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The map label for this gene is prs [H]

Identifier: 50085938

GI number: 50085938

Start: 2844457

End: 2845410

Strand: Direct

Name: prs [H]

Synonym: ACIAD2907

Alternate gene names: 50085938

Gene position: 2844457-2845410 (Clockwise)

Preceding gene: 50085937

Following gene: 50085939

Centisome position: 79.04

GC content: 43.82

Gene sequence:

>954_bases
ATGCCCAATCTTGTCGTTTTTAGTGGAAATGCTCATCCACAGTTCGCTCAAAAAGTCGTCAGCCACTTACATATTCCTCT
AGGTGCGGCATCAGTCGGACATTTCTCCGATGGTGAAATTTCAGTAGAAATTACTGAAAATGTTCGTGGTAAAGACGTTT
TTATCGTGCAGCCAACTTGTGCTCCAACCAATGATAACCTGATGGAAATCTTGGTAATGGCAGATGCCTTGCGTCGTGCC
AGTGCTGGGCGTATTACCGCTGTTATTCCTTACTTTGGTTATGCTCGTCAAGATCGTCGCCCACGTTCAGCACGTGTTCC
AATTACAGCAAAAGTGGTTGCAGACATGCTCACTACTGTCGGTGTAGATCGTGTTGTGATGATCGACCTTCATGCCGATC
AGATTCAAGGCTTTTTCGATATCCCTGTCGACAACATCTACGGTACACCTGCTTTGCTTGCTGATTTGCGTCAGCAATCG
CATGACAATTTGATGGTGGTTTCACCTGACGTTGGTGGTGTAGTACGTGCACGTGCTGTTGCAAAACAGATGGGTGATAT
TGATCTTGCAATCATCGACAAGCGTCGTCAAAAAGCAAATGAATCACAAGTGATGCATTTGATTGGTGATGTAAAAGATC
GTGACTGTGTCATCGTCGATGATATGGTAGATACTGCTGGTACGCTTTGCAAAGCAGCAGATGCATTAAAGCAATTTGGT
GCTCGCCGCGTTGTTGCCTATGCCACTCACCCTGTTTTATCAGGTAAGGCATTAGAAAACTTGCAAAATTCTGTGCTTGA
TGAATTGGTAGTGACAGACACTATTCCTCTTTCTCCTGAAGCACTGAATCTTGGTAAAATCCGTCAAGTTTCTGTTGCGA
GTATGGTGGCTGAAACAATTCGTCGTATTAATAACGAAGAATCTATTAGCGCAATGTTCGATAGTTATCTATAA

Upstream 100 bases:

>100_bases
TGCGCTCGGGCGAAGCATTGCTTAACCCTTTAGGTCAATAAATATTTTCCTTTGCGCGCGGGTGAAGCGTTGCTTCACGT
AATCCTCGCTCAGGTGCTTC

Downstream 100 bases:

>100_bases
TAGCCCAAATTTTTTCTTAACCCTGGCCTTGGCTGGGGTTTTCTATCACTAAACTGGTCGCAAGTTTAGTTTATTTAACC
TTAATGAGGATTTATCTCAT

Product: ribose-phosphate pyrophosphokinase

Products: NA

Alternate protein names: RPPK; Phosphoribosyl pyrophosphate synthase; P-Rib-PP synthase; PRPP synthase [H]

Number of amino acids: Translated: 317; Mature: 316

Protein sequence:

>317_residues
MPNLVVFSGNAHPQFAQKVVSHLHIPLGAASVGHFSDGEISVEITENVRGKDVFIVQPTCAPTNDNLMEILVMADALRRA
SAGRITAVIPYFGYARQDRRPRSARVPITAKVVADMLTTVGVDRVVMIDLHADQIQGFFDIPVDNIYGTPALLADLRQQS
HDNLMVVSPDVGGVVRARAVAKQMGDIDLAIIDKRRQKANESQVMHLIGDVKDRDCVIVDDMVDTAGTLCKAADALKQFG
ARRVVAYATHPVLSGKALENLQNSVLDELVVTDTIPLSPEALNLGKIRQVSVASMVAETIRRINNEESISAMFDSYL

Sequences:

>Translated_317_residues
MPNLVVFSGNAHPQFAQKVVSHLHIPLGAASVGHFSDGEISVEITENVRGKDVFIVQPTCAPTNDNLMEILVMADALRRA
SAGRITAVIPYFGYARQDRRPRSARVPITAKVVADMLTTVGVDRVVMIDLHADQIQGFFDIPVDNIYGTPALLADLRQQS
HDNLMVVSPDVGGVVRARAVAKQMGDIDLAIIDKRRQKANESQVMHLIGDVKDRDCVIVDDMVDTAGTLCKAADALKQFG
ARRVVAYATHPVLSGKALENLQNSVLDELVVTDTIPLSPEALNLGKIRQVSVASMVAETIRRINNEESISAMFDSYL
>Mature_316_residues
PNLVVFSGNAHPQFAQKVVSHLHIPLGAASVGHFSDGEISVEITENVRGKDVFIVQPTCAPTNDNLMEILVMADALRRAS
AGRITAVIPYFGYARQDRRPRSARVPITAKVVADMLTTVGVDRVVMIDLHADQIQGFFDIPVDNIYGTPALLADLRQQSH
DNLMVVSPDVGGVVRARAVAKQMGDIDLAIIDKRRQKANESQVMHLIGDVKDRDCVIVDDMVDTAGTLCKAADALKQFGA
RRVVAYATHPVLSGKALENLQNSVLDELVVTDTIPLSPEALNLGKIRQVSVASMVAETIRRINNEESISAMFDSYL

Specific function: Utilized by both the de novo and the salvage pathways by which endogenously formed or exogenously added pyrimidine, purine, or pyridine bases are converted to the corresponding ribonucleoside monophosphates. [C]

COG id: COG0462

COG function: function code FE; Phosphoribosylpyrophosphate synthetase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ribose-phosphate pyrophosphokinase family [H]

Homologues:

Organism=Homo sapiens, GI4506127, Length=315, Percent_Identity=48.5714285714286, Blast_Score=310, Evalue=1e-84,
Organism=Homo sapiens, GI4506129, Length=315, Percent_Identity=47.9365079365079, Blast_Score=308, Evalue=3e-84,
Organism=Homo sapiens, GI84875539, Length=317, Percent_Identity=47.3186119873817, Blast_Score=307, Evalue=9e-84,
Organism=Homo sapiens, GI28557709, Length=315, Percent_Identity=47.3015873015873, Blast_Score=301, Evalue=5e-82,
Organism=Homo sapiens, GI194018537, Length=343, Percent_Identity=33.8192419825073, Blast_Score=177, Evalue=8e-45,
Organism=Homo sapiens, GI4506133, Length=346, Percent_Identity=32.9479768786127, Blast_Score=177, Evalue=1e-44,
Organism=Homo sapiens, GI310128524, Length=153, Percent_Identity=31.3725490196078, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI310115209, Length=153, Percent_Identity=31.3725490196078, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI310118259, Length=153, Percent_Identity=31.3725490196078, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI310119946, Length=153, Percent_Identity=31.3725490196078, Blast_Score=81, Evalue=1e-15,
Organism=Escherichia coli, GI1787458, Length=314, Percent_Identity=69.1082802547771, Blast_Score=461, Evalue=1e-131,
Organism=Caenorhabditis elegans, GI25149168, Length=315, Percent_Identity=44.7619047619048, Blast_Score=291, Evalue=2e-79,
Organism=Caenorhabditis elegans, GI17554702, Length=315, Percent_Identity=44.7619047619048, Blast_Score=290, Evalue=6e-79,
Organism=Caenorhabditis elegans, GI71989924, Length=315, Percent_Identity=44.7619047619048, Blast_Score=288, Evalue=2e-78,
Organism=Caenorhabditis elegans, GI17554704, Length=310, Percent_Identity=44.5161290322581, Blast_Score=284, Evalue=4e-77,
Organism=Caenorhabditis elegans, GI17570245, Length=338, Percent_Identity=33.1360946745562, Blast_Score=188, Evalue=3e-48,
Organism=Saccharomyces cerevisiae, GI6319403, Length=312, Percent_Identity=46.7948717948718, Blast_Score=279, Evalue=4e-76,
Organism=Saccharomyces cerevisiae, GI6320946, Length=311, Percent_Identity=46.3022508038585, Blast_Score=278, Evalue=6e-76,
Organism=Saccharomyces cerevisiae, GI6321776, Length=320, Percent_Identity=45, Blast_Score=276, Evalue=4e-75,
Organism=Saccharomyces cerevisiae, GI6322667, Length=207, Percent_Identity=40.5797101449275, Blast_Score=153, Evalue=4e-38,
Organism=Saccharomyces cerevisiae, GI6324511, Length=112, Percent_Identity=41.9642857142857, Blast_Score=103, Evalue=4e-23,
Organism=Drosophila melanogaster, GI21355239, Length=317, Percent_Identity=47.9495268138801, Blast_Score=300, Evalue=7e-82,
Organism=Drosophila melanogaster, GI45551540, Length=339, Percent_Identity=44.8377581120944, Blast_Score=291, Evalue=3e-79,
Organism=Drosophila melanogaster, GI24651458, Length=356, Percent_Identity=33.4269662921348, Blast_Score=204, Evalue=9e-53,
Organism=Drosophila melanogaster, GI24651456, Length=356, Percent_Identity=33.4269662921348, Blast_Score=204, Evalue=9e-53,
Organism=Drosophila melanogaster, GI281362873, Length=356, Percent_Identity=33.4269662921348, Blast_Score=203, Evalue=1e-52,
Organism=Drosophila melanogaster, GI24651454, Length=356, Percent_Identity=33.4269662921348, Blast_Score=203, Evalue=1e-52,
Organism=Drosophila melanogaster, GI24651462, Length=204, Percent_Identity=36.7647058823529, Blast_Score=141, Evalue=7e-34,
Organism=Drosophila melanogaster, GI24651464, Length=204, Percent_Identity=36.7647058823529, Blast_Score=141, Evalue=7e-34,
Organism=Drosophila melanogaster, GI45552010, Length=204, Percent_Identity=36.7647058823529, Blast_Score=140, Evalue=8e-34,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000842
- InterPro:   IPR005946
- InterPro:   IPR000836 [H]

Pfam domain/function: PF00156 Pribosyltran [H]

EC number: =2.7.6.1 [H]

Molecular weight: Translated: 34474; Mature: 34343

Theoretical pI: Translated: 6.10; Mature: 6.10

Prosite motif: PS00103 PUR_PYR_PR_TRANSFER ; PS00114 PRPP_SYNTHETASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
3.5 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPNLVVFSGNAHPQFAQKVVSHLHIPLGAASVGHFSDGEISVEITENVRGKDVFIVQPTC
CCCEEEEECCCCHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEECCCCCCEEEEECCCC
APTNDNLMEILVMADALRRASAGRITAVIPYFGYARQDRRPRSARVPITAKVVADMLTTV
CCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHCCCCCCCCCCCCHHHHHHHHHHHC
GVDRVVMIDLHADQIQGFFDIPVDNIYGTPALLADLRQQSHDNLMVVSPDVGGVVRARAV
CCCEEEEEEEEHHHHCCEEECCHHHCCCCHHHHHHHHHCCCCCEEEECCCCCHHHHHHHH
AKQMGDIDLAIIDKRRQKANESQVMHLIGDVKDRDCVIVDDMVDTAGTLCKAADALKQFG
HHHHCCCEEEEECCHHHHCCHHHHHHHHHCCCCCCEEEECCHHHHHHHHHHHHHHHHHCC
ARRVVAYATHPVLSGKALENLQNSVLDELVVTDTIPLSPEALNLGKIRQVSVASMVAETI
CCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHH
RRINNEESISAMFDSYL
HHCCCHHHHHHHHHHCC
>Mature Secondary Structure 
PNLVVFSGNAHPQFAQKVVSHLHIPLGAASVGHFSDGEISVEITENVRGKDVFIVQPTC
CCEEEEECCCCHHHHHHHHHHHCCCCCCCCCCCCCCCEEEEEEECCCCCCEEEEECCCC
APTNDNLMEILVMADALRRASAGRITAVIPYFGYARQDRRPRSARVPITAKVVADMLTTV
CCCCCHHHHHHHHHHHHHHCCCCCEEEEECCCCCHHCCCCCCCCCCCCHHHHHHHHHHHC
GVDRVVMIDLHADQIQGFFDIPVDNIYGTPALLADLRQQSHDNLMVVSPDVGGVVRARAV
CCCEEEEEEEEHHHHCCEEECCHHHCCCCHHHHHHHHHCCCCCEEEECCCCCHHHHHHHH
AKQMGDIDLAIIDKRRQKANESQVMHLIGDVKDRDCVIVDDMVDTAGTLCKAADALKQFG
HHHHCCCEEEEECCHHHHCCHHHHHHHHHCCCCCCEEEECCHHHHHHHHHHHHHHHHHCC
ARRVVAYATHPVLSGKALENLQNSVLDELVVTDTIPLSPEALNLGKIRQVSVASMVAETI
CCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHH
RRINNEESISAMFDSYL
HHCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA