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The map label for this gene is thi3 [C]

Identifier: 50086143

GI number: 50086143

Start: 3063916

End: 3064341

Strand: Reverse

Name: thi3 [C]

Synonym: ACIAD3140

Alternate gene names: 50086143

Gene position: 3064341-3063916 (Counterclockwise)

Preceding gene: 50086144

Following gene: 50086142

Centisome position: 85.15

GC content: 39.67

Gene sequence:

>426_bases
ATGATCGTGGTCTGTCCATCATGTGGTGCAAAAAATCGAGTTCCTGAAAATAAATTGGCTGAGCAGCCGCAATGTGGGCA
ATGTCACGCAAAGCTACTGCCACTTGCACCTATCGAATTAAATGAACAAAATTTCAGTCATTTTATCACCTATAGCGATT
TGCCCGTGTTGATTGATTTATGGGCAGAATGGTGTGGTCCATGCAAAATGATGGCGCCTCATTTTGCACACGTAGCTGCT
CAAAATCCGCAGGTTATTTTTGCAAAAATTAATACGGAAACTTCACCAAGACTTAGTCAGGCATTTCATGTCAGAAGTAT
TCCTACACTGGTTTTAATGAATAAAACCACCGAAATTGCTAGAATAAGTGGTGCTTTAAGATCAACCGAACTTCAACAAT
GGTTAGATCAGCAATTACATTCTTAA

Upstream 100 bases:

>100_bases
TGGAATATACACCATTTTGATATTTATCATGGCATTTGGTTTGAAAAAGCCATTACCACCCAATTAGAATTTTTACATCG
ACATATGGGAGTAAATTAGC

Downstream 100 bases:

>100_bases
TCTCGGAGTTAATGTGTTAGACGCTCATATCAGCCCAGAAGGGACTTTATCACTTCAAACGATTGCCATGCCTGCAGATA
CCAACTGGAGTGGTGATGTA

Product: thioredoxin C-3

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 141; Mature: 141

Protein sequence:

>141_residues
MIVVCPSCGAKNRVPENKLAEQPQCGQCHAKLLPLAPIELNEQNFSHFITYSDLPVLIDLWAEWCGPCKMMAPHFAHVAA
QNPQVIFAKINTETSPRLSQAFHVRSIPTLVLMNKTTEIARISGALRSTELQQWLDQQLHS

Sequences:

>Translated_141_residues
MIVVCPSCGAKNRVPENKLAEQPQCGQCHAKLLPLAPIELNEQNFSHFITYSDLPVLIDLWAEWCGPCKMMAPHFAHVAA
QNPQVIFAKINTETSPRLSQAFHVRSIPTLVLMNKTTEIARISGALRSTELQQWLDQQLHS
>Mature_141_residues
MIVVCPSCGAKNRVPENKLAEQPQCGQCHAKLLPLAPIELNEQNFSHFITYSDLPVLIDLWAEWCGPCKMMAPHFAHVAA
QNPQVIFAKINTETSPRLSQAFHVRSIPTLVLMNKTTEIARISGALRSTELQQWLDQQLHS

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: COG0526

COG function: function code OC; Thiol-disulfide isomerase and thioredoxins

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Escherichia coli, GI1788936, Length=140, Percent_Identity=35.7142857142857, Blast_Score=105, Evalue=9e-25,
Organism=Escherichia coli, GI87082331, Length=103, Percent_Identity=35.9223300970874, Blast_Score=81, Evalue=3e-17,
Organism=Caenorhabditis elegans, GI212646193, Length=98, Percent_Identity=28.5714285714286, Blast_Score=67, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6319925, Length=85, Percent_Identity=37.6470588235294, Blast_Score=67, Evalue=8e-13,
Organism=Saccharomyces cerevisiae, GI6323072, Length=73, Percent_Identity=38.3561643835616, Blast_Score=67, Evalue=8e-13,
Organism=Drosophila melanogaster, GI28573567, Length=103, Percent_Identity=31.0679611650485, Blast_Score=66, Evalue=6e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: 1.8.1.8 [C]

Molecular weight: Translated: 15800; Mature: 15800

Theoretical pI: Translated: 7.47; Mature: 7.47

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

4.3 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
7.1 %Cys+Met (Translated Protein)
4.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
7.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIVVCPSCGAKNRVPENKLAEQPQCGQCHAKLLPLAPIELNEQNFSHFITYSDLPVLIDL
CEEECCCCCCCCCCCCHHHCCCCCCCCCHHEECCCCCEEECCCCCCEEEEECCCHHHHHH
WAEWCGPCKMMAPHFAHVAAQNPQVIFAKINTETSPRLSQAFHVRSIPTLVLMNKTTEIA
HHHHCCCHHHHCHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHCCCCEEEEECCCHHHH
RISGALRSTELQQWLDQQLHS
HHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MIVVCPSCGAKNRVPENKLAEQPQCGQCHAKLLPLAPIELNEQNFSHFITYSDLPVLIDL
CEEECCCCCCCCCCCCHHHCCCCCCCCCHHEECCCCCEEECCCCCCEEEEECCCHHHHHH
WAEWCGPCKMMAPHFAHVAAQNPQVIFAKINTETSPRLSQAFHVRSIPTLVLMNKTTEIA
HHHHCCCHHHHCHHHHHHHCCCCCEEEEEECCCCCCHHHHHHHHCCCCEEEEECCCHHHH
RISGALRSTELQQWLDQQLHS
HHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8652661 [H]