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The map label for this gene is gltR [H]

Identifier: 50086264

GI number: 50086264

Start: 3187102

End: 3187956

Strand: Direct

Name: gltR [H]

Synonym: ACIAD3274

Alternate gene names: 50086264

Gene position: 3187102-3187956 (Clockwise)

Preceding gene: 50086260

Following gene: 50086265

Centisome position: 88.56

GC content: 40.35

Gene sequence:

>855_bases
ATGTTCCAAACCGTGGTTGAATGCGGAACAATGGCTAAGGCATCAATGCAACTACATTGCGTACCATCCAATATCACAAC
GCGTATTAAACAACTTGAAGAAGAACTAGGATCACCGCTATTTTATCGGGAAGGTAAAACACTCAAACTGACACCATCAG
GTGAAATTTTTCTGGAATATTGCCATAAGATTTTAGCCTTATGTGATGAAGCAAAACGTAGTATCCACCCTGATGCACCA
CCTTCTGGCCCACTCAGAATTGGCGCGATAGAATCCTCAGCCAGCACCCATTTACCACGCCTTTTGGCACAGTATCATCA
GCACTATCCAGATGTTTCAATTCAAATTATTACAGGAACGTGGAAACAACTGTTACTGGATGTCAGCCAGCATAAACTGG
ATGCGGCCATGGTGGCTGGTGCAATTGATTTTCCATGTTTAAATAAGGTTGAAATATATCAGGAAAATATGGTGCTGATT
GCACCTGCATCAATGGGTATCATCCGCAATCAGGAAGATTTGATCAACAAAGAAATCTTTATGTGGACTGAAGGCTGTCC
TTATCGTGCAGCATTGGAAACATGGCTAAAACTCAAACATATTTCACTACCGATAACCAGTATCACCAATTACGCCACTA
TCATAGGCTGTGTGAGTGCAGGTTTAGGTGTATCTCTGATTCCAAAAAGTATCTATGCACAATATAAAAATCTTCCTCAA
TTGTGCAGTTATGAGTTTGATCGTCTGGCCACTATTCCTGTTCATTTTTTCTGGCATCAGAAAATTCTAAATCATAAAGC
CCGAGATGCCTTTCTTAAGCTCTTGACGCTCGAATTTTTAGAAAAAAATCAATGA

Upstream 100 bases:

>100_bases
TTTCATCATATGCACATGGATAGTTAAATAAAATTAACTTATATTGAGTCAAATATTCATTAAAAGTGAATGATAAAACA
TGGATATCACTCAGTTAAAA

Downstream 100 bases:

>100_bases
AAATTACCATTTTGATTTTATTCTCAAGTCAAAAATTCGCTATACTCAAGAAAATACACAACAAGATAGACTGACAATAT
GAAACTAAAAACACTTGCTC

Product: transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 284; Mature: 284

Protein sequence:

>284_residues
MFQTVVECGTMAKASMQLHCVPSNITTRIKQLEEELGSPLFYREGKTLKLTPSGEIFLEYCHKILALCDEAKRSIHPDAP
PSGPLRIGAIESSASTHLPRLLAQYHQHYPDVSIQIITGTWKQLLLDVSQHKLDAAMVAGAIDFPCLNKVEIYQENMVLI
APASMGIIRNQEDLINKEIFMWTEGCPYRAALETWLKLKHISLPITSITNYATIIGCVSAGLGVSLIPKSIYAQYKNLPQ
LCSYEFDRLATIPVHFFWHQKILNHKARDAFLKLLTLEFLEKNQ

Sequences:

>Translated_284_residues
MFQTVVECGTMAKASMQLHCVPSNITTRIKQLEEELGSPLFYREGKTLKLTPSGEIFLEYCHKILALCDEAKRSIHPDAP
PSGPLRIGAIESSASTHLPRLLAQYHQHYPDVSIQIITGTWKQLLLDVSQHKLDAAMVAGAIDFPCLNKVEIYQENMVLI
APASMGIIRNQEDLINKEIFMWTEGCPYRAALETWLKLKHISLPITSITNYATIIGCVSAGLGVSLIPKSIYAQYKNLPQ
LCSYEFDRLATIPVHFFWHQKILNHKARDAFLKLLTLEFLEKNQ
>Mature_284_residues
MFQTVVECGTMAKASMQLHCVPSNITTRIKQLEEELGSPLFYREGKTLKLTPSGEIFLEYCHKILALCDEAKRSIHPDAP
PSGPLRIGAIESSASTHLPRLLAQYHQHYPDVSIQIITGTWKQLLLDVSQHKLDAAMVAGAIDFPCLNKVEIYQENMVLI
APASMGIIRNQEDLINKEIFMWTEGCPYRAALETWLKLKHISLPITSITNYATIIGCVSAGLGVSLIPKSIYAQYKNLPQ
LCSYEFDRLATIPVHFFWHQKILNHKARDAFLKLLTLEFLEKNQ

Specific function: Positive regulator of glutamate biosynthesis (gltAB genes). Negatively regulates its own expression [H]

COG id: COG0583

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787806, Length=232, Percent_Identity=34.4827586206897, Blast_Score=166, Evalue=1e-42,
Organism=Escherichia coli, GI1790208, Length=243, Percent_Identity=27.5720164609054, Blast_Score=99, Evalue=3e-22,
Organism=Escherichia coli, GI87082132, Length=236, Percent_Identity=25.8474576271186, Blast_Score=92, Evalue=5e-20,
Organism=Escherichia coli, GI157672245, Length=160, Percent_Identity=29.375, Blast_Score=86, Evalue=3e-18,
Organism=Escherichia coli, GI1788887, Length=238, Percent_Identity=24.7899159663866, Blast_Score=78, Evalue=7e-16,
Organism=Escherichia coli, GI1790262, Length=243, Percent_Identity=23.4567901234568, Blast_Score=73, Evalue=2e-14,
Organism=Escherichia coli, GI1787879, Length=247, Percent_Identity=26.3157894736842, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1789639, Length=165, Percent_Identity=28.4848484848485, Blast_Score=69, Evalue=4e-13,
Organism=Escherichia coli, GI1787601, Length=134, Percent_Identity=28.3582089552239, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1786401, Length=162, Percent_Identity=27.1604938271605, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI87081904, Length=186, Percent_Identity=24.1935483870968, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1788297, Length=233, Percent_Identity=21.8884120171674, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1787530, Length=222, Percent_Identity=25.6756756756757, Blast_Score=63, Evalue=2e-11,
Organism=Escherichia coli, GI1788481, Length=243, Percent_Identity=26.3374485596708, Blast_Score=62, Evalue=4e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 32050; Mature: 32050

Theoretical pI: Translated: 7.55; Mature: 7.55

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.8 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
5.3 %Cys+Met (Translated Protein)
2.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
5.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFQTVVECGTMAKASMQLHCVPSNITTRIKQLEEELGSPLFYREGKTLKLTPSGEIFLEY
CCHHHHHHCCHHHCCEEEEEECCHHHHHHHHHHHHHCCCEEEECCCEEEECCCCHHHHHH
CHKILALCDEAKRSIHPDAPPSGPLRIGAIESSASTHLPRLLAQYHQHYPDVSIQIITGT
HHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCCEEEEEECC
WKQLLLDVSQHKLDAAMVAGAIDFPCLNKVEIYQENMVLIAPASMGIIRNQEDLINKEIF
HHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHEECCCEEEEEECCCCCCCCHHHHHCCEEE
MWTEGCPYRAALETWLKLKHISLPITSITNYATIIGCVSAGLGVSLIPKSIYAQYKNLPQ
EEECCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCHH
LCSYEFDRLATIPVHFFWHQKILNHKARDAFLKLLTLEFLEKNQ
HHCCCHHHEEEHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MFQTVVECGTMAKASMQLHCVPSNITTRIKQLEEELGSPLFYREGKTLKLTPSGEIFLEY
CCHHHHHHCCHHHCCEEEEEECCHHHHHHHHHHHHHCCCEEEECCCEEEECCCCHHHHHH
CHKILALCDEAKRSIHPDAPPSGPLRIGAIESSASTHLPRLLAQYHQHYPDVSIQIITGT
HHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCHHHHHHHHHHHHHHHCCCCEEEEEECC
WKQLLLDVSQHKLDAAMVAGAIDFPCLNKVEIYQENMVLIAPASMGIIRNQEDLINKEIF
HHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHEECCCEEEEEECCCCCCCCHHHHHCCEEE
MWTEGCPYRAALETWLKLKHISLPITSITNYATIIGCVSAGLGVSLIPKSIYAQYKNLPQ
EEECCCCHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCHH
LCSYEFDRLATIPVHFFWHQKILNHKARDAFLKLLTLEFLEKNQ
HHCCCHHHEEEHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9023181; 9308178; 9384377 [H]