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The map label for this gene is metC [H]

Identifier: 50086218

GI number: 50086218

Start: 3136252

End: 3137445

Strand: Direct

Name: metC [H]

Synonym: ACIAD3222

Alternate gene names: 50086218

Gene position: 3136252-3137445 (Clockwise)

Preceding gene: 50086187

Following gene: 50086219

Centisome position: 87.15

GC content: 41.54

Gene sequence:

>1194_bases
ATGTTAGATGATAAAAAACCACAAACTTCGTTAATTCATGCGCCAAGAAAAGCCCCACAATACATTCACAGCATTCAACC
TCCCTTGTTTCGTGCATCTACCATTATTTTTCCTACTACAGCGCACCTTTTTGATCGGCATTGGAGCGATCCTTATGATT
ATAGTTATGGAACACATGGCACACCCACAACCTTTACTTTAGGTGATCAATTGGCTGAAATTGAAGGGGGACAATATTGT
TTACTTGCACCGAGCGGCTTATCTGCAATTAATCTGGTCAATTCAACTTTTCTAAGTCATGGCGATGAAGTCTGGGTACC
AGATAATATCTATGGCCCGAACATGGAACACCTAAACAATTTGCGACAACGCTATGGCATTCAAGTTCGTATCTACAATC
CAATTGATGCAGAATCGTTTATACCTTCAGAGAAAACCAGGCTACTCTGGCTTGAAGCTGCTGGTTCAATTACGATGGAG
TTTCCTGATTTAATACAACTTGTTCGAAAGGCACAGGCAGCACAGGTACTCACAGCATTAGATAATACCTGGGGTGCAGG
ATTGGCCTTCAATGCCTTCGACTTTTCTAATGAGCATCTATCAGTCGATATAACCGTACATGCTTTAACAAAATACCCAA
GCGGTGGCGGTGATATTTTGATGGGTAGCGTCATAACACGCGACAAGAATTTGTATCAACAACTCTTTAAAATTCATGCC
AATCAGGGAATCTGTGTGTCGGGCGACGATACCGCACAAATTATTCGCAGCTTGGCGCATATGCGTCTGCGCTATCAGCA
GCAAGCTGAAAATGCACAGAAACTATTGGAGTGGCTTCAACAACAACCGCAATGTATTCAGGTTTTACATCCCGCCGCAT
CAAATAGTCCTGGACATGATTACTGGAAGAGCATCTGTAAAAATGGTCAAAGTGCTGGATTGGTGAGTGTGATTTTTGAT
CCAAAATATGATTTGGCTGCAATCCGTCGCTTTTGTGATGCCCTAAACTTGTTTAAATTAGGTTTTAGCTGGGGTGGTCC
TGTGAGCTTGGTCATGCTATATGACTTAAAACAGATGCGAATATTGAACAATACACATTTACAACAAGGCTTACTGGTTC
GATTTTGTGTAGGACTGGAAGATCCAGAAGATTTAATACAAGATATTCAAAACGCACTACAACAACTCGAATAG

Upstream 100 bases:

>100_bases
AATAACGACTTTCAAAAAAAAATTAACAAATCAGACTAAAACTGGCGCAATCATTTATTTTTTTTTACATTAGTCAAAAT
TCCATTTAGATATTTGCACC

Downstream 100 bases:

>100_bases
AGACAACAATACAGGAACAGCTTATGGGTACACCAATCATCATTGCAAAAAAAACCAATGATATTCAACAGGATATTATT
TTACATTCTGAATTTGCCAA

Product: cystathionine beta-lyase, PLP-dependent (beta-cystathionase)

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase; ORF5 [H]

Number of amino acids: Translated: 397; Mature: 397

Protein sequence:

>397_residues
MLDDKKPQTSLIHAPRKAPQYIHSIQPPLFRASTIIFPTTAHLFDRHWSDPYDYSYGTHGTPTTFTLGDQLAEIEGGQYC
LLAPSGLSAINLVNSTFLSHGDEVWVPDNIYGPNMEHLNNLRQRYGIQVRIYNPIDAESFIPSEKTRLLWLEAAGSITME
FPDLIQLVRKAQAAQVLTALDNTWGAGLAFNAFDFSNEHLSVDITVHALTKYPSGGGDILMGSVITRDKNLYQQLFKIHA
NQGICVSGDDTAQIIRSLAHMRLRYQQQAENAQKLLEWLQQQPQCIQVLHPAASNSPGHDYWKSICKNGQSAGLVSVIFD
PKYDLAAIRRFCDALNLFKLGFSWGGPVSLVMLYDLKQMRILNNTHLQQGLLVRFCVGLEDPEDLIQDIQNALQQLE

Sequences:

>Translated_397_residues
MLDDKKPQTSLIHAPRKAPQYIHSIQPPLFRASTIIFPTTAHLFDRHWSDPYDYSYGTHGTPTTFTLGDQLAEIEGGQYC
LLAPSGLSAINLVNSTFLSHGDEVWVPDNIYGPNMEHLNNLRQRYGIQVRIYNPIDAESFIPSEKTRLLWLEAAGSITME
FPDLIQLVRKAQAAQVLTALDNTWGAGLAFNAFDFSNEHLSVDITVHALTKYPSGGGDILMGSVITRDKNLYQQLFKIHA
NQGICVSGDDTAQIIRSLAHMRLRYQQQAENAQKLLEWLQQQPQCIQVLHPAASNSPGHDYWKSICKNGQSAGLVSVIFD
PKYDLAAIRRFCDALNLFKLGFSWGGPVSLVMLYDLKQMRILNNTHLQQGLLVRFCVGLEDPEDLIQDIQNALQQLE
>Mature_397_residues
MLDDKKPQTSLIHAPRKAPQYIHSIQPPLFRASTIIFPTTAHLFDRHWSDPYDYSYGTHGTPTTFTLGDQLAEIEGGQYC
LLAPSGLSAINLVNSTFLSHGDEVWVPDNIYGPNMEHLNNLRQRYGIQVRIYNPIDAESFIPSEKTRLLWLEAAGSITME
FPDLIQLVRKAQAAQVLTALDNTWGAGLAFNAFDFSNEHLSVDITVHALTKYPSGGGDILMGSVITRDKNLYQQLFKIHA
NQGICVSGDDTAQIIRSLAHMRLRYQQQAENAQKLLEWLQQQPQCIQVLHPAASNSPGHDYWKSICKNGQSAGLVSVIFD
PKYDLAAIRRFCDALNLFKLGFSWGGPVSLVMLYDLKQMRILNNTHLQQGLLVRFCVGLEDPEDLIQDIQNALQQLE

Specific function: Methionine biosynthesis; third step. [C]

COG id: COG0626

COG function: function code E; Cystathionine beta-lyases/cystathionine gamma-synthases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trans-sulfuration enzymes family [H]

Homologues:

Organism=Homo sapiens, GI21361334, Length=387, Percent_Identity=25.3229974160207, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI25453487, Length=382, Percent_Identity=25.3926701570681, Blast_Score=88, Evalue=1e-17,
Organism=Homo sapiens, GI299473759, Length=387, Percent_Identity=22.4806201550388, Blast_Score=69, Evalue=9e-12,
Organism=Escherichia coli, GI1789383, Length=405, Percent_Identity=28.641975308642, Blast_Score=187, Evalue=2e-48,
Organism=Escherichia coli, GI1790375, Length=376, Percent_Identity=27.1276595744681, Blast_Score=142, Evalue=5e-35,
Organism=Caenorhabditis elegans, GI71980708, Length=381, Percent_Identity=30.4461942257218, Blast_Score=155, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI17560056, Length=383, Percent_Identity=27.6762402088773, Blast_Score=128, Evalue=4e-30,
Organism=Caenorhabditis elegans, GI17538055, Length=382, Percent_Identity=26.1780104712042, Blast_Score=124, Evalue=6e-29,
Organism=Saccharomyces cerevisiae, GI6321170, Length=325, Percent_Identity=30.7692307692308, Blast_Score=161, Evalue=2e-40,
Organism=Saccharomyces cerevisiae, GI6319307, Length=353, Percent_Identity=28.328611898017, Blast_Score=116, Evalue=6e-27,
Organism=Saccharomyces cerevisiae, GI6321904, Length=397, Percent_Identity=24.9370277078086, Blast_Score=75, Evalue=2e-14,
Organism=Saccharomyces cerevisiae, GI6323333, Length=414, Percent_Identity=23.6714975845411, Blast_Score=74, Evalue=5e-14,
Organism=Saccharomyces cerevisiae, GI6321254, Length=422, Percent_Identity=21.8009478672986, Blast_Score=72, Evalue=1e-13,
Organism=Drosophila melanogaster, GI19922554, Length=397, Percent_Identity=30.7304785894207, Blast_Score=137, Evalue=2e-32,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000277
- InterPro:   IPR006233
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01053 Cys_Met_Meta_PP [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 44575; Mature: 44575

Theoretical pI: Translated: 6.27; Mature: 6.27

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLDDKKPQTSLIHAPRKAPQYIHSIQPPLFRASTIIFPTTAHLFDRHWSDPYDYSYGTHG
CCCCCCCCHHHHHCCCHHHHHHHHCCCCCHHCCEEEECCHHHHHHHCCCCCCCCCCCCCC
TPTTFTLGDQLAEIEGGQYCLLAPSGLSAINLVNSTFLSHGDEVWVPDNIYGPNMEHLNN
CCCEEECCCHHHHCCCCCEEEECCCCCHHHHHHHHHHHHCCCCEECCCCCCCCCHHHHHH
LRQRYGIQVRIYNPIDAESFIPSEKTRLLWLEAAGSITMEFPDLIQLVRKAQAAQVLTAL
HHHHHCCEEEEECCCCHHHCCCCCCCEEEEEEECCCEEECCHHHHHHHHHHHHHHHHHHH
DNTWGAGLAFNAFDFSNEHLSVDITVHALTKYPSGGGDILMGSVITRDKNLYQQLFKIHA
HCCCCCCEEEEEEECCCCEEEEEEEEEEEECCCCCCCCEEECHHHHCCHHHHHHHHHHHC
NQGICVSGDDTAQIIRSLAHMRLRYQQQAENAQKLLEWLQQQPQCIQVLHPAASNSPGHD
CCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCHH
YWKSICKNGQSAGLVSVIFDPKYDLAAIRRFCDALNLFKLGFSWGGPVSLVMLYDLKQMR
HHHHHHCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
ILNNTHLQQGLLVRFCVGLEDPEDLIQDIQNALQQLE
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MLDDKKPQTSLIHAPRKAPQYIHSIQPPLFRASTIIFPTTAHLFDRHWSDPYDYSYGTHG
CCCCCCCCHHHHHCCCHHHHHHHHCCCCCHHCCEEEECCHHHHHHHCCCCCCCCCCCCCC
TPTTFTLGDQLAEIEGGQYCLLAPSGLSAINLVNSTFLSHGDEVWVPDNIYGPNMEHLNN
CCCEEECCCHHHHCCCCCEEEECCCCCHHHHHHHHHHHHCCCCEECCCCCCCCCHHHHHH
LRQRYGIQVRIYNPIDAESFIPSEKTRLLWLEAAGSITMEFPDLIQLVRKAQAAQVLTAL
HHHHHCCEEEEECCCCHHHCCCCCCCEEEEEEECCCEEECCHHHHHHHHHHHHHHHHHHH
DNTWGAGLAFNAFDFSNEHLSVDITVHALTKYPSGGGDILMGSVITRDKNLYQQLFKIHA
HCCCCCCEEEEEEECCCCEEEEEEEEEEEECCCCCCCCEEECHHHHCCHHHHHHHHHHHC
NQGICVSGDDTAQIIRSLAHMRLRYQQQAENAQKLLEWLQQQPQCIQVLHPAASNSPGHD
CCCEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCCHH
YWKSICKNGQSAGLVSVIFDPKYDLAAIRRFCDALNLFKLGFSWGGPVSLVMLYDLKQMR
HHHHHHCCCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
ILNNTHLQQGLLVRFCVGLEDPEDLIQDIQNALQQLE
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8898392 [H]