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The map label for this gene is cusC [C]

Identifier: 50086115

GI number: 50086115

Start: 3036462

End: 3037856

Strand: Direct

Name: cusC [C]

Synonym: ACIAD3111

Alternate gene names: 50086115

Gene position: 3036462-3037856 (Clockwise)

Preceding gene: 50086114

Following gene: 50086116

Centisome position: 84.38

GC content: 45.73

Gene sequence:

>1395_bases
ATGTCATCATCTAAACTTACTACGCTGTGTGCCATGCTTATAGCCTCCTCAACGCTGGTGGGCTGTGCTGCAGTGGTGAA
AACACCATACAACGCACCCACTGTACAAACGCCATCGAGCTTTCAATACGACAAGACGCAGGCCACATCAAATTATGCTA
ATTATGCTGACCGCTGGTGGACATTGTTTGGCGATGCACAGCTTAATCAACTGGTCGATCAGGTGATTGCCAAAAATACG
GATTTAGCTGTTGCAGGCATTACGCTTCAGCAAGCTCGCTTAAAAGCTGGCTTGGCTGCAGATCAGCAAGGCCCACGCGT
TAATTCAAGTGTTTCGACCAGTCAGAATATTGACGTAAACTCAGGTGATAAAAGTTCAAATGGCCTCTCGCTCAATGCCG
GGGTGAGTTATGAGCTGGATTTATTTGGTAAACTGGCGCGTCAGACCGAAGCAGCCAAATGGGAAGCATTGGCCACAGCG
CAAGATTTACAGGCGACTGCACAAACCCTGATTGGTACCACCACAAAGCTCTATTGGCAACTGGCTTACTTAAATGAAAG
CTTAAGTACCGCACAACAAAGCTTGGCCACCTCTGAAAAACTGTATAGTTTGGTGAACACTCAATACCAAGCAGGTGCTG
TTTCTGGGCTGGATTTAACACAAGCTGAACAATCAGTTCAAAGCCAAAAAGCCAATTTAAGCCAGATCCAACAAAGCTTG
GTAGAAACCCGCACAGCGTTGGCCGTACTGTTGCACATTCCCGTGCAGCAATTAAATATACAAGAACCACAGCGCCTGCC
TCAGGTCAATTTACCGCAAATTCAAGCGGGATTACCGGCCAGCATTTTGTCACGACGTCCAGATTTACGCGCAGCTGAGT
TACGCTTACGCGAAACCTTGGCAACCAAAGATGCCACCACGGCCAGTTATTATCCATCGATCAGTCTAACGGGAAGTTTA
GGTTCAAGCAGTACATCACTCACAGAGCTGATTAAAAACCCAGTGTTGGCGCTTGGTGCGAATTTGAGTTTGCCTTTTTT
GCAATATAATGACATGAAGAAGAATATTGCCATTAGTCAACTCGATTATGAAAAAGCCATTATTCAGTATCGTCAGACCT
TGTATCAGGCTTTTGCCGATGTTGAAAATGCACTTTCTGCCCGTACCGAGTTGAATCAGCAAGTTCAATTTCAGCAACGA
AATCTCGAACTGGCAGAGAAAGCAGAACGCCTGACCGATGTGCGTTATCTTAATGGTGCAATTGCGCTCAAAAATGTACT
AGATCAGCAGCAAACAACACGAACTGCGCGCTTAAGTTTGGTCAATACCAAGCAAAATCAATATAATGCCTATGTTACGC
TCATGCAGGCACTGGGTGGCTCTCCAATTCAATAA

Upstream 100 bases:

>100_bases
GCTCTACCCTGATAGGTGTGGTGTTTGGCTTCTTGCCCGCCAGAAATGCTGCCCAGCTCGATCCTGTTGCCGCTTTGTCT
AGAGAATAAGAGGAGCTCTC

Downstream 100 bases:

>100_bases
AAGATATAAAAAAAGCCACTACGGTGGCTTACTTTTCTTGAACAAAATAATTTTCTAGATAAGGATCTTTTCCTTTGAGA
TTTTTTCGATATTTCATAAC

Product: outer membrane protein precursor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 464; Mature: 463

Protein sequence:

>464_residues
MSSSKLTTLCAMLIASSTLVGCAAVVKTPYNAPTVQTPSSFQYDKTQATSNYANYADRWWTLFGDAQLNQLVDQVIAKNT
DLAVAGITLQQARLKAGLAADQQGPRVNSSVSTSQNIDVNSGDKSSNGLSLNAGVSYELDLFGKLARQTEAAKWEALATA
QDLQATAQTLIGTTTKLYWQLAYLNESLSTAQQSLATSEKLYSLVNTQYQAGAVSGLDLTQAEQSVQSQKANLSQIQQSL
VETRTALAVLLHIPVQQLNIQEPQRLPQVNLPQIQAGLPASILSRRPDLRAAELRLRETLATKDATTASYYPSISLTGSL
GSSSTSLTELIKNPVLALGANLSLPFLQYNDMKKNIAISQLDYEKAIIQYRQTLYQAFADVENALSARTELNQQVQFQQR
NLELAEKAERLTDVRYLNGAIALKNVLDQQQTTRTARLSLVNTKQNQYNAYVTLMQALGGSPIQ

Sequences:

>Translated_464_residues
MSSSKLTTLCAMLIASSTLVGCAAVVKTPYNAPTVQTPSSFQYDKTQATSNYANYADRWWTLFGDAQLNQLVDQVIAKNT
DLAVAGITLQQARLKAGLAADQQGPRVNSSVSTSQNIDVNSGDKSSNGLSLNAGVSYELDLFGKLARQTEAAKWEALATA
QDLQATAQTLIGTTTKLYWQLAYLNESLSTAQQSLATSEKLYSLVNTQYQAGAVSGLDLTQAEQSVQSQKANLSQIQQSL
VETRTALAVLLHIPVQQLNIQEPQRLPQVNLPQIQAGLPASILSRRPDLRAAELRLRETLATKDATTASYYPSISLTGSL
GSSSTSLTELIKNPVLALGANLSLPFLQYNDMKKNIAISQLDYEKAIIQYRQTLYQAFADVENALSARTELNQQVQFQQR
NLELAEKAERLTDVRYLNGAIALKNVLDQQQTTRTARLSLVNTKQNQYNAYVTLMQALGGSPIQ
>Mature_463_residues
SSSKLTTLCAMLIASSTLVGCAAVVKTPYNAPTVQTPSSFQYDKTQATSNYANYADRWWTLFGDAQLNQLVDQVIAKNTD
LAVAGITLQQARLKAGLAADQQGPRVNSSVSTSQNIDVNSGDKSSNGLSLNAGVSYELDLFGKLARQTEAAKWEALATAQ
DLQATAQTLIGTTTKLYWQLAYLNESLSTAQQSLATSEKLYSLVNTQYQAGAVSGLDLTQAEQSVQSQKANLSQIQQSLV
ETRTALAVLLHIPVQQLNIQEPQRLPQVNLPQIQAGLPASILSRRPDLRAAELRLRETLATKDATTASYYPSISLTGSLG
SSSTSLTELIKNPVLALGANLSLPFLQYNDMKKNIAISQLDYEKAIIQYRQTLYQAFADVENALSARTELNQQVQFQQRN
LELAEKAERLTDVRYLNGAIALKNVLDQQQTTRTARLSLVNTKQNQYNAYVTLMQALGGSPIQ

Specific function: In Pathogenic Strains It Allows The Bacteria To Invade Brain Microvascular Endothelial Cells (Bmec) Thus Allowing It To Cross The Blood-Brain Barrier And Cause Neonatal Meningitis. [C]

COG id: COG1538

COG function: function code MU; Outer membrane protein

Gene ontology:

Cell location: Attached To The Outer Membrane By A Lipid Anchor [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the outer membrane factor (OMF) (TC 1.B.17) family [H]

Homologues:

Organism=Escherichia coli, GI1786785, Length=469, Percent_Identity=28.1449893390192, Blast_Score=164, Evalue=1e-41,
Organism=Escherichia coli, GI2367348, Length=486, Percent_Identity=23.4567901234568, Blast_Score=78, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003423
- InterPro:   IPR010131 [H]

Pfam domain/function: PF02321 OEP [H]

EC number: NA

Molecular weight: Translated: 50577; Mature: 50445

Theoretical pI: Translated: 8.51; Mature: 8.51

Prosite motif: PS00013 PROKAR_LIPOPROTEIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
0.9 %Met     (Translated Protein)
1.3 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
0.6 %Met     (Mature Protein)
1.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSSSKLTTLCAMLIASSTLVGCAAVVKTPYNAPTVQTPSSFQYDKTQATSNYANYADRWW
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
TLFGDAQLNQLVDQVIAKNTDLAVAGITLQQARLKAGLAADQQGPRVNSSVSTSQNIDVN
EEECCHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCC
SGDKSSNGLSLNAGVSYELDLFGKLARQTEAAKWEALATAQDLQATAQTLIGTTTKLYWQ
CCCCCCCCEEECCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
LAYLNESLSTAQQSLATSEKLYSLVNTQYQAGAVSGLDLTQAEQSVQSQKANLSQIQQSL
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCCCCCCHHHHHHHHHHHHCCHHHHHHHH
VETRTALAVLLHIPVQQLNIQEPQRLPQVNLPQIQAGLPASILSRRPDLRAAELRLRETL
HHHHHHHHHHHHCCHHHCCCCCHHHCCCCCCCHHCCCCCHHHHCCCCCCHHHHHHHHHHH
ATKDATTASYYPSISLTGSLGSSSTSLTELIKNPVLALGANLSLPFLQYNDMKKNIAISQ
HHCCCCCCEECCCEEEECCCCCCHHHHHHHHHCCHHEECCCCCCCCHHHCCCHHCCCHHH
LDYEKAIIQYRQTLYQAFADVENALSARTELNQQVQFQQRNLELAEKAERLTDVRYLNGA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
IALKNVLDQQQTTRTARLSLVNTKQNQYNAYVTLMQALGGSPIQ
HHHHHHHHHHHHHHHHHHEEEECCCHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure 
SSSKLTTLCAMLIASSTLVGCAAVVKTPYNAPTVQTPSSFQYDKTQATSNYANYADRWW
CCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
TLFGDAQLNQLVDQVIAKNTDLAVAGITLQQARLKAGLAADQQGPRVNSSVSTSQNIDVN
EEECCHHHHHHHHHHHHCCCCEEEEEHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCC
SGDKSSNGLSLNAGVSYELDLFGKLARQTEAAKWEALATAQDLQATAQTLIGTTTKLYWQ
CCCCCCCCEEECCCCCEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHH
LAYLNESLSTAQQSLATSEKLYSLVNTQYQAGAVSGLDLTQAEQSVQSQKANLSQIQQSL
HHHHHHHHHHHHHHHHHHHHHHHHHHCCHHCCCCCCCCHHHHHHHHHHHHCCHHHHHHHH
VETRTALAVLLHIPVQQLNIQEPQRLPQVNLPQIQAGLPASILSRRPDLRAAELRLRETL
HHHHHHHHHHHHCCHHHCCCCCHHHCCCCCCCHHCCCCCHHHHCCCCCCHHHHHHHHHHH
ATKDATTASYYPSISLTGSLGSSSTSLTELIKNPVLALGANLSLPFLQYNDMKKNIAISQ
HHCCCCCCEECCCEEEECCCCCCHHHHHHHHHCCHHEECCCCCCCCHHHCCCHHCCCHHH
LDYEKAIIQYRQTLYQAFADVENALSARTELNQQVQFQQRNLELAEKAERLTDVRYLNGA
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
IALKNVLDQQQTTRTARLSLVNTKQNQYNAYVTLMQALGGSPIQ
HHHHHHHHHHHHHHHHHHEEEECCCHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]