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The map label for this gene is mdh [H]

Identifier: 50085956

GI number: 50085956

Start: 2858161

End: 2859345

Strand: Direct

Name: mdh [H]

Synonym: ACIAD2929

Alternate gene names: 50085956

Gene position: 2858161-2859345 (Clockwise)

Preceding gene: 50085955

Following gene: 50085957

Centisome position: 79.42

GC content: 43.29

Gene sequence:

>1185_bases
ATGGCAAAGCCTTATTACGAATTTTTTTGTCCAGTAAAAGTGATTGCAGGCAATGCTGCTTTAGAACATATTCCATTTGA
ACTTGCGACCTTAGGTTCAAAACGTCCAATGATCATCACCGATAAAGGTGTAAGAGCCAATCACCTGCTTGAACCCATTG
AAGCCGCTTTCAGCTCTACTGATGCCGAAATTGGTTATATCTTTGATGATGTGCCACCTGATTCAAGTTTACAAACGGTA
AGAAAAGCAGCTCAGCTTTATCGCGATCATCATTGTGATGCGATTATTGCAATTGGCGGCGGTTCAGTCATTGATACTTC
AAAAGCTACCAATATTTTAGTCTCTGAAGGCGGAGATGACCTGCTAAAATATTCTGGCGCTCACAATTTACCCAAACCCC
TTAAGCCATTTTTTGTGATTCCCACTACGTCTGGTACAGGCTCTGAAGCCACCATGGTGGCTGTGGTATCCGACACAGAA
AAAAATGTCAAAATGGCTTTTGCATCGTATTACTTGATGCCACACGCGGCCATTCTTGACCCACGTATGACACTGACCTT
GCCTGCTCATTTAACCGCCATGACAGGTATGGATGCCTTAACGCATTGTGTTGAAGCATATACCTGTTTAGCATCTAATC
CGCTCAGTGATGCTTACGCCAGCGCAGGTATCAAGAAAATCAGTGAACACCTTTTTAACGTTATTGAAAACCCAAGCGAT
TCACAAGGGCGTCTGGAGCTTGCACAAGCATCAACCATGGCGGGCATTGCCTTCTCAAATTCGATGGTAGGTTTGGTACA
TTCGCTGGGACATGCACTTGGTGCAGTAGCACATCTGCCCCATGGCTTATGCATGAATTTATTTTTACCCTATGTACTGG
AGTACAATAAGGAAGTAAACGGCGATAAAATTGGTGAGTTGTTATTGCCACTTGCAGGCGCAGATATTTATGCGCAAACA
CCTGCAAATTTACGCGCAGATAAAGCCATTTCAACCATTCTGGCAATGCGTGATCGCCTGTTTAGCTTAACAAAGTTACC
GCGTACATTACGTGAAACAGGTAAAATTACCGAAGCCCAACTGGATGAAGTGGCTGAAAAGGCGCTCAATGATGGTTCGA
TTATTTACAACCCGAAAGAAGCGAATATTCAGGATTTAAAAGCAATATTACACAAAGCCTGGTAA

Upstream 100 bases:

>100_bases
AGCAATATCCAACTGAGCTCAGTTTGAAAGACAAATTAAGCGAAGCTGCCAACATTTATCTGAAAGTCGCACAATCATAC
TTAAAACGGAGTATATAAAA

Downstream 100 bases:

>100_bases
TAGCAAAATTTGTACATTCGCCTACAGGCCTGAGTTCTCAATGAATTCAGGTCTTTTTATTTAAAATAAACTTTGCATTC
ATCCATTTGTTTTCCAATTT

Product: alcohol dehydrogenase

Products: NA

Alternate protein names: MEDH [H]

Number of amino acids: Translated: 394; Mature: 393

Protein sequence:

>394_residues
MAKPYYEFFCPVKVIAGNAALEHIPFELATLGSKRPMIITDKGVRANHLLEPIEAAFSSTDAEIGYIFDDVPPDSSLQTV
RKAAQLYRDHHCDAIIAIGGGSVIDTSKATNILVSEGGDDLLKYSGAHNLPKPLKPFFVIPTTSGTGSEATMVAVVSDTE
KNVKMAFASYYLMPHAAILDPRMTLTLPAHLTAMTGMDALTHCVEAYTCLASNPLSDAYASAGIKKISEHLFNVIENPSD
SQGRLELAQASTMAGIAFSNSMVGLVHSLGHALGAVAHLPHGLCMNLFLPYVLEYNKEVNGDKIGELLLPLAGADIYAQT
PANLRADKAISTILAMRDRLFSLTKLPRTLRETGKITEAQLDEVAEKALNDGSIIYNPKEANIQDLKAILHKAW

Sequences:

>Translated_394_residues
MAKPYYEFFCPVKVIAGNAALEHIPFELATLGSKRPMIITDKGVRANHLLEPIEAAFSSTDAEIGYIFDDVPPDSSLQTV
RKAAQLYRDHHCDAIIAIGGGSVIDTSKATNILVSEGGDDLLKYSGAHNLPKPLKPFFVIPTTSGTGSEATMVAVVSDTE
KNVKMAFASYYLMPHAAILDPRMTLTLPAHLTAMTGMDALTHCVEAYTCLASNPLSDAYASAGIKKISEHLFNVIENPSD
SQGRLELAQASTMAGIAFSNSMVGLVHSLGHALGAVAHLPHGLCMNLFLPYVLEYNKEVNGDKIGELLLPLAGADIYAQT
PANLRADKAISTILAMRDRLFSLTKLPRTLRETGKITEAQLDEVAEKALNDGSIIYNPKEANIQDLKAILHKAW
>Mature_393_residues
AKPYYEFFCPVKVIAGNAALEHIPFELATLGSKRPMIITDKGVRANHLLEPIEAAFSSTDAEIGYIFDDVPPDSSLQTVR
KAAQLYRDHHCDAIIAIGGGSVIDTSKATNILVSEGGDDLLKYSGAHNLPKPLKPFFVIPTTSGTGSEATMVAVVSDTEK
NVKMAFASYYLMPHAAILDPRMTLTLPAHLTAMTGMDALTHCVEAYTCLASNPLSDAYASAGIKKISEHLFNVIENPSDS
QGRLELAQASTMAGIAFSNSMVGLVHSLGHALGAVAHLPHGLCMNLFLPYVLEYNKEVNGDKIGELLLPLAGADIYAQTP
ANLRADKAISTILAMRDRLFSLTKLPRTLRETGKITEAQLDEVAEKALNDGSIIYNPKEANIQDLKAILHKAW

Specific function: Unknown

COG id: COG1454

COG function: function code C; Alcohol dehydrogenase, class IV

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the iron-containing alcohol dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI133922590, Length=325, Percent_Identity=30.7692307692308, Blast_Score=124, Evalue=1e-28,
Organism=Escherichia coli, GI48994951, Length=387, Percent_Identity=30.4909560723514, Blast_Score=195, Evalue=4e-51,
Organism=Escherichia coli, GI87082107, Length=303, Percent_Identity=36.6336633663366, Blast_Score=179, Evalue=4e-46,
Organism=Escherichia coli, GI1789163, Length=381, Percent_Identity=30.1837270341207, Blast_Score=170, Evalue=2e-43,
Organism=Escherichia coli, GI1787493, Length=389, Percent_Identity=32.133676092545, Blast_Score=167, Evalue=1e-42,
Organism=Escherichia coli, GI1789386, Length=381, Percent_Identity=23.8845144356955, Blast_Score=87, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17537053, Length=315, Percent_Identity=29.8412698412698, Blast_Score=150, Evalue=1e-36,
Organism=Saccharomyces cerevisiae, GI6321181, Length=389, Percent_Identity=33.6760925449871, Blast_Score=215, Evalue=1e-56,
Organism=Drosophila melanogaster, GI24657991, Length=316, Percent_Identity=30.0632911392405, Blast_Score=121, Evalue=7e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001670
- InterPro:   IPR018211 [H]

Pfam domain/function: PF00465 Fe-ADH [H]

EC number: =1.1.1.244 [H]

Molecular weight: Translated: 42472; Mature: 42341

Theoretical pI: Translated: 6.15; Mature: 6.15

Prosite motif: PS00913 ADH_IRON_1 ; PS00060 ADH_IRON_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAKPYYEFFCPVKVIAGNAALEHIPFELATLGSKRPMIITDKGVRANHLLEPIEAAFSST
CCCCCHHHHCCHHEEECCHHHHHCCCHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHCCC
DAEIGYIFDDVPPDSSLQTVRKAAQLYRDHHCDAIIAIGGGSVIDTSKATNILVSEGGDD
CCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCEEECCCCCEEEEECCCCH
LLKYSGAHNLPKPLKPFFVIPTTSGTGSEATMVAVVSDTEKNVKMAFASYYLMPHAAILD
HHHCCCCCCCCCCCCCEEEEECCCCCCCCEEEEEEEECCCCHHHHHHHHHHHHCCHHHCC
PRMTLTLPAHLTAMTGMDALTHCVEAYTCLASNPLSDAYASAGIKKISEHLFNVIENPSD
CCEEEEECHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCC
SQGRLELAQASTMAGIAFSNSMVGLVHSLGHALGAVAHLPHGLCMNLFLPYVLEYNKEVN
CCCCEEHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCC
GDKIGELLLPLAGADIYAQTPANLRADKAISTILAMRDRLFSLTKLPRTLRETGKITEAQ
CHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
LDEVAEKALNDGSIIYNPKEANIQDLKAILHKAW
HHHHHHHHCCCCCEEECCCCCCHHHHHHHHHHCC
>Mature Secondary Structure 
AKPYYEFFCPVKVIAGNAALEHIPFELATLGSKRPMIITDKGVRANHLLEPIEAAFSST
CCCCHHHHCCHHEEECCHHHHHCCCHHHHCCCCCCEEEECCCCCHHHHHHHHHHHHCCC
DAEIGYIFDDVPPDSSLQTVRKAAQLYRDHHCDAIIAIGGGSVIDTSKATNILVSEGGDD
CCCEEEEECCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCEEECCCCCEEEEECCCCH
LLKYSGAHNLPKPLKPFFVIPTTSGTGSEATMVAVVSDTEKNVKMAFASYYLMPHAAILD
HHHCCCCCCCCCCCCCEEEEECCCCCCCCEEEEEEEECCCCHHHHHHHHHHHHCCHHHCC
PRMTLTLPAHLTAMTGMDALTHCVEAYTCLASNPLSDAYASAGIKKISEHLFNVIENPSD
CCEEEEECHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCC
SQGRLELAQASTMAGIAFSNSMVGLVHSLGHALGAVAHLPHGLCMNLFLPYVLEYNKEVN
CCCCEEHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHCCCCC
GDKIGELLLPLAGADIYAQTPANLRADKAISTILAMRDRLFSLTKLPRTLRETGKITEAQ
CHHHHHHHHHHCCCCEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHH
LDEVAEKALNDGSIIYNPKEANIQDLKAILHKAW
HHHHHHHHCCCCCEEECCCCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1644761; 1995642 [H]