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The map label for this gene is fucA [C]

Identifier: 50086446

GI number: 50086446

Start: 3411814

End: 3412539

Strand: Direct

Name: fucA [C]

Synonym: ACIAD3485

Alternate gene names: 50086446

Gene position: 3411814-3412539 (Clockwise)

Preceding gene: 50086441

Following gene: 50086457

Centisome position: 94.81

GC content: 40.91

Gene sequence:

>726_bases
ATGTTAAATGAACAACAAATCCGAATAGACTTAGCAGCGGCCTTCCGTGCATGTGCAAAACTGGGTTTACATGAAGGTGT
TGCCAATCACTTTAGTGCGGCAGTTTCAGAGGATGGAAAAAAGTTTCTTCTCAATCCCAAATGGATGCATTTTTCTCGTA
TTAAAGCCAGTGATCTGGTTTTGGTTGATGCAGATGATCCACAAAGTTTTAATCGGGGTGAGATTGATTCAACTGCATGG
ACCATTCACGGCCAGATTCATAGCATGCGTCCAGACATTCGTGTGGTCATGCATTTACACCCTATTTATACCACCACACT
TTCGTGTTTAAAGAATCCTGAAATTTTACCCATAGACCAAAATAGTGCGCGCTATTTCCAACGCGTAGCTTATGATTTTA
ATTATTCGGGTATGGCCGACCAGCGCGCCGAAGGTCAACGTTTGGCTCAACTCCTCCAAGACAAAAATCGTTTACTGATG
GGAAATCATGGTGTGATTGTCAGTTCACATAAGATCGGCATTGCTTTTGATGATATGTATACCATAGAGCGTGCCAGTCA
ACTCCTAGTCAATGCTTATGCGACAGGGCAAGAGCTCAGTGTTCTAGATGATGATATCGCTGAAAAAACAGCAAAAGACT
GGGAAAAAATTGATGATTATTCTCTGGCACATTTTGAAGAGATGAAAATTATTTTAATGAAAGAAGATCCGAGTTTCATG
GATTAA

Upstream 100 bases:

>100_bases
AGTAATTTTGAAATTCCTAGTCATTACTCCAAAAAATGCGATGCAAAAACTCAAGTAAAAAGTCATAGACTTTCATCTAA
ATCAATCATGAGATGAACCA

Downstream 100 bases:

>100_bases
GTGCTTAGAAATAGTTAAATCGAAGCACGCTTCGATTTAACTTATGGTTTGATGATGGATGCTTTGCATTTTTTTATTTA
GCCCATTTCCAGACCCGCTT

Product: hypothetical protein

Products: Dihydroxyacetone phosphate; L-Lactaldehyde [C]

Alternate protein names: NA

Number of amino acids: Translated: 241; Mature: 241

Protein sequence:

>241_residues
MLNEQQIRIDLAAAFRACAKLGLHEGVANHFSAAVSEDGKKFLLNPKWMHFSRIKASDLVLVDADDPQSFNRGEIDSTAW
TIHGQIHSMRPDIRVVMHLHPIYTTTLSCLKNPEILPIDQNSARYFQRVAYDFNYSGMADQRAEGQRLAQLLQDKNRLLM
GNHGVIVSSHKIGIAFDDMYTIERASQLLVNAYATGQELSVLDDDIAEKTAKDWEKIDDYSLAHFEEMKIILMKEDPSFM
D

Sequences:

>Translated_241_residues
MLNEQQIRIDLAAAFRACAKLGLHEGVANHFSAAVSEDGKKFLLNPKWMHFSRIKASDLVLVDADDPQSFNRGEIDSTAW
TIHGQIHSMRPDIRVVMHLHPIYTTTLSCLKNPEILPIDQNSARYFQRVAYDFNYSGMADQRAEGQRLAQLLQDKNRLLM
GNHGVIVSSHKIGIAFDDMYTIERASQLLVNAYATGQELSVLDDDIAEKTAKDWEKIDDYSLAHFEEMKIILMKEDPSFM
D
>Mature_241_residues
MLNEQQIRIDLAAAFRACAKLGLHEGVANHFSAAVSEDGKKFLLNPKWMHFSRIKASDLVLVDADDPQSFNRGEIDSTAW
TIHGQIHSMRPDIRVVMHLHPIYTTTLSCLKNPEILPIDQNSARYFQRVAYDFNYSGMADQRAEGQRLAQLLQDKNRLLM
GNHGVIVSSHKIGIAFDDMYTIERASQLLVNAYATGQELSVLDDDIAEKTAKDWEKIDDYSLAHFEEMKIILMKEDPSFM
D

Specific function: Fucose metabolism; third step. [C]

COG id: COG0235

COG function: function code G; Ribulose-5-phosphate 4-epimerase and related epimerases and aldolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the aldolase class II family [H]

Homologues:

Organism=Homo sapiens, GI9951927, Length=196, Percent_Identity=30.1020408163265, Blast_Score=81, Evalue=7e-16,
Organism=Homo sapiens, GI62912453, Length=196, Percent_Identity=30.1020408163265, Blast_Score=81, Evalue=7e-16,
Organism=Homo sapiens, GI9943848, Length=196, Percent_Identity=30.1020408163265, Blast_Score=81, Evalue=8e-16,
Organism=Homo sapiens, GI89276787, Length=199, Percent_Identity=26.1306532663317, Blast_Score=77, Evalue=9e-15,
Organism=Homo sapiens, GI9257190, Length=198, Percent_Identity=26.2626262626263, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI297307160, Length=199, Percent_Identity=26.1306532663317, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI297307158, Length=198, Percent_Identity=26.2626262626263, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI9257192, Length=198, Percent_Identity=26.2626262626263, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI29826321, Length=198, Percent_Identity=27.7777777777778, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI29826325, Length=197, Percent_Identity=27.9187817258883, Blast_Score=71, Evalue=1e-12,
Organism=Homo sapiens, GI29826319, Length=198, Percent_Identity=27.7777777777778, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI29826323, Length=197, Percent_Identity=27.9187817258883, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI115533216, Length=193, Percent_Identity=30.0518134715026, Blast_Score=76, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI115533218, Length=193, Percent_Identity=30.0518134715026, Blast_Score=76, Evalue=2e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001303 [H]

Pfam domain/function: PF00596 Aldolase_II [H]

EC number: 4.1.2.17 [C]

Molecular weight: Translated: 27384; Mature: 27384

Theoretical pI: Translated: 5.53; Mature: 5.53

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLNEQQIRIDLAAAFRACAKLGLHEGVANHFSAAVSEDGKKFLLNPKWMHFSRIKASDLV
CCCCHHEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCEEHEECCCCCEE
LVDADDPQSFNRGEIDSTAWTIHGQIHSMRPDIRVVMHLHPIYTTTLSCLKNPEILPIDQ
EEECCCCCCCCCCCCCCEEEEEEEEEECCCCCEEEEEEECHHHHHHHHHHCCCCEEEECC
NSARYFQRVAYDFNYSGMADQRAEGQRLAQLLQDKNRLLMGNHGVIVSSHKIGIAFDDMY
CHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCEEECCCCEEEECCEEEEEECHHH
TIERASQLLVNAYATGQELSVLDDDIAEKTAKDWEKIDDYSLAHFEEMKIILMKEDPSFM
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHCCEEEEEEECCCCCC
D
C
>Mature Secondary Structure
MLNEQQIRIDLAAAFRACAKLGLHEGVANHFSAAVSEDGKKFLLNPKWMHFSRIKASDLV
CCCCHHEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEECCCCCEEHEECCCCCEE
LVDADDPQSFNRGEIDSTAWTIHGQIHSMRPDIRVVMHLHPIYTTTLSCLKNPEILPIDQ
EEECCCCCCCCCCCCCCEEEEEEEEEECCCCCEEEEEEECHHHHHHHHHHCCCCEEEECC
NSARYFQRVAYDFNYSGMADQRAEGQRLAQLLQDKNRLLMGNHGVIVSSHKIGIAFDDMY
CHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCEEECCCCEEEECCEEEEEECHHH
TIERASQLLVNAYATGQELSVLDDDIAEKTAKDWEKIDDYSLAHFEEMKIILMKEDPSFM
HHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCHHHHCCEEEEEEECCCCCC
D
C

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Ca2+; Co2+; Mg2+; Mn2+; Zn2+ [C]

Kcat value (1/min): 19.3 [C]

Specific activity: 21.0

Km value (mM): 0.7 {L-fuculose} [C]

Substrates: L-Fuculose 1-phosphate [C]

Specific reaction: L-Fuculose 1-phosphate <==> Dihydroxyacetone phosphate + L-Lactaldehyde [C]

General reaction: Elimination of an aldehyde C-C bond; Cleavage [C]

Inhibitor: EDTA; Phosphoglycolohydroxamate [C]

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10984043 [H]