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The map label for this gene is folP [H]

Identifier: 50085894

GI number: 50085894

Start: 2788851

End: 2789702

Strand: Reverse

Name: folP [H]

Synonym: ACIAD2852

Alternate gene names: 50085894

Gene position: 2789702-2788851 (Counterclockwise)

Preceding gene: 50085895

Following gene: 50085893

Centisome position: 77.52

GC content: 43.19

Gene sequence:

>852_bases
ATGCATTTAAGCCCTTTGCCTCAAAAACAATTGAAATGTGGATCATATTTACTTGATTTATCTGAGCCACAGGTCATGGG
GATTTTAAATGTAACACCAGACTCGTTTAGCGATGGTGGACAGCATCATCAAAAAGAGAAAGCATATGCACATGCCATGC
AAATGATTGGTGATGGTGCATCTATTATTGATATTGGTGGAGAATCGACACGTCCAGGCGCATCCTCTGTTGAGATTGAG
GAAGAAATACGACGTGTAGTACCAGTGGTGGAGATGCTATCTAAAGAGAAAATCATCTTGTCAATTGATACCAGCCAGCC
AGAAGTGATTAAAGCTGCCATAGAAGCAGGTGCGCATATTTGGAATGATGTAAGGGCATTAACCCGCCCTCAGGCGATTG
AAACAGCAGCACAACTTGATATTCCTGTCATCATCATGCATATGCGTGGCGAACCCACTACCATGAATCAATTAGATCAG
TATGGCGATGTTGTTGCAGAGGTGATGCATGAGTTAAGTCAGCGTATTCAAGACGCACTTGATCATGGAATACGAGTTGA
AAATATTGTGGTTGATCCTGGTTTTGGTTTTGCAAAGAATGCTGGGCAGAATTTAAAACTTTTAAACGAGTTATGGAAGT
TTAATGCAATGGGGTATCCGATACTCTCTGGTTTATCCCGAAAACGTTTTATTGGTGAAGCCTTACAAGGAGCGACCGCC
GATCAGCGTGCTATTGGTAGCGTAGCAGGGCATCTGATAAGCCTACAACAAGGTGCTTCAATCGTCAGGGTTCATGATGT
CAAGGCTATGGTAGATGCAATACGCGTTTGGCAAGCAGCACTCAATGCCTGA

Upstream 100 bases:

>100_bases
CAGCTCTTTTTTATTTGGATGTTATTTGACTGGGTGTCAAATGAAATCATTTTTTTAAAACGTATATACTCAAGCTATTT
ATCAATAAATGGAGTAAAAA

Downstream 100 bases:

>100_bases
GTTGAAACTGCTGTATTAAAAACAGTCGCCTTTTGATAAAACTTATGATATAAGCAGCACGTTTTTATTAAAAAGATGTG
CTGATGTTTAACGATCTTCT

Product: 7,8-dihydropteroate synthase

Products: NA

Alternate protein names: DHPS; Dihydropteroate pyrophosphorylase [H]

Number of amino acids: Translated: 283; Mature: 283

Protein sequence:

>283_residues
MHLSPLPQKQLKCGSYLLDLSEPQVMGILNVTPDSFSDGGQHHQKEKAYAHAMQMIGDGASIIDIGGESTRPGASSVEIE
EEIRRVVPVVEMLSKEKIILSIDTSQPEVIKAAIEAGAHIWNDVRALTRPQAIETAAQLDIPVIIMHMRGEPTTMNQLDQ
YGDVVAEVMHELSQRIQDALDHGIRVENIVVDPGFGFAKNAGQNLKLLNELWKFNAMGYPILSGLSRKRFIGEALQGATA
DQRAIGSVAGHLISLQQGASIVRVHDVKAMVDAIRVWQAALNA

Sequences:

>Translated_283_residues
MHLSPLPQKQLKCGSYLLDLSEPQVMGILNVTPDSFSDGGQHHQKEKAYAHAMQMIGDGASIIDIGGESTRPGASSVEIE
EEIRRVVPVVEMLSKEKIILSIDTSQPEVIKAAIEAGAHIWNDVRALTRPQAIETAAQLDIPVIIMHMRGEPTTMNQLDQ
YGDVVAEVMHELSQRIQDALDHGIRVENIVVDPGFGFAKNAGQNLKLLNELWKFNAMGYPILSGLSRKRFIGEALQGATA
DQRAIGSVAGHLISLQQGASIVRVHDVKAMVDAIRVWQAALNA
>Mature_283_residues
MHLSPLPQKQLKCGSYLLDLSEPQVMGILNVTPDSFSDGGQHHQKEKAYAHAMQMIGDGASIIDIGGESTRPGASSVEIE
EEIRRVVPVVEMLSKEKIILSIDTSQPEVIKAAIEAGAHIWNDVRALTRPQAIETAAQLDIPVIIMHMRGEPTTMNQLDQ
YGDVVAEVMHELSQRIQDALDHGIRVENIVVDPGFGFAKNAGQNLKLLNELWKFNAMGYPILSGLSRKRFIGEALQGATA
DQRAIGSVAGHLISLQQGASIVRVHDVKAMVDAIRVWQAALNA

Specific function: DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide [H]

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain [H]

Homologues:

Organism=Escherichia coli, GI87082224, Length=267, Percent_Identity=50.561797752809, Blast_Score=265, Evalue=2e-72,
Organism=Saccharomyces cerevisiae, GI6324073, Length=322, Percent_Identity=32.9192546583851, Blast_Score=147, Evalue=2e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006390
- InterPro:   IPR011005
- InterPro:   IPR000489 [H]

Pfam domain/function: PF00809 Pterin_bind [H]

EC number: =2.5.1.15 [H]

Molecular weight: Translated: 30833; Mature: 30833

Theoretical pI: Translated: 5.78; Mature: 5.78

Prosite motif: PS50972 PTERIN_BINDING ; PS00792 DHPS_1 ; PS00793 DHPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHLSPLPQKQLKCGSYLLDLSEPQVMGILNVTPDSFSDGGQHHQKEKAYAHAMQMIGDGA
CCCCCCCHHHHHHHHHEEECCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHCCCC
SIIDIGGESTRPGASSVEIEEEIRRVVPVVEMLSKEKIILSIDTSQPEVIKAAIEAGAHI
CEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHH
WNDVRALTRPQAIETAAQLDIPVIIMHMRGEPTTMNQLDQYGDVVAEVMHELSQRIQDAL
HHHHHHHHCCHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
DHGIRVENIVVDPGFGFAKNAGQNLKLLNELWKFNAMGYPILSGLSRKRFIGEALQGATA
HCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHCCHHHHHHHHHHHCCCH
DQRAIGSVAGHLISLQQGASIVRVHDVKAMVDAIRVWQAALNA
HHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MHLSPLPQKQLKCGSYLLDLSEPQVMGILNVTPDSFSDGGQHHQKEKAYAHAMQMIGDGA
CCCCCCCHHHHHHHHHEEECCCCCEEEEEECCCCCCCCCCHHHHHHHHHHHHHHHHCCCC
SIIDIGGESTRPGASSVEIEEEIRRVVPVVEMLSKEKIILSIDTSQPEVIKAAIEAGAHI
CEEECCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHHHHH
WNDVRALTRPQAIETAAQLDIPVIIMHMRGEPTTMNQLDQYGDVVAEVMHELSQRIQDAL
HHHHHHHHCCHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
DHGIRVENIVVDPGFGFAKNAGQNLKLLNELWKFNAMGYPILSGLSRKRFIGEALQGATA
HCCCEEEEEEECCCCCCCCCCCCCHHHHHHHHHHCCCCCHHHHCCHHHHHHHHHHHCCCH
DQRAIGSVAGHLISLQQGASIVRVHDVKAMVDAIRVWQAALNA
HHHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12471157 [H]