISEIELKKIDYIVIGTRPIDVEPLC
KNMDQLNIDGKTIICMANAVTIEDVQNNFVKNKKVSVIRMMPNMNASIQKSVTALATKNASNETMKFVSEMFELCGIVEN
IDEDKFGTLTAISGCSPSYIISFFKAMTDYAIDKGFEKEQAFRIIEEAIIGSVMNASKSEVELRTMVDQICVPNGSTIEG
QKILDNKNFEKIIQEALTAATKKATK

Sequences:

>Translated_266_residues
MKRVLFIGLGHMGSSLVKGVLKNSNNKIEVFGYDVIKEVQDKAIKNIQGLRPLKDISEIELKKIDYIVIGTRPIDVEPLC
KNMDQLNIDGKTIICMANAVTIEDVQNNFVKNKKVSVIRMMPNMNASIQKSVTALATKNASNETMKFVSEMFELCGIVEN
IDEDKFGTLTAISGCSPSYIISFFKAMTDYAIDKGFEKEQAFRIIEEAIIGSVMNASKSEVELRTMVDQICVPNGSTIEG
QKILDNKNFEKIIQEALTAATKKATK
>Mature_266_residues
MKRVLFIGLGHMGSSLVKGVLKNSNNKIEVFGYDVIKEVQDKAIKNIQGLRPLKDISEIELKKIDYIVIGTRPIDVEPLC
KNMDQLNIDGKTIICMANAVTIEDVQNNFVKNKKVSVIRMMPNMNASIQKSVTALATKNASNETMKFVSEMFELCGIVEN
IDEDKFGTLTAISGCSPSYIISFFKAMTDYAIDKGFEKEQAFRIIEEAIIGSVMNASKSEVELRTMVDQICVPNGSTIEG
QKILDNKNFEKIIQEALTAATKKATK

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI198041662, Length=270, Percent_Identity=22.2222222222222, Blast_Score=86, Evalue=3e-17,
Organism=Homo sapiens, GI21361454, Length=264, Percent_Identity=21.969696969697, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI24797097, Length=266, Percent_Identity=21.4285714285714, Blast_Score=73, Evalue=2e-13,
Organism=Homo sapiens, GI24797095, Length=266, Percent_Identity=21.4285714285714, Blast_Score=73, Evalue=3e-13,
Organism=Escherichia coli, GI1786585, Length=273, Percent_Identity=27.1062271062271, Blast_Score=102, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI17540664, Length=281, Percent_Identity=25.9786476868327, Blast_Score=82, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17569021, Length=274, Percent_Identity=21.1678832116788, Blast_Score=79, Evalue=2e-15,
Organism=Drosophila melanogaster, GI24648116, Length=286, Percent_Identity=22.3776223776224, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI21358587, Length=266, Percent_Identity=21.8045112781955, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI24647700, Length=166, Percent_Identity=22.289156626506, Blast_Score=72, Evalue=5e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 29530; Mature: 29530

Theoretical pI: Translated: 7.82; Mature: 7.82

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.9 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
6.4 %Cys+Met (Translated Protein)
1.9 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
6.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRVLFIGLGHMGSSLVKGVLKNSNNKIEVFGYDVIKEVQDKAIKNIQGLRPLKDISEIE
CCEEEEEECCHHHHHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHHHHCCCCHHHHHHHH
LKKIDYIVIGTRPIDVEPLCKNMDQLNIDGKTIICMANAVTIEDVQNNFVKNKKVSVIRM
HHHCCEEEECCCCCCCCHHHCCCHHCCCCCCEEEEEECCEEHHHHHHHHHCCCCEEEEEE
MPNMNASIQKSVTALATKNASNETMKFVSEMFELCGIVENIDEDKFGTLTAISGCSPSYI
CCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCHHHH
ISFFKAMTDYAIDKGFEKEQAFRIIEEAIIGSVMNASKSEVELRTMVDQICVPNGSTIEG
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCC
QKILDNKNFEKIIQEALTAATKKATK
HHHHCCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKRVLFIGLGHMGSSLVKGVLKNSNNKIEVFGYDVIKEVQDKAIKNIQGLRPLKDISEIE
CCEEEEEECCHHHHHHHHHHHHCCCCEEEEECHHHHHHHHHHHHHHHHCCCCHHHHHHHH
LKKIDYIVIGTRPIDVEPLCKNMDQLNIDGKTIICMANAVTIEDVQNNFVKNKKVSVIRM
HHHCCEEEECCCCCCCCHHHCCCHHCCCCCCEEEEEECCEEHHHHHHHHHCCCCEEEEEE
MPNMNASIQKSVTALATKNASNETMKFVSEMFELCGIVENIDEDKFGTLTAISGCSPSYI
CCCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCEEEECCCCHHHH
ISFFKAMTDYAIDKGFEKEQAFRIIEEAIIGSVMNASKSEVELRTMVDQICVPNGSTIEG
HHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHCCCCCCCCC
QKILDNKNFEKIIQEALTAATKKATK
HHHHCCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9537320 [H]