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The map label for this gene is dtd

Identifier: 50086517

GI number: 50086517

Start: 3488548

End: 3488988

Strand: Direct

Name: dtd

Synonym: ACIAD3563

Alternate gene names: 50086517

Gene position: 3488548-3488988 (Clockwise)

Preceding gene: 50086513

Following gene: 50086520

Centisome position: 96.94

GC content: 42.4

Gene sequence:

>441_bases
ATGCGAGCCTTAATCCAACGAGTAAAAGAAGCCAAGGTTATAGTGGATGATGTCATTACCGGTGAAATTCGGCAGGGTCT
GCTGGTATTTTTAGGCTTAGGACGTGATGACCAACTCGAAAATGGCAAAAAGCTGATCGATAAAATTCTCAAATATCGTG
TTTTCGATGATGAGAACGGTAAAATGGGCTGGAACCTCAGTCAGGCGCAAGGTGGCTTATTGCTGGTATCACAATTTACC
CTCATGGCTCAAACCCAAAAAGGATTACGCCCAGATTTTGGCCCAGCCATGCCGCCACAACAAGCCAAAGTACTCTATGA
TCAACTGGTAGAATATGCACAATCACAATTTGATCATGTTGAAACAGGTATTTTTGCTGCCGACATGCAAGTACATCTAA
TTAATGACGGGCCTGTAACTTTTCAGCTCGAAATATTATAA

Upstream 100 bases:

>100_bases
TGATTTGTATAAGACCTTTGTCGCTGATCGTAGGTTTACTGCTCTCAACGACCTACCAGATATCTGCTAAAATCTGGATT
ATTTGATGTGTTGATTTATT

Downstream 100 bases:

>100_bases
AAAACGCCCTTAAAGGGCGTTTTTTAACATCGATTCTTAGAACGATTTACCTGTTTTTTCTTTTAAAAACTGACGTGCCT
GCTTGATTTTCTGTTTAACT

Product: D-tyrosyl-tRNA(Tyr) deacylase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 146; Mature: 146

Protein sequence:

>146_residues
MRALIQRVKEAKVIVDDVITGEIRQGLLVFLGLGRDDQLENGKKLIDKILKYRVFDDENGKMGWNLSQAQGGLLLVSQFT
LMAQTQKGLRPDFGPAMPPQQAKVLYDQLVEYAQSQFDHVETGIFAADMQVHLINDGPVTFQLEIL

Sequences:

>Translated_146_residues
MRALIQRVKEAKVIVDDVITGEIRQGLLVFLGLGRDDQLENGKKLIDKILKYRVFDDENGKMGWNLSQAQGGLLLVSQFT
LMAQTQKGLRPDFGPAMPPQQAKVLYDQLVEYAQSQFDHVETGIFAADMQVHLINDGPVTFQLEIL
>Mature_146_residues
MRALIQRVKEAKVIVDDVITGEIRQGLLVFLGLGRDDQLENGKKLIDKILKYRVFDDENGKMGWNLSQAQGGLLLVSQFT
LMAQTQKGLRPDFGPAMPPQQAKVLYDQLVEYAQSQFDHVETGIFAADMQVHLINDGPVTFQLEIL

Specific function: Hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr). Could be a defense mechanism against a harmful effect of D-tyrosine

COG id: COG1490

COG function: function code J; D-Tyr-tRNAtyr deacylase

Gene ontology:

Cell location: Cytoplasm (Probable)

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DTD family

Homologues:

Organism=Homo sapiens, GI30795227, Length=148, Percent_Identity=41.2162162162162, Blast_Score=100, Evalue=5e-22,
Organism=Escherichia coli, GI1790320, Length=145, Percent_Identity=51.0344827586207, Blast_Score=153, Evalue=5e-39,
Organism=Caenorhabditis elegans, GI115533292, Length=148, Percent_Identity=41.2162162162162, Blast_Score=94, Evalue=3e-20,
Organism=Saccharomyces cerevisiae, GI6319982, Length=148, Percent_Identity=38.5135135135135, Blast_Score=107, Evalue=8e-25,
Organism=Drosophila melanogaster, GI281361569, Length=146, Percent_Identity=41.7808219178082, Blast_Score=100, Evalue=2e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DTD_ACIAD (Q6F6W0)

Other databases:

- EMBL:   CR543861
- RefSeq:   YP_048027.1
- ProteinModelPortal:   Q6F6W0
- SMR:   Q6F6W0
- STRING:   Q6F6W0
- GeneID:   2879769
- GenomeReviews:   CR543861_GR
- KEGG:   aci:ACIAD3563
- NMPDR:   fig|62977.3.peg.3220
- eggNOG:   COG1490
- HOGENOM:   HBG286048
- OMA:   MKAVIQR
- PhylomeDB:   Q6F6W0
- ProtClustDB:   PRK05273
- BioCyc:   ASP62977:ACIAD3563-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00518
- InterPro:   IPR003732
- Gene3D:   G3DSA:3.50.80.10
- PANTHER:   PTHR10472
- TIGRFAMs:   TIGR00256

Pfam domain/function: PF02580 Tyr_Deacylase; SSF69500 DTyrtRNA_deacyls

EC number: NA

Molecular weight: Translated: 16400; Mature: 16400

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: NA

Important sites: ACT_SITE 80-80

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRALIQRVKEAKVIVDDVITGEIRQGLLVFLGLGRDDQLENGKKLIDKILKYRVFDDENG
CHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEECCCCCCCCCHHHHHHHHHHHCCCCCCCC
KMGWNLSQAQGGLLLVSQFTLMAQTQKGLRPDFGPAMPPQQAKVLYDQLVEYAQSQFDHV
CCCCCHHCCCCCEEEEHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
ETGIFAADMQVHLINDGPVTFQLEIL
HCCEEEECEEEEEECCCCEEEEEEEC
>Mature Secondary Structure
MRALIQRVKEAKVIVDDVITGEIRQGLLVFLGLGRDDQLENGKKLIDKILKYRVFDDENG
CHHHHHHHHHHHHHHHHHHHHHHHHCEEEEEECCCCCCCCCHHHHHHHHHHHCCCCCCCC
KMGWNLSQAQGGLLLVSQFTLMAQTQKGLRPDFGPAMPPQQAKVLYDQLVEYAQSQFDHV
CCCCCHHCCCCCEEEEHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHH
ETGIFAADMQVHLINDGPVTFQLEIL
HCCEEEECEEEEEECCCCEEEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA