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The map label for this gene is trxA [C]

Identifier: 50086050

GI number: 50086050

Start: 2967309

End: 2967647

Strand: Direct

Name: trxA [C]

Synonym: ACIAD3037

Alternate gene names: 50086050

Gene position: 2967309-2967647 (Clockwise)

Preceding gene: 50086044

Following gene: 50086051

Centisome position: 82.46

GC content: 40.41

Gene sequence:

>339_bases
TTGGAGCAAACTATGTCTGCCAATATTGTAAATACAACCGATGCTAACTTCCAAGCAGACGTGTTAGATGCTGAAACACC
TGTACTTGTAGATTTTTGGGCAGGCTGGTGTGCGCCATGTAAAGCTATCGCACCTGTTTTAGAAGATTTGTCTCGTGAAT
ACGAAGGTAAAGTAAAAATTGTAAAAGTTGACGTCACTGCATGTGAAGATACGGCTGTGAAATACAATATTCGTAATATT
CCTGCACTTCTTCTATTCAAAGACGGTAAAGTTGTTGCACAACAAGTCGGTGCTGCACCGCGCTCAAAACTTGCTGCCTT
TATTGATGAAAACGTTTAA

Upstream 100 bases:

>100_bases
GATAAACTTGAATAATGTAGATCAACCCCTATATTGATATAGAAGACAATGTCATACTTGAAGTTTCATTCGCCGAACTT
CTATATCTTTTAAAAATAAT

Downstream 100 bases:

>100_bases
TCCGTTTTTGTGAATAAAATTTAAATACGCTATTGTTCAATAGCGTATTTTTTTTGCAGGGAAATTGACAAATATCATCA
TCTGACTTATAGTTCTTGAG

Product: thioredoxin

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 112; Mature: 112

Protein sequence:

>112_residues
MEQTMSANIVNTTDANFQADVLDAETPVLVDFWAGWCAPCKAIAPVLEDLSREYEGKVKIVKVDVTACEDTAVKYNIRNI
PALLLFKDGKVVAQQVGAAPRSKLAAFIDENV

Sequences:

>Translated_112_residues
MEQTMSANIVNTTDANFQADVLDAETPVLVDFWAGWCAPCKAIAPVLEDLSREYEGKVKIVKVDVTACEDTAVKYNIRNI
PALLLFKDGKVVAQQVGAAPRSKLAAFIDENV
>Mature_112_residues
MEQTMSANIVNTTDANFQADVLDAETPVLVDFWAGWCAPCKAIAPVLEDLSREYEGKVKIVKVDVTACEDTAVKYNIRNI
PALLLFKDGKVVAQQVGAAPRSKLAAFIDENV

Specific function: Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 thioredoxin domain [H]

Homologues:

Organism=Homo sapiens, GI21361403, Length=107, Percent_Identity=39.2523364485981, Blast_Score=84, Evalue=3e-17,
Organism=Homo sapiens, GI224493972, Length=105, Percent_Identity=37.1428571428571, Blast_Score=73, Evalue=6e-14,
Organism=Homo sapiens, GI42794771, Length=105, Percent_Identity=37.1428571428571, Blast_Score=70, Evalue=3e-13,
Organism=Homo sapiens, GI5031973, Length=109, Percent_Identity=29.3577981651376, Blast_Score=65, Evalue=1e-11,
Organism=Homo sapiens, GI50592994, Length=85, Percent_Identity=41.1764705882353, Blast_Score=64, Evalue=2e-11,
Organism=Homo sapiens, GI21361657, Length=100, Percent_Identity=35, Blast_Score=64, Evalue=2e-11,
Organism=Escherichia coli, GI87082331, Length=108, Percent_Identity=49.0740740740741, Blast_Score=119, Evalue=4e-29,
Organism=Escherichia coli, GI1788936, Length=108, Percent_Identity=35.1851851851852, Blast_Score=92, Evalue=8e-21,
Organism=Escherichia coli, GI87081747, Length=105, Percent_Identity=34.2857142857143, Blast_Score=69, Evalue=9e-14,
Organism=Caenorhabditis elegans, GI17510299, Length=71, Percent_Identity=46.4788732394366, Blast_Score=70, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI212646193, Length=95, Percent_Identity=32.6315789473684, Blast_Score=69, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI71998175, Length=71, Percent_Identity=43.6619718309859, Blast_Score=69, Evalue=7e-13,
Organism=Caenorhabditis elegans, GI17554386, Length=97, Percent_Identity=36.0824742268041, Blast_Score=65, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17509965, Length=82, Percent_Identity=34.1463414634146, Blast_Score=65, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI17556044, Length=81, Percent_Identity=37.037037037037, Blast_Score=64, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI71980562, Length=68, Percent_Identity=38.2352941176471, Blast_Score=62, Evalue=4e-11,
Organism=Caenorhabditis elegans, GI71980565, Length=68, Percent_Identity=38.2352941176471, Blast_Score=62, Evalue=4e-11,
Organism=Saccharomyces cerevisiae, GI6323072, Length=73, Percent_Identity=49.3150684931507, Blast_Score=73, Evalue=8e-15,
Organism=Saccharomyces cerevisiae, GI6321648, Length=73, Percent_Identity=42.4657534246575, Blast_Score=67, Evalue=6e-13,
Organism=Drosophila melanogaster, GI28573567, Length=100, Percent_Identity=38, Blast_Score=87, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24639826, Length=94, Percent_Identity=37.2340425531915, Blast_Score=74, Evalue=1e-14,
Organism=Drosophila melanogaster, GI17648013, Length=85, Percent_Identity=41.1764705882353, Blast_Score=74, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24583090, Length=85, Percent_Identity=41.1764705882353, Blast_Score=74, Evalue=2e-14,
Organism=Drosophila melanogaster, GI24664269, Length=92, Percent_Identity=38.0434782608696, Blast_Score=70, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24658597, Length=109, Percent_Identity=34.8623853211009, Blast_Score=67, Evalue=2e-12,
Organism=Drosophila melanogaster, GI19921434, Length=82, Percent_Identity=36.5853658536585, Blast_Score=65, Evalue=6e-12,
Organism=Drosophila melanogaster, GI21358065, Length=93, Percent_Identity=34.4086021505376, Blast_Score=65, Evalue=7e-12,

Paralogues:

None

Copy number: 3,500 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005746
- InterPro:   IPR017936
- InterPro:   IPR012336
- InterPro:   IPR017937
- InterPro:   IPR013766
- InterPro:   IPR012335 [H]

Pfam domain/function: PF00085 Thioredoxin [H]

EC number: NA

Molecular weight: Translated: 12199; Mature: 12199

Theoretical pI: Translated: 4.35; Mature: 4.35

Prosite motif: PS00194 THIOREDOXIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.7 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
2.7 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEQTMSANIVNTTDANFQADVLDAETPVLVDFWAGWCAPCKAIAPVLEDLSREYEGKVKI
CCCCCCCCEEECCCCCEEEEEECCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCCEEE
VKVDVTACEDTAVKYNIRNIPALLLFKDGKVVAQQVGAAPRSKLAAFIDENV
EEEEEEECCCCEEEEECCCCCEEEEEECCHHHHHHHCCCCHHHHHHHHCCCC
>Mature Secondary Structure
MEQTMSANIVNTTDANFQADVLDAETPVLVDFWAGWCAPCKAIAPVLEDLSREYEGKVKI
CCCCCCCCEEECCCCCEEEEEECCCCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCCEEE
VKVDVTACEDTAVKYNIRNIPALLLFKDGKVVAQQVGAAPRSKLAAFIDENV
EEEEEEECCCCEEEEECCCCCEEEEEECCHHHHHHHCCCCHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Reduction reactions; participates in dithiol-disulfide exchange reactions [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3040729; 2917572 [H]