| Definition | Acinetobacter sp. ADP1 chromosome, complete genome. |
|---|---|
| Accession | NC_005966 |
| Length | 3,598,621 |
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The map label for this gene is dkg [H]
Identifier: 50086270
GI number: 50086270
Start: 3192464
End: 3193357
Strand: Reverse
Name: dkg [H]
Synonym: ACIAD3281
Alternate gene names: 50086270
Gene position: 3193357-3192464 (Counterclockwise)
Preceding gene: 50086273
Following gene: 50086269
Centisome position: 88.74
GC content: 41.95
Gene sequence:
>894_bases ATGATAGAACCAAAATTAAAGATAGAGACGGCGCAGACCAATCCCATGAGCATAGAAAAAAATATTCCAGATTTAATCCT TCACGACGGACATTCAATTCCTGCATTAGGATTTGGAACTTATACATTAAAAGGTCAGCAGGGCGTAGACACGATGCTTC GGGCTTTAGGGCATGGCTATCGCATGCTGGATTCTGCGTTTAATTATGAAAATGAAGGTGCTGTAGGAGCAGCGGTACGG CAGTCGGGTCTGTTACGAGATGAGATCTTTATCACTTCAAAGTTGCCAGGTCGACATCATGCTTATGATAAAGCAATGGA AACCATTGAAGAATCTTTATACCGTATGCAATTTGACTATCTGGATCTGTATTTAATTCATTGGCCAAATCCACAACAGG GTTTATATATTGAAGCATGGCAAGCTTTAATTGATGCTCAGAAAAAAGGTTATATCCGTTCGATTGGCGTAAGCAACTTT TTACCCAAGCACATCGAAACCTTACGCCGTGAAACAGGAGTTATTCCTGTGATCAATCAGGTCGAGTTACATCCTTATTT TAATCAGGCCGAGCAAAGAGCATATGATGAGTCTCAGCAGATCATAACGATGGCATGGAGCCCACTTGGACGAGCAAAGG CAATTTTAGATGATGCTGTGTTAAAACAGATTGCTCAGGAGACGTCTCGTACAGTGGTACAAGTGGTTTTAAGATGGCAA GTGCAGATGGGGGTGATTCCAATTCCAAAAGCAGCCAGTGATCAGAATCAAATGGCCAATCAGGCGATTTTTGATTTTAG CCTTTCGGATGATCAAGTCCAGCGAATTAATGCCTTAACATGTGCTGACGGACGGATTCGCAATCAGGATCCAGCAGTTT ATGAAGAGTTTTAA
Upstream 100 bases:
>100_bases AGGATCAGTATCGTGTGAAATAGCATTTTTAATACAAATTGACAGGCCTCTTCACAGCGTGATATCCAAAGACTACTGGG GTTAGCAGACGGTTCATGGC
Downstream 100 bases:
>100_bases CGCAACACAAAATCGGGCATCAATGGCAAGATTTTCACAATGTGTCATCTTTTGCCCTGTTTTATCTACAATACCCTTAT AGAATAAGCGATTTAGCCAT
Product: 2,5-diketo-D-gluconate reductase
Products: NA
Alternate protein names: 2,5-DKG reductase B; 2,5-DKGR B; 25DKGR-B; AKR5D [H]
Number of amino acids: Translated: 297; Mature: 297
Protein sequence:
>297_residues MIEPKLKIETAQTNPMSIEKNIPDLILHDGHSIPALGFGTYTLKGQQGVDTMLRALGHGYRMLDSAFNYENEGAVGAAVR QSGLLRDEIFITSKLPGRHHAYDKAMETIEESLYRMQFDYLDLYLIHWPNPQQGLYIEAWQALIDAQKKGYIRSIGVSNF LPKHIETLRRETGVIPVINQVELHPYFNQAEQRAYDESQQIITMAWSPLGRAKAILDDAVLKQIAQETSRTVVQVVLRWQ VQMGVIPIPKAASDQNQMANQAIFDFSLSDDQVQRINALTCADGRIRNQDPAVYEEF
Sequences:
>Translated_297_residues MIEPKLKIETAQTNPMSIEKNIPDLILHDGHSIPALGFGTYTLKGQQGVDTMLRALGHGYRMLDSAFNYENEGAVGAAVR QSGLLRDEIFITSKLPGRHHAYDKAMETIEESLYRMQFDYLDLYLIHWPNPQQGLYIEAWQALIDAQKKGYIRSIGVSNF LPKHIETLRRETGVIPVINQVELHPYFNQAEQRAYDESQQIITMAWSPLGRAKAILDDAVLKQIAQETSRTVVQVVLRWQ VQMGVIPIPKAASDQNQMANQAIFDFSLSDDQVQRINALTCADGRIRNQDPAVYEEF >Mature_297_residues MIEPKLKIETAQTNPMSIEKNIPDLILHDGHSIPALGFGTYTLKGQQGVDTMLRALGHGYRMLDSAFNYENEGAVGAAVR QSGLLRDEIFITSKLPGRHHAYDKAMETIEESLYRMQFDYLDLYLIHWPNPQQGLYIEAWQALIDAQKKGYIRSIGVSNF LPKHIETLRRETGVIPVINQVELHPYFNQAEQRAYDESQQIITMAWSPLGRAKAILDDAVLKQIAQETSRTVVQVVLRWQ VQMGVIPIPKAASDQNQMANQAIFDFSLSDDQVQRINALTCADGRIRNQDPAVYEEF
Specific function: Catalyzes the reduction of 2,5-diketo-D-gluconic acid (25DKG) to 2-keto-L-gulonic acid (2KLG). 25DKGR-B has higher catalytic efficiency than 25DKGR-A [H]
COG id: COG0656
COG function: function code R; Aldo/keto reductases, related to diketogulonate reductase
Gene ontology:
Cell location: Cytoplasm (Probable) [H]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the aldo/keto reductase family [H]
Homologues:
Organism=Homo sapiens, GI310109922, Length=273, Percent_Identity=35.5311355311355, Blast_Score=162, Evalue=4e-40, Organism=Homo sapiens, GI5174695, Length=293, Percent_Identity=33.1058020477816, Blast_Score=161, Evalue=6e-40, Organism=Homo sapiens, GI5453543, Length=291, Percent_Identity=33.3333333333333, Blast_Score=160, Evalue=9e-40, Organism=Homo sapiens, GI24497577, Length=288, Percent_Identity=32.2916666666667, Blast_Score=160, Evalue=9e-40, Organism=Homo sapiens, GI5174391, Length=288, Percent_Identity=32.2916666666667, Blast_Score=160, Evalue=9e-40, Organism=Homo sapiens, GI310109920, Length=291, Percent_Identity=33.3333333333333, Blast_Score=160, Evalue=1e-39, Organism=Homo sapiens, GI45446745, Length=291, Percent_Identity=32.9896907216495, Blast_Score=158, Evalue=4e-39, Organism=Homo sapiens, GI4503285, Length=291, Percent_Identity=32.9896907216495, Blast_Score=158, Evalue=4e-39, Organism=Homo sapiens, GI24497583, Length=290, Percent_Identity=33.448275862069, Blast_Score=158, Evalue=7e-39, Organism=Homo sapiens, GI24497585, Length=291, Percent_Identity=31.9587628865979, Blast_Score=150, Evalue=9e-37, Organism=Homo sapiens, GI223468663, Length=277, Percent_Identity=31.7689530685921, Blast_Score=147, Evalue=1e-35, Organism=Homo sapiens, GI300116273, Length=264, Percent_Identity=32.9545454545455, Blast_Score=145, Evalue=6e-35, Organism=Homo sapiens, GI93277124, Length=294, Percent_Identity=28.2312925170068, Blast_Score=140, Evalue=1e-33, Organism=Homo sapiens, GI291291012, Length=255, Percent_Identity=32.156862745098, Blast_Score=140, Evalue=2e-33, Organism=Homo sapiens, GI4502049, Length=312, Percent_Identity=30.4487179487179, Blast_Score=132, Evalue=4e-31, Organism=Homo sapiens, GI300116271, Length=276, Percent_Identity=31.1594202898551, Blast_Score=127, Evalue=1e-29, Organism=Homo sapiens, GI310109924, Length=147, Percent_Identity=33.3333333333333, Blast_Score=90, Evalue=3e-18, Organism=Homo sapiens, GI310109926, Length=123, Percent_Identity=38.2113821138211, Blast_Score=82, Evalue=6e-16, Organism=Homo sapiens, GI207028673, Length=123, Percent_Identity=37.3983739837398, Blast_Score=80, Evalue=2e-15, Organism=Escherichia coli, GI87082198, Length=254, Percent_Identity=39.3700787401575, Blast_Score=206, Evalue=2e-54, Organism=Escherichia coli, GI1786400, Length=254, Percent_Identity=35.8267716535433, Blast_Score=157, Evalue=1e-39, Organism=Escherichia coli, GI1788081, Length=266, Percent_Identity=30.0751879699248, Blast_Score=94, Evalue=1e-20, Organism=Escherichia coli, GI48994888, Length=248, Percent_Identity=27.8225806451613, Blast_Score=69, Evalue=4e-13, Organism=Caenorhabditis elegans, GI17537077, Length=294, Percent_Identity=34.3537414965986, Blast_Score=168, Evalue=4e-42, Organism=Caenorhabditis elegans, GI17537075, Length=294, Percent_Identity=34.3537414965986, Blast_Score=166, Evalue=2e-41, Organism=Caenorhabditis elegans, GI17561298, Length=276, Percent_Identity=32.6086956521739, Blast_Score=157, Evalue=5e-39, Organism=Caenorhabditis elegans, GI17552492, Length=277, Percent_Identity=31.4079422382672, Blast_Score=156, Evalue=1e-38, Organism=Caenorhabditis elegans, GI17538386, Length=270, Percent_Identity=34.8148148148148, Blast_Score=155, Evalue=2e-38, Organism=Caenorhabditis elegans, GI17564128, Length=290, Percent_Identity=33.7931034482759, Blast_Score=153, Evalue=9e-38, Organism=Caenorhabditis elegans, GI71998625, Length=272, Percent_Identity=31.6176470588235, Blast_Score=152, Evalue=2e-37, Organism=Caenorhabditis elegans, GI17537079, Length=301, Percent_Identity=29.9003322259136, Blast_Score=147, Evalue=9e-36, Organism=Caenorhabditis elegans, GI17561300, Length=276, Percent_Identity=30.7971014492754, Blast_Score=134, Evalue=4e-32, Organism=Caenorhabditis elegans, GI17566692, Length=293, Percent_Identity=30.0341296928328, Blast_Score=131, Evalue=4e-31, Organism=Caenorhabditis elegans, GI17550248, Length=281, Percent_Identity=29.1814946619217, Blast_Score=118, Evalue=4e-27, Organism=Caenorhabditis elegans, GI17562292, Length=272, Percent_Identity=27.5735294117647, Blast_Score=111, Evalue=5e-25, Organism=Saccharomyces cerevisiae, GI6320576, Length=305, Percent_Identity=31.4754098360656, Blast_Score=157, Evalue=2e-39, Organism=Saccharomyces cerevisiae, GI6324694, Length=307, Percent_Identity=32.2475570032573, Blast_Score=154, Evalue=1e-38, Organism=Saccharomyces cerevisiae, GI6322556, Length=260, Percent_Identity=32.6923076923077, Blast_Score=148, Evalue=9e-37, Organism=Saccharomyces cerevisiae, GI6321896, Length=317, Percent_Identity=29.0220820189274, Blast_Score=132, Evalue=7e-32, Organism=Saccharomyces cerevisiae, GI6319625, Length=293, Percent_Identity=30.0341296928328, Blast_Score=115, Evalue=6e-27, Organism=Saccharomyces cerevisiae, GI6320079, Length=280, Percent_Identity=28.5714285714286, Blast_Score=110, Evalue=3e-25, Organism=Drosophila melanogaster, GI20129731, Length=276, Percent_Identity=33.695652173913, Blast_Score=157, Evalue=6e-39, Organism=Drosophila melanogaster, GI24662789, Length=298, Percent_Identity=33.5570469798658, Blast_Score=157, Evalue=1e-38, Organism=Drosophila melanogaster, GI24657054, Length=271, Percent_Identity=32.8413284132841, Blast_Score=149, Evalue=2e-36, Organism=Drosophila melanogaster, GI24663317, Length=286, Percent_Identity=30.7692307692308, Blast_Score=147, Evalue=9e-36, Organism=Drosophila melanogaster, GI21356425, Length=277, Percent_Identity=32.129963898917, Blast_Score=144, Evalue=5e-35, Organism=Drosophila melanogaster, GI24644950, Length=314, Percent_Identity=30.2547770700637, Blast_Score=137, Evalue=6e-33, Organism=Drosophila melanogaster, GI24662785, Length=295, Percent_Identity=33.8983050847458, Blast_Score=137, Evalue=7e-33, Organism=Drosophila melanogaster, GI45553081, Length=287, Percent_Identity=28.9198606271777, Blast_Score=137, Evalue=8e-33, Organism=Drosophila melanogaster, GI24662781, Length=296, Percent_Identity=33.1081081081081, Blast_Score=134, Evalue=6e-32, Organism=Drosophila melanogaster, GI221378297, Length=334, Percent_Identity=28.7425149700599, Blast_Score=130, Evalue=1e-30, Organism=Drosophila melanogaster, GI281366140, Length=251, Percent_Identity=27.8884462151394, Blast_Score=112, Evalue=2e-25,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR001395 - InterPro: IPR018170 - InterPro: IPR020471 - InterPro: IPR023210 [H]
Pfam domain/function: PF00248 Aldo_ket_red [H]
EC number: =1.1.1.274 [H]
Molecular weight: Translated: 33671; Mature: 33671
Theoretical pI: Translated: 5.60; Mature: 5.60
Prosite motif: PS00062 ALDOKETO_REDUCTASE_2
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.3 %Cys (Translated Protein) 3.0 %Met (Translated Protein) 3.4 %Cys+Met (Translated Protein) 0.3 %Cys (Mature Protein) 3.0 %Met (Mature Protein) 3.4 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MIEPKLKIETAQTNPMSIEKNIPDLILHDGHSIPALGFGTYTLKGQQGVDTMLRALGHGY CCCCCEEEEECCCCCCCCCCCCCCEEEECCCCCCEECCCEEEECCCCCHHHHHHHHCCHH RMLDSAFNYENEGAVGAAVRQSGLLRDEIFITSKLPGRHHAYDKAMETIEESLYRMQFDY HHHHHHHCCCCCCCHHHHHHHCCCCCHHEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCC LDLYLIHWPNPQQGLYIEAWQALIDAQKKGYIRSIGVSNFLPKHIETLRRETGVIPVINQ EEEEEEECCCCCCCCHHHHHHHHHHHHHCCCEEECCHHHCCHHHHHHHHHHCCCCEEECE VELHPYFNQAEQRAYDESQQIITMAWSPLGRAKAILDDAVLKQIAQETSRTVVQVVLRWQ EEECCHHHHHHHHHHHHHHEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH VQMGVIPIPKAASDQNQMANQAIFDFSLSDDQVQRINALTCADGRIRNQDPAVYEEF HHCCCEECCCCCCCHHHHHHHHHEEECCCHHHHHHHHHEEECCCCCCCCCCCHHCCC >Mature Secondary Structure MIEPKLKIETAQTNPMSIEKNIPDLILHDGHSIPALGFGTYTLKGQQGVDTMLRALGHGY CCCCCEEEEECCCCCCCCCCCCCCEEEECCCCCCEECCCEEEECCCCCHHHHHHHHCCHH RMLDSAFNYENEGAVGAAVRQSGLLRDEIFITSKLPGRHHAYDKAMETIEESLYRMQFDY HHHHHHHCCCCCCCHHHHHHHCCCCCHHEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCC LDLYLIHWPNPQQGLYIEAWQALIDAQKKGYIRSIGVSNFLPKHIETLRRETGVIPVINQ EEEEEEECCCCCCCCHHHHHHHHHHHHHCCCEEECCHHHCCHHHHHHHHHHCCCCEEECE VELHPYFNQAEQRAYDESQQIITMAWSPLGRAKAILDDAVLKQIAQETSRTVVQVVLRWQ EEECCHHHHHHHHHHHHHHEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH VQMGVIPIPKAASDQNQMANQAIFDFSLSDDQVQRINALTCADGRIRNQDPAVYEEF HHCCCEECCCCCCCHHHHHHHHHEEECCCHHHHHHHHHEEECCCCCCCCCCCHHCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: NA