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The map label for this gene is fadE [H]

Identifier: 50086187

GI number: 50086187

Start: 3118628

End: 3119800

Strand: Direct

Name: fadE [H]

Synonym: ACIAD3191

Alternate gene names: 50086187

Gene position: 3118628-3119800 (Clockwise)

Preceding gene: 50086180

Following gene: 50086218

Centisome position: 86.66

GC content: 40.41

Gene sequence:

>1173_bases
ATGCAATCTGGAGCTATTCGCCCAATCGACTCTATGCTGGGACGCAATCTATTTTCAGAAGAGCATCATGCTTTTCGTGA
TACTGTCAGAAAATTTTATGAAAAAGAAGTGGTTCCCAATATTGAAAAATATGAAGCACAACAACATGTAGATCGTGATT
TATGGAACAAGGCTGGCGAATTGGGATTATTGTGTACCACTATGCCCGAGCAATATGGTGGCTCTGGGGTAGATCGTCTT
TACAGCATGATTTTAATTGAAGAACAAGCCTATGCGATGGATTCAAGTACAGGCTTTTCTTTACACTCCGATATTGTGGC
CAATTACATTCATAATTTTGGTAACGAAGAACAAAAACAAAAATGGTTGCCTAAAATGGCAACGGGAGAAGTCGTGACAG
CCATTGCGATGACAGAACCAGGAACAGGCTCAGACTTGCAAGCAGTACGAACCAGCGCTGTACTTGATGGCGATGAATAT
GTCATCAATGGCTCTAAAATTTTTATTACCAATGGCTATCTGTGCGATATGGCGGTTGTAGTATGTAAAACAGGAAATAC
AGACAAAGGCTCTGCCAATTTATCGTTGATTATTGTGGAAGCTGATCGCGCTGGATTTAATAAAGGCAAACCTCTTAATA
AAATAGGAATGAAAGGTCAGGATACTTGTGAACTTTTCTTCGATAACGTCCGCGTTCCGAAAGAGAATCTTCTTGGTATG
GAAGGTATGGGTTTTATGATGCTAATGAAGGAGCTGGCATGGGAGCGCATGTTAGTTGCAATTATCTGCCAAGCTGGCGC
TGAAGCAGCATTTGCACATACTGTACAATACACCAAAGATCGCAAAGCATTTGGCAAACCAATTGGGACTTTTCAAAACA
CGCGCTTTAAATTGGCCGAGCTAAGAACCGAGATTGATTTTTGTCGTGCCTATTTAGATCGATGTATGCAACTACAACTT
GAAGAACAACTCGGCATTGATGCTGCTGCTGCCGCTAAATATAAAATTTCAGATATGTTTTCGAAAGTTGTAGATGAATG
TTTACAGTTACATGGTGGTTATGGCTATATGCTGGAATATCCGATTGCACGTGCCTATATCGATAATCGTGCGAATCGTA
TCTATGCTGGCACCAATGAAATTATGAAAGAATTAATTTCTCGAACCCTTTAA

Upstream 100 bases:

>100_bases
TCATTTAAAGATTTGAATTGAGCATTCTTCACATTGTGTCAACCACCTGAATTCGCTTTTACTGCAATCATATCTCAAAC
AAAAAATAAAGGACCGATAC

Downstream 100 bases:

>100_bases
AAGTTAAGTTTTCATAAACAAAAAAAGGAGCTTTGTTTAAGCTCCTTTTTTTGTTTAGCTCAAGTTAGGATACTAATTTG
GGTTTTGTTTTACGCTCAAC

Product: acyl coenzyme A dehydrogenase

Products: 2,3-dehydroacyl-CoA; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 390; Mature: 390

Protein sequence:

>390_residues
MQSGAIRPIDSMLGRNLFSEEHHAFRDTVRKFYEKEVVPNIEKYEAQQHVDRDLWNKAGELGLLCTTMPEQYGGSGVDRL
YSMILIEEQAYAMDSSTGFSLHSDIVANYIHNFGNEEQKQKWLPKMATGEVVTAIAMTEPGTGSDLQAVRTSAVLDGDEY
VINGSKIFITNGYLCDMAVVVCKTGNTDKGSANLSLIIVEADRAGFNKGKPLNKIGMKGQDTCELFFDNVRVPKENLLGM
EGMGFMMLMKELAWERMLVAIICQAGAEAAFAHTVQYTKDRKAFGKPIGTFQNTRFKLAELRTEIDFCRAYLDRCMQLQL
EEQLGIDAAAAAKYKISDMFSKVVDECLQLHGGYGYMLEYPIARAYIDNRANRIYAGTNEIMKELISRTL

Sequences:

>Translated_390_residues
MQSGAIRPIDSMLGRNLFSEEHHAFRDTVRKFYEKEVVPNIEKYEAQQHVDRDLWNKAGELGLLCTTMPEQYGGSGVDRL
YSMILIEEQAYAMDSSTGFSLHSDIVANYIHNFGNEEQKQKWLPKMATGEVVTAIAMTEPGTGSDLQAVRTSAVLDGDEY
VINGSKIFITNGYLCDMAVVVCKTGNTDKGSANLSLIIVEADRAGFNKGKPLNKIGMKGQDTCELFFDNVRVPKENLLGM
EGMGFMMLMKELAWERMLVAIICQAGAEAAFAHTVQYTKDRKAFGKPIGTFQNTRFKLAELRTEIDFCRAYLDRCMQLQL
EEQLGIDAAAAAKYKISDMFSKVVDECLQLHGGYGYMLEYPIARAYIDNRANRIYAGTNEIMKELISRTL
>Mature_390_residues
MQSGAIRPIDSMLGRNLFSEEHHAFRDTVRKFYEKEVVPNIEKYEAQQHVDRDLWNKAGELGLLCTTMPEQYGGSGVDRL
YSMILIEEQAYAMDSSTGFSLHSDIVANYIHNFGNEEQKQKWLPKMATGEVVTAIAMTEPGTGSDLQAVRTSAVLDGDEY
VINGSKIFITNGYLCDMAVVVCKTGNTDKGSANLSLIIVEADRAGFNKGKPLNKIGMKGQDTCELFFDNVRVPKENLLGM
EGMGFMMLMKELAWERMLVAIICQAGAEAAFAHTVQYTKDRKAFGKPIGTFQNTRFKLAELRTEIDFCRAYLDRCMQLQL
EEQLGIDAAAAAKYKISDMFSKVVDECLQLHGGYGYMLEYPIARAYIDNRANRIYAGTNEIMKELISRTL

Specific function: Unknown

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4501857, Length=377, Percent_Identity=48.2758620689655, Blast_Score=373, Evalue=1e-103,
Organism=Homo sapiens, GI226958412, Length=390, Percent_Identity=33.3333333333333, Blast_Score=229, Evalue=4e-60,
Organism=Homo sapiens, GI7656849, Length=383, Percent_Identity=33.420365535248, Blast_Score=222, Evalue=4e-58,
Organism=Homo sapiens, GI4557233, Length=374, Percent_Identity=34.2245989304813, Blast_Score=216, Evalue=3e-56,
Organism=Homo sapiens, GI226958414, Length=341, Percent_Identity=34.6041055718475, Blast_Score=212, Evalue=6e-55,
Organism=Homo sapiens, GI4557231, Length=378, Percent_Identity=31.7460317460317, Blast_Score=190, Evalue=2e-48,
Organism=Homo sapiens, GI187960098, Length=378, Percent_Identity=31.7460317460317, Blast_Score=190, Evalue=2e-48,
Organism=Homo sapiens, GI76496475, Length=386, Percent_Identity=33.9378238341969, Blast_Score=189, Evalue=4e-48,
Organism=Homo sapiens, GI4501859, Length=374, Percent_Identity=29.144385026738, Blast_Score=189, Evalue=4e-48,
Organism=Homo sapiens, GI4557235, Length=386, Percent_Identity=33.9378238341969, Blast_Score=189, Evalue=4e-48,
Organism=Homo sapiens, GI21361497, Length=379, Percent_Identity=34.5646437994723, Blast_Score=186, Evalue=5e-47,
Organism=Homo sapiens, GI4503943, Length=382, Percent_Identity=29.0575916230367, Blast_Score=131, Evalue=1e-30,
Organism=Homo sapiens, GI7669494, Length=367, Percent_Identity=29.1553133514986, Blast_Score=122, Evalue=4e-28,
Organism=Homo sapiens, GI38505218, Length=382, Percent_Identity=27.4869109947644, Blast_Score=112, Evalue=7e-25,
Organism=Homo sapiens, GI48976061, Length=356, Percent_Identity=28.9325842696629, Blast_Score=108, Evalue=1e-23,
Organism=Homo sapiens, GI211971008, Length=356, Percent_Identity=28.9325842696629, Blast_Score=107, Evalue=1e-23,
Organism=Escherichia coli, GI87081958, Length=344, Percent_Identity=31.6860465116279, Blast_Score=154, Evalue=7e-39,
Organism=Escherichia coli, GI1786223, Length=381, Percent_Identity=26.509186351706, Blast_Score=119, Evalue=4e-28,
Organism=Caenorhabditis elegans, GI17538396, Length=403, Percent_Identity=34.9875930521092, Blast_Score=233, Evalue=2e-61,
Organism=Caenorhabditis elegans, GI17551932, Length=377, Percent_Identity=33.42175066313, Blast_Score=213, Evalue=1e-55,
Organism=Caenorhabditis elegans, GI17505929, Length=378, Percent_Identity=33.8624338624339, Blast_Score=209, Evalue=2e-54,
Organism=Caenorhabditis elegans, GI17534899, Length=362, Percent_Identity=32.3204419889503, Blast_Score=200, Evalue=1e-51,
Organism=Caenorhabditis elegans, GI17533517, Length=370, Percent_Identity=32.1621621621622, Blast_Score=198, Evalue=3e-51,
Organism=Caenorhabditis elegans, GI17508101, Length=372, Percent_Identity=30.6451612903226, Blast_Score=193, Evalue=1e-49,
Organism=Caenorhabditis elegans, GI17570075, Length=375, Percent_Identity=31.2, Blast_Score=188, Evalue=4e-48,
Organism=Caenorhabditis elegans, GI17569725, Length=378, Percent_Identity=30.6878306878307, Blast_Score=186, Evalue=2e-47,
Organism=Caenorhabditis elegans, GI17506239, Length=376, Percent_Identity=30.8510638297872, Blast_Score=182, Evalue=3e-46,
Organism=Caenorhabditis elegans, GI71985184, Length=371, Percent_Identity=34.2318059299191, Blast_Score=176, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI71990804, Length=280, Percent_Identity=34.6428571428571, Blast_Score=153, Evalue=1e-37,
Organism=Caenorhabditis elegans, GI71985192, Length=322, Percent_Identity=34.472049689441, Blast_Score=145, Evalue=2e-35,
Organism=Caenorhabditis elegans, GI17534353, Length=377, Percent_Identity=26.2599469496021, Blast_Score=134, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI71982178, Length=276, Percent_Identity=29.3478260869565, Blast_Score=134, Evalue=1e-31,
Organism=Caenorhabditis elegans, GI32563615, Length=226, Percent_Identity=33.6283185840708, Blast_Score=126, Evalue=2e-29,
Organism=Caenorhabditis elegans, GI17562446, Length=335, Percent_Identity=28.955223880597, Blast_Score=103, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17531909, Length=242, Percent_Identity=23.9669421487603, Blast_Score=84, Evalue=1e-16,
Organism=Drosophila melanogaster, GI21355753, Length=390, Percent_Identity=34.8717948717949, Blast_Score=216, Evalue=3e-56,
Organism=Drosophila melanogaster, GI21356377, Length=374, Percent_Identity=32.8877005347594, Blast_Score=213, Evalue=2e-55,
Organism=Drosophila melanogaster, GI24666513, Length=376, Percent_Identity=30.5851063829787, Blast_Score=192, Evalue=2e-49,
Organism=Drosophila melanogaster, GI24646207, Length=374, Percent_Identity=31.0160427807487, Blast_Score=187, Evalue=1e-47,
Organism=Drosophila melanogaster, GI24660351, Length=376, Percent_Identity=31.3829787234043, Blast_Score=186, Evalue=2e-47,
Organism=Drosophila melanogaster, GI281363737, Length=380, Percent_Identity=28.9473684210526, Blast_Score=165, Evalue=4e-41,
Organism=Drosophila melanogaster, GI19920834, Length=388, Percent_Identity=29.639175257732, Blast_Score=141, Evalue=6e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.3

Molecular weight: Translated: 43709; Mature: 43709

Theoretical pI: Translated: 5.33; Mature: 5.33

Prosite motif: PS00073 ACYL_COA_DH_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
4.9 %Met     (Translated Protein)
6.9 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
4.9 %Met     (Mature Protein)
6.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQSGAIRPIDSMLGRNLFSEEHHAFRDTVRKFYEKEVVPNIEKYEAQQHVDRDLWNKAGE
CCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCC
LGLLCTTMPEQYGGSGVDRLYSMILIEEQAYAMDSSTGFSLHSDIVANYIHNFGNEEQKQ
CEEEEECCCHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCHHHHH
KWLPKMATGEVVTAIAMTEPGTGSDLQAVRTSAVLDGDEYVINGSKIFITNGYLCDMAVV
HHCCCCCCCCEEEEEEEECCCCCCHHHHHHHHHEECCCCEEEECCEEEEECCHHHHEEEE
VCKTGNTDKGSANLSLIIVEADRAGFNKGKPLNKIGMKGQDTCELFFDNVRVPKENLLGM
EEECCCCCCCCCCEEEEEEECCCCCCCCCCCCHHHCCCCCCHHHHHHHCCCCCHHHCCCC
EGMGFMMLMKELAWERMLVAIICQAGAEAAFAHTVQYTKDRKAFGKPIGTFQNTRFKLAE
CCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHH
LRTEIDFCRAYLDRCMQLQLEEQLGIDAAAAAKYKISDMFSKVVDECLQLHGGYGYMLEY
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECC
PIARAYIDNRANRIYAGTNEIMKELISRTL
HHHHHHHHCCCCEEEECHHHHHHHHHHHCC
>Mature Secondary Structure
MQSGAIRPIDSMLGRNLFSEEHHAFRDTVRKFYEKEVVPNIEKYEAQQHVDRDLWNKAGE
CCCCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCC
LGLLCTTMPEQYGGSGVDRLYSMILIEEQAYAMDSSTGFSLHSDIVANYIHNFGNEEQKQ
CEEEEECCCHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCCHHHHH
KWLPKMATGEVVTAIAMTEPGTGSDLQAVRTSAVLDGDEYVINGSKIFITNGYLCDMAVV
HHCCCCCCCCEEEEEEEECCCCCCHHHHHHHHHEECCCCEEEECCEEEEECCHHHHEEEE
VCKTGNTDKGSANLSLIIVEADRAGFNKGKPLNKIGMKGQDTCELFFDNVRVPKENLLGM
EEECCCCCCCCCCEEEEEEECCCCCCCCCCCCHHHCCCCCCHHHHHHHCCCCCHHHCCCC
EGMGFMMLMKELAWERMLVAIICQAGAEAAFAHTVQYTKDRKAFGKPIGTFQNTRFKLAE
CCCHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHH
LRTEIDFCRAYLDRCMQLQLEEQLGIDAAAAAKYKISDMFSKVVDECLQLHGGYGYMLEY
HHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECC
PIARAYIDNRANRIYAGTNEIMKELISRTL
HHHHHHHHCCCCEEEECHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA; acceptor

Specific reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8759838; 8969508; 9384377 [H]