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The map label for this gene is ribB/A [H]

Identifier: 50086523

GI number: 50086523

Start: 3493308

End: 3494429

Strand: Direct

Name: ribB/A [H]

Synonym: ACIAD3570

Alternate gene names: 50086523

Gene position: 3493308-3494429 (Clockwise)

Preceding gene: 50086522

Following gene: 50086524

Centisome position: 97.07

GC content: 46.97

Gene sequence:

>1122_bases
ATGCCGCTTAGTCATGTTGAAGCGCTTGTCGAAGATATCCGCGCAGGCAAAATGGTCATTCTGATGGATGACGAAGATCG
TGAAAACGAAGGTGATCTGGTGATGGCTGCAACGCATGTCCGCCCAGAAGACATCAATTTCATGATTACTCATGCACGCG
GACTGGTCTGCCTAACGCTGAGCCGCGAGCGTTGCCAGCAACTGAATTTACCACTGATGGTCGATCATAACGGCGCACAG
CACGCAACCAACTTTACCCTTTCCATTGAAGCAGCAGAAGGGATTACCACAGGAATTTCGGCGGCAGAACGTGCGCATAC
CATTCGTACAGCCGTTGCTGCACATGCCAAGCCAAGCGATATTGTTCAACCAGGTCATATTTTTCCATTAATGGCTCAAC
CAGGCGGTGTATTACATCGTGCCGGTCATACCGAAGCAGGCTGTGATTTAACTCGTCTGGCAGGACTTGAACCTGCTTCT
GTGATTTGTGAAATCATCAATGAAGACGGCACCATGGCACGTCGTGAAGATTTAGAGGTGTTTGCTGAAAAACATGGTTT
AAAAATTGGAACCATTGCAGACCTGATTCACTATCGAATGACCAATGAACAAACGGTTGAACGTTTAGGGCAACAAACCA
TTGAAACCGATTACGGTTCGTTTGAACTCTATCGCTACCGTGAAATTGGTAATCCAGATATCCATTTGGCGCTGGTGAAA
GGTGAGCCCAAAGACGGTGTAACCACAGTGCGTGTACATGGCTTTAATCCAACACGTGACTTACTCAAGCTGAAAAAACA
GGATGGCGAGCCAGCCTGGAATCTGGATCGCGCCCTTCAAAGCATTGCCAGTGCTGAACGTGGGGTACTGGTGTGGATTG
GACAAAATCATCTACAGGATCTGGGACCAGCATTAGAAAGTCTGACCCAGCCTAAGCCACTCAAATCAAATGCAGCACTT
TCTCACCAGTACCAAACCATTGGAGTGGGTGCACAAATTTTACGTGACTTGGGCGTTGAAAAGATGAAGCTACTCAGTTC
GCCTTTACGTTTCAATGCATTATCTGGATTTAACTTGGAAGTGGTGGAATATATCACCGCAGATCAAACTATAGAGAACT
AA

Upstream 100 bases:

>100_bases
AAATAACAGAAGCATAGGCAAATATCGATAAAACACGGTAGACTATGCGATCAATTGTGAAAGGTAACAGTCTTCGGACA
CAGTGAGAAGGTAAAGGCTT

Downstream 100 bases:

>100_bases
TCGAGGTTGTTATGGCAATTCGCCGAATTGAAGGTTTATTACATCTCGCGAGCGAAGGCCGTTACGCGATTTTGGTCGGT
CGTTTTAACAGTTTTGTCGT

Product: bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II

Products: NA

Alternate protein names: DHBP synthase [H]

Number of amino acids: Translated: 373; Mature: 372

Protein sequence:

>373_residues
MPLSHVEALVEDIRAGKMVILMDDEDRENEGDLVMAATHVRPEDINFMITHARGLVCLTLSRERCQQLNLPLMVDHNGAQ
HATNFTLSIEAAEGITTGISAAERAHTIRTAVAAHAKPSDIVQPGHIFPLMAQPGGVLHRAGHTEAGCDLTRLAGLEPAS
VICEIINEDGTMARREDLEVFAEKHGLKIGTIADLIHYRMTNEQTVERLGQQTIETDYGSFELYRYREIGNPDIHLALVK
GEPKDGVTTVRVHGFNPTRDLLKLKKQDGEPAWNLDRALQSIASAERGVLVWIGQNHLQDLGPALESLTQPKPLKSNAAL
SHQYQTIGVGAQILRDLGVEKMKLLSSPLRFNALSGFNLEVVEYITADQTIEN

Sequences:

>Translated_373_residues
MPLSHVEALVEDIRAGKMVILMDDEDRENEGDLVMAATHVRPEDINFMITHARGLVCLTLSRERCQQLNLPLMVDHNGAQ
HATNFTLSIEAAEGITTGISAAERAHTIRTAVAAHAKPSDIVQPGHIFPLMAQPGGVLHRAGHTEAGCDLTRLAGLEPAS
VICEIINEDGTMARREDLEVFAEKHGLKIGTIADLIHYRMTNEQTVERLGQQTIETDYGSFELYRYREIGNPDIHLALVK
GEPKDGVTTVRVHGFNPTRDLLKLKKQDGEPAWNLDRALQSIASAERGVLVWIGQNHLQDLGPALESLTQPKPLKSNAAL
SHQYQTIGVGAQILRDLGVEKMKLLSSPLRFNALSGFNLEVVEYITADQTIEN
>Mature_372_residues
PLSHVEALVEDIRAGKMVILMDDEDRENEGDLVMAATHVRPEDINFMITHARGLVCLTLSRERCQQLNLPLMVDHNGAQH
ATNFTLSIEAAEGITTGISAAERAHTIRTAVAAHAKPSDIVQPGHIFPLMAQPGGVLHRAGHTEAGCDLTRLAGLEPASV
ICEIINEDGTMARREDLEVFAEKHGLKIGTIADLIHYRMTNEQTVERLGQQTIETDYGSFELYRYREIGNPDIHLALVKG
EPKDGVTTVRVHGFNPTRDLLKLKKQDGEPAWNLDRALQSIASAERGVLVWIGQNHLQDLGPALESLTQPKPLKSNAALS
HQYQTIGVGAQILRDLGVEKMKLLSSPLRFNALSGFNLEVVEYITADQTIEN

Specific function: Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate [H]

COG id: COG0108

COG function: function code H; 3,4-dihydroxy-2-butanone 4-phosphate synthase

Gene ontology:

Cell location: Membrane-Associated [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the GTP cyclohydrolase II family [H]

Homologues:

Organism=Escherichia coli, GI1789420, Length=203, Percent_Identity=50.7389162561576, Blast_Score=219, Evalue=2e-58,
Organism=Saccharomyces cerevisiae, GI6320695, Length=204, Percent_Identity=40.6862745098039, Blast_Score=169, Evalue=9e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017945
- InterPro:   IPR000422
- InterPro:   IPR000926
- InterPro:   IPR016299 [H]

Pfam domain/function: PF00926 DHBP_synthase; PF00925 GTP_cyclohydro2 [H]

EC number: =4.1.99.12 [H]

Molecular weight: Translated: 41039; Mature: 40908

Theoretical pI: Translated: 5.53; Mature: 5.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPLSHVEALVEDIRAGKMVILMDDEDRENEGDLVMAATHVRPEDINFMITHARGLVCLTL
CCHHHHHHHHHHHCCCCEEEEECCCCCCCCCCEEEEEECCCCCCCCEEEEECCCEEEEEE
SRERCQQLNLPLMVDHNGAQHATNFTLSIEAAEGITTGISAAERAHTIRTAVAAHAKPSD
CHHHHHHCCCCEEEECCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCC
IVQPGHIFPLMAQPGGVLHRAGHTEAGCDLTRLAGLEPASVICEIINEDGTMARREDLEV
CCCCCCEEEEECCCCCEEEECCCCCCCCCHHHHCCCCHHHHHHHHHCCCCCHHHHHHHHH
FAEKHGLKIGTIADLIHYRMTNEQTVERLGQQTIETDYGSFELYRYREIGNPDIHLALVK
HHHHCCCEEHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCEEEEEEE
GEPKDGVTTVRVHGFNPTRDLLKLKKQDGEPAWNLDRALQSIASAERGVLVWIGQNHLQD
CCCCCCEEEEEEECCCCHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCEEEEECCHHHHH
LGPALESLTQPKPLKSNAALSHQYQTIGVGAQILRDLGVEKMKLLSSPLRFNALSGFNLE
HHHHHHHHCCCCCCCCCCHHHHCCEEECHHHHHHHHCCHHHHHHHCCCCCEEECCCCCCC
VVEYITADQTIEN
EEEEECCCCCCCC
>Mature Secondary Structure 
PLSHVEALVEDIRAGKMVILMDDEDRENEGDLVMAATHVRPEDINFMITHARGLVCLTL
CHHHHHHHHHHHCCCCEEEEECCCCCCCCCCEEEEEECCCCCCCCEEEEECCCEEEEEE
SRERCQQLNLPLMVDHNGAQHATNFTLSIEAAEGITTGISAAERAHTIRTAVAAHAKPSD
CHHHHHHCCCCEEEECCCCCCCCEEEEEEECCCCCHHHHHHHHHHHHHHHHHHHCCCCCC
IVQPGHIFPLMAQPGGVLHRAGHTEAGCDLTRLAGLEPASVICEIINEDGTMARREDLEV
CCCCCCEEEEECCCCCEEEECCCCCCCCCHHHHCCCCHHHHHHHHHCCCCCHHHHHHHHH
FAEKHGLKIGTIADLIHYRMTNEQTVERLGQQTIETDYGSFELYRYREIGNPDIHLALVK
HHHHCCCEEHHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCEEEEEEEECCCCCEEEEEEE
GEPKDGVTTVRVHGFNPTRDLLKLKKQDGEPAWNLDRALQSIASAERGVLVWIGQNHLQD
CCCCCCEEEEEEECCCCHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCEEEEECCHHHHH
LGPALESLTQPKPLKSNAALSHQYQTIGVGAQILRDLGVEKMKLLSSPLRFNALSGFNLE
HHHHHHHHCCCCCCCCCCHHHHCCEEECHHHHHHHHCCHHHHHHHCCCCCEEECCCCCCC
VVEYITADQTIEN
EEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]