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The map label for this gene is aroP [H]

Identifier: 50085992

GI number: 50085992

Start: 2898161

End: 2899519

Strand: Direct

Name: aroP [H]

Synonym: ACIAD2969

Alternate gene names: 50085992

Gene position: 2898161-2899519 (Clockwise)

Preceding gene: 50085990

Following gene: 50085993

Centisome position: 80.54

GC content: 41.87

Gene sequence:

>1359_bases
TTGAACAACGATTCTTCAAAACTTCAGCGGGGCTTAAAAAATCGTCATATCCAGTTGATTGCCATGGGTGGTGCAATTGG
TACAGGATTATTTTTAGGATCTGCACAAGTTATTCAATCTGCTGGCCCATCTATCATTTTGGGCTACGCGATTGGCGGCT
TAATAGCTTTTTTAATTATGCGTCAGCTTGGGGAAATGATTGTACATGAACCCGTTGCAGGTTCATTTAGTCATTTTGCT
TACAAATACTGGGGTAAATTTCCTGGTTTTTTGGCCGGTTGGAACTACTGGGTACTTTATATTTTGGTCGCAATGACCGA
ATTGACGGCTGTAGGTAAATATATTAACTACTGGTGGCCCCAAATCCCTGCGTGGCAATCTGTTTTATTTTTCTTTGTGG
TGATTACACTCGTCAACCTGACCAATGTGAAATTTTACGGAGAATCCGAGTTTTGGCTCGCCATTATTAAAGTTGTTGCC
GTTATTTCCATGATCATTTTTGGTCTGTACTTATTATTTACAGCAGACTCGAGCTCGACTGCCTCATTTAGCAACTTATG
GGCACATGGTGGTTTCTTTCCAAACGGTTTTGAAGGCCTGTTTTATATGCTGGCCTTTTTAATGTTTGCTTTTGGTGGTA
TCGAACTGATCGGGATGGCTGCGGCTGAAGCTGAAAATCCAGCCAAAACCATTCCAAAAGCAATCAATCAGGTGGTATTC
CGTATTTTGGTGTTTTATGTAGGCTCACTCACCATCTTGTTATCTTTGGTGCCTTGGAATCAGTTGGATCTGGGTGGCTT
GGATAAAAGCCCATTTGTGATGATTTTTAGCCAATTAGGCATTGGCTGGGCTGCACATCTGCTGAACTTTATTATTTTAA
CGGCTGCGCTATCGGTTTATAACAGCGGTATGTTTGCCAACAGTCGCATGCTGTTTGGTCTGGCACAGCAAGGCAATGCA
CCAAAAATCTTTACCAAAGTCAATAAACAAGGTGTTCCTATTCCTGCGGTATTATTTTCTGCGCTTTTGATCTTTGGCTG
CGTACTTTTAAACTACTTTGTACCAGAAGATGCACTGGGTCATTTGATGTACGTGGTGGTAGGTGCCTTGGTACTCAACT
GGGCCATGATCAGCTTGACACATTTGAAGTTTAAAGCTGCGGTGAAAAAGCTCAAACTCAATGTGACCTTTCCGGCACTT
TGGGCACCAGTGAGTAACTATTTGGTGCTGATTTTTATTGCGCTGGTGCTGTTTATTATGTGGCAACAAGGCTTTAAAGA
ATCGGTAATTATGATTCCAGTGTGGATTGTTTTGATGTTTGGTCTGTTTCATTTGCTGACCAATAAAGACCACACCTGA

Upstream 100 bases:

>100_bases
TAAGTTCAACTAAAGTCGACTGCTTTCTCTCATGCTCGACTAGGCTAAATTCTATCTATCCATTAGAATACAACGCTTAT
TCATGGTCGAGTGAAGTCCT

Downstream 100 bases:

>100_bases
CCTGTAAAAAAATAGATAAAATTAAAAAAGTTATTACTTCGGTAATAACTTTTTTGTTTATACTCACATCTCGATGCGCT
CTTAGCTTAACTGGATAGAG

Product: aromatic amino acid APC transporter

Products: L-tryptophan [Cytoplasm]; Proton [Cytoplasm]; Proton [Cytoplasm]; L-tyrosine [Cytoplasm]; Proton [Cytoplasm]; L-phenylalanine [Cytoplasm] [C]

Alternate protein names: General aromatic amino acid permease [H]

Number of amino acids: Translated: 452; Mature: 452

Protein sequence:

>452_residues
MNNDSSKLQRGLKNRHIQLIAMGGAIGTGLFLGSAQVIQSAGPSIILGYAIGGLIAFLIMRQLGEMIVHEPVAGSFSHFA
YKYWGKFPGFLAGWNYWVLYILVAMTELTAVGKYINYWWPQIPAWQSVLFFFVVITLVNLTNVKFYGESEFWLAIIKVVA
VISMIIFGLYLLFTADSSSTASFSNLWAHGGFFPNGFEGLFYMLAFLMFAFGGIELIGMAAAEAENPAKTIPKAINQVVF
RILVFYVGSLTILLSLVPWNQLDLGGLDKSPFVMIFSQLGIGWAAHLLNFIILTAALSVYNSGMFANSRMLFGLAQQGNA
PKIFTKVNKQGVPIPAVLFSALLIFGCVLLNYFVPEDALGHLMYVVVGALVLNWAMISLTHLKFKAAVKKLKLNVTFPAL
WAPVSNYLVLIFIALVLFIMWQQGFKESVIMIPVWIVLMFGLFHLLTNKDHT

Sequences:

>Translated_452_residues
MNNDSSKLQRGLKNRHIQLIAMGGAIGTGLFLGSAQVIQSAGPSIILGYAIGGLIAFLIMRQLGEMIVHEPVAGSFSHFA
YKYWGKFPGFLAGWNYWVLYILVAMTELTAVGKYINYWWPQIPAWQSVLFFFVVITLVNLTNVKFYGESEFWLAIIKVVA
VISMIIFGLYLLFTADSSSTASFSNLWAHGGFFPNGFEGLFYMLAFLMFAFGGIELIGMAAAEAENPAKTIPKAINQVVF
RILVFYVGSLTILLSLVPWNQLDLGGLDKSPFVMIFSQLGIGWAAHLLNFIILTAALSVYNSGMFANSRMLFGLAQQGNA
PKIFTKVNKQGVPIPAVLFSALLIFGCVLLNYFVPEDALGHLMYVVVGALVLNWAMISLTHLKFKAAVKKLKLNVTFPAL
WAPVSNYLVLIFIALVLFIMWQQGFKESVIMIPVWIVLMFGLFHLLTNKDHT
>Mature_452_residues
MNNDSSKLQRGLKNRHIQLIAMGGAIGTGLFLGSAQVIQSAGPSIILGYAIGGLIAFLIMRQLGEMIVHEPVAGSFSHFA
YKYWGKFPGFLAGWNYWVLYILVAMTELTAVGKYINYWWPQIPAWQSVLFFFVVITLVNLTNVKFYGESEFWLAIIKVVA
VISMIIFGLYLLFTADSSSTASFSNLWAHGGFFPNGFEGLFYMLAFLMFAFGGIELIGMAAAEAENPAKTIPKAINQVVF
RILVFYVGSLTILLSLVPWNQLDLGGLDKSPFVMIFSQLGIGWAAHLLNFIILTAALSVYNSGMFANSRMLFGLAQQGNA
PKIFTKVNKQGVPIPAVLFSALLIFGCVLLNYFVPEDALGHLMYVVVGALVLNWAMISLTHLKFKAAVKKLKLNVTFPAL
WAPVSNYLVLIFIALVLFIMWQQGFKESVIMIPVWIVLMFGLFHLLTNKDHT

Specific function: Permease that is involved in the transport across the cytoplasmic membrane of the aromatic amino acids (phenylalanine, tyrosine, and tryptophan) [H]

COG id: COG1113

COG function: function code E; Gamma-aminobutyrate permease and related permeases

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Homo sapiens, GI110347453, Length=355, Percent_Identity=25.6338028169014, Blast_Score=92, Evalue=7e-19,
Organism=Homo sapiens, GI258645169, Length=409, Percent_Identity=24.6943765281174, Blast_Score=89, Evalue=1e-17,
Organism=Homo sapiens, GI258614005, Length=410, Percent_Identity=24.390243902439, Blast_Score=82, Evalue=9e-16,
Organism=Homo sapiens, GI258614003, Length=410, Percent_Identity=24.390243902439, Blast_Score=82, Evalue=1e-15,
Organism=Homo sapiens, GI114326544, Length=381, Percent_Identity=22.5721784776903, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI114326550, Length=381, Percent_Identity=22.5721784776903, Blast_Score=77, Evalue=4e-14,
Organism=Homo sapiens, GI4507047, Length=379, Percent_Identity=23.4828496042216, Blast_Score=76, Evalue=6e-14,
Organism=Homo sapiens, GI115648063, Length=446, Percent_Identity=23.9910313901345, Blast_Score=76, Evalue=6e-14,
Organism=Homo sapiens, GI115648022, Length=446, Percent_Identity=23.9910313901345, Blast_Score=76, Evalue=6e-14,
Organism=Homo sapiens, GI181337167, Length=334, Percent_Identity=25.748502994012, Blast_Score=75, Evalue=1e-13,
Organism=Escherichia coli, GI1786302, Length=450, Percent_Identity=61.7777777777778, Blast_Score=561, Evalue=1e-161,
Organism=Escherichia coli, GI1786789, Length=449, Percent_Identity=55.456570155902, Blast_Score=509, Evalue=1e-145,
Organism=Escherichia coli, GI48994972, Length=438, Percent_Identity=40.8675799086758, Blast_Score=325, Evalue=5e-90,
Organism=Escherichia coli, GI1786602, Length=400, Percent_Identity=45.5, Blast_Score=324, Evalue=6e-90,
Organism=Escherichia coli, GI1790653, Length=439, Percent_Identity=38.0410022779043, Blast_Score=320, Evalue=9e-89,
Organism=Escherichia coli, GI87081915, Length=412, Percent_Identity=35.6796116504854, Blast_Score=283, Evalue=1e-77,
Organism=Escherichia coli, GI87081708, Length=389, Percent_Identity=36.2467866323907, Blast_Score=263, Evalue=2e-71,
Organism=Escherichia coli, GI1789017, Length=420, Percent_Identity=34.0476190476191, Blast_Score=254, Evalue=1e-68,
Organism=Escherichia coli, GI1788480, Length=391, Percent_Identity=36.3171355498721, Blast_Score=248, Evalue=8e-67,
Organism=Caenorhabditis elegans, GI17532491, Length=371, Percent_Identity=25.6064690026954, Blast_Score=82, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI17531343, Length=367, Percent_Identity=23.433242506812, Blast_Score=75, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17540018, Length=339, Percent_Identity=23.598820058997, Blast_Score=69, Evalue=5e-12,
Organism=Caenorhabditis elegans, GI17537453, Length=378, Percent_Identity=23.2804232804233, Blast_Score=67, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6321053, Length=472, Percent_Identity=31.9915254237288, Blast_Score=228, Evalue=1e-60,
Organism=Saccharomyces cerevisiae, GI6320772, Length=443, Percent_Identity=34.9887133182844, Blast_Score=228, Evalue=2e-60,
Organism=Saccharomyces cerevisiae, GI6324061, Length=440, Percent_Identity=33.8636363636364, Blast_Score=228, Evalue=2e-60,
Organism=Saccharomyces cerevisiae, GI6324924, Length=480, Percent_Identity=32.0833333333333, Blast_Score=211, Evalue=2e-55,
Organism=Saccharomyces cerevisiae, GI6322892, Length=400, Percent_Identity=32, Blast_Score=201, Evalue=3e-52,
Organism=Saccharomyces cerevisiae, GI6324553, Length=394, Percent_Identity=34.5177664974619, Blast_Score=199, Evalue=1e-51,
Organism=Saccharomyces cerevisiae, GI6320717, Length=479, Percent_Identity=28.1837160751566, Blast_Score=196, Evalue=8e-51,
Organism=Saccharomyces cerevisiae, GI6324990, Length=442, Percent_Identity=31.9004524886878, Blast_Score=195, Evalue=1e-50,
Organism=Saccharomyces cerevisiae, GI6319824, Length=469, Percent_Identity=27.9317697228145, Blast_Score=193, Evalue=4e-50,
Organism=Saccharomyces cerevisiae, GI6321629, Length=402, Percent_Identity=31.592039800995, Blast_Score=193, Evalue=4e-50,
Organism=Saccharomyces cerevisiae, GI6324059, Length=441, Percent_Identity=33.3333333333333, Blast_Score=192, Evalue=9e-50,
Organism=Saccharomyces cerevisiae, GI6319543, Length=399, Percent_Identity=29.3233082706767, Blast_Score=184, Evalue=3e-47,
Organism=Saccharomyces cerevisiae, GI6320251, Length=481, Percent_Identity=27.4428274428274, Blast_Score=175, Evalue=1e-44,
Organism=Saccharomyces cerevisiae, GI6319542, Length=483, Percent_Identity=26.9151138716356, Blast_Score=175, Evalue=1e-44,
Organism=Saccharomyces cerevisiae, GI6319608, Length=405, Percent_Identity=29.8765432098765, Blast_Score=174, Evalue=3e-44,
Organism=Saccharomyces cerevisiae, GI6322967, Length=395, Percent_Identity=28.8607594936709, Blast_Score=154, Evalue=3e-38,
Organism=Saccharomyces cerevisiae, GI6324981, Length=399, Percent_Identity=29.0726817042606, Blast_Score=130, Evalue=3e-31,
Organism=Saccharomyces cerevisiae, GI6320364, Length=465, Percent_Identity=26.2365591397849, Blast_Score=118, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24667468, Length=344, Percent_Identity=25.2906976744186, Blast_Score=89, Evalue=6e-18,
Organism=Drosophila melanogaster, GI24666159, Length=471, Percent_Identity=23.1422505307856, Blast_Score=86, Evalue=4e-17,
Organism=Drosophila melanogaster, GI221512776, Length=471, Percent_Identity=23.1422505307856, Blast_Score=86, Evalue=4e-17,
Organism=Drosophila melanogaster, GI161077963, Length=387, Percent_Identity=25.3229974160207, Blast_Score=72, Evalue=1e-12,
Organism=Drosophila melanogaster, GI221331183, Length=431, Percent_Identity=24.1299303944316, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI17647653, Length=431, Percent_Identity=24.1299303944316, Blast_Score=69, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24664379, Length=431, Percent_Identity=24.1299303944316, Blast_Score=69, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 50106; Mature: 50106

Theoretical pI: Translated: 9.74; Mature: 9.74

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.8 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNDSSKLQRGLKNRHIQLIAMGGAIGTGLFLGSAQVIQSAGPSIILGYAIGGLIAFLIM
CCCCHHHHHHHHHHCCEEEEEECCHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHH
RQLGEMIVHEPVAGSFSHFAYKYWGKFPGFLAGWNYWVLYILVAMTELTAVGKYINYWWP
HHHHHHHHCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
QIPAWQSVLFFFVVITLVNLTNVKFYGESEFWLAIIKVVAVISMIIFGLYLLFTADSSST
CCCHHHHHHHHHHHHHHHHHHCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
ASFSNLWAHGGFFPNGFEGLFYMLAFLMFAFGGIELIGMAAAEAENPAKTIPKAINQVVF
CHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHHHHH
RILVFYVGSLTILLSLVPWNQLDLGGLDKSPFVMIFSQLGIGWAAHLLNFIILTAALSVY
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHH
NSGMFANSRMLFGLAQQGNAPKIFTKVNKQGVPIPAVLFSALLIFGCVLLNYFVPEDALG
HCCCCCCCHHHEEECCCCCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHH
HLMYVVVGALVLNWAMISLTHLKFKAAVKKLKLNVTFPALWAPVSNYLVLIFIALVLFIM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCHHHHHHHHHHHHHHHHHHHHHHH
WQQGFKESVIMIPVWIVLMFGLFHLLTNKDHT
HHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCC
>Mature Secondary Structure
MNNDSSKLQRGLKNRHIQLIAMGGAIGTGLFLGSAQVIQSAGPSIILGYAIGGLIAFLIM
CCCCHHHHHHHHHHCCEEEEEECCHHHHHHHHHHHHHHHCCCCCEEHHHHHHHHHHHHHH
RQLGEMIVHEPVAGSFSHFAYKYWGKFPGFLAGWNYWVLYILVAMTELTAVGKYINYWWP
HHHHHHHHCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCC
QIPAWQSVLFFFVVITLVNLTNVKFYGESEFWLAIIKVVAVISMIIFGLYLLFTADSSST
CCCHHHHHHHHHHHHHHHHHHCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCC
ASFSNLWAHGGFFPNGFEGLFYMLAFLMFAFGGIELIGMAAAEAENPAKTIPKAINQVVF
CHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHCCHHHHHHHHHCCCCHHHHHHHHHHHHHH
RILVFYVGSLTILLSLVPWNQLDLGGLDKSPFVMIFSQLGIGWAAHLLNFIILTAALSVY
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHCHHHHHHHHHHHHHHHHHHHH
NSGMFANSRMLFGLAQQGNAPKIFTKVNKQGVPIPAVLFSALLIFGCVLLNYFVPEDALG
HCCCCCCCHHHEEECCCCCCCHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHH
HLMYVVVGALVLNWAMISLTHLKFKAAVKKLKLNVTFPALWAPVSNYLVLIFIALVLFIM
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCHHHHHHHHHHHHHHHHHHHHHHH
WQQGFKESVIMIPVWIVLMFGLFHLLTNKDHT
HHHCCCCCHHHHHHHHHHHHHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-tryptophan [Periplasm]; Proton [Periplasm]; Proton [Periplasm]; L-tyrosine [Periplasm]; Proton [Periplasm]; L-phenylalanine [Periplasm] [C]

Specific reaction: L-tryptophan [Periplasm] + Proton [Periplasm] = L-tryptophan [Cytoplasm] + Proton [Cytoplasm] Proton [Periplasm] + L-tyrosine [Periplasm] = Proton [Cytoplasm] + L-tyrosine [Cytoplasm] Proton [Periplasm] + L-phenylalanine [Periplasm] = Proton [Cytoplasm] +

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]