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The map label for this gene is yngG [H]

Identifier: 50085866

GI number: 50085866

Start: 2757745

End: 2758725

Strand: Direct

Name: yngG [H]

Synonym: ACIAD2820

Alternate gene names: 50085866

Gene position: 2757745-2758725 (Clockwise)

Preceding gene: 50085859

Following gene: 50085867

Centisome position: 76.63

GC content: 41.39

Gene sequence:

>981_bases
CTGTTTCTAGGTTTCCACTGTTTTTGCTGGGTAGGTAAAGGTATGAGCAATCAAAAGGACATCGATATTCTGGTGAGTGA
GGTAGGCCCTCGCGATGGTTTGCAAAGTATTAAGCAGACTATGCCAACTGATATGAAGAAAATGTGGATTTCAGCTTTAT
CTGAAGCAGGAGTGCGAGAAATTGAGGTGGGATCATTCGTACCACCAAAATTATTACCGCAGATGGCCGATTGTGCTGAC
TTGGTTCAGCATGCATTAACTTTAGAAAATGTATTTGTTACTGCGTTAGTACCGAACTTACGTGGTGCAGAGTCAGCATT
TAAATCAGGTGTTCAAAAAATCACAATTCCTGTTTCAGTAAGTGAACCTCATTCTTTATCCAATGTAAGAAAAACTCACG
AACAGATGTACTCAGAGGTTGCATCAATCGTTGCATTGCGGAATGAGCAATATCCGAATGTTTTGATTGAAGCTGGATTA
TCGACAGTATTTGGATGCACGATCCAAGGGATTGTGACTGAAAAAGAAAGCTTATTCATGGCCAATAAAATGGCTGCCTT
AGGTATTGATGAGGTGGGTTTAGCAGACACTGTTGGATATGCCACACCGTTACAGGTCAAGAGTCTATTTAAACAACTGA
AAATTGAATTAGGAAATATTGCAGGTAGTGCACATTTTCATAATACACGCGGACAAGGCTTAGCGAATGTGCTTGCAGCC
TATGAGGTAGGAGTGACAACTTTTGATGCCTCTCAGGGCGGAATAGGAGGATGTCCCTACGCTCCTGGTGCATCAGGAAA
CATTGTGACTGAGGACCTTGTTTTTTTACTCGAAAGTATGGGCCTCCGTACAGGTATTGATATTGAAAAGTTAGTTGCCG
CTAGAGAGTGGTTAAAAAAAGCATTACCAAATGAACCGCTATATGGATTCATCCCTGATGCGGGTGTAGGTAAAGCTTTT
AAATATGCAAAGGATATGTGA

Upstream 100 bases:

>100_bases
CTCCATCAAATTATTAGATCAAAGTCTAAGCATATTTGTAGATATTATTTATTTGCATTTAAAATAGAATAGTGCTCTAC
TAGATAGAACTAGACGAAAT

Downstream 100 bases:

>100_bases
AATGAGTATTGAAAAACCAAATAATCTTCCGCTATCAGGTATTCGTGTACTTGAATTTGTTCATATGGTTATGGGACCAG
CATGTGGATTAATGTTGGCT

Product: hydroxymethylglutaryl-CoA lyase

Products: NA

Alternate protein names: HL; HMG-CoA lyase; 3-hydroxy-3-methylglutarate-CoA lyase [H]

Number of amino acids: Translated: 326; Mature: 326

Protein sequence:

>326_residues
MFLGFHCFCWVGKGMSNQKDIDILVSEVGPRDGLQSIKQTMPTDMKKMWISALSEAGVREIEVGSFVPPKLLPQMADCAD
LVQHALTLENVFVTALVPNLRGAESAFKSGVQKITIPVSVSEPHSLSNVRKTHEQMYSEVASIVALRNEQYPNVLIEAGL
STVFGCTIQGIVTEKESLFMANKMAALGIDEVGLADTVGYATPLQVKSLFKQLKIELGNIAGSAHFHNTRGQGLANVLAA
YEVGVTTFDASQGGIGGCPYAPGASGNIVTEDLVFLLESMGLRTGIDIEKLVAAREWLKKALPNEPLYGFIPDAGVGKAF
KYAKDM

Sequences:

>Translated_326_residues
MFLGFHCFCWVGKGMSNQKDIDILVSEVGPRDGLQSIKQTMPTDMKKMWISALSEAGVREIEVGSFVPPKLLPQMADCAD
LVQHALTLENVFVTALVPNLRGAESAFKSGVQKITIPVSVSEPHSLSNVRKTHEQMYSEVASIVALRNEQYPNVLIEAGL
STVFGCTIQGIVTEKESLFMANKMAALGIDEVGLADTVGYATPLQVKSLFKQLKIELGNIAGSAHFHNTRGQGLANVLAA
YEVGVTTFDASQGGIGGCPYAPGASGNIVTEDLVFLLESMGLRTGIDIEKLVAAREWLKKALPNEPLYGFIPDAGVGKAF
KYAKDM
>Mature_326_residues
MFLGFHCFCWVGKGMSNQKDIDILVSEVGPRDGLQSIKQTMPTDMKKMWISALSEAGVREIEVGSFVPPKLLPQMADCAD
LVQHALTLENVFVTALVPNLRGAESAFKSGVQKITIPVSVSEPHSLSNVRKTHEQMYSEVASIVALRNEQYPNVLIEAGL
STVFGCTIQGIVTEKESLFMANKMAALGIDEVGLADTVGYATPLQVKSLFKQLKIELGNIAGSAHFHNTRGQGLANVLAA
YEVGVTTFDASQGGIGGCPYAPGASGNIVTEDLVFLLESMGLRTGIDIEKLVAAREWLKKALPNEPLYGFIPDAGVGKAF
KYAKDM

Specific function: Involved in the catabolism of branched amino acids such as leucine (Probable) [H]

COG id: COG0119

COG function: function code E; Isopropylmalate/homocitrate/citramalate synthases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the HMG-CoA lyase family [H]

Homologues:

Organism=Homo sapiens, GI62198232, Length=280, Percent_Identity=36.7857142857143, Blast_Score=192, Evalue=5e-49,
Organism=Homo sapiens, GI109150427, Length=296, Percent_Identity=34.1216216216216, Blast_Score=190, Evalue=1e-48,
Organism=Homo sapiens, GI109150422, Length=280, Percent_Identity=35, Blast_Score=189, Evalue=3e-48,
Organism=Homo sapiens, GI260654708, Length=123, Percent_Identity=43.0894308943089, Blast_Score=112, Evalue=6e-25,
Organism=Caenorhabditis elegans, GI17510563, Length=283, Percent_Identity=38.86925795053, Blast_Score=187, Evalue=7e-48,
Organism=Drosophila melanogaster, GI24582381, Length=299, Percent_Identity=34.1137123745819, Blast_Score=182, Evalue=2e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000891 [H]

Pfam domain/function: PF00682 HMGL-like [H]

EC number: =4.1.3.4 [H]

Molecular weight: Translated: 35067; Mature: 35067

Theoretical pI: Translated: 5.67; Mature: 5.67

Prosite motif: PS50991 PYR_CT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.4 %Met     (Mature Protein)
4.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFLGFHCFCWVGKGMSNQKDIDILVSEVGPRDGLQSIKQTMPTDMKKMWISALSEAGVRE
CCCCEEEEEEECCCCCCCCCHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHHHHCCCCE
IEVGSFVPPKLLPQMADCADLVQHALTLENVFVTALVPNLRGAESAFKSGVQKITIPVSV
EECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCEEEEEEEEC
SEPHSLSNVRKTHEQMYSEVASIVALRNEQYPNVLIEAGLSTVFGCTIQGIVTEKESLFM
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ANKMAALGIDEVGLADTVGYATPLQVKSLFKQLKIELGNIAGSAHFHNTRGQGLANVLAA
HHHHHHCCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHH
YEVGVTTFDASQGGIGGCPYAPGASGNIVTEDLVFLLESMGLRTGIDIEKLVAAREWLKK
HHHCCEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHH
ALPNEPLYGFIPDAGVGKAFKYAKDM
HCCCCCCEEECCCCCCCHHHHHHHCC
>Mature Secondary Structure
MFLGFHCFCWVGKGMSNQKDIDILVSEVGPRDGLQSIKQTMPTDMKKMWISALSEAGVRE
CCCCEEEEEEECCCCCCCCCHHHHHHHCCCHHHHHHHHHHCCHHHHHHHHHHHHHCCCCE
IEVGSFVPPKLLPQMADCADLVQHALTLENVFVTALVPNLRGAESAFKSGVQKITIPVSV
EECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHCCCEEEEEEEEC
SEPHSLSNVRKTHEQMYSEVASIVALRNEQYPNVLIEAGLSTVFGCTIQGIVTEKESLFM
CCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ANKMAALGIDEVGLADTVGYATPLQVKSLFKQLKIELGNIAGSAHFHNTRGQGLANVLAA
HHHHHHCCCCCCCCHHHHCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHH
YEVGVTTFDASQGGIGGCPYAPGASGNIVTEDLVFLLESMGLRTGIDIEKLVAAREWLKK
HHHCCEEEECCCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHH
ALPNEPLYGFIPDAGVGKAFKYAKDM
HCCCCCCEEECCCCCCCHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9387222; 9384377 [H]