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The map label for this gene is ipk

Identifier: 50085937

GI number: 50085937

Start: 2842937

End: 2843776

Strand: Direct

Name: ipk

Synonym: ACIAD2903

Alternate gene names: 50085937

Gene position: 2842937-2843776 (Clockwise)

Preceding gene: 50085936

Following gene: 50085938

Centisome position: 79.0

GC content: 38.69

Gene sequence:

>840_bases
ATGATTCGTGTAGCATCCCCTGCCAAAATTAATTTATTTTTGCATATTACAGGCCGTCGTAATGACGGCTATCACGAGTT
ACAAAGTATTTTCCAACTAATCGATCTTTACGACTGGATGACTTTCACACCTCGAACTGAAGCCGAAGATAATTTAAGCA
TTACAGGCATTGAACAAGTCGATCTTGAACAAAACCTGATTTTTCGTGCGGCTCAACTGCTTAAACTGTATGCAAAAAAA
TATTGCGGTCTGAATATTCAGATTGAAAAGCAGATTCCGATGGGTGCAGGTCTGGGTGGTGGTTCATCCAATGCCGCAAC
AACACTTCTGGTCTTAAATCAGCTCTGGGATTGTGGCTTAAATCTCGATCAATTGGCAGCTTTGGGTGTGAAACTAGGTG
CCGATGTTCCTATTTTTATTTATGGTAAAAATGCATGGGCTGAAGGCATTGGAGAGAAACTTACTTTTGTGGATTTAGAT
CAAAAACAATACATTATTTTGAAACCTGACTGTTTTATCAGCACCCAATTGCTTTTTTCACAAAAAACGTTGACAAGAGA
TTCCAATCGCACTACATTTTGCGCCTATCAGTTAAAGCCTTCTGATTTTGGAAATAACTTTGAAGCTCTTGCTCGTAGTC
TATATCCAGAAGTAGAAGAAGCAATGCAATATCTTGATCAGTTTGGTCAGGCAAAGCTTACAGGTACAGGTGCTTGTGTT
TTTACTGAGGTCACTCCTGAAATGAATGTGAGCGAAATTGTTCAACATGCACCATGTAAATCTTATGTGGTACATAGCTT
GAACAAATCACCATTATCTCATTTCATGACTGATATTTAG

Upstream 100 bases:

>100_bases
AAACTCTTCCCAATAAACTGATTTTAAAGCAGTCACTTGCAGATAATCAGGAAAACCGTATTACAATGATTATTCAAAAT
CGTTAAGTCAAGTTGGGTTT

Downstream 100 bases:

>100_bases
GGGCGTCGCCAAGTGGTAAGGCACCGGGTTTTGATCTCGGCATCCGTTGGTTCGAATCCAGCCGCCCCTGCCATTACACC
TGTGAATTCTGTATTAGGGG

Product: 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase

Products: NA

Alternate protein names: CMK; 4-(cytidine-5'-diphospho)-2-C-methyl-D-erythritol kinase

Number of amino acids: Translated: 279; Mature: 279

Protein sequence:

>279_residues
MIRVASPAKINLFLHITGRRNDGYHELQSIFQLIDLYDWMTFTPRTEAEDNLSITGIEQVDLEQNLIFRAAQLLKLYAKK
YCGLNIQIEKQIPMGAGLGGGSSNAATTLLVLNQLWDCGLNLDQLAALGVKLGADVPIFIYGKNAWAEGIGEKLTFVDLD
QKQYIILKPDCFISTQLLFSQKTLTRDSNRTTFCAYQLKPSDFGNNFEALARSLYPEVEEAMQYLDQFGQAKLTGTGACV
FTEVTPEMNVSEIVQHAPCKSYVVHSLNKSPLSHFMTDI

Sequences:

>Translated_279_residues
MIRVASPAKINLFLHITGRRNDGYHELQSIFQLIDLYDWMTFTPRTEAEDNLSITGIEQVDLEQNLIFRAAQLLKLYAKK
YCGLNIQIEKQIPMGAGLGGGSSNAATTLLVLNQLWDCGLNLDQLAALGVKLGADVPIFIYGKNAWAEGIGEKLTFVDLD
QKQYIILKPDCFISTQLLFSQKTLTRDSNRTTFCAYQLKPSDFGNNFEALARSLYPEVEEAMQYLDQFGQAKLTGTGACV
FTEVTPEMNVSEIVQHAPCKSYVVHSLNKSPLSHFMTDI
>Mature_279_residues
MIRVASPAKINLFLHITGRRNDGYHELQSIFQLIDLYDWMTFTPRTEAEDNLSITGIEQVDLEQNLIFRAAQLLKLYAKK
YCGLNIQIEKQIPMGAGLGGGSSNAATTLLVLNQLWDCGLNLDQLAALGVKLGADVPIFIYGKNAWAEGIGEKLTFVDLD
QKQYIILKPDCFISTQLLFSQKTLTRDSNRTTFCAYQLKPSDFGNNFEALARSLYPEVEEAMQYLDQFGQAKLTGTGACV
FTEVTPEMNVSEIVQHAPCKSYVVHSLNKSPLSHFMTDI

Specific function: Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol

COG id: COG1947

COG function: function code I; 4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the GHMP kinase family. IspE subfamily

Homologues:

Organism=Escherichia coli, GI1787459, Length=279, Percent_Identity=43.7275985663082, Blast_Score=215, Evalue=3e-57,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): ISPE_ACIAD (Q6F8J0)

Other databases:

- EMBL:   CR543861
- RefSeq:   YP_047447.1
- ProteinModelPortal:   Q6F8J0
- SMR:   Q6F8J0
- STRING:   Q6F8J0
- GeneID:   2879844
- GenomeReviews:   CR543861_GR
- KEGG:   aci:ACIAD2903
- NMPDR:   fig|62977.3.peg.2640
- eggNOG:   COG1947
- HOGENOM:   HBG734593
- OMA:   LNLFLHV
- PhylomeDB:   Q6F8J0
- ProtClustDB:   PRK00343
- BioCyc:   ASP62977:ACIAD2903-MONOMER
- HAMAP:   MF_00061
- InterPro:   IPR006204
- InterPro:   IPR013750
- InterPro:   IPR004424
- InterPro:   IPR020568
- InterPro:   IPR014721
- Gene3D:   G3DSA:3.30.230.10
- PANTHER:   PTHR20861:SF2
- PIRSF:   PIRSF010376
- TIGRFAMs:   TIGR00154

Pfam domain/function: PF08544 GHMP_kinases_C; PF00288 GHMP_kinases_N; SSF54211 Ribosomal_S5_D2-typ_fold

EC number: =2.7.1.148

Molecular weight: Translated: 31173; Mature: 31173

Theoretical pI: Translated: 5.12; Mature: 5.12

Prosite motif: NA

Important sites: ACT_SITE 9-9 ACT_SITE 135-135

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIRVASPAKINLFLHITGRRNDGYHELQSIFQLIDLYDWMTFTPRTEAEDNLSITGIEQV
CEEECCCCEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCHHH
DLEQNLIFRAAQLLKLYAKKYCGLNIQIEKQIPMGAGLGGGSSNAATTLLVLNQLWDCGL
CCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHCCC
NLDQLAALGVKLGADVPIFIYGKNAWAEGIGEKLTFVDLDQKQYIILKPDCFISTQLLFS
CHHHHHHHHHHCCCCCEEEEEECCHHHHCCCCEEEEEECCCCCEEEECCCCEEEHHHHHH
QKTLTRDSNRTTFCAYQLKPSDFGNNFEALARSLYPEVEEAMQYLDQFGQAKLTGTGACV
HHHHCCCCCCEEEEEEEECCCCCCCCHHHHHHHHCHHHHHHHHHHHHHCCEEEECCCEEE
FTEVTPEMNVSEIVQHAPCKSYVVHSLNKSPLSHFMTDI
EEECCCCCCHHHHHHHCCHHHHHHHHCCCCHHHHHHHCC
>Mature Secondary Structure
MIRVASPAKINLFLHITGRRNDGYHELQSIFQLIDLYDWMTFTPRTEAEDNLSITGIEQV
CEEECCCCEEEEEEEEECCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCEEEECCHHH
DLEQNLIFRAAQLLKLYAKKYCGLNIQIEKQIPMGAGLGGGSSNAATTLLVLNQLWDCGL
CCHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHHHHHCCC
NLDQLAALGVKLGADVPIFIYGKNAWAEGIGEKLTFVDLDQKQYIILKPDCFISTQLLFS
CHHHHHHHHHHCCCCCEEEEEECCHHHHCCCCEEEEEECCCCCEEEECCCCEEEHHHHHH
QKTLTRDSNRTTFCAYQLKPSDFGNNFEALARSLYPEVEEAMQYLDQFGQAKLTGTGACV
HHHHCCCCCCEEEEEEEECCCCCCCCHHHHHHHHCHHHHHHHHHHHHHCCEEEECCCEEE
FTEVTPEMNVSEIVQHAPCKSYVVHSLNKSPLSHFMTDI
EEECCCCCCHHHHHHHCCHHHHHHHHCCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA