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The map label for this gene is hemA

Identifier: 50085934

GI number: 50085934

Start: 2839251

End: 2840546

Strand: Reverse

Name: hemA

Synonym: ACIAD2900

Alternate gene names: 50085934

Gene position: 2840546-2839251 (Counterclockwise)

Preceding gene: 50085943

Following gene: 50085931

Centisome position: 78.93

GC content: 43.9

Gene sequence:

>1296_bases
ATGTCTTTCTTTGCATTGGGTGTCAACCATCAAACTGCTTCTGTCGAGTTGAGAGAACAAGTCGCGTTCAATGCTGAACG
TTTAAAGGACTTGCTAGCTCAGCAGCGTAATCATGCCCATTTAAATGATATGGTGGTGGTGTCGACGTGTAATCGCACAG
AAGTCTATGCCATGACAGAACATGCTGACATACTGCTAAATTGGCTCGCCCAAACAAATGGTATTGATATTAAACAGCTT
CTTCATCATGTTTATCGTTACGAAGATGCACAGGCTGTTACACATCTGATGCGTGTTGCAAGTGGCTTAGATTCCCTTAT
GTTAGGTGAGCCTCAAATTTTGGGGCAGGTTAAAAGTGCCTTGGCACTGTCCAAAGAAAGCCATACAGTGTCACGCGACC
TAAATCGTATTTTTGAATACGCATTTTATGCAGCCAAGCGGGTTCGTTCAGAAACTGCTGTGGGAAGCCATGCTGTTTCG
ATGGGTTATGCTGTAGCTCAATTGGCATTACAGGTATTTAGTAATCCTGAAAAACTTACTGTCATGATGGTTGCTGCGGG
TGAAATGAATACGCTCGTTGCCAAGCATTTGGCTGAAATGGGTGTGGCAAAGGTCATTATCTGTAACCGTAGTCGTGAAC
GTGCCGAGTCTCTGGCGCAAGAAATTGCGCATCAGGTCGAAGTTGAAATTATTGGGTTTGATCAGTTGGCAGCGAATTTA
CACCGTGCAGATGTCGTGTCTAGTTGTACTGGAAGTCTGCATCAAGTGATTTTTTATCAAGATGTCAAGGCAGCACTGAA
AAAGCGTCGCTATAACCAAATGCTCCTAGTTGATTTGGCTGTTCCACGAGATATTGATTCTAAGGTTGAAACACTAGATG
GCGTCTATCTATATGGTGTAGATGATCTGCAAAGCGTGATTGATGAAAATCTGGCGCAACGCCGACAGGCTGCAGTAGAA
GCTGAAGTCATGGTGAGTCAGCTTGCAAGCCAGTTGCTCACCCATCAGAAAATCCAGCAGGCAGGCAGTACAATTCAGAT
GTATCGTGAGTTCAGTCAACAACAAAGTCAGGATGAGATAGCACGGGCATTAACAGATCTGAATAAAGGTCATGATGCTG
AAGACGTTCTTAAACAATTCGCCCATCGTCTAACTCAAAAAATGATGCATCCGACCTCTATTTTGCTCAGAGAGGCAGCA
CAGCATGAAAGTCCAGATTATTTTGAGTGGATGAAAGAACAACTGACAGACGTATTTGAGCATCAGCGCAAGCCTAAAAA
CAATCTGGATCGATAA

Upstream 100 bases:

>100_bases
ACCGGTTATTCATTTGTCGCAATTTTTAGTAATCCAAGTAATGCTTTTTATGACACCGATATTGCACAATAGCATAAATT
TAGCGAAATGATGATCTGAT

Downstream 100 bases:

>100_bases
TTCAAGATAATAATCTTAAGTTGATCTGTTTGCTTAATTCATTGAGCTGTTGACGTAGATTGCGTGATTCAATCAATGAA
ATAGGTGCCTTTAACTTTTG

Product: glutamyl-tRNA reductase

Products: NA

Alternate protein names: GluTR

Number of amino acids: Translated: 431; Mature: 430

Protein sequence:

>431_residues
MSFFALGVNHQTASVELREQVAFNAERLKDLLAQQRNHAHLNDMVVVSTCNRTEVYAMTEHADILLNWLAQTNGIDIKQL
LHHVYRYEDAQAVTHLMRVASGLDSLMLGEPQILGQVKSALALSKESHTVSRDLNRIFEYAFYAAKRVRSETAVGSHAVS
MGYAVAQLALQVFSNPEKLTVMMVAAGEMNTLVAKHLAEMGVAKVIICNRSRERAESLAQEIAHQVEVEIIGFDQLAANL
HRADVVSSCTGSLHQVIFYQDVKAALKKRRYNQMLLVDLAVPRDIDSKVETLDGVYLYGVDDLQSVIDENLAQRRQAAVE
AEVMVSQLASQLLTHQKIQQAGSTIQMYREFSQQQSQDEIARALTDLNKGHDAEDVLKQFAHRLTQKMMHPTSILLREAA
QHESPDYFEWMKEQLTDVFEHQRKPKNNLDR

Sequences:

>Translated_431_residues
MSFFALGVNHQTASVELREQVAFNAERLKDLLAQQRNHAHLNDMVVVSTCNRTEVYAMTEHADILLNWLAQTNGIDIKQL
LHHVYRYEDAQAVTHLMRVASGLDSLMLGEPQILGQVKSALALSKESHTVSRDLNRIFEYAFYAAKRVRSETAVGSHAVS
MGYAVAQLALQVFSNPEKLTVMMVAAGEMNTLVAKHLAEMGVAKVIICNRSRERAESLAQEIAHQVEVEIIGFDQLAANL
HRADVVSSCTGSLHQVIFYQDVKAALKKRRYNQMLLVDLAVPRDIDSKVETLDGVYLYGVDDLQSVIDENLAQRRQAAVE
AEVMVSQLASQLLTHQKIQQAGSTIQMYREFSQQQSQDEIARALTDLNKGHDAEDVLKQFAHRLTQKMMHPTSILLREAA
QHESPDYFEWMKEQLTDVFEHQRKPKNNLDR
>Mature_430_residues
SFFALGVNHQTASVELREQVAFNAERLKDLLAQQRNHAHLNDMVVVSTCNRTEVYAMTEHADILLNWLAQTNGIDIKQLL
HHVYRYEDAQAVTHLMRVASGLDSLMLGEPQILGQVKSALALSKESHTVSRDLNRIFEYAFYAAKRVRSETAVGSHAVSM
GYAVAQLALQVFSNPEKLTVMMVAAGEMNTLVAKHLAEMGVAKVIICNRSRERAESLAQEIAHQVEVEIIGFDQLAANLH
RADVVSSCTGSLHQVIFYQDVKAALKKRRYNQMLLVDLAVPRDIDSKVETLDGVYLYGVDDLQSVIDENLAQRRQAAVEA
EVMVSQLASQLLTHQKIQQAGSTIQMYREFSQQQSQDEIARALTDLNKGHDAEDVLKQFAHRLTQKMMHPTSILLREAAQ
HESPDYFEWMKEQLTDVFEHQRKPKNNLDR

Specific function: Catalyzes the NADPH-dependent reduction of glutamyl- tRNA(Glu) to glutamate 1-semialdehyde (GSA)

COG id: COG0373

COG function: function code H; Glutamyl-tRNA reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutamyl-tRNA reductase family

Homologues:

Organism=Escherichia coli, GI1787461, Length=419, Percent_Identity=43.1980906921241, Blast_Score=320, Evalue=1e-88,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): HEM1_ACIAD (Q6F8J3)

Other databases:

- EMBL:   CR543861
- RefSeq:   YP_047444.1
- ProteinModelPortal:   Q6F8J3
- SMR:   Q6F8J3
- STRING:   Q6F8J3
- GeneID:   2878313
- GenomeReviews:   CR543861_GR
- KEGG:   aci:ACIAD2900
- NMPDR:   fig|62977.3.peg.2637
- eggNOG:   COG0373
- HOGENOM:   HBG732626
- OMA:   GPILNRL
- PhylomeDB:   Q6F8J3
- ProtClustDB:   PRK00045
- BioCyc:   ASP62977:ACIAD2900-MONOMER
- GO:   GO:0005737
- HAMAP:   MF_00087
- InterPro:   IPR000343
- InterPro:   IPR015896
- InterPro:   IPR015895
- InterPro:   IPR016040
- InterPro:   IPR018214
- InterPro:   IPR006151
- Gene3D:   G3DSA:3.40.50.720
- PIRSF:   PIRSF000445
- TIGRFAMs:   TIGR01035

Pfam domain/function: PF00745 GlutR_dimer; PF05201 GlutR_N; PF01488 Shikimate_DH; SSF69075 4pyrrol_synth_GluRdtase_C; SSF69742 GlutR

EC number: =1.2.1.70

Molecular weight: Translated: 48659; Mature: 48528

Theoretical pI: Translated: 6.47; Mature: 6.47

Prosite motif: PS00747 GLUTR

Important sites: ACT_SITE 50-50 BINDING 105-105 BINDING 116-116

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSFFALGVNHQTASVELREQVAFNAERLKDLLAQQRNHAHLNDMVVVSTCNRTEVYAMTE
CCEEEEECCCCHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCEEEEEECCCCEEEEEHH
HADILLNWLAQTNGIDIKQLLHHVYRYEDAQAVTHLMRVASGLDSLMLGEPQILGQVKSA
HHHHHHHHHHHCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHCHHHHHCCCHHHHHHHHHH
LALSKESHTVSRDLNRIFEYAFYAAKRVRSETAVGSHAVSMGYAVAQLALQVFSNPEKLT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEE
VMMVAAGEMNTLVAKHLAEMGVAKVIICNRSRERAESLAQEIAHQVEVEIIGFDQLAANL
EEEEECCCHHHHHHHHHHHHCHHEEEEECCCHHHHHHHHHHHHHHHHHEEECHHHHHHHH
HRADVVSSCTGSLHQVIFYQDVKAALKKRRYNQMLLVDLAVPRDIDSKVETLDGVYLYGV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHCCEEEECH
DDLQSVIDENLAQRRQAAVEAEVMVSQLASQLLTHQKIQQAGSTIQMYREFSQQQSQDEI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
ARALTDLNKGHDAEDVLKQFAHRLTQKMMHPTSILLREAAQHESPDYFEWMKEQLTDVFE
HHHHHHCCCCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
HQRKPKNNLDR
HHCCCCCCCCC
>Mature Secondary Structure 
SFFALGVNHQTASVELREQVAFNAERLKDLLAQQRNHAHLNDMVVVSTCNRTEVYAMTE
CEEEEECCCCHHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCEEEEEECCCCEEEEEHH
HADILLNWLAQTNGIDIKQLLHHVYRYEDAQAVTHLMRVASGLDSLMLGEPQILGQVKSA
HHHHHHHHHHHCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHCHHHHHCCCHHHHHHHHHH
LALSKESHTVSRDLNRIFEYAFYAAKRVRSETAVGSHAVSMGYAVAQLALQVFSNPEKLT
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEE
VMMVAAGEMNTLVAKHLAEMGVAKVIICNRSRERAESLAQEIAHQVEVEIIGFDQLAANL
EEEEECCCHHHHHHHHHHHHCHHEEEEECCCHHHHHHHHHHHHHHHHHEEECHHHHHHHH
HRADVVSSCTGSLHQVIFYQDVKAALKKRRYNQMLLVDLAVPRDIDSKVETLDGVYLYGV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHCCEEEECH
DDLQSVIDENLAQRRQAAVEAEVMVSQLASQLLTHQKIQQAGSTIQMYREFSQQQSQDEI
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHH
ARALTDLNKGHDAEDVLKQFAHRLTQKMMHPTSILLREAAQHESPDYFEWMKEQLTDVFE
HHHHHHCCCCCCHHHHHHHHHHHHHHHHHCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHH
HQRKPKNNLDR
HHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA