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The map label for this gene is mlaA [H]

Identifier: 50086034

GI number: 50086034

Start: 2947926

End: 2948852

Strand: Direct

Name: mlaA [H]

Synonym: ACIAD3018

Alternate gene names: 50086034

Gene position: 2947926-2948852 (Clockwise)

Preceding gene: 50086033

Following gene: 50086035

Centisome position: 81.92

GC content: 40.45

Gene sequence:

>927_bases
ATGCATTACTCAAAACTTGTCTTTGTCGGTCTTTTATCAGCAGGTATGTCTTTTTCGATATTTGCTCAGGATGCTCAAGC
AGATATTGCATCAAATACGTCTGCTCGTCAGGCAGCCATGTCTGATCAAGATACAAATGATCAGTCTTCAAGTACAACCT
CTCACTTTCAATCTATCCGCGATTTAAAAAATGAGCTAAAAAATGTGAAGGCAAGTGATTTTAAAGTCAATGCGAATGCC
GCACAGCCAGACGATGTAAAAGATCCACTCCAACCATTGAACCGTGAATTTTATGCATTTAATGATATGTTGGATCGCAA
CATTGTTCGACCTATTGCTGTGCAATACGCGGCAAAAACACCAGAAGATGTTCGTGGTTCTTATCGTCAATTTAGAAAAA
ACCTAGGTGAGCCTTGGAATGCAGTAAACCAGATTATTCAAGGTCGACCAGGTCGCGCAGCAAAAACCTTAGGTCGTTTT
ACCATTAATACACTTACTACATTAGGACTTGCCGACCCAGCCCGTCGTTTAGGTTTACCTGCTGAAGAAGAAAGCTTTGG
CGTAACGTTAGGTTACTATGGCGTGCCTTCTGGTCCTTTTTTAATGTTACCTTTTTTTGGCCCAAGTACATTACGTGATG
GTTTAGGTTTAGCGGTTGATAGTCAGGCAAGGCCTCAAAAATATATTATGGATGATCAGCAAGGACTGTATTGGTCAACT
AACCTTGTACAGGCGATTGATACTCGCTCACAGCTTTTAGATATCGAGCAAATACTGCAAGGCGATAAGTATGCTGTTAT
TCGAGATTTGTATTTACAAAGAAAGAGCTTCCAAATTTCTGAGAAAAAAGGCAATTCAACAGAACAGATCAGTTTTGTGG
GAGATGATGACGATGATCAGGATAATGACGCGACGACCTCAAAATAA

Upstream 100 bases:

>100_bases
TATTTGCTTTAATAGTAGAAATAAAGAAACTGTTAAATAAAAACGATCTTATTTAAAATGATATAAACTTTCACCTCATA
GATGGTGGTCAAGGATTTCT

Downstream 100 bases:

>100_bases
AAATCTCGAAATGAATCTCGATAAAAAGATTGCTATATGCGTGTCAGATCGCTAGCAATCTTTGGTTTTCTATAGTACAT
CTACTATTATGGTAAATACG

Product: lipoprotein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 308; Mature: 308

Protein sequence:

>308_residues
MHYSKLVFVGLLSAGMSFSIFAQDAQADIASNTSARQAAMSDQDTNDQSSSTTSHFQSIRDLKNELKNVKASDFKVNANA
AQPDDVKDPLQPLNREFYAFNDMLDRNIVRPIAVQYAAKTPEDVRGSYRQFRKNLGEPWNAVNQIIQGRPGRAAKTLGRF
TINTLTTLGLADPARRLGLPAEEESFGVTLGYYGVPSGPFLMLPFFGPSTLRDGLGLAVDSQARPQKYIMDDQQGLYWST
NLVQAIDTRSQLLDIEQILQGDKYAVIRDLYLQRKSFQISEKKGNSTEQISFVGDDDDDQDNDATTSK

Sequences:

>Translated_308_residues
MHYSKLVFVGLLSAGMSFSIFAQDAQADIASNTSARQAAMSDQDTNDQSSSTTSHFQSIRDLKNELKNVKASDFKVNANA
AQPDDVKDPLQPLNREFYAFNDMLDRNIVRPIAVQYAAKTPEDVRGSYRQFRKNLGEPWNAVNQIIQGRPGRAAKTLGRF
TINTLTTLGLADPARRLGLPAEEESFGVTLGYYGVPSGPFLMLPFFGPSTLRDGLGLAVDSQARPQKYIMDDQQGLYWST
NLVQAIDTRSQLLDIEQILQGDKYAVIRDLYLQRKSFQISEKKGNSTEQISFVGDDDDDQDNDATTSK
>Mature_308_residues
MHYSKLVFVGLLSAGMSFSIFAQDAQADIASNTSARQAAMSDQDTNDQSSSTTSHFQSIRDLKNELKNVKASDFKVNANA
AQPDDVKDPLQPLNREFYAFNDMLDRNIVRPIAVQYAAKTPEDVRGSYRQFRKNLGEPWNAVNQIIQGRPGRAAKTLGRF
TINTLTTLGLADPARRLGLPAEEESFGVTLGYYGVPSGPFLMLPFFGPSTLRDGLGLAVDSQARPQKYIMDDQQGLYWST
NLVQAIDTRSQLLDIEQILQGDKYAVIRDLYLQRKSFQISEKKGNSTEQISFVGDDDDDQDNDATTSK

Specific function: Actively prevents phospholipid accumulation at the cell surface. Probably maintains lipid asymmetry in the outer membrane by retrograde trafficking of phospholipids from the outer membrane to the inner membrane [H]

COG id: COG2853

COG function: function code M; Surface lipoprotein

Gene ontology:

Cell location: Cell outer membrane; Lipid-anchor (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the mlaA family [H]

Homologues:

Organism=Escherichia coli, GI1788688, Length=200, Percent_Identity=36, Blast_Score=113, Evalue=2e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR007428 [H]

Pfam domain/function: PF04333 VacJ [H]

EC number: NA

Molecular weight: Translated: 34224; Mature: 34224

Theoretical pI: Translated: 4.90; Mature: 4.90

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHYSKLVFVGLLSAGMSFSIFAQDAQADIASNTSARQAAMSDQDTNDQSSSTTSHFQSIR
CCCHHHHHHHHHHCCCEEEEEECCHHHHHHCCCHHHHHHHCCCCCCCCCCHHHHHHHHHH
DLKNELKNVKASDFKVNANAAQPDDVKDPLQPLNREFYAFNDMLDRNIVRPIAVQYAAKT
HHHHHHHCCCCCCEEEECCCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCC
PEDVRGSYRQFRKNLGEPWNAVNQIIQGRPGRAAKTLGRFTINTLTTLGLADPARRLGLP
CHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHCCCC
AEEESFGVTLGYYGVPSGPFLMLPFFGPSTLRDGLGLAVDSQARPQKYIMDDQQGLYWST
CCCCCCCEEEEECCCCCCCEEEEECCCCHHHHCCCCEEECCCCCCHHHHCCCCCCCEEHH
NLVQAIDTRSQLLDIEQILQGDKYAVIRDLYLQRKSFQISEKKGNSTEQISFVGDDDDDQ
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCEECCCCCCCCEEEEEECCCCCCC
DNDATTSK
CCCCCCCC
>Mature Secondary Structure
MHYSKLVFVGLLSAGMSFSIFAQDAQADIASNTSARQAAMSDQDTNDQSSSTTSHFQSIR
CCCHHHHHHHHHHCCCEEEEEECCHHHHHHCCCHHHHHHHCCCCCCCCCCHHHHHHHHHH
DLKNELKNVKASDFKVNANAAQPDDVKDPLQPLNREFYAFNDMLDRNIVRPIAVQYAAKT
HHHHHHHCCCCCCEEEECCCCCCCCCHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHCCC
PEDVRGSYRQFRKNLGEPWNAVNQIIQGRPGRAAKTLGRFTINTLTTLGLADPARRLGLP
CHHHHHHHHHHHHHCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCCHHHHCCCC
AEEESFGVTLGYYGVPSGPFLMLPFFGPSTLRDGLGLAVDSQARPQKYIMDDQQGLYWST
CCCCCCCEEEEECCCCCCCEEEEECCCCHHHHCCCCEEECCCCCCHHHHCCCCCCCEEHH
NLVQAIDTRSQLLDIEQILQGDKYAVIRDLYLQRKSFQISEKKGNSTEQISFVGDDDDDQ
HHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHCCEECCCCCCCCEEEEEECCCCCCC
DNDATTSK
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9205837; 9278503 [H]